@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10S1_HUMAN: (2016-01-11 )
MTSRSVCEKMTMTTENPNQTVVSHFFLEGLRYTAKHSSLFFLLFLLIYSITVAGNLLILLTVGSDSHLSLPMYHFLGHLSFLDACLSTVTVPKVMAGLLTLDGKVISFEGCAVQLYCFHFLASTECFLYTVMAYDRYLAICQPLHYPVAMNRRMCAEMAGITWAIGATHAAIHTSLTFRLLYCGPCHIAYFFCDIPPVLKLACTDTTINELVMLASIGIVAAGCLILIVISYIFIVAAVLRIRTAQGRQRAFSPCTAQLTGVLLYYVPPVCIYLQPRSSEAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKHALQRLLCSSFRESTAGSPPP
Atome Classification :
(20 SA)
----------------------------------------------------------.........--10........--20.....------...--30--------.-.......40......-----------..50---.......---------..60..--..---....70-----------------------------........80----........--90.-------.----.......--100..-.....110....------..-------.120.....-------------------------..130--.--------......140--........---150..-......160-.........170...----------....180.----.---.....190-----------..-------------------------------------------------------.------------.....200..-.--...--.210........---------------220...---.--...230.....---..240.--.-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------..--..250...---....--------260.....-----..270....-----...--------------280-.-...------.-------------....290.......300--....----....310------------------------------.....-----..--------------.320.......330----------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------MT
S
R
S
V
C
E
K
--MTMTTENP
N
Q
--
T
V
V
S
H
F
F
------
L
E
G
--
L
R
--------
Y
-
T
A
K
H
S
S
L
F
F
L
L
F
L
L
I
-----------
Y
S
I
----TVAG
N
L
L
---------
I
L
L
T
VG--SD---SHLS
L
P
-----------------------------
M
Y
H
F
L
G
H
L
S
F
----
L
D
A
C
L
S
T
V
--
T
-
V
-------
P
----
K
V
M
A
G
L
L
--TLDG
K
-
V
I
S
FEG
C
A
V
Q
L
Y
------
C
F
-------
H
F
L
AST
E
C
F
-------------------------
L
Y
T
V
M
--
A
--------
Y
D
R
Y
L
A
I
C
---QPLHYPVA---
M
N
-
R
R
-
M
C
A
E
MAG---
I
T
W
AIGA
T
H
A
A
I
H
T
S
----------
L
T
F
R
L
L
Y
C----G---P
C
H
I
A
Y
F
------------FC-------------------------------------------------------D------------IP
P
V
L
K
L
ACT-D--
T
T
I
--
N
E
L
-
V
M
L
A
S
I
G
I
---------------
V
A
A
G
C
L
---
I
--
L
I
V
I
S
Y
I
F
I
V
A
---
A
V
L
R
I
R--T-----------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------QG--RQRAFS
P
C
---
T
A
Q
L
--------
T
G
V
L
L
Y
YV-----P
P
V
C
I
Y
LQP-----RSS--------------E---A-GAG------A-------------
P
A
V
F
Y
T
I
V
T
P
M
L
N
P
F
I
---
Y
T
LR----
N
K
E
V
K
H
-------------------------------
A
L
Q
R
L
-----
L
C
--------------
S
S
F
R
E
STAGSPPP-----------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
85.37
19%
-151
- C1 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
-----------
A
V
L
----
A
I
L
G
N
V
L
---------
V
C
W
A
V
W
--
L
N
---
S
N
L
Q
N
V
-----------------------------
T
N
Y
F
V
V
S
L
A
A
----
A
D
I
A
V
G
V
L
--
A
-
I
-------
P
----
F
A
I
T
I
S
T
-----
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
------
F
V
-------
L
V
L
T
Q
S
S
I
F
-------------------------
S
L
L
A
I
--
A
--------
I
D
R
Y
I
A
I
R
---
I
P
L
R
Y
N
G
L
---
V
T
-
G
T
-
R
A
K
G
I
I
A
---
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----------
G
W
N
N
C
G
Q
--------------
S
Q
------------
G
C
-------------------------------------------------------
G
------------
E
G
Q
---
V
A
C
L
-
F
--
E
D
V
VP
M
N
Y
-
M
V
Y
F
N
F
F
A
---------------
C
V
L
V
P
L
---
L
--
L
M
L
G
V
Y
L
R
I
F
L
---
A
A
R
R
Q
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
--
E
V
H
A
A
K
S
L
---
A
I
I
V
--------
G
L
F
A
L
C
W
L
-----
P
L
H
I
I
N
C
F
T
-----
F
F
C
PDCSHA--------
P
---
L
-
W
L
M
------
Y
-------------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
---
Y
A
Y
R
----
I
R
E
F
R
Q
-------------------------------
T
F
R
K
I
-----
I
R
--------------
S
H
V
L
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
84.90
18%
-147
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
-----------
V
L
A
----
I
V
F
G
N
V
L
---------
V
I
T
A
I
A
--
K
F
---
E
R
L
Q
T
V
-----------------------------
T
N
Y
F
I
T
S
L
A
C
----
A
D
L
V
M
G
L
A
--
V
-
V
-------
P
----
F
G
A
A
H
I
L
---
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
------
I
D
-------
V
L
C
V
T
A
S
I
E
-------------------------
T
L
C
V
I
--
A
--------
V
D
R
Y
F
A
I
T
---
S
P
F
K
Y
Q
S
L
---
L
T
-
K
N
-
K
A
R
V
I
I
L
---
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
----------
M
H
W
Y
R
A
T
-----------
H
Q
E
A
I
------------
N
C
-------------------------------------------------------
Y
------------
A
E
----
E
T
C
C
-
D
--
F
F
T
--
N
Q
A
-
Y
A
I
A
S
S
I
V
---------------
S
F
Y
V
P
L
---
V
--
I
M
V
F
V
Y
S
R
V
F
Q
---
E
A
K
R
Q
L
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
--
E
H
K
A
L
K
T
L
---
G
I
I
M
--------
G
T
F
T
L
C
W
L
-----
P
F
F
I
V
N
I
V
H
-----
V
I
Q
DNLI----------
R
---
K
-
E
V
Y
------
I
-------------
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
---
Y
C
-
R
----
S
P
D
F
R
I
-------------------------------
A
F
Q
E
L
-----
L
C
--------------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
84.86
18%
-146
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
-----------
C
L
V
----
T
V
G
L
N
L
L
---------
V
L
Y
A
V
R
--
S
E
---
R
K
L
H
T
V
-----------------------------
G
N
L
Y
I
V
S
L
S
V
----
A
D
L
I
V
G
A
V
--
V
-
M
-------
P
----
M
N
I
L
Y
L
L
---
M
S
K
W
-
S
L
G
R
P
L
C
L
F
W
L
S
------
M
D
-------
Y
V
A
S
T
A
S
I
F
-------------------------
S
V
F
I
L
--
C
--------
I
D
R
Y
R
S
V
Q
---
Q
P
L
R
Y
L
K
Y
---
R
T
-
K
T
-
R
A
S
A
T
I
L
---
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-----------
W
N
H
---------------
R
R
E
D
------------
K
C
-------------------------------------------------------
E
------------
T
D
F
Y
----------
D
----
V
T
W
-
F
K
V
M
T
A
I
I
---------------
N
F
Y
L
P
T
---
L
--
L
M
L
W
F
Y
A
K
I
Y
K
---
A
V
R
Q
H
C
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
--
E
R
K
A
A
K
Q
L
---
G
F
I
M
--------
A
A
F
I
L
C
W
I
-----
P
Y
F
I
F
F
M
V
I
-----
A
F
C
KNCC----------
N
---
E
-
H
L
H
------
M
-------------
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
---
Y
P
L
C
----
N
E
N
F
K
K
-------------------------------
T
F
K
R
I
-----
L
H
--------------
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
83.24
18%
-150
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
-----------
I
L
A
----
I
V
F
G
N
G
L
---------
V
C
M
A
V
L
--
K
E
---
R
A
L
Q
T
T
-----------------------------
T
N
Y
L
V
V
S
L
A
V
----
A
D
L
L
V
A
T
L
--
V
-
M
-------
P
----
W
V
V
Y
L
E
V
--
T
G
G
V
W
-
N
F
S
R
I
C
C
D
V
F
V
T
------
L
D
-------
V
M
M
C
T
A
S
I
W
-------------------------
N
L
C
A
I
--
S
--------
I
D
R
Y
T
A
V
V
---
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
-
C
R
-
R
V
A
L
M
I
T
---
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
----------
G
F
N
T
T
--------------
G
D
P
T
------------
V
C
-------------------------------------------------------
S
------------
I
S
N
-----------------
P
D
-
F
V
I
Y
S
S
V
V
---------------
S
F
Y
L
P
F
---
G
--
V
T
V
L
V
Y
A
R
I
Y
V
---
V
L
K
Q
R
R
--
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
--
E
K
K
A
T
Q
M
V
---
A
I
V
L
--------
G
A
F
I
V
C
W
L
-----
P
F
F
L
T
H
V
L
N
-----
T
H
C
QTCHV---------
S
---
P
-
E
L
Y
------
S
-------------
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
---
Y
T
T
F
----
N
I
E
F
R
K
-------------------------------
A
F
L
K
I
-----
L
S
--------------
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
81.23
16%
-146
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
-----------
S
L
V
----
T
I
I
G
N
I
L
---------
V
M
V
S
I
K
--
V
N
---
R
H
L
Q
T
V
-----------------------------
N
N
Y
F
L
F
S
L
A
C
----
A
D
L
I
I
G
V
F
--
S
-
M
-------
N
----
L
Y
T
L
Y
T
V
---
I
G
Y
W
-
P
L
G
P
V
V
C
D
L
W
L
A
------
L
D
-------
Y
V
V
S
N
A
S
V
M
-------------------------
N
L
L
I
I
--
S
--------
F
D
R
Y
F
C
V
T
---
K
P
L
T
Y
P
V
K
---
R
T
-
T
K
-
M
A
G
M
M
I
A
---
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
----------
F
W
Q
F
I
V
G
V
---------
R
T
V
E
D
G
------------
E
C
-------------------------------------------------------
Y
------------
I
Q
F
F
------------
S
--
N
A
A
-
V
T
F
G
T
A
I
A
---------------
A
F
Y
L
P
V
---
I
--
I
M
T
V
L
Y
W
H
I
S
R
---
A
S
K
S
R
I
--
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
--
E
K
K
V
T
R
T
I
---
L
A
I
L
--------
L
A
F
I
I
T
W
A
-----
P
Y
N
V
M
V
L
I
N
-----
T
F
C
APCI----------
P
---
N
-
T
V
W
------
T
-------------
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
---
Y
A
L
C
----
N
A
T
F
K
K
-------------------------------
T
F
K
H
L
-----
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
77.50
16%
-133
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------------------------------------
M
N
G
-
T
E
G
P
N
--
F
Y
V
P
F
S
N
K
T
G
--
V
V
R
S
P
F
E
------
A
P
Q
--
Y
Y
--------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-----------
I
M
L
----
G
F
P
I
N
F
L
---------
T
L
Y
V
T
V
--
Q
H
---
K
K
L
R
T
P
-----------------------------
L
N
Y
I
L
L
N
L
A
V
----
A
D
L
F
M
V
F
G
--
G
---------
F
----
T
T
T
L
Y
T
S
--
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
------
F
A
-------
T
L
G
G
E
I
A
L
W
-------------------------
S
L
V
V
L
--
A
--------
I
E
R
Y
V
V
V
C
---
K
P
M
S
-
N
F
R
---
F
G
-
E
N
-
H
A
I
M
G
V
A
---
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
----------
G
W
S
R
Y
I
P
E
----
G
------------------------------------------------------------------------------------------------
M
Q
C
S
C
G
I
D
YY
T
P
H
--
E
E
T
-
N
N
E
S
F
V
I
Y
---------------
M
F
V
V
H
F
---
I
--
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
--
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
--
A
S
A
T
T
Q
K
A
---
E
K
E
V
--------
T
R
M
V
I
I
M
V
-----
I
A
F
L
I
C
W
L
P
-----
Y
A
G
--------------
V
---
A
-
F
Y
I
------
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
---
Y
I
M
M
----
N
K
Q
F
R
N
-------------------------------
C
M
V
T
T
-----
L
C
CGKNPST-------
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
76.57
16%
-139
- C1 -
4OCV
6
?
A:
[24-378]
-------------------------------------------------------------------------
T
N
E
A
L
F
--
D
V
A
S
H
F
A
------
L
E
G
--
T
V
--------
D
-
S
I
E
P
Y
G
D
G
H
I
N
--
T
T
-----------
Y
L
V
----
T
T
D
G
P
R
Y
---------
I
L
Q
R
M
N
--
T
G
---
I
F
P
D
-------------------------------
T
V
N
L
M
R
N
V
E
L
----
V
T
S
T
L
K
A
Q
--
G
-
K
-------
E
----
T
L
D
I
V
R
T
--
T
S
G
D
T
-
W
A
E
I
D
G
G
A
W
R
V
Y
------
K
F
IEH
T
M
S
Y
N
L
V
P
N
P
D
V
F
-------------------------
R
E
A
G
R
--
A
--------
F
G
D
F
Q
N
F
L
---
S
G
--
F
D
A
N
---
Q
L
-
T
E
-
T
I
A
H
F
H
D
---
T
P
H
R
F
E
D
F
K
K
A
L
A
A
D
----------
E
L
G
R
A
A
G
C
----
G
---
P
E
I
E
F
Y
L
S
H
ADQYA
V
V
M
D
G
L
R
-------------------------------------------------------
D
------------
G
S
I
P
L
R
V
T
H
N
-
D
--
T
K
L
--
N
N
I
-
L
M
D
A
T
T
G
K
---------------
A
R
A
I
I
D
---
L
DT
I
M
P
G
S
M
L
F
D
F
G
---
D
S
I
R
F
G
AS
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
--
D
E
R
D
L
D
K
V
H
F
S
T
E
L
F
--------
R
A
Y
T
E
G
F
V
-----
G
E
L
R
D
S
I
T
A
-----
R
E
A
--------------
E
---
L
L
P
F
S
------
G
-------------
N
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
GD
V
Y
F
A
----
T
K
Y
P
E
H
-------------------------------
N
L
V
R
S
R
T
Q
I
K
L
V
--------------
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T---------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
76.52
17%
-147
- C1 -
2Z73
5
OPSD_TODPA
A:
[31-334]
----------------------------------------------------------------------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
-----------
G
I
I
----
G
C
G
G
N
G
I
---------
V
I
Y
L
F
T
--
K
T
---
K
S
L
Q
T
P
-----------------------------
A
N
M
F
I
I
N
L
A
F
----
S
D
F
T
F
S
L
V
--
N
G
F
-------
P
----
L
M
T
I
S
C
F
---
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
------
I
G
-------
G
I
F
G
F
M
S
I
M
-------------------------
T
M
A
M
I
--
S
--------
I
D
R
Y
N
V
I
G
---
R
P
M
A
A
S
K
K
---
M
S
-
H
R
-
R
A
F
I
M
I
I
---
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
----------
G
W
G
A
Y
T
L
-----------
E
G
V
L
C
------------
N
C
-------------------------------------------------------
S
------------
F
D
Y
I
S
------
R
--
D
S
T
--
T
R
S
-
N
I
L
C
M
F
I
L
---------------
G
F
F
G
P
I
---
L
--
I
I
F
F
C
Y
F
N
I
V
M
---
S
V
S
N
H
E
--
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
--
E
M
R
L
A
K
I
S
---
I
V
I
V
--------
S
Q
F
L
L
S
W
S
-----
P
Y
A
V
V
A
L
L
A
-----
Q
F
G
PLEWV---------
T
---
P
-
Y
A
A
------
Q
-------------
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
---
Y
S
V
S
----
H
P
K
F
R
E
-------------------------------
A
I
S
Q
T
-----
F
P
--------------
W
V
L
T
C
C
Q
F
D
D
K
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.24
15%
-136
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
------------------------------------------------------------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
-----------
F
L
L
----
S
L
L
G
N
S
L
---------
V
M
L
V
I
L
--
Y
S
---
R
V
G
R
S
V
-----------------------------
T
D
V
Y
L
L
N
L
A
L
----
A
D
L
L
F
A
L
T
----
L
-------
P
----
I
W
A
A
S
K
----
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
------
L
K
-------
E
V
N
F
Y
S
G
I
L
-------------------------
L
L
A
C
I
--
S
--------
V
D
R
Y
L
A
I
V
---
H
A
T
R
T
L
T
----
Q
K
-
R
H
-
L
V
K
F
V
C
L
---
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
----------
F
R
Q
A
Y
H
-----------
P
N
N
S
S
P
------------
V
C
-------------------------------------------------------
Y
------------
E
V
L
G
N
----
D
-
T
--
A
K
W
--
R
M
V
-
L
R
I
L
P
H
T
F
---------------
G
F
I
V
P
L
---
F
--
V
M
L
F
C
Y
G
F
T
L
R
---
T
L
F
K
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
--
K
H
R
A
M
R
V
I
---
F
A
V
V
--------
L
I
F
L
L
C
W
L
-----
P
Y
N
L
V
L
L
A
D
-----
T
L
M
RTQVIQE
S
C
E
R
R
N
-
N
I
--
G
-
R
A
L
------
D
-------------
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
---
Y
A
F
I
----
G
Q
N
F
R
H
-------------------------------
G
F
L
K
I
-----
L
A
--------------
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
73.98
17%
-126
- C1 -
1U19
14
OPSD_BOVIN
A:
[37-329]
----------------------------------------------------------------------------------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-----------
I
M
L
----
G
F
P
I
N
F
L
---------
T
L
Y
V
T
V
--
Q
H
---
K
K
L
R
T
P
-----------------------------
L
N
Y
I
L
L
N
L
A
V
----
A
D
L
F
M
V
F
G
--
G
-
F
-------
T
----
T
T
L
Y
T
S
L
---
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
------
F
A
-------
T
L
G
G
E
I
A
L
W
-------------------------
S
L
V
V
L
--
A
--------
I
E
R
Y
V
V
V
C
---
K
P
M
S
N
F
R
F
----
G
-
E
N
-
H
A
I
M
G
V
A
---
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
----------
G
W
S
R
Y
I
P
-----------
E
G
M
Q
C
------------
S
C
-------------------------------------------------------
G
------------
I
D
Y
Y
T
P
---
H
-
E
--
E
T
N
--
N
E
S
-
F
V
I
Y
M
F
V
V
---------------
H
F
I
I
P
L
---
I
--
V
I
F
F
C
Y
G
Q
L
V
F
---
T
V
K
E
A
A
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
--
E
K
E
V
T
R
M
V
---
I
I
M
V
--------
I
A
F
L
I
C
W
L
-----
P
Y
A
G
V
A
F
Y
I
-----
F
T
H
QGSDF---------
G
---
P
-
I
F
M
------
T
-------------
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
---
Y
I
M
M
----
N
K
Q
F
R
N
-------------------------------
C
M
V
T
T
-----
L
C
--------------
C
G
K
N
P
L
G
D
D
E
A
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
73.65
13%
-147
- C1 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
-------------------------------------------------------------------------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
-----------
V
V
T
----
S
V
V
G
N
V
V
---------
V
M
W
I
I
L
--
A
H
---
K
R
M
R
T
V
-----------------------------
T
N
Y
F
L
V
N
L
A
F
----
A
E
A
S
M
A
A
F
--
N
-
T
-------
V
----
V
N
F
T
Y
A
V
---
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
------
F
P
-------
I
A
A
V
F
A
S
I
Y
-------------------------
S
M
T
A
V
--
A
--------
F
D
R
Y
M
A
I
I
---
H
P
L
Q
P
R
L
-----
S
-
A
T
-
A
T
K
V
V
I
C
---
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
----------
Y
S
T
T
E
------------
T
M
P
S
R
V
------------
V
C
-------------------------------------------------------
M
------------
I
E
W
P
E
H
---
P
-
N
--
K
I
Y
--
E
K
V
-
Y
H
I
C
V
T
V
L
---------------
I
Y
F
L
P
L
---
L
--
V
I
G
Y
A
Y
T
V
V
G
I
---
T
L
W
A
S
E
--
I
PGDSSDRYH
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
--
K
R
K
V
V
K
M
M
---
I
V
V
V
--------
C
T
F
A
I
C
W
L
-----
P
F
H
I
F
F
L
L
P
-----
Y
I
N
PDLYL---------
K
KFI
Q
-
Q
V
Y
------
L
-------------
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
---
Y
C
C
L
----
N
D
R
F
R
L
-------------------------------
G
F
K
H
A
-----
F
R
--------------
C
C
P
F
I
S
A
G
D
Y
E
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
73.47
18%
-105
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------------------------------------------------
M
N
G
T
E
G
P
N
--
F
Y
V
P
F
S
N
K
T
G
--
V
V
R
S
P
F
E
------
A
P
Q
YY
L
A
--------
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-----------
M
-
L
----
G
F
P
I
N
F
L
---------
T
L
Y
V
T
V
--
Q
H
---
K
K
L
R
T
P
-----------------------------
L
N
Y
I
L
L
N
L
A
V
----
A
D
L
F
M
V
F
G
--
G
-
F
-------
T
----
T
T
L
Y
T
S
L
--
H
G
Y
-
F
-
V
F
G
P
T
G
C
N
L
E
G
F
------
F
A
-------
T
L
G
G
E
I
A
L
W
-------------------------
S
L
V
V
L
--
A
--------
I
E
R
Y
V
V
V
C
---
K
P
M
S
-
N
F
R
---
F
G
-
E
N
-
H
A
I
M
G
V
A
---
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
----------
G
W
S
R
Y
I
P
E
----
G
MQC
S
C
G
I
D
Y
Y
------------
T
P
-------------------------------------------------------
H
------------
E
E
T
N
N
E
S
F
V
I
-
Y
--
M
F
V
--
V
H
F
-
I
I
P
L
I
V
I
F
---------------
F
C
Y
G
Q
L
---
V
--
F
T
V
K
E
---
A
A
A
---
Q
Q
Q
E
S
A
--
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
A
E
K
E
V
T
R
M
---
V
I
I
M
--------
V
I
A
F
L
I
C
W
-----
L
P
Y
A
G
V
A
F
Y
-----
I
F
T
--------------
H
---
Q
-
G
S
D
FGPIFM
T
-------------
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
---
Y
I
M
M
----
N
K
Q
F
R
N
-------------------------------
C
M
V
T
T
-----
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
71.51
13%
-112
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
-----------
V
L
A
----
I
V
F
G
N
V
L
---------
V
I
T
A
I
A
--
K
F
---
E
R
L
Q
T
V
-----------------------------
T
N
Y
F
I
T
S
L
A
C
----
A
D
L
V
M
G
L
A
--
V
-
V
-------
P
----
F
G
A
A
H
I
L
--
M
--
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
------
I
D
-------
V
L
C
V
T
A
S
I
E
-------------------------
T
L
C
V
I
--
A
--------
V
D
R
Y
F
A
I
T
---
S
P
F
K
Y
Q
S
L
---
L
T
-
K
N
-
K
A
R
V
I
I
L
---
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
----------
M
H
W
Y
--------
R
---
A
T
H
Q
E
A
I
------------
N
C
-------------------------------------------------------
Y
------------
A
E
E
---
T
C
C
D
-
F
--
F
T
N
--
Q
A
Y
-
A
I
A
S
S
I
V
S
---------------
F
Y
V
P
L
V
---
I
--
M
V
F
V
Y
S
R
V
F
Q
E
---
A
K
R
Q
L
N
--
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
--
L
R
I
D
E
G
L
R
---
L
K
I
Y
K
D
TEGYYT
I
G
I
G
H
L
L
T
-----
K
S
P
S
L
N
A
A
K
-----
S
E
L
--------------
D
---
K
-
A
I
G
------
R
-------------
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
---
Q
D
V
D
----
A
A
V
R
G
I
-------------------------------
L
R
N
A
K
-----
L
K
--------------
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
26
HHSearch
68.92
14%
-142
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-498]
---------------------------------------------------------------------------------------------------------------
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
-----------
F
L
T
----
G
I
V
G
N
G
L
---------
V
I
L
V
M
G
--
Y
Q
---
K
K
L
R
S
M
-----------------------------
T
D
K
Y
R
L
H
L
S
V
----
A
D
L
L
F
V
-
I
--
T
-
L
-------
P
----
F
W
A
V
D
A
V
----
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
------
I
Y
-------
T
V
N
L
Y
S
S
V
W
-------------------------
I
L
A
F
I
--
S
--------
L
D
R
Y
L
A
I
V
---
H
A
T
N
S
Q
R
P
---
R
K
-
L
L
-
A
E
K
V
V
Y
V
---
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
----------
F
A
N
V
S
E
------------
A
D
D
R
Y
------------
I
C
-------------------------------------------------------
D
------------
R
F
Y
P
N
---------
D
L
W
--
V
V
V
-
F
Q
F
Q
H
I
M
V
---------------
G
L
I
L
P
G
---
I
--
V
I
L
S
C
Y
C
I
I
I
S
---
K
L
S
H
S
G
--
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
--
K
R
K
A
L
K
T
T
---
V
I
L
I
--------
L
A
F
F
A
C
W
L
-----
P
Y
Y
I
G
I
S
I
D
-----
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
---
H
-
K
W
I
------
S
-------------
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
---
Y
A
F
L
----
G
A
K
F
K
T
-------------------------------
S
A
Q
H
A
-----
L
T
--------------
S
G
R
P
L
E
V
L
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
68.90
18%
-131
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
----------------------------------------------------------------------------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
-----------
C
C
F
----
I
I
L
E
N
I
F
---------
V
L
L
T
I
W
--
K
T
---
K
K
F
H
R
P
-----------------------------
M
Y
Y
F
I
G
N
L
A
L
----
S
D
L
L
A
G
V
A
--
Y
-
T
-------
A
----
N
L
L
L
S
G
A
----
T
T
Y
-
K
L
T
P
A
Q
W
F
L
R
E
G
------
S
M
-------
F
V
A
L
S
A
S
V
F
-------------------------
S
L
L
A
I
--
A
--------
I
E
R
Y
I
T
M
L
---
K
-----------
N
-
N
F
-
R
L
F
L
L
I
S
---
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
----------
G
W
N
C
I
--------------
S
A
L
S
------------
S
C
-------------------------------------------------------
S
------------
T
V
L
P
L
--------------
Y
H
K
-
H
Y
I
L
F
C
T
T
---------------
V
F
T
L
L
L
---
L
--
S
I
V
I
L
Y
C
R
I
Y
S
---
L
V
R
T
R
N
--
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
E
--
N
V
A
L
L
K
T
V
---
I
I
V
L
--------
S
V
F
I
A
C
W
A
-----
P
L
F
I
L
L
L
L
D
-----
V
G
C
KVKT----------
C
D
I
-
L
-
F
R
A
------
E
-------------
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
---
Y
T
L
T
----
N
K
E
M
R
R
-------------------------------
A
F
I
R
I
-----
M
G
--------------
R
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
59.37
13%
-132
- C1 -
2B1X
8
?
A:
[1-441]
----------------------------------------------------------
M
L
S
N
E
L
R
Q
T
--
L
Q
K
G
L
H
D
V
N
S
DW
T
V
P
A
A
I
I
------
N
D
P
--
E
V
--------
H
-
D
V
E
R
E
R
I
F
G
H
A
W
V
F
L
A
HESEIPERG
D
Y
V
V
----
R
Y
I
S
E
D
Q
---------
F
I
V
C
R
D
--
E
G
---
G
E
I
R
G
H
LNACRHRGMQVCRAE
M
G
N
T
S
H
F
R
C
PYHGW
T
Y
S
N
T
G
S
L
V
G
----
V
P
A
G
K
D
A
Y
GN
Q
-
L
-------
K
----
K
S
D
W
N
L
R
--
P
M
P
-
N
-
L
A
S
Y
K
G
L
I
F
G
S
L
DPHADS
L
E
-------
D
Y
L
G
D
L
K
F
Y
-------------------------
L
D
I
V
L
DR
S
--------
D
A
G
L
Q
V
V
G
---
A
P
Q
R
W
V
I
D
---
A
N
W
K
L
-
G
A
D
N
F
V
G
---
D
A
Y
H
T
M
M
T
H
R
S
M
V
E
L
GLAPPDPQFA
L
Y
G
E
H
I
H
T
----
G
---
H
G
H
G
L
G
I
------------
I
G
-------------------------------------------------------
P
P
PGMPLPEFMGL
P
E
N
I
V
E
E
L
E
R
-
R
--
L
T
P
--
E
Q
V
-
E
I
F
R
P
T
A
F
---------------
I
H
G
T
V
F
---
P
--
N
L
S
I
G
N
F
L
M
G
K
---
D
H
L
S
A
P
--
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
--
T
L
R
L
W
H
P
L
---
G
P
D
K
--------
M
E
V
M
S
F
F
L
V
EKDA
P
D
W
F
K
D
E
S
Y
-----
K
S
Y
--------------
L
---
R
-
T
F
G
------
I
-------------
S
G
G
F
E
Q
D
D
A
E
N
W
R
S
I
T
---
R
V
M
G
----
G
Q
F
A
K
T
G
E
L
N
YQMGRGVLEPDPNWTGPGEAYPLDYAE
A
N
Q
R
N
-----
F
L
--------------
E
Y
W
M
Q
L
M
L
A
E
S
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
58.63
16%
-135
- C1 -
4HU8
3
?
A:
[3-452]
N
E
I
T
L
T
IG
Q
Q
K
D
LASMVPAKFAG
Q
E
L
S
W
T
S
SDPET
A
S
V
T
DKG
I
V
T
A
L
K
FSSGGANLFL
K
A
P
A
T
G
E
A
I
--
I
T
V
T
A
G
K
Q
S
H
--
S
V
K
V
I
T
T
VKGKED
I
E
K
--
L
P
--------
P
-
L
K
D
H
F
K
D
Y
F
L
I
G
N
I
F
-----------
N
N
R
----
D
V
S
G
S
M
M
DNDWLAHHY
A
I
L
T
P
E
--
N
H
MKP
S
N
L
T
N
N
-----------------------------
R
N
E
T
T
G
E
I
T
Y
TF
S
T
A
D
R
M
V
N
A
A
--
I
-
A
-------
E
G
L
--
K
I
H
G
H
T
L
--
L
W
H
Q
Q
-
I
P
P
W
Q
R
S
M
E
S
A
A
------
K
D
-------
A
A
L
S
V
M
K
K
Y
-------------------------
I
T
E
V
M
--
T
H
Y
KGKIYS
W
D
V
L
N
E
I
F
PDG
R
G
D
N
W
T
T
A
---
M
R
-
P
E
N
P
W
F
K
S
I
G
---
S
D
F
V
Y
E
A
Y
L
A
A
R
Q
A
D
----------
P
N
A
I
L
Y
Y
N
D
Y
NM
D
---
Q
A
G
K
A
A
L
------------
I
A
-------------------------------------------------------
A
------------
M
V
R
D
V
N
A
K
Y
K
-
Q
--
A
Y
P
--
R
E
T
R
L
L
I
E
G
I
G
M
QSHHNMDVP
A
S
N
I
R
N
T
I
N
R
Y
R
E
L
G
V
--
K
I
S
V
S
E
L
D
I
L
C
MG
W
S
A
F
R
G
S
--
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
AD
K
D
D
M
T
I
A
T
---
N
R
N
I
--------
L
D
Q
A
Y
K
F
N
-----
E
Y
M
K
L
Y
L
E
N
SDIIE
R
V
S
--------------
M
---
W
-
G
V
S
------
D
-------------
R
Y
S
W
R
S
G
G
L
P
L
L
F
D
--------
A
----
D
N
K
A
K
P
-------------------------------
A
Y
Y
S
F
-----
V
----------------
R
A
R
E
D
Y
E
A
A
K
A
------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
56.84
11%
-150
- C1 -
4AN8
2
CSE1_THET8
A:
[8-500]
----------------------------------------------------------
L
E
K
F
N
L
I
D
E
PW
I
P
V
L
K
G
G
R
V
V
--
E
V
G
I
G
E
A
------
L
L
R
--
A
H
EFARIETP
S
-
P
L
E
E
A
V
L
H
R
L
L
L
A
V
L
-----------
H
R
A
L
SGP
R
C
P
E
D
V
L
---------
D
W
W
R
K
G
GF
P
Q
---
D
P
I
R
D
Y
-----------------------------
L
N
R
F
R
D
R
F
F
L
----
F
H
P
E
A
P
F
L
--
Q
-
V
ADLPEEN
P
----
L
P
W
S
K
L
L
P
E
L
A
N
L
P
-
K
A
T
Y
A
Q
A
A
R
A
L
L
------
V
H
-------
Q
A
F
A
P
G
G
L
L
RRYGVGSAKDAPVA
R
P
A
L
F
L
P
T
G
QN
L
L
E
T
L
--
L
--------
L
N
L
V
P
Y
T
P
---
E
D
D
A
P
I
W
E
---
V
P
-
P
L
-
R
L
G
D
L
E
G
AR
T
K
W
P
L
T
G
R
T
R
V
Y
T
W
P
A
----------
R
G
V
R
L
L
D
E
----
G
---
D
G
V
R
F
M
G
------------
Y
G
P
G
VEPLEATHRDPM
V
A
Q
R
L
D
AKG
N
L
L
V
LRLSEERSFWRDFSAMLPRQGGKVA
A
T
L
E
------------
H
A
E
N
L
Q
G
E
L
E
-
D
--
E
G
L
--
E
G
R
-
I
T
L
R
V
L
G
Q
---------------
V
S
D
Q
A
K
---
V
--
L
D
I
R
R
E
V
Y
P
L
P
---
S
G
L
L
T
P
--
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
--
N
L
E
K
A
L
K
M
---
A
E
E
L
--------
G
Q
G
L
K
H
L
A
-----
Q
E
V
A
K
A
V
V
Y
-----
L
E
E
--------------
L
---
T
-
K
L
A
------
N
S
LPL---------
E
R
L
Y
W
H
A
L
D
G
A
F
P
R
F
F
---
A
R
V
E
EEA
S
L
D
L
W
R
E
-------------------------------
A
L
R
G
A
-----
A
L
--------------
E
A
W
K
A
T
R
R
F
L
G
T
G
A
RH
L
K
A
L
A
Q
G
E
Q
E
F
G
R
L
L
G
E
L--------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
56.37
30%
-147
- C1 -
2Y02
7
ADRB1_MELGA
A:
[9-140]
----------------------------------------------------------------------------------------------------
Q
--------
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
-------------------
V
A
G
N
V
L
---------
V
I
A
A
I
G
--
S
T
---
Q
R
L
Q
T
L
-----------------------------
T
N
L
F
I
T
S
L
A
C
----
A
D
L
V
V
G
L
L
--
V
-
V
-------
P
F
G
A
T
L
V
V
R
G
T
W
---
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
------
C
V
-------
T
A
S
I
E
T
L
C
-----------------------------
V
I
--
A
--------
I
D
R
Y
L
A
I
T
---
S
P
F
R
Y
Q
S
L
---
M
T
-
R
A
-
R
A
K
V
I
I
C
---
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
H
W
W
R
D
E
D
----
P
---
Q
A
L
K
C
Y
Q
------------
D
P
-------------------------------------------------------
G
------------
C
C
D
F
V
T
N
R
A
Y
-
A
--
I
A
S
--
S
I
I
-
S
F
Y
I
P
L
L
I
---------------
M
I
F
V
A
L
---
R
--
V
Y
R
E
A
K
E
Q
S
R
V
---
M
L
M
R
E
H
--
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
--
T
L
G
I
I
M
G
V
---
F
T
L
C
--------
W
L
P
F
F
L
V
N
-----
I
V
N
V
F
N
R
D
L
-----
V
P
D
--------------
W
---
L
-
F
V
A
------
F
-------------
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
---
R
S
P
D
----
F
R
K
A
F
K
-------------------------------
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.35
30%
-149
- C1 -
2Y03
4
ADRB1_MELGA
A:
[9-140]
----------------------------------------------------------------------------------------------------
Q
--------
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
-------------------
V
A
G
N
V
L
---------
V
I
A
A
I
G
--
S
T
---
Q
R
L
Q
T
L
-----------------------------
T
N
L
F
I
T
S
L
A
C
----
A
D
L
V
V
G
L
L
--
V
-
V
-------
P
F
G
A
T
L
V
V
R
G
T
W
---
L
W
G
S
-
F
L
C
E
L
W
T
S
L
D
V
L
------
C
V
-------
T
A
S
I
E
T
L
C
-----------------------------
V
I
--
A
--------
I
D
R
Y
L
A
I
T
---
S
P
F
R
Y
Q
S
L
---
M
T
-
R
A
-
R
A
K
V
I
I
C
---
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
H
W
W
R
D
E
D
----
P
---
Q
A
L
K
C
Y
Q
------------
D
P
-------------------------------------------------------
G
------------
C
C
D
F
V
T
N
R
A
Y
-
A
--
I
A
S
--
S
I
I
-
S
F
Y
I
P
L
L
I
---------------
M
I
F
V
A
L
---
R
--
V
Y
R
E
A
K
E
Q
I
R
S
---
R
V
M
L
M
R
--
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
--
L
K
T
L
G
I
I
M
---
G
V
F
T
--------
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
R
-----
D
L
V
--------------
P
---
D
-
W
L
F
------
V
-------------
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
---
Y
C
R
S
----
P
D
F
R
K
A
-------------------------------
F
K
R
L
L
-----
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------