@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10J3_HUMAN: (2016-01-11 )
MPKLNSTFVTEFLFEGFSSFRRQHKLVFFVVFLTLYLLTLSGNVIIMTIIRLDHHLHTPMYFFLCMLSISETCYTVAIIPHMLSGLLNPHQPIATQSCATQLFFYLTFGINNCFLLTVMGYDRYVAICNPLRYSVIMGKRACIQLASGSLGIGLGMAIVQVTSVFGLPFCDAFVISHFFCDVRHLLKLACTDTTVNEIINFVVSVCVLVLPMGLVFISYVLIISTILKIASAEGQKKAFATCASHLTVVIIHYGCASIIYLKPKSQSSLGQDRLISVTYTHHSPTEPCCVQPEEQGGQRCSAQSRGAKNSVSLMKRGCEGFSFAFINMY
Atome Classification :
(20 SA)
----------------.........10........20........30------------------------...--.....40------.-.......50..------------------......60........70.......-.80...---------.....90........100.........110...--...-----------------.120.......130.......140--.........150-------------------------........160.-......170...-....180-------...-----------......190-----.--------....--..-..200....-...210--------------.........220......------.230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------....-...240.......250.--------...------...260.....------------.----------.270--.--........280.......290..-----.....300.......310....-...320---------....-....---------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MPK
L
N
S
T
F
V
T
E
F
L
F
E
G
F
S
S
F
R
R
Q
H
K
L
V
F
F
V
V
------------------------
F
L
T
--
L
Y
L
L
TLS------G-
N
V
I
I
M
T
I
I
RLD------------------HHLH
T
P
M
Y
F
F
L
C
M
L
S
ISET
C
Y
T
V
A
I
-
I
P
H
M
L
S
---------
G
LLNPHQPI
A
T
Q
S
C
A
T
--
Q
L
F
F
Y
L
T
FGIN
N
C
F
L
--
L
T
V-----------------MGYD
R
Y
V
A
I
CNP
L
R
Y
S
V
I
MG
K
R
----
A
C
I
Q
LASGSL
G
--------------------------
I
G
L
G
M
A
I
V
Q
V
T
S
-VFGL
P
F
C
D
A
F
V
I
-
S
H
F
F
C
---------
D
V
R
-----------
H
L
L
K
LAC-------T--------D
T
T
V
--
N
E
-
I
I
N
F
V
V
S
V
C
-
V
L
V
L
----------------
P
M
G
L
V
F
I
S
Y
V
L
I
I
S
T
I
L
K
------
I
AS-----------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------EG
Q
K
-
K
A
F
A
T
C
A
S
H
L
T
V
V
I
I
HY--------GC
A
------
S
I
I
Y
LKPKSQS------------S----------LG----Q--
D
R
L
I
S
V
T
Y
THHSPTEPCCVQ
P
E
E-----QGGQRCSAQSRGAK
N
S
V
S
L
M
K
R-GCEGF----------
S
F
A
F
-
I
NMY---------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
83.65
15%
-126
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
------------------------------------------
F
I
V
L
V
------------------------
A
G
S
--
L
S
L
V
T
I
I
------
G
-
N
I
L
V
M
V
S
I
K
V
N
------------------
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
---------
Y
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
--
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
--
L
L
I
-----------------
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
----
M
A
G
M
M
I
A
A
A
W
V
--------------------------
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
V
R
--
T
V
-
E
D
G
E
C
---------
Y
I
Q
-----------
F
F
------------------------
S
--
N
A
-
A
V
T
F
G
T
A
I
A
-
A
F
Y
L
----------------
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
-
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
--------
A
P
Y
------
N
V
M
V
L
I
N
T
F
C
A
------------
P
CI--------
P
N
----
T
--
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
-----
N
A
T
F
K
-
K
T
F
K
H
L
L
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
81.31
15%
-137
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------
S
S
-
V
Y
I
T
V
------------------------
E
L
A
--
I
A
V
L
A
I
L
------
G
-
N
V
L
V
C
W
A
V
W
L
N
------------------
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
---------
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
--
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
-----------------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
----
R
A
K
G
I
I
A
I
C
W
V
--------------------------
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
--------
S
Q
G
C
---------
G
E
G
-----------
Q
V
---
A
C
-------
L
--------
F
E
D
V
VP
M
N
-
Y
M
V
Y
F
N
F
F
A
-
C
V
L
V
----------------
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
------
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
E
V
-
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
--------
L
P
L
------
H
I
I
N
C
F
T
F
F
C
P
------------
D
CSHA------
P
L
----
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
-----
I
R
E
F
R
-
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
80.94
14%
-123
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
------------------------
Y
M
F
L
-
L
I
M
L
G
F
P
------
I
-
N
F
L
T
L
Y
V
T
V
Q
H
------------------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
---------
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
-----------------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-------------
F
R
F
G
E
N
H
A
I
--------------------------
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
---
V
G
W
-
S
R
Y
I
P
---------
E
--------------
G
M
Q
C
S
C
-------
G
I
DYYTPHE
E
T
N
N
--
E
S
-
F
V
I
Y
M
F
V
V
H
--
F
I
I
----------------
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
------
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
------
F
Y
I
F
T
H
Q
G
S
D
F
------------
G
----------
P
I
----
F
--
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-----
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
-
K
T
E
T
S
----------
Q
V
A
P
-
A
------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
80.53
19%
-118
* C4 *
4NNB
2
?
A:
[4-527]
T
S
L
Y
I
T
A
A
P
I
GA
V
P
K
F
L
D
P
F
E
A
T
F
I
P
S
F
L
L
E
G
F
F
D
A
D
R
C
A
S
I
A
A
D
L
K
T
D
G
W
E
V
V
P
A
G
G
R
L
L
Q
V
GHAQPIAH
F
P
K
--
P
W
L
A
A
L
S
------
N
-
K
L
A
R
R
I
V
L
Q
L
T
T
Y
G
W
I
V
S
EQG
D
L
L
W
EHE
R
Q
H
H
Y
L
P
P
A
L
I
E
A
I
E
K
E
S
P
A
L
L
K
N
M
E
-
E
A
G
W
I
A
C
A
A
GYWQAG
K
A
R
S
P
Y
L
P
I
T
P
E
A
I
T
E
--
E
T
I
R
S
M
R
A
G
A
A
V
V
H
L
--
H
T
R
D
LSD
R
R
R
I
E
I
P
GL
G
V
V
T
V
G
S
Q
R
N
Q
I
V
L
D
D
Y
D
A
I
V
P
M
V
K
K
R
EPA
A
I
L
N
L
S
T
S
V
R
G
DRHGARSKLRRAHLKFYDDVGSAPE
V
A
S
L
S
P
A
A
V
V
F
Q
G
-
G
G
G
Y
D
N
A
P
D
F
L
D
-
A
Q
F
D
H
---------
F
E
R
V
GTRPEVEVFN
H
A
I
V
D
N
A
-------
T
--------
S
L
Y
R
--
D
R
-
L
L
R
T
G
K
P
V
L
-
F
M
L
V
AG
V
D
Q
Y
R
R
DPITGEVE
D
D
S
L
I
A
R
V
V
R
E
E
I
S
S
L
L
A
------
D
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
H
R
-
R
A
V
E
L
A
I
G
Q
L
R
P
V
V
E
R
L
--------
R
A
S
F
PV
S
K
I
S
I
L
L
P
G
P
M
Q
N
L
------------
L
----------
V
D
----
V
--
A
L
G
L
G
L
D
G
I
R
V
G
L
E
D
G
L
T
V
N
D
A
R
V----
P
G
G
V
R
K
A
---
R
G
T
W
E
Q
V
S
L
V
R
E
-
E
L
L
G
R
----------
G
A
T
I
-
L
T
A
A
Q
V
R
D
M
F
GLGI-----------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
80.52
15%
-125
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-328]
------------------------------------------
L
W
A
A
A
------------------------
Y
T
V
--
I
V
V
T
S
V
V
------
G
-
N
V
V
V
M
W
I
I
L
A
H
------------------
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
---------
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
--
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
--
M
T
A
-----------------
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
----
A
T
K
V
V
I
C
V
I
W
V
--------------------------
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
T
-----
M
P
-
S
R
V
V
C
---------
M
I
E
-----------
W
P
E
H
P
------------------
N
K
I
Y
--
E
K
-
V
Y
H
I
C
V
T
V
L
-
I
Y
F
L
----------------
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
------
S
E
I
PGDSSDRYH
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
-
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
--------
L
P
F
------
H
I
F
F
L
L
P
Y
I
N
P
------------
D
----------
L
Y
LKKF
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
-----
N
D
R
F
R
-
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
-
D
Y
E
G
L
----------
E
M
K
S
-
T
R
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
77.95
13%
-130
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-499]
-------------------------------------
F
N
K
I
-
F
L
P
T
I
------------------------
Y
S
I
--
I
F
L
T
G
I
V
------
G
-
N
G
L
V
I
L
V
M
G
Y
Q
------------------
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
---------
D
A
V
-
A
N
W
Y
F
G
N
F
L
C
K
A
--
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
--
L
A
F
-----------------
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
----
A
E
K
V
V
Y
V
G
V
W
I
--------------------------
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
S
E
-----
A
D
-
D
R
Y
I
C
---------
D
R
F
-----------
Y
P
N
---------------------
D
L
W
--
V
V
-
V
F
Q
F
Q
H
I
M
V
-
G
L
I
L
----------------
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
------
S
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
-
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
--------
L
P
Y
------
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
----------
V
H
----
K
--
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
-----
G
A
K
F
K
-
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
-
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
77.68
15%
-121
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------
P
L
V
V
V
------------------------
L
S
T
--
I
C
L
V
T
V
G
------
L
-
N
L
L
V
L
Y
A
V
R
S
E
------------------
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
---------
Y
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
--
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
--
V
F
I
-----------------
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
----
R
A
S
A
T
I
L
G
A
W
F
--------------------------
L
S
F
L
W
V
I
P
I
L
G
--
W
N
H
--------
R
-
R
E
D
K
C
---------
E
T
D
-----------
F
Y
D
--------------------------
V
T
-
W
F
K
V
M
T
A
I
I
-
N
F
Y
L
----------------
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
------
H
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
E
R
-
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
--------
I
P
Y
------
F
I
F
F
M
V
I
A
F
C
K
------------
N
CC--------
N
E
----
H
--
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
-----
N
E
N
F
K
-
K
T
F
K
R
I
L
H
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.01
23%
-151
- C3 -
4U14
1
ENLYS_BPT4
A:
[12-235]
------------------------------------------
V
V
F
I
A
------------------------
F
L
T
G
F
L
A
L
V
T
I
I
------
G
-
N
I
L
V
I
V
A
F
K
V
N
------------------
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
---------
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
----
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
-----------------
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
---
A
K
R
---------
T
T
K
R
A
G
--------------------------
V
M
I
G
L
A
W
V
-
I
S
F
-
V
L
W
A
P
---
A
I
L
F
-
W
Q
Y
F
V
---------
G
K
R
-----------
T
V
P
P
G
E
C
-------
F
--------
I
Q
F
L
--
S
E
P
T
I
T
F
G
T
A
I
A
-
A
F
Y
M
----------------
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
C
F
E
M
L
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
L
R
L
K
I
Y
K
D
C
E
G
Y
Y
T
I
G
I
G
H
L
--------
L
T
K
------
S
P
S
L
N
A
A
K
S
E
L
------------
D
----------
K
A
----
I
--
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
-----
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
-
R
C
A
L
I
----------
N
M
V
F
-
Q
M
G
E
---------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
75.53
14%
-116
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------
D
E
V
W
V
V
G
M
G
I
V
------------------------
M
S
L
--
I
V
L
A
I
V
F
------
G
-
N
V
L
V
I
T
A
I
A
K
F
------------------
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
---------
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
--
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
-----------------
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
----
K
A
R
V
I
I
L
M
V
W
I
--------------------------
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
W
Y
R
A
T
H
Q
E
A
I
N
-
C
Y
A
E
---------------------------
E
T
C
C
----------------
D
F
F
T
--
N
Q
-
A
Y
A
I
A
S
S
I
V
-
S
F
Y
V
----------------
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
------
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
-
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
--------
Y
T
I
------
G
I
G
H
L
L
T
K
S
P
S
------------
L
----------
N
A
----
A
--
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
-----
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
-
Y
D
S
L
D
----------
A
V
R
R
-
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
27
HHSearch
74.43
13%
-136
* C3 *
2Z73
5
OPSD_TODPA
A:
[31-334]
------------------------------------
D
A
V
Y
Y
-
S
L
G
I
F
------------------------
I
G
I
--
C
G
I
I
G
C
G
------
G
-
N
G
I
V
I
Y
L
F
T
K
T
------------------
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
---------
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
--
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
-----------------
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
----
R
A
F
I
M
I
I
F
V
W
L
--------------------------
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
----
E
G
-
V
L
C
N
C
---------
S
F
D
-----------
Y
I
S
R
--------------------
D
S
T
--
T
R
-
S
N
I
L
C
M
F
I
L
-
G
F
F
G
----------------
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
-
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
--------
S
P
Y
------
A
V
V
A
L
L
A
Q
F
G
P
------------
L
EWV-------
T
P
----
Y
--
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
-----
H
P
K
F
R
-
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
-
D
D
K
E
T
----------
E
D
D
K
-
D
A
E
T
---------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
73.88
14%
-94
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-330]
-------------------------------------
W
Q
F
S
-
M
L
A
A
Y
------------------------
M
F
L
--
L
I
M
L
G
F
P
------
I
-
N
F
L
T
L
Y
V
T
V
Q
H
------------------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
---------
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
-----------------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
----
H
A
I
M
G
V
A
F
T
W
V
--------------------------
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
----
E
G
-
M
Q
C
S
C
---------
G
I
D
-----------
Y
Y
T
P
H
------------------
E
E
T
N
--
N
E
-
S
F
V
I
Y
M
F
V
V
-
H
F
I
I
----------------
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
------
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
------
A
G
V
A
F
Y
I
F
T
H
Q
------------
G
SDF-------
G
P
----
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
-----
N
K
Q
F
R
-
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
-
D
E
A
S
T
----------
T
V
S
K
-
T
E
T
S
---------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
73.66
14%
-91
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
------------------------
M
F
L
--
L
I
M
L
G
F
P
------
I
-
N
F
L
T
L
Y
V
T
V
Q
H
------------------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
---------
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
-----------------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-------------
F
R
F
G
E
N
H
A
I
--------------------------
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
---
V
G
W
-
S
R
Y
I
P
---------
E
--------------
G
M
Q
C
S
C
G
I
DYYTP
H
--------
E
E
T
N
--
N
E
-
S
F
V
I
Y
M
F
V
V
-
H
F
I
I
----------------
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
------
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
-
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
--------
V
I
A
------
F
L
I
C
W
L
P
Y
A
G
V
------------
A
----------
F
Y
----
I
--
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-
N
P
L
G
D
DEA
S
T
T
V
S
K
T
E
T
S
Q
-
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
70.39
15%
-120
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
------------------------------------
E
N
S
I
K
-
L
T
S
V
V
------------------------
F
I
L
--
I
C
C
F
I
I
L
------
E
-
N
I
F
V
L
L
T
I
W
K
T
------------------
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
---------
S
G
A
-
T
T
Y
K
L
T
P
A
Q
W
F
L
--
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
--
L
L
A
-----------------
I
A
I
E
R
Y
I
T
M
L
K
--------
N
N
F
----
R
L
F
L
L
I
S
A
C
W
V
--------------------------
I
S
L
I
L
G
G
L
P
I
M
G
-
W
N
C
I
-------
S
-
A
L
S
S
C
---------
S
T
V
-----------
L
P
L
--------------------------
Y
H
-
K
H
Y
I
L
F
C
T
T
-
V
F
T
L
----------------
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
------
R
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
E
N
V
-
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
--------
A
P
L
------
F
I
L
L
L
L
D
V
G
C
K
------------
V
KT--------
C
D
I
L
--
F
--
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
-----
N
K
E
M
R
-
R
A
F
I
R
I
M
G
R
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.54
23%
-154
- C3 -
4DAJ
2
ACM3_RAT (first)
A:
[12-205]
------------------------------------------
V
V
F
I
A
------------------------
F
L
T
G
F
L
A
L
V
T
I
I
------
G
-
N
I
L
V
I
V
A
F
K
V
N
------------------
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
---------
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
----
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
-----------------
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
---
A
K
R
---------
T
T
K
R
A
G
--------------------------
V
M
I
G
L
A
W
V
-
I
S
F
-
V
L
W
A
P
---
A
I
L
F
-
W
Q
Y
F
V
---------
G
K
R
-----------
T
V
P
P
G
E
C
-------
F
--------
I
Q
F
L
--
S
E
P
T
I
T
F
G
T
A
I
A
-
A
F
Y
M
----------------
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
------
M
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
-
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
------
I
G
H
L
L
T
K
S
P
S
L
------------
N
----------
A
A
----
K
--
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
-----
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
-
D
S
L
D
A
----------
V
R
R
A
-
A
L
I
N
---------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
69.36
12%
-110
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-322]
-------------------------------------
L
N
K
Y
-
V
V
I
I
A
------------------------
Y
A
L
--
V
F
L
L
S
L
L
------
G
-
N
S
L
V
M
L
V
I
L
Y
S
------------------
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
---------
S
K
V
-
N
G
W
I
F
G
T
F
L
C
K
V
--
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
--
L
A
C
-----------------
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
-
K
R
H
----
L
V
K
F
V
C
L
G
C
W
G
--------------------------
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
H
P
----
N
N
-
S
S
P
V
C
---------
Y
E
V
-----------
L
G
N
D
-------------------
T
A
K
W
--
R
M
-
V
L
R
I
L
P
H
T
F
-
G
F
I
V
----------------
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
------
A
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
-
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
--------
L
P
Y
------
N
L
V
L
L
A
D
T
L
M
R
------------
T
QVIQE
S
C
E
R
R
N
N
I
G
--
R
--
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
-----
G
Q
N
F
R
-
H
G
F
L
K
I
L
A
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.58
23%
-158
- C3 -
4U16
1
?
A:
[12-198]
------------------------------------------
V
V
F
I
A
------------------------
F
L
T
G
F
L
A
L
V
T
I
I
------
G
-
N
I
L
V
I
V
A
F
K
V
N
------------------
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
---------
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
----
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
-----------------
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
---
A
K
R
---------
T
T
K
R
A
G
--------------------------
V
M
I
G
L
A
W
V
-
I
S
F
-
V
L
W
A
P
---
A
I
L
F
-
W
Q
Y
F
V
---------
G
K
R
-----------
T
V
P
P
G
E
C
-------
F
--------
I
Q
F
L
--
S
E
P
T
I
T
F
G
T
A
I
A
-
A
F
Y
M
----------------
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
------
M
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
-
I
D
E
G
G
G
S
G
G
D
E
A
E
K
L
F
N
--------
Q
D
V
------
D
A
A
V
R
G
I
L
R
N
A
------------
K
----------
L
K
----
P
--
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
-----
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
-
N
L
A
K
S
----------
R
W
Y
N
-
Q
T
P
N
---------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
68.38
16%
-170
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[42-236]
------------------------------------------
G
M
G
I
V
------------------------
M
S
L
--
I
V
L
A
I
V
F
------
G
-
N
V
L
V
I
T
A
I
A
K
F
------------------
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
---------
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
--
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
-----------------
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
----
K
A
R
V
I
I
L
M
V
W
I
--------------------------
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-----
Q
-
E
A
I
N
C
---------
Y
A
E
---------------
E
T
C
-------
C
--------
D
F
F
T
--
N
Q
-
A
Y
A
I
A
S
S
I
V
-
S
F
Y
V
----------------
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
------
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
-
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
--------
Y
T
I
------
G
I
G
H
L
L
T
K
S
P
S
------------
L
----------
N
A
----
A
--
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
-----
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
-
Y
D
S
L
D
----------
A
V
R
R
-
A
A
L
I
---------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.05
23%
-154
- C3 -
4U15
1
ACM3_RAT
A:
[12-198]
------------------------------------------
V
V
F
I
A
------------------------
F
L
T
G
F
L
A
L
V
T
I
I
------
G
-
N
I
L
V
I
V
A
F
K
V
N
------------------
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
---------
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
----
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
-----------------
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
---
A
K
R
---------
T
T
K
R
A
G
--------------------------
V
M
I
G
L
A
W
V
-
I
S
F
-
V
L
W
A
P
---
A
I
L
F
-
W
Q
Y
F
V
---------
G
K
R
-----------
T
V
P
P
G
E
C
-------
F
--------
I
Q
F
L
--
S
E
P
T
I
T
F
G
T
A
I
A
-
A
F
Y
M
----------------
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
------
M
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
-
I
D
E
G
G
G
S
G
G
D
E
A
E
K
L
F
N
--------
Q
D
V
------
D
A
A
V
R
G
I
L
R
N
A
------------
K
----------
L
K
----
P
--
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
-----
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
-
N
L
A
K
S
----------
R
W
Y
N
-
Q
T
P
N
---------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
67.40
13%
-131
- C4 -
4Q6T
6
?
A:
[4-340]
----------------
A
P
F
V
L
A
-
Y
T
D
G
Q
V
E
A
S
Y
S
N
L
Q
A
F
H
R
N
L
S
A
V
G
------------------------
L
G
S
--
T
Y
G
L
T
V
T
GKLRQD
G
M
N
E
T
T
Q
N
I
I
R
F
A
------------------
K
S
Q
S
L
P
L
Y
P
T
V
S
D
Y
N
E
D
I
G
A
F
D
P
A
I
-
S
H
S
I
L
N
D
R
-------
A
L
S
A
G
T
V
K
Q
L
V
K
L
A
K
E
--
G
G
F
A
G
I
N
L
D
F
E
K
V
E
P
--
R
N
R
-----------------
A
A
F
C
A
F
V
K
T
L
G
N
A
L
H
A
--
S
N
K
K
----
L
I
I
S
I
P
P
K
L
S
D
--------------------------
T
E
P
E
Y
L
Q
G
Y
D
Y
K
-
A
L
G
A
A
-
V
D
Y
F
Q
V
M
T
Y
D
Q
V
GPGWSSGGF
H
N
E
-----------
A
W
P
G
P
E
S
-------
G
--------
F
D
W
Q
--
Q
A
-
L
L
S
Y
A
V
S
R
V
P
A
S
K
V
----------------
L
A
G
L
P
T
Y
G
Q
D
Y
S
I
G
N
R
V
H
------
W
S
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
I
I
-
A
E
H
-------
R
A
A
I
H
R
D
--------
A
A
S
------
A
T
P
Y
A
T
W
G
P
V
K
------------
S
----------
F
V
----
D
--
G
----
V
E
W
T
P
E
R
A
Q
P
--
V
L
W
Y
D
D
--------------
A
A
S
I
K
T
K
T
A
L
V
T
R
L
G
L
G
G
T
----------
S
V
W
A
M
G
Y
E
N
A
G
F
W
A
A
L
Q
S
G
L
K---------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.57
25%
-152
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[125-258]
----------------------------------------
K
V
T
I
V
G
L
------------------------
Y
L
A
--
V
C
V
G
G
L
L
------
G
-
N
C
L
V
M
Y
V
I
L
R
H
------------------
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
-
L
V
L
L
T
-
L
P
F
Q
G
T
---------
D
I
L
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
--
T
S
T
F
T
--
L
T
A
-----------------
M
S
V
D
R
Y
V
A
I
C
H
P
--------------------
T
S
S
K
A
--------------------------
Q
A
V
N
V
A
I
W
A
L
A
S
-
V
V
G
V
P
V
A
I
M
G
S
A
-
Q
V
E
D
E
---------
E
I
E
-----------
C
L
V
E
I
P
T
-------
P
--------
Q
D
Y
W
--
G
P
-
V
F
A
I
C
I
F
L
F
-
S
F
I
V
----------------
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
R
G
------
V
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
R
-
E
K
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
--------
A
V
F
------
V
G
C
W
T
P
V
Q
V
F
V
------------
L
----------
A
Q
----
G
--
L
G
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
-----
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------