@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10J1_HUMAN: (2016-01-11 )
MLLCFRFGNQSMKRENFTLITDFVFQGFSSFHEQQITLFGVFLALYILTLAGNIIIVTIIRMDLHLHTPMYFFLSMLSTSETVYTLVILPRMLSSLVGMSQPISLAGCATQMFFFVTFGITNCFLLTAMGYDRYVAICNPLRYMVIMNKRLRIQLVLGACSIGLIVAITQVTSVFRLPFCARKVPHFFCDIRPVMKLSCIDTTVNEILTLIISVLVLVVPMGLVFISYVLIISTILKIASVEGRKKAFATCASHLTVVIVHYSCASIAYLKPKSENTREHDQLISVTYTVITPLLNPVVYTLRNKEVKDALCRAVGGKFS
Atome Classification :
(20 SA)
---------------------------------------------------.........10.........20....-....30------........40........50.---........60..-----..---....70........80.......-.90........100.......110.......120.......130.......140..--------------------------------------------------.....150......---.160...--....170.-------......180.......190-...-----......-------200-----......------...210.........220-...-----.-.---..230..----.-----------..-----..240---------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------....---------....----------250.......260.----......270.....---.------------.------280-------.....---..290.------...---------...300.......310.......320----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------
M
L
L
C
F
RFGNQ-SMKRENF
T
L
I
T
D
F
V
F
-
Q
G
F
S
S
F
------
H
E
Q
Q
I
T
L
F
G
V
F
L
A
L
Y
I
L
T
L-A---G
N
I
I
I
V
T
I
I
R
M
D
-----
L
H
---LH
T
P
M
Y
F
F
L
S
M
LSTSE
T
V
Y
T
L
V
I
-
L
P
R
M
L
S
S
L
VGMSQP
I
S
L
A
G
C
A
T
Q
M
F
F
F
V
T
FGIT
N
C
F
L
L
TAMGYDR
Y
V
A
I
C
N
P
L
R
Y
M
--------------------------------------------------
V
I
MNK
R
L
R
I
Q
L
V
LG---ACS
I
G
L
I
--
V
A
I
T
Q
V
T
S
-------
V
FRL
P
F
C
A
R
KV
P
H
F
F
CD---IR
P
-----
V
M
K
L
S
C
-------
I
-------
D
T
T
V
N
E
------
I
L
T
L
--
I
I
S
V
L
V
L
V
V
P
M
G
-
L
V
F
-----
I
-
S
---
Y
V
L
I
I
S
T
----
I
-----------
L
K
-----
I
AS-----------------------------------------------------------------------------------------------------------------------------------------------------------------V-----------------------------------------------------------------------------------------------------------------------------------------------------------------E
G
R
K
---------
K
A
F
A
----------
T
C
A
S
H
L
T
V
V
I
V
HYS----C
A
S
I
A
Y
LKPKSENT---
R
------------
E
------
H
D
Q
-------
L
I
S
V
T
---
Y
T
V
I
T
P
------
L
L
N
---------
P
V
V
Y
T
LRN
K
E
V
K
D
A
L
C
R
A
VGGKFS------------------------------
37
HHSearch
90.03
16%
-147
- C3 -
2Z73
5
OPSD_TODPA
A:
[29-332]
----------------------------------------------------------------------------------
V
P
------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
-
G
---
G
N
G
I
V
I
Y
L
F
T
K
T
-----
K
S
---
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
--------------------------------------------------
K
K
M
S
H
R
R
A
F
I
M
I
I
F
---
V
W
L
W
S
V
L
--
W
A
I
G
P
I
F
G
-------
W
G
A
Y
T
L
---
E
G
V
L
C
N
C
S
---
F
D
Y
-----
I
S
-------------------
R
D
S
T
T
R
------
S
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
-
I
I
F
-----
F
-
C
---
Y
F
N
I
V
M
S
----
V
-----------
S
N
-----
H
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
---------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
---------
R
L
A
K
----------
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
----
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
EWV
T
------------
P
------
Y
A
A
-------
Q
L
P
V
M
---
F
A
K
A
S
A
------
I
H
N
---------
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
------------------------------
35
HHSearch
89.15
17%
-140
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
-
G
---
L
N
L
L
V
L
Y
A
V
R
S
E
-----
R
K
---
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
--------------------------------------------------
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
---
A
W
F
L
S
F
L
--
W
V
I
P
I
L
G
W
--------
N
H
-------
R
R
E
D
K
C
E
---
T
D
F
-----
Y
D
-----------------------
V
T
------
W
F
K
V
--
M
T
A
I
I
N
F
Y
L
P
T
L
-
L
M
L
-----
W
-
F
---
Y
A
K
I
Y
K
A
----
V
-----------
R
Q
-----
H
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM
N
R
E
R
---------
K
A
A
K
----------
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
----
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
CC-
N
------------
E
------
H
L
H
-------
M
F
T
I
W
---
L
G
Y
I
N
S
------
T
L
N
---------
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------
33
HHSearch
87.80
18%
-141
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
-
I
---
G
N
I
L
V
M
V
S
I
K
V
N
-----
R
H
---
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
--------------------------------------------------
V
K
R
T
T
K
M
A
G
M
M
I
A
A
---
A
W
V
L
S
F
I
--
L
W
A
P
A
I
L
F
-------
W
Q
F
I
V
G
V
R
-
T
V
E
D
G
E
C
Y
---
I
Q
F
-----
F
-----------------------
S
N
A
------
A
V
T
F
--
G
T
A
I
A
A
F
Y
L
P
V
I
-
I
M
T
-----
V
-
L
---
Y
W
H
I
S
R
A
----
S
-----------
K
S
-----
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
---------
K
V
T
R
----------
T
I
L
A
I
L
L
A
F
I
I
T
W
A
----
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
CI-
P
------------
N
------
T
V
W
-------
T
I
G
Y
W
---
L
C
Y
I
N
S
------
T
I
N
---------
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------
39
HHSearch
87.33
16%
-139
- C3 -
2KS9
1
NK1R_HUMAN
A:
[31-324]
--------------------------------------------------------------------------------------------
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
-
V
---
G
N
V
V
V
M
W
I
I
L
A
H
-----
K
R
---
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
--------------------------------------------------
L
--
S
A
T
A
T
K
V
V
I
C
V
---
I
W
V
L
A
L
L
--
L
A
F
P
Q
G
Y
Y
-------
S
T
T
E
T
----
M
P
S
R
V
V
C
M
---
I
E
W
-----
P
E
H
P
-----------------
N
K
I
Y
E
K
------
V
Y
H
I
--
C
V
T
V
L
I
Y
F
L
P
L
L
-
V
I
G
-----
Y
-
A
---
Y
T
V
V
G
I
T
----
L
-----------
W
A
-----
S
E
I
PGDSSDRYH
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
---------
K
V
V
K
----------
M
M
I
V
V
V
C
T
F
A
I
C
W
L
----
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
---
L
------------
Y
LKKFI
Q
Q
V
Y
-------
L
A
I
M
W
---
L
A
M
S
S
T
------
M
Y
N
---------
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
------------------------------
52
Fugue
86.73
16%
-127
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------------------------------
M
N
G
T
E
G
P
N
F
-
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
-
E
A
P
Q
Y
Y
------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
---
G
F
P
I
N
F
L
T
L
Y
V
T
-----
V
Q
H
KK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-------------------------------------------------------
N
F
R
F
G
E
N
H
A
I
M
---
G
V
A
F
T
W
V
--
M
A
L
A
C
A
A
P
-------
P
L
--
V
G
W
S
R
Y
I
P
E
G
---------------
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
------
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
-
V
I
F
-----
F
-
C
---
Y
G
Q
L
V
F
T
----
V
-----------
K
E
-----
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---------
K
A
E
K
----------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
----
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
------------
H
------
Q
G
S
DFGPIFM
T
I
P
A
F
---
F
A
K
T
S
A
------
V
Y
N
---------
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A--------------
57
Fugue
80.68
16%
-138
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------------------------------------------------
S
F
K
C
-------
A
L
T
K
T
G
F
-----------------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
-
L
---
G
N
S
V
A
I
W
M
F
V
F
H
-----
M
K
---
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
-------------------------------------------------------
G
R
L
K
K
K
N
A
I
C
---
I
S
V
L
V
W
L
--
I
V
V
V
A
I
S
P
-------
I
L
F
Y
S
G
---------
T
G
---
V
R
K
-----
N
K
T
I
T
C
-------
Y
-------
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
--
C
T
T
V
A
M
F
C
V
P
L
V
-
L
I
L
-----
G
-
C
---
Y
G
L
I
V
R
A
----
L
-----------
I
Y
K
M
K
K
Y
T
C
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
Y
I
Y
N
PEDGDPD
N
G
V
N
----------
P
G
T
D
F
K
D
I
V
C
P
L
C
G
----
V
G
K
D
Q
F
E
E
V
E
E
P
L
R
---
R
------------
K
------
S
I
Y
-------
L
V
I
I
V
---
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
---------
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
40
HHSearch
80.42
18%
-137
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[59-495]
-----------------------------------------------------------------------------------
K
------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
-
L
---
E
N
I
F
V
L
L
T
I
W
K
T
-----
K
K
---
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
-
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
----------------------------------------------------------
N
N
F
R
L
F
L
L
I
S
A
---
C
W
V
I
S
L
I
--
L
G
G
L
P
I
M
G
-------
W
N
C
I
------
S
A
L
S
S
C
S
---
T
V
L
-----
P
L
-----------------------
Y
H
------
K
H
Y
I
--
L
F
C
T
T
V
F
T
L
L
L
L
-
S
I
V
-----
I
-
L
---
Y
C
R
I
Y
S
L
----
V
-----------
R
T
-----
R
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
S
E
N
V
---------
A
L
L
K
----------
T
V
I
I
V
L
S
V
F
I
A
C
W
A
----
P
L
F
I
L
L
L
L
D
V
G
C
K
V
---
K
TC
D
I
--------
L
------
F
R
A
-------
E
Y
F
L
V
---
L
A
V
L
N
S
------
G
T
N
---------
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-------------------------------
53
Fugue
77.82
16%
-107
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
-
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
-----
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-------------------------------------------------------
N
F
R
F
G
E
N
H
A
I
M
---
G
V
A
F
T
W
V
--
M
A
L
A
C
A
A
P
-------
P
L
--
V
G
W
S
R
Y
I
P
E
G
---------------
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
------
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
-
V
I
F
-----
F
-
C
---
Y
G
Q
L
V
F
T
----
V
KEAAAQQQESA
T
T
-----
Q
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
---------
R
M
V
I
----------
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
----
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
---
G
------------
P
------
I
F
M
-------
T
I
P
A
F
---
F
A
K
T
S
A
------
V
Y
N
---------
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA--------
41
HHSearch
76.63
16%
-123
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-326]
-------------------------------------------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
-
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
-----
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--------------------------------------------------
R
F
-
G
E
N
H
A
I
M
G
V
A
F
---
T
W
V
M
A
L
A
--
C
A
A
P
P
L
V
G
-------
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
---
I
D
Y
-----
Y
T
P
H
-----------------
E
E
T
N
N
E
------
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
-
V
I
F
-----
F
-
C
---
Y
G
Q
L
V
F
T
----
V
-----------
K
E
-----
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
---------
E
V
T
R
----------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
----
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
SDF
G
------------
P
------
I
F
M
-------
T
I
P
A
F
---
F
A
K
T
S
A
------
V
Y
N
---------
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------------------------------
60
Fugue
75.77
14%
-147
- C3 -
2W7O
3
POLK_HUMAN
A:
[15-501]
----------------------------------------KEK
I
N
K
I
I
M
E
A
T
K
G
S
R
F
Y
G
N
E
-
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
-
Q
Q
K
A
Q
I
------
T
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
-
E
---
Q
S
---
R
N
L
S
N
T
I
-----
V
H
---
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
-
A
V
G
S
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
DPNFMAMSLD
E
A
Y
L
NI
T
K
H
L
E
E
R
Q
NWPEDKRRYFIKQN
S
V
V
F
G
TS
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
TT
L
T
A
S
A
G
I
A
PN
T
M
L
A
K
V
C
S
D
K
NKPN
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
---
L
-
P
-----
I
R
K
V
S
G
-------
I
-------
G
K
V
T
E
K
------
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
-
L
L
S
L
L
FSE
T
-
S
---
W
H
Y
F
L
H
I
----
S
-----------
L
G
-----
L
G
S
T
H
L
T
R
DGERK-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
E
---------
R
T
F
S
----------
E
I
N
K
A
E
E
Q
Y
S
L
C
Q
E
----
L
C
S
E
L
A
Q
D
L
Q
K
E
R
L
---
K
------------
G
------
R
T
V
-------
T
I
K
L
K
N
VN
F
E
V
K
T
R
------
A
S
T
---------
V
S
S
V
V
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
ADFPHPLRLR
L
M
G
V
R
I
SSFPNE--------
55
Fugue
73.90
14%
-140
- C2 -
4QLA
1
HYEP_BOMMO
A:
[19-442]
LDLEEWWGPPELKQKQDT
S
I
K
P
F
E
I
T
FS
E
T
M
V
K
E
L
K
E
R
I
K
K
RRPFAPPLEG
V
G
F
K
Y
G
F
N
S
K
-
Q
L
D
S
W
L
K
Y
W
A
E
E
Y
P
F
-
A
E
R
Q
K
F
L
N
Q
Y
P
H
F
K
T
N
I
Q
G
L
N
I
H
F
M
R
I
T
P
K
V
-
P
---
K
G
V
E
I
V
P
L
L
L
L
H
G
W
PGS
V
R
---
E
F
Y
E
A
I
P
H
L
T
A
V
S
K
D
R
N
F
A
L
E
I
I
-
A
P
S
L
P
G
--
Y
G
F
S
D
A
A
V
R
P
G
L
A
-----
A
A
E
V
A
V
I
F
K
N
L
M
A
R
L
G
Y
K
Q
Y
Y
V
Q
G
G
--
D
W
G
--------------------------------------------------
A
L
I
G
S
A
M
A
T
F
F
P
K
E
---
I
I
G
F
H
S
N
--
M
A
L
T
L
S
P
A
-------
A
T
F
L
E
F
V
G
A
L
F
P
S
L
I
V
E
PEL
A
N
R
-----
L
Y
P
L
S
E
-------
K
-------
Y
S
T
L
L
E
------
E
L
G
Y
--
M
H
I
Q
A
T
K
P
D
T
V
G
-
I
G
L
-----
T
D
S
---
P
A
G
L
L
A
Y
----
I
-----------
L
E
-----
K
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
N
P
---------
D
L
R
S
KEDGGLSYRW
T
K
D
Q
L
I
D
N
L
M
L
Y
W
S
T
KS
I
V
T
S
M
R
L
Y
A
E
S
F
S
S
R
---
H
------------
F
------
D
L
K
-------
L
D
E
I
Q
---
V
Q
V
P
T
W
------
V
L
Q
A
KHEL
A
Y
Q
P
P
C
I
L
K
M
K
Y
P
K
L
V
N
A
S
V
I
E
D
G
G
H
F
L
AFEL
P
E
I
F
A
K
D
V
L
K
A
I
G
E
F
R
K
L
K
N------
19
PsiBlast_PDB
72.22
22%
-163
- C3 -
2YCW
7
ADRB1_MELGA
A:
[3-219]
--------------------------------------------------------------------------------
A
E
L
L
------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
-----
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
--------------------------------------------------
S
L
M
T
-
R
A
R
A
K
V
I
I
-----
C
T
V
W
A
I
--
S
A
L
V
S
F
------------
L
P
I
----
M
M
H
W
W
R
D
---
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
------
A
Y
A
I
--
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
-----
V
-
A
L
R
V
Y
R
E
A
K
E
Q
----
I
-----------
R
K
-----
I
D
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
K
---------
R
V
M
L
----------
M
R
E
H
K
A
L
K
T
L
G
I
I
M
----
G
V
F
T
L
C
W
L
P
F
F
L
V
N
---
I
------------
V
------
N
V
F
-------
N
R
D
L
V
---
P
D
W
L
F
V
------
A
F
N
---------
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
------------------------------
20
PsiBlast_PDB
71.75
22%
-160
- C3 -
2YCX
3
ADRB1_MELGA
A:
[9-219]
--------------------------------------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
-----
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
--------------------------------------------------
S
L
M
T
-
R
A
R
A
K
V
I
I
-----
C
T
V
W
A
I
--
S
A
L
V
S
F
------------
L
P
I
----
M
M
H
W
W
R
D
---
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
------
A
Y
A
I
--
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
-----
V
-
A
L
R
V
Y
R
E
A
K
E
Q
----
I
-----------
R
K
-----
I
D
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
K
---------
R
V
M
L
----------
M
R
E
H
K
A
L
K
T
L
G
I
I
M
----
G
V
F
T
L
C
W
L
P
F
F
L
V
N
---
I
------------
V
------
N
V
F
-------
N
R
D
L
V
---
P
D
W
L
F
V
------
A
F
N
---------
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
------------------------------
44
HHSearch
71.69
14%
-120
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-------------------------------------------------------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
-
L
---
G
N
S
L
V
M
L
V
I
L
Y
S
-----
R
V
---
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
--------------------------------------------------
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
---
C
W
G
L
S
M
N
--
L
S
L
P
F
F
L
F
-------
R
Q
A
Y
H
P
---
N
N
S
S
P
V
C
Y
---
E
V
L
-----
G
N
D
------------------
T
A
K
W
R
M
------
V
L
R
I
--
L
P
H
T
F
G
F
I
V
P
L
F
-
V
M
L
-----
F
-
C
---
Y
G
F
T
L
R
T
----
L
-----------
F
K
-----
A
H
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
---------
R
A
M
R
----------
V
I
F
A
V
V
L
I
F
L
L
C
W
L
----
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
---
Q
VIQE
S
C
E
R
R
N
N
I
G
------
R
A
L
-------
D
A
T
E
I
---
L
G
F
L
H
S
------
C
L
N
---------
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-------------------------------
3
PsiBlast_PDB
70.72
19%
-148
- C3 -
3SN6
1
ENLYS_BPT4
R:
[151-388]
--------------------------------------------------------
R
W
Y
N
Q
-
T
P
N
R
A
K
-
R
V
I
T
T
F
R
T
-
G
T
W
D
A
----------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
IVF
G
N
V
L
V
I
T
A
I
A
K
F
-----
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--------------------------------------------------
S
L
L
T
K
N
K
A
R
V
I
I
L
---------
M
V
--
W
I
V
S
G
L
T
S
-------
F
L
P
I
Q
M
H
W
Y
R
---
Q
E
A
----
I
N
C
-----
Y
A
E
E
T
C
-------
C
-------
D
F
F
T
N
Q
------
A
Y
A
I
--
A
S
S
I
V
S
F
Y
V
P
L
V
-
I
M
V
-----
F
-
V
---
Y
S
R
V
F
Q
E
AKRQ
L
-----------
Q
K
-----
I
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
R
C
---------
L
K
E
H
----------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
----
L
C
W
L
P
F
F
I
V
N
I
V
H
V
---
I
------------
Q
------
D
N
L
-------
I
R
K
E
V
---
Y
I
L
L
N
W
------
I
G
Y
---------
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
------------------------------
11
PsiBlast_PDB
67.69
19%
-141
- C3 -
4LDO
3
ENLYS_BPT4
A:
[151-361]
--------------------------------------------------------
R
W
Y
N
Q
-
T
P
N
R
A
K
-
R
V
I
T
T
F
R
T
-
G
T
W
D
A
Y
------
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-----
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--------------------------------------------------
S
L
L
T
K
N
K
A
R
V
I
I
L
---------
M
V
--
W
I
V
S
G
L
T
S
-------
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----
I
N
C
-----
Y
A
E
E
T
C
-------
C
-------
D
F
F
T
N
Q
------
A
Y
A
I
--
A
S
S
I
V
S
F
Y
V
P
L
V
-
I
M
V
-----
F
-
V
---
Y
S
R
V
F
Q
E
----
A
-----------
K
R
-----
Q
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
L
K
---------
E
H
K
A
----------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
----
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
---
D
------------
N
------
L
I
R
-------
K
E
V
Y
I
---
L
L
N
W
I
G
------
Y
V
N
---------
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------
12
PsiBlast_PDB
67.52
19%
-138
- C3 -
4QKX
2
ADRB2_HUMAN
A:
[151-361]
--------------------------------------------------------
R
W
Y
N
Q
-
T
P
N
R
A
K
-
R
V
I
T
T
F
R
T
-
G
T
W
D
A
Y
------
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-----
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--------------------------------------------------
S
L
L
T
K
N
K
A
R
V
I
I
L
---------
M
V
--
W
I
V
S
G
L
T
S
-------
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----
I
N
C
-----
Y
A
E
E
T
C
-------
C
-------
D
F
F
T
N
Q
------
A
Y
A
I
--
A
S
S
I
V
S
F
Y
V
P
L
V
-
I
M
V
-----
F
-
V
---
Y
S
R
V
F
Q
E
----
A
-----------
K
R
-----
Q
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
L
K
---------
E
H
K
A
----------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
----
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
---
D
------------
N
------
L
I
R
-------
K
E
V
Y
I
---
L
L
N
W
I
G
------
Y
V
N
---------
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------
9
PsiBlast_PDB
67.38
19%
-139
- C3 -
4LDE
3
ENLYS_BPT4
A:
[151-361]
--------------------------------------------------------
R
W
Y
N
Q
-
T
P
N
R
A
K
-
R
V
I
T
T
F
R
T
-
G
T
W
D
A
Y
------
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-----
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--------------------------------------------------
S
L
L
T
K
N
K
A
R
V
I
I
L
---------
M
V
--
W
I
V
S
G
L
T
S
-------
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----
I
N
C
-----
Y
A
E
E
T
C
-------
C
-------
D
F
F
T
N
Q
------
A
Y
A
I
--
A
S
S
I
V
S
F
Y
V
P
L
V
-
I
M
V
-----
F
-
V
---
Y
S
R
V
F
Q
E
----
A
-----------
K
R
-----
Q
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
L
K
---------
E
H
K
A
----------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
----
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
---
D
------------
N
------
L
I
R
-------
K
E
V
Y
I
---
L
L
N
W
I
G
------
Y
V
N
---------
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------
10
PsiBlast_PDB
67.15
19%
-143
- C3 -
4LDL
3
ADRB2_HUMAN (first)
A:
[151-361]
--------------------------------------------------------
R
W
Y
N
Q
-
T
P
N
R
A
K
-
R
V
I
T
T
F
R
T
-
G
T
W
D
A
Y
------
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-----
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--------------------------------------------------
S
L
L
T
K
N
K
A
R
V
I
I
L
---------
M
V
--
W
I
V
S
G
L
T
S
-------
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----
I
N
C
-----
Y
A
E
E
T
C
-------
C
-------
D
F
F
T
N
Q
------
A
Y
A
I
--
A
S
S
I
V
S
F
Y
V
P
L
V
-
I
M
V
-----
F
-
V
---
Y
S
R
V
F
Q
E
----
A
-----------
K
R
-----
Q
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
L
K
---------
E
H
K
A
----------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
----
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
---
D
------------
N
------
L
I
R
-------
K
E
V
Y
I
---
L
L
N
W
I
G
------
Y
V
N
---------
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------
36
HHSearch
64.91
17%
-160
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
---------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
-
F
---
G
N
V
L
V
I
T
A
I
A
K
F
-----
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--------------------------------------------------
S
L
L
T
K
N
K
A
R
V
I
I
L
M
---
V
W
I
V
S
G
L
--
T
S
F
L
P
I
Q
M
H------
W
Y
R
A
T
----
H
Q
E
A
I
N
C
Y
---
A
E
---------
E
T
C
-------
C
-------
D
F
F
T
N
Q
------
A
Y
A
I
--
A
S
S
I
V
S
F
Y
V
P
L
V
-
I
M
V
-----
F
-
V
---
Y
S
R
V
F
Q
E
----
A
-----------
K
R
-----
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
---------
R
I
D
E
----------
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
----
T
I
G
I
G
H
L
L
T
K
S
P
S
L
---
N
------------
A
------
A
K
S
-------
E
L
D
K
A
---
I
G
R
N
T
N
------
G
V
I
---------
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
------------------------------