@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10V1_HUMAN: (2016-01-11 )
MEGINKTAKMQFFFRPFSPDPEVQMLIFVVFLMMYLTSLGGNATIAVIVQINHSLHTPMYFFLANLAVLEIFYTSSITPLALANLLSMGKTPVSITGCGTQMFFFVFLGGADCVLLVVMAYDQFIAICHPLRYRLIMSWSLCVELLVGSLVLGFLLSLPLTILIFHLPFCHNDEIYHFYCDMPAVMRLACADTRVHKTALYIISFIVLSIPLSLISISYVFIVVAILRIRSAEGRQQAYSTCSSHILVVLLQYGCTSFIYLSPSSSYSPEMGRVVSVAYTFITPILNPLIYSLRNKELKDALRKALRKF
Atome Classification :
(20 SA)
.........10.------------.......--20........30........40........50........60........70........80........90........100.......110.......120.......130........140.......150......-.160.......170.......180.......190.-------........200.....-..210.......220......-.230.--------..----....240..--------------..--------------...250.-..-------....260..---...--.----.270.-------......280.......290.......300.......------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEGINKT
A
K
M
Q
F
------------
F
F
RPFSP--DP
E
V
Q
M
L
I
F
V
V
F
L
M
M
Y
L
T
SLGGN
A
T
I
A
V
I
V
Q
INHSLH
T
P
M
Y
F
F
L
A
N
L
A
V
L
E
I
F
YTSSI
T
P
L
A
L
A
N
L
L
SMGKT
P
V
S
I
T
GCG
T
Q
M
F
F
F
V
F
LGG
A
D
C
V
L
L
V
V
M
A
Y
D
Q
F
I
A
I
C
H
P
L
-
R
Y
R
L
I
M
S
W
S
L
C
V
E
L
L
V
G
S
L
V
L
G
F
L
L
S
L
-
P
L
T
I
L
I
F
HLPFCHND
E
I
Y
H
F
YCD
M
P
A
V
M
R
L
AC--A-------DTR
V
H
K
T
A
L
Y
I
I
S
F
I
V
-
L
S
I
P
L
S
L
I
S
I
S
Y
V
F
I
V
V
A
I
L
R
-IRSAE--------
G
R
----
Q
Q
A
Y
S
T
C
S
S
--------------
H
I
--------------
L
V
V
L
L
Q
Y-GC-------
T
S
F
I
Y
LSPS---SSY--S----PEM
G
R
-------
V
V
S
V
A
Y
T
F
I
T
P
I
L
N
P
L
I
Y
S
LR
N
K
E
L
K
D
A
L
R
K
A
L
R
KF------------------
11
PsiBlast_PDB
89.81
22%
-159
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
------------------
10
PsiBlast_PDB
88.45
22%
-157
- C1 -
3VG9
8
?
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
------------------
6
PsiBlast_PDB
88.08
22%
-150
- C1 -
2YDO
3
?
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
--------
S
----------
T
L
Q
K
--------------
E
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
------------------
9
PsiBlast_PDB
87.42
22%
-154
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
------------------
4
PsiBlast_PDB
86.19
22%
-148
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
-
I
I
-------
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
45
Fugue
85.94
17%
-129
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
-
T
E
G
P
N
F
Y
V
PFSNKTGVVRSP
F
E
A
P
Q
Y
Y
LA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
-----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
----------
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
A
A
S
A
--------
T
T
----
Q
K
A
E
K
E
V
T
R
--------------
M
V
--------------
I
I
M
V
I
A
F
-
L
I
-------
C
W
L
P
Y
A
G
V
A
---
F
Y
I
--
F
----
T
H
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
KNPSTTVSKTETS
Q
V
A
P
A
3
PsiBlast_PDB
85.93
22%
-146
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
-
I
I
-------
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
7
PsiBlast_PDB
85.63
22%
-150
- C1 -
2YDV
6
?
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
--------
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
------------------
1
PsiBlast_PDB
85.59
22%
-148
- C1 -
3PWH
1
?
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
-
I
I
-------
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
2
PsiBlast_PDB
85.10
22%
-150
- C1 -
3REY
1
AA2AR_HUMAN
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
-
I
I
-------
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
8
PsiBlast_PDB
84.96
22%
-151
- C1 -
4UG2
3
?
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------------------
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
L
A
-------
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
------------------
5
PsiBlast_PDB
84.35
22%
-150
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[23-305]
------------------------------------------------------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
--------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
-
I
I
-------
N
C
F
T
F
F
C
P
D
---
C
S
H
--
A
----
P
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
38
HHSearch
82.99
18%
-149
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-322]
---------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-
P
Q
G
Y
Y
S
T
-
T
E
----
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
------------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
-
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
-
S
E
I
P
G
DSSDRYH
E
Q
V
----
S
A
K
R
K
V
V
K
M
--------------
M
I
--------------
V
V
V
C
T
F
A
-
I
C
-------
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
DL
Y
LKKF
I
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
------------------
18
PsiBlast_PDB
82.51
21%
-153
- C1 -
3DQB
6
GNAT1_BOVIN (first)
A:
[58-321]
---------------------------------------------------------
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
-
A
L
A
--------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
IDYYTP-
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
-
V
K
E
A
A
--------
A
Q
----
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------------
L
I
C
W
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
---
S
D
F
--
G
----
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------
17
PsiBlast_PDB
82.18
21%
-145
- C1 -
1F88
7
OPSD_BOVIN
A:
[58-321]
---------------------------------------------------------
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
-
A
L
A
--------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
I
DYYTP-
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
-
V
K
E
A
A
--------
A
--------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------------
L
I
C
W
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
---
S
D
F
--
G
----
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------
16
PsiBlast_PDB
80.91
21%
-149
- C1 -
3C9L
13
OPSD_BOVIN
A:
[58-321]
---------------------------------------------------------
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
-
A
L
A
--------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
IDYYTP-
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
-
V
K
E
A
A
--------
A
Q
----
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------------
L
I
C
W
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
---
S
D
F
--
G
----
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------
20
PsiBlast_PDB
80.25
21%
-149
- C1 -
3PXO
5
OPSD_BOVIN
A:
[58-321]
---------------------------------------------------------
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
-
A
L
A
--------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
IDYYTP-
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
-
V
K
E
A
A
--------
A
Q
----
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------------
L
I
C
W
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
---
S
D
F
--
G
----
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------
19
PsiBlast_PDB
80.20
21%
-149
- C1 -
3PQR
9
OPSD_BOVIN
A:
[58-321]
---------------------------------------------------------
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
-
A
L
A
--------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
IDYYTP-
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
-
V
K
E
A
A
--------
A
Q
----
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------------
L
I
C
W
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
---
S
D
F
--
G
----
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------
14
PsiBlast_PDB
80.19
22%
-129
- C1 -
2X72
7
GNAT1_BOVIN (first)
A:
[61-322]
---------------------------------------------------------
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
-
A
L
A
--------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
IDYYTP-
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
-
V
K
E
A
A
--------
A
Q
----
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------------
L
I
C
W
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
---
S
C
F
--
G
----
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------
15
PsiBlast_PDB
80.09
21%
-153
- C1 -
3CAP
5
OPSD_BOVIN
A:
[58-321]
---------------------------------------------------------
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
-
A
L
A
--------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
IDYYTP-
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
-
V
K
E
A
A
--------
A
Q
----
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------------
L
I
C
W
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
Q
G
---
S
D
F
--
G
----
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------------------