@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10X1_HUMAN: (2016-01-11 )
MVLNVYCCFFQISDIQTMKINQTILKEFILVGFSVYPHVQTFLFVVFFCLYLLTLAGNLIIMGLTWVDRSLHTPMYLFLSALSFSETCYTLTIVPKMLEDLLAKDRSISVTGCSLQMCFFLGLGGTNCIILTLMGYDRFLAICNPLRYPLLMTNIVCGQLVASACTAGFFISLTETALIFRDSFCRPNLVKHFFCHMLAVIRLSCIDSNHTEFIITLISVSGLLGTLLLIILTDVFIISTVLRIPSAEGKQKAFTTCASHLTVVIIHFGFASIVYLKPEASGDDTLIAVPYTVITPFLSPIIFSLRNKDMKNAFRRMMGNTVALKK
Atome Classification :
(20 SA)
----------------------------------------.........10........20--........30-------.........40...-.....50........60........70........80.....--------------...90..-......100-....----...110........120.......130.......140.......150--........160...----....170.......180-.........190-........200...--------.--------...210.........220.......230.......240---.....-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.---.250.......260...-----...--------.270.......280--------------........290.....--..300.......310......-----------.320....-------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------
M
V
L
N
V
Y
C
C
F
F
Q
ISD
I
Q
T
M
KI
N
--
Q
T
I
L
K
E
F
I
L
--------
V
GFSV
Y
P
H
V
Q
T
F
L
F
-
V
V
F
F
C
L
Y
L
L
T
LAG
N
L
I
I
M
G
L
T
WVDRSLH
T
P
M
Y
L
F
L
S
A
LSFSE--------------
T
C
Y
T
L
T
I
-
V
P
K
M
L
E
D
L
L
-AKDR----
S
I
S
V-TG
C
S
L
Q
M
C
F
F
LGLGGT
N
C
I
I
L
T
LMG
Y
D
R
F
L
A
I
C
N
P
LR
Y
P
L
L
---
M
T
N
I
V
C
G
Q
L
V
A
S
A
C----TA
G
F
F
I
S
LT
E
T
A
L
I
F---RDSFCR
P
N
L
V
K
--
H
F
F
C
H
M
L
A
V
I
R
L
SC--------I--------DSNH--
T
E
F
I
I
T
L
I
S
V
S
G
L
L
G
T
L
L
L
I
I
L
T
D
V
F
I
I
S
T
V
----
L
RIPS-----------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------E---G
K
Q
K
A
F
T
T
C
A
S
H
L
T
V
V
I
-----
I
HF--------G
F
A
S
I
V
Y
LKPEAS---------------GD
D
T
L
I
A
V
P
Y
T
V
I
T
P
F
--
L
S
P
I
I
F
S
L
RN
K
D
M
K
N
A
F
R
R
MM-----------GNTVALKK-------------
23
HHSearch
92.93
16%
-137
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-----------------------------------------------------------------------------------------
V
V
F
I
V
-
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
--------------
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
----
P
L
G
P
-
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
----
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
---
F
I
V
G
--
V
R
T
V
E
--
D
G
E
C
Y
I
Q
F
F
-------------------------
S
--
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
----
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
-----
I
T
W
--------
A
P
Y
N
V
M
V
L
I
N
T
F
C
APCIP----------
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
--
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
-----------
M
--------------------
42
Fugue
91.91
17%
-134
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
--
S
P
F
E
A
P
Q
Y
Y
--------
L
A
---
E
P
W
Q
F
S
M
L
A
-
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--------------
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
----
V
F
G
P
-
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---------------------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
---
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
---
Q
C
S
C
--------
G
I
DYYTPHE
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
----
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
-----
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
---------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----------
C
C
G
K
N
P
S
T
TVSKTETS
Q
V
A
P
A
27
HHSearch
91.84
17%
-138
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------------------------------------------
P
L
V
-
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
--------------
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
----
S
L
G
R
-
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
----
F
L
S
F
L
W
V
I
P
I
L
-
G
W
N
---
H
--------
R
R
--
E
D
K
C
E
T
D
F
Y
D
---------------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
----
R
Q
H
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
---
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
-----
L
C
W
--------
I
P
Y
F
I
F
F
M
V
I
A
F
C
KNCCN----------
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
--
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
-----------
H
I
-------------------
31
HHSearch
89.47
18%
-133
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-471]
-----------------------------------------------------------------------------------------
S
S
V
Y
I
-
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--------------
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
----
C
A
A
C
-
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
----
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
---
N
C
G
Q
---------
S
Q
G
C
G
E
G
Q
---
V
A
C
--------
L
--------
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
----
R
R
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
---
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
-----
L
C
W
--------
L
P
L
H
I
I
N
C
F
T
F
F
C
PDCSHAP--------
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----------
R
S
H
V
L
R
Q
--------------
29
HHSearch
88.85
15%
-133
- C3 -
2Z73
5
OPSD_TODPA
A:
[30-333]
-------------------------------------------------------------------------------------
P
D
A
V
Y
Y
S
L
G
-
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
--------------
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
----
I
F
G
F
-
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
----
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
---
A
Y
T
----
L
E
G
V
--
L
C
N
C
S
F
D
Y
I
S
---------------------
R
D
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
----
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
-----
L
S
W
--------
S
P
Y
A
V
V
A
L
L
A
Q
F
G
PLEWVT---------
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
--
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-----------
P
W
V
L
T
C
C
Q
-------------
32
HHSearch
86.55
14%
-134
- C3 -
2KS9
1
NK1R_HUMAN
A:
[31-324]
----------------------------------------------------------------------------------------
Q
I
V
L
W
A
-
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
--------------
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
----
Y
Y
G
L
-
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
----
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
---
T
E
-----
T
M
P
S
--
R
V
V
C
M
I
E
W
P
E
H
P
-------------------
N
K
I
Y
--
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
----
W
A
S
E
I
PGDSSDRYH
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
-----
I
C
W
--------
L
P
F
H
I
F
F
L
L
P
Y
I
N
PDLYLKKFI------
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
--
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-----------
R
C
C
P
F
I
S
A
-------------
25
HHSearch
85.48
15%
-131
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
----------------------------------------------------------------------------------------
W
V
V
G
M
G
-
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
--------------
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
----
T
F
G
N
-
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
---
Y
R
A
T
----
H
Q
E
--
A
I
N
C
Y
A
E
----
E
T
C
--------
C
--------
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
----
K
R
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
---
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
-----
L
C
W
--------
L
P
F
F
I
V
N
I
V
H
V
I
Q
DNLIR----------
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
--
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-----------
C
L
-------------------
33
HHSearch
80.60
13%
-137
* C3 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------------------------------------------
Y
A
-
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
--------------
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
----
N
F
S
R
-
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
----
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
---
T
T
-------
G
D
--
P
T
V
C
S
I
S
N
------------------------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
----
K
Q
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
---
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
-----
V
C
W
--------
L
P
F
F
L
T
H
V
L
N
T
H
C
QTCHVS---------
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
--
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
-----------
S
C
-------------------
46
Fugue
80.56
17%
-107
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
--
S
P
F
E
A
P
Q
Y
Y
--------
L
A
---
E
P
W
Q
F
S
M
L
A
-
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--------------
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
----
V
F
G
P
-
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---------
S
N
F
R
F
G
E
N
H
A
I
M
G
----
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
---
L
V
G
W
S
R
-----------
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
--------
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----
E
A
A
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
ESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
-----
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
---------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDE
A
S
T
T
V
S
K
T
ETSQVAPA-----
30
HHSearch
79.23
17%
-127
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
--------------------------------------------------------------------------------------
E
N
S
I
K
L
T
S
-
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
--------------
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
----
K
L
T
P
-
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
----
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
---
C
I
-------
S
A
--
L
S
S
C
S
T
V
L
P
L
---------------------------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
----
R
T
R
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
---
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
-----
A
C
W
--------
A
P
L
F
I
L
L
L
L
D
V
G
C
KVKTC
D
I
--------
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
--
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
-----------
G
R
P
L
-----------------
50
Fugue
79.04
15%
-138
- C2 -
4TQG
1
?
A:
[1-319]
------------------------------------------------------------
S
--
Q
I
N
D
K
T
I
M
I
--------
F
G
-------
G
S
G
S
L
-
G
N
R
L
I
E
T
Y
I
N
---
N
N
I
I
V
N
Y
S
R
-
D
E
S
K
H
W
S
M
E
L
K
Y
K
S
D
K
L
K
N
--------------
I
I
G
D
I
R
D
-
F
E
K
V
Q
Q
S
I
M
-
R
I
N
P
----
D
I
I
I
-
I
A
A
A
L
K
H
I
D
R
C
E
Y
E
I
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
I
N
R
S
N
L
S
---
N
L
K
A
V
C
F
V
S
T
D
K
A
C
SPVN
S
Y
G
M
S
K
A
I
C
E
T
L
V
V
E
---
K
S
K
Y
I
K
D
--
I
K
--
Y
V
C
V
R
Y
G
N
V
L
N
F
T
L
--------
T
--------
H
T
S
M
--
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
N
S
G
E
I
V
I
P
-------
K
L
N
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
I
K
D
M
I
E
L
F
A
D
K
Y
P
I
V
I
T
G
----
L
R
S
--------
G
E
R
M
Y
E
S
L
I
N
D
T
Q
---------------
S
M
K
T
V
P
K
G
D
Y
Y
H
I
L
P
T
--
Y
D
P
T
I
V
T
E
E
F
Y
E
Y
S
S
K
Q
N
I
L
S
-----------
K
Q
E
L
E
N
Y
L
N
Q-----------
34
HHSearch
77.22
15%
-108
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-327]
---------------------------------------------------------------------------------------
W
Q
F
S
M
L
A
-
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
--------------
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
----
V
F
G
P
-
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
----
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
---
R
Y
I
----
P
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
P
H
-------------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
----
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
-----
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGSDFG---------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----------
C
C
G
K
N
P
L
G
-------------
24
HHSearch
73.34
13%
-131
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-498]
--------------------------------------------------------------------------------------
N
F
N
K
I
F
L
P
-
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
--------------
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
----
Y
F
G
N
-
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
----
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
---
V
S
-----
E
A
D
D
--
R
Y
I
C
D
R
F
Y
P
N
----------------------
D
L
W
--
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
----
S
H
S
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
---
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
-----
A
C
W
--------
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
--
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
-----------
T
S
G
R
P
L
E
V
-------------
35
HHSearch
73.13
14%
-125
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
---------------------------------------------------------------------------------------
L
N
K
Y
V
V
I
-
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
--------------
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
----
I
F
G
T
-
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
----
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
---
A
Y
H
----
P
N
N
S
--
S
P
V
C
Y
E
V
L
G
N
D
--------------------
T
A
K
W
--
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
----
F
K
A
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
-----
L
C
W
--------
L
P
Y
N
L
V
L
L
A
D
T
L
M
RTQVIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
--
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
-----------
A
M
H
G
-----------------
48
Fugue
71.04
15%
-146
* C2 *
4KPP
4
?
A:
[2-396]
DF
T
K
E
K
F
Q
L
L
A
I
S
S
L
T
L
P
W
L
I
S
L
A
F
N
Y
H
H
P
A
L
T
Q
T
L
L
S
G
L
A
V
V
S
A
S
F
L
I
S
W
A
A
E
T
A
E
M
D
V
P
--
R
S
-
F
S
L
A
I
V
--------
A
L
L
A
V
L
P
E
Y
A
V
D
G
Y
-
F
A
W
K
A
G
S
V
G
G
E
Y
V
H
Y
A
T
A
N
M
T
G
A
N
R
L
L
I
G
I
G
W
S
L
V
A
F
I
A
F
R
T
L
KSK
E
V
E
L
D
DGI
R
L
E
I
F
F
L
F
L
-
A
T
L
Y
A
F
T
L
P
-
L
K
G
H
IS
P
F
D
A
L
V
-
F
V
S
L
Y
A
I
Y
I
Y
L
S
T
K
A
E
R
E
E
V
E
V
G
G
V
P
A
Y
L
C
S
L
K
T
E
T
R
R
L
S
V
---
V
V
L
F
L
F
A
G
F
T
I
L
M
S
----
V
E
A
F
S
E
G
L
L
E
T
A
R
I
A
GID
E
F
L
A
V
Q
W
I
A
P
L
--
A
S
E
S
P
E
L
I
V
A
I
Y
F
V
--------
R
--------
R
F
R
V
--
S
A
S
M
N
A
L
I
S
S
K
V
N
Q
W
T
L
L
I
G
T
I
A
I
I
Y
S
I
S
A
F
KL
Q
S
L
P
L
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---
S
E
E
V
L
L
T
A
A
Q
S
L
F
A
V
A
I
L
L
DLK
I
S
W
--------
K
E
A
S
A
L
F
L
L
F
I
V
Q
---------------
L
L
F
P
G
V
E
V
R
Y
I
I
S
A
I
Y
I
I
L
S
L
P
I
L
F
A
K
R
K
E
I
V
E
S
F
R
T
V
K
-----------
R
L
I
-
S
L
E
--------------
43
Fugue
69.20
17%
-147
* C4 *
3FMG
2
VP7_ROTRH
A:
[28-262]
------------------------------------------
T
S
T
L
C
L
Y
Y
P
T
E
A
A
T
E
I
N
D
N
S
W
K
D
T
L
S
Q
L
F
L
T
K
GWPTGS
V
Y
F
K
E
Y
T
D
I
A
S
F
S
V
D
P
Q
L
Y
C
D
Y
N
V
V
L
M
K
Y
---------
D
A
T
L
Q
L
D
M
S
E
L
A
D
L
I
L
N
E
W
--------------
L
C
N
P
M
D
I
-
T
L
Y
Y
Y
Q
Q
T
D
-
E
A
N
K
----
W
I
S
M
G
S
S
C
T
I
K
V
C
P
L
---------------------------------------------
N
T
Q
----
T
L
G
---------------------------------------
I
G
C
--------
L
--------
T
T
D
T
--
A
T
F
E
E
V
A
T
A
-------
E
K
L
V
I
T
D
V
V
D
G
V
N
H
K
----
L
D
V
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---
C
T
I
R
N
C
K
K
L
G
P
R
E
N
V
A
V
-----
I
Q
V
--------
G
---------------------------
G
S
D
V
L
D
I
T
A
D
P
T
T
A
P
---
Q
T
E
R
M
M
R
I
N
W
K
K
W
W
Q
V
F
Y
T
V
V
-----------
D
Y
V
N
Q
I
I
Q
A
M
S
K---------
10
PsiBlast_PDB
63.62
24%
-139
- C3 -
3EML
8
ENLYS_BPT4
A:
[18-153]
-----------------------------------------------------------------------
I
--------
M
G
S
S
V
Y
I
T
V
E
--------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--------------
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
-
S
T
G
F
----
C
A
A
C
-
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
----
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
---
N
C
G
Q
S
Q
G
C
G
E
G
--
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
--------
M
--------
V
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
----
M
L
R
I
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
-----
G
H
L
--------
L
T
K
S
P
S
L
N
A
A
K
S
E
---------------
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
--
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-----------
K
L
K
P
V
Y
D
S
-------------
14
PsiBlast_PDB
63.58
23%
-141
- C3 -
2YDO
1
?
A:
[6-138]
----------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
--------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
--------------
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
-
S
T
G
F
----
C
A
A
C
-
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
----
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
---
N
C
G
Q
P
K
E
G
K
A
H
--
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--------
D
--------
V
V
P
M
--
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
----
R
Q
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
---------------
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
--
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
-----------
R
E
F
R
Q
T
F
R
-------------
15
PsiBlast_PDB
63.34
23%
-140
- C3 -
2YDV
4
?
A:
[3-138]
-----------------------------------------------------------------------
I
--------
M
G
S
S
V
Y
I
T
V
E
--------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
--------------
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
-
S
T
G
F
----
C
A
A
C
-
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
----
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
---
N
C
G
Q
P
K
E
G
K
A
H
--
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--------
D
--------
V
V
P
M
--
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
----
R
Q
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
S
Q
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
-----
I
V
G
--------
L
F
A
L
C
W
L
P
L
H
I
I
N
---------------
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
--
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
-----------
R
I
R
E
F
R
Q
T
-------------
9
PsiBlast_PDB
62.37
24%
-144
- C3 -
4EIY
18
AA2AR_HUMAN (first)
A:
[28-163]
-----------------------------------------------------------------------
I
--------
M
G
S
S
V
Y
I
T
V
E
--------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
--------------
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
-
S
T
G
F
----
C
A
A
C
-
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
----
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
---
N
C
G
Q
P
K
E
G
K
N
H
--
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--------
D
--------
V
V
P
M
--
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
----
R
Q
L
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
-----
N
A
A
--------
Q
V
K
D
A
L
T
K
M
R
A
A
A
---------------
L
D
A
Q
K
M
K
D
F
R
H
G
F
D
I
L
--
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
-----------
A
A
E
Q
L
K
T
T
-------------