@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O11G2_HUMAN: (2016-01-11 )
MHFLSQNDLNINLIPHLCLHRHSVIAGAFTIHRHMKIFNSPSNSSTFTGFILLGFPCPREGQILLFVLFTVVYLLTLMGNGSIICAVHWDQRLHAPMYILLANFSFLEICYVTSTVPSMLANFLSDTKIISFSGCFLQFYFFFSLGSTECFFLAVMAFDRYLAICRPLRYPTIMTRRLCTNLVVNCWVLGFIWFLIPIVNISQMSFCGSRIIDHFLCDPAPLLTLTCKKGPVIELVFSVLSPLPVFMLFLFIVGSYALVVRAVLRVPSAAGRRKAFSTCGSHLAVVSLFYGSVLVMYGSPPSKNEAGKQKTVTLFYSVVTPLLNPVIYSLRNKDMRKALKKFWGT
Atome Classification :
(20 SA)
------------------------------.........10........20......-------..30........40........50......-..60........70...-.....80........90........100.......110...-....120..-.....130.......140.......150.......160.......170.---......180.......190.......200..------....----.---.210.......220......--.230.-----.....---...240-----.-----......250.......260......------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------270.--------......----280.......290------------------------------.-.......300..------------.------------..-------..310..-.....320.......330.......340...----------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------MHFLSQNDL
N
I
N
L
I
P
H
L
C
L
H
R
HSV
I
A
G
-------
A
F
T
I
H
R
H
M
K
I
FNSPSNSS
T
F
T
G
F
I
L
L
GFPC-PREGQ
I
L
L
F
V
L
F
T
V
V
Y
L
-
L
T
LMGN
G
S
I
I
C
A
V
HWDQRLHA
P
M
Y
I
L
LANF
S
F
L
E
I
C
Y
V
TS
T
-
V
P
S
M
L
A
N
F
L-SDT
K
I
I
SF
S
G
C
F
L
Q
F
Y
F
F
F
SLGS
T
E
C
F
F
L
A
V
M
A
F
D
R
Y
L
A
I
CRPLR
Y
P
T
I
---
M
T
R
R
L
C
T
N
L
V
V
N
C
W
V
L
G
F
I
W
F
L
I
P
I
VN-
I
S
Q
------
M
S
F
C
----
G
---
S
R
I
I
D
H
FLCDPA
P
L
L
T
L
TCK--KG--
P
-----
V
I
E
L
V
---
F
S
V
LS
P
-----
L
-----
P
V
F
M
L
F
L
F
I
V
G
S
Y
A
L
V
V
R
A
V
L
RVPS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------AGR
R
--------
K
A
F
S
T
C
----
G
S
H
L
A
V
V
S
L
F
YG-------------------------------
S
-
V
L
V
M
YGSPPSKN------------E------------AG-------KQ
K
T
V
T
L
-
F
Y
S
V
V
T
P
L
L
N
P
V
I
Y
S
LR
N
K
D
M
R
K
A
L
K
K
FWGT----------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
85.91
18%
-147
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-442]
-----------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
-
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
N
H
---------------------
R
R
E
D
K
C
E
T
D
F
Y
--------
D
----------
V
T
W
F
---
K
V
M
T
A
I
-----
I
-----
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
--------
K
A
A
K
Q
L
----
G
F
I
M
A
A
F
I
L
C
W
I
-------------------------------
P
-
Y
F
I
F
F
M
V
I
A
F
C
K
------------
N
CC----------
N
E
-------
H
L
H
M
F
T
I
-
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
83.87
18%
-156
- C3 -
3EML
13
ENLYS_BPT4
A:
[22-467]
----------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
-
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
------
C
G
Q
--------------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
FE
D
V
--
V
-----
P
M
N
Y
M
---
V
Y
F
N
F
F
-----
A
-----
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
--------
H
A
A
K
S
L
----
A
I
I
V
G
L
F
A
L
C
W
L
-------------------------------
P
-
L
H
I
I
N
C
F
T
F
F
C
P
DCSH--------
A
------------
P
L
-------
W
L
M
Y
L
A
I
-
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
83.55
18%
-126
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------------------------------------------
M
N
G
T
E
G
P
-------
N
F
Y
V
P
F
S
N
K
--
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
----
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
------
Y
I
P
E
----
G
MQC
S
C
G
I
D
Y
Y
T
P
H
E
E
T
------
N
--
N
E
--
S
-----
F
V
I
Y
M
---
F
V
V
H
F
I
-----
I
-----
P
L
I
V
I
F
-
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
--------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
-------------------------------
G
-
V
A
F
Y
I
F
T
H
Q
G
S
D
------------
F
------------
G
P
-------
I
F
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
GKNPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
83.11
18%
-144
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
------
A
T
H
Q
------------
E
A
I
N
C
Y
A
E
----
E
T
C
C
--
D
F
--
F
-----
T
N
Q
A
Y
---
A
I
A
S
S
I
-----
V
-----
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
--------
K
A
L
K
T
L
----
G
I
I
M
G
T
F
T
L
C
W
L
-------------------------------
P
-
F
F
I
V
N
I
V
H
V
I
Q
D
NL----------
I
------------
R
K
-------
E
V
Y
I
L
L
N
-
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.57
21%
-147
- C3 -
2YCW
7
ADRB1_MELGA
A:
[16-296]
--------------------------------------------------------------------------------------------------------
L
L
M
A
L
V
V
L
-
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
---------------------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
--
Q
D
--
P
GCCDF
V
T
N
R
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
-----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
----
G
I
I
M
G
V
F
T
L
C
W
L
-------------------------------
P
F
F
L
V
N
I
V
N
V
F
N
R
D
------------
L
------------
V
P
-------
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.56
21%
-147
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[16-296]
--------------------------------------------------------------------------------------------------------
L
L
M
A
L
V
V
L
-
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
---------------------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
--
Q
D
--
P
GCCDF
V
T
N
R
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
-----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
----
G
I
I
M
G
V
F
T
L
C
W
L
-------------------------------
P
F
F
L
V
N
I
V
N
V
F
N
R
D
------------
L
------------
V
P
-------
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.74
21%
-143
- C3 -
2YCX
3
ADRB1_MELGA
A:
[16-294]
--------------------------------------------------------------------------------------------------------
L
L
M
A
L
V
V
L
-
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
---------------------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
--
Q
D
--
P
GCCDF
V
T
N
R
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
-----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
----
G
I
I
M
G
V
F
T
L
C
W
L
-------------------------------
P
F
F
L
V
N
I
V
N
V
F
N
R
D
------------
L
------------
V
P
-------
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
77.32
18%
-94
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
-----
S
N
K
T
G
V
V
R
S
-------
P
F
E
A
P
Q
Y
Y
-------------------
L
A
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
-
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
GM
Q
C
S
C
----
G
------
I
D
Y
Y
T
P
H
E
E
T
------
N
--
N
E
--
S
-----
F
V
I
Y
M
---
F
V
V
H
F
I
-----
I
-----
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
--------
K
A
E
K
E
V
----
T
R
M
V
I
I
M
V
I
A
F
L
-------------------------------
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
------------
F
------------
T
H
QGSDFGP
I
F
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
GKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.89
21%
-146
- C3 -
2YCY
6
ADRB1_MELGA
A:
[16-296]
--------------------------------------------------------------------------------------------------------
L
L
M
A
L
V
V
L
-
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
---------------------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
--
Q
D
--
P
GCCDF
V
T
N
R
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
-----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
----
G
I
I
M
G
V
F
T
L
C
W
L
-------------------------------
P
F
F
L
V
N
I
V
N
V
F
N
R
D
------------
L
------------
V
P
-------
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.68
21%
-146
- C3 -
2VT4
8
ADRB1_MELGA
A:
[16-296]
--------------------------------------------------------------------------------------------------------
L
L
M
A
L
V
V
L
-
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
---------------------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
--
Q
D
--
P
GCCDF
V
T
N
R
A
---
Y
A
I
A
S
S
I
I
SF
Y
I
-----
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
------
K
A
L
K
T
L
----
G
I
I
M
G
V
F
T
L
C
W
L
-------------------------------
P
F
F
L
V
N
I
V
N
V
F
N
R
D
------------
L
------------
V
P
-------
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
76.24
18%
-146
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-471]
------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
-
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
------
T
--------------
G
D
P
T
V
C
S
I
S
N
---------------------
P
D
F
---
V
I
Y
S
S
V
-----
V
-----
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
--------
K
A
T
Q
M
V
----
A
I
V
L
G
A
F
I
V
C
W
L
-------------------------------
P
-
F
F
L
T
H
V
L
N
T
H
C
Q
TCH---------
V
------------
S
P
-------
E
L
Y
S
A
T
T
-
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
74.43
17%
-148
* C3 *
2Z73
5
OPSD_TODPA
A:
[31-331]
------------------------------------------------------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
-
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
------
Y
T
L
-----------
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------
R
D
--
S
-----
T
T
R
S
N
---
I
L
C
M
F
I
-----
L
-----
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
--------
R
L
A
K
I
S
----
I
V
I
V
S
Q
F
L
L
S
W
S
-------------------------------
P
-
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW---------
V
------------
T
P
-------
Y
A
A
Q
L
P
V
-
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
73.20
19%
-141
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-493]
------------------------------------------------------------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
-
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
N
C
------
I
--------------
S
A
L
S
S
C
S
T
V
L
P
L
-----------------
Y
H
-
K
H
---
Y
I
L
F
C
T
-----
T
-----
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
--------
A
L
L
K
T
V
----
I
I
V
L
S
V
F
I
A
C
W
A
-------------------------------
P
-
L
F
I
L
L
L
L
D
V
G
C
K
------------
V
KTC
D
--------
I
L
-------
F
R
A
E
Y
F
L
-
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
71.01
15%
-149
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
-
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
------
I
V
G
V
----
R
-----
T
V
E
D
G
E
C
Y
I
Q
F
F
------------------
S
N
A
A
V
---
T
F
G
T
A
I
-----
A
-----
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
--------
K
V
T
R
T
I
----
L
A
I
L
L
A
F
I
I
T
W
A
-------------------------------
P
-
Y
N
V
M
V
L
I
N
T
F
C
A
PC----------
I
------------
P
N
-------
T
V
W
T
I
G
Y
-
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
70.45
15%
-146
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-322]
----------------------------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
-
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
------
E
T
------------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
---
P
--
N
K
--
I
-----
Y
E
K
V
Y
---
H
I
C
V
T
V
-----
L
-----
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
--------
K
V
V
K
M
M
----
I
V
V
V
C
T
F
A
I
C
W
L
-------------------------------
P
-
F
H
I
F
F
L
L
P
Y
I
N
P
------------
D
LYLKKF------
I
Q
-------
Q
V
Y
L
A
I
M
-
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
69.32
15%
-127
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
-
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
------------------
H
---
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
--
F
F
TN
Q
-----
A
Y
A
I
A
---
S
S
I
V
S
F
-----
Y
-----
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
D
--------
E
G
L
R
L
K
----
I
Y
K
D
T
E
G
Y
Y
T
I
G
-------------------------------
I
-
G
H
L
L
T
K
S
P
-
S
L
N
------------
A
------------
A
K
-------
S
E
L
D
K
A
I
-
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
26
HHSearch
69.17
14%
-144
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-493]
-----------------------------------------------------------------------------------------------
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
-
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
------
S
E
------------
A
D
D
R
Y
I
C
D
R
F
Y
P
--------
N
D
--
L
-----
W
V
V
V
F
---
Q
F
Q
H
I
M
-----
V
-----
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
--------
K
A
L
K
T
T
----
V
I
L
I
L
A
F
F
A
C
W
L
-------------------------------
P
-
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
------------
V
H
-------
K
W
I
S
I
T
E
-
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
65.15
16%
-103
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-323]
-------------------------------------------------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
------
Y
I
P
-----------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
--
E
E
--
T
-----
N
N
E
S
F
---
V
I
Y
M
F
V
-----
V
-----
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
QQQESA
T
T
----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
--------
E
V
T
R
M
V
----
I
I
M
V
I
A
F
L
I
C
W
L
-------------------------------
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
GSD---------
F
------------
G
P
-------
I
F
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
64.81
15%
-129
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
--------------------------------------------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
-
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
------
Y
H
P
-----------
N
N
S
S
P
V
C
Y
E
V
L
G
N
----
D
--
T
A
--
K
-----
W
R
M
V
L
---
R
I
L
P
H
T
-----
F
-----
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
--------
R
A
M
R
V
I
----
F
A
V
V
L
I
F
L
L
C
W
L
-------------------------------
P
-
Y
N
L
V
L
L
A
D
T
L
M
R
------------
T
QVIQE
S
C
E
R
R
N
N
I
G
-------
R
A
L
D
A
T
E
-
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
60.49
15%
-138
- C1 -
2GIC
2
NCAP_VSIVA
A:
[2-422]
SV
T
V
K
R
IIDN
T
V
I
V
P
K
L
P
A
N
E
D
P
V
E
Y
P
A
D
Y
F
R
K
S
K
E
I
P
L
Y
I
N
T
T
K
S
L
S
D
L
R
G
Y
V
Y
Q
G
L
K
S
GNVS
I
I
H
V
N
S
Y
L
Y
G
A
L
K
D
I
R
G
K
L
D
K
D
W
S
S
F
G
I
N
I
G
K
A
G
D
T
I
G
I
F
D
L
V
S
L
K
A
L
D
G
V
L
P
D
G
V
S
D
A
S
R
T
S
A
D
D
K
W
L
P
L
Y
L
L
G
L
Y
R
V
G
R
T
Q
M
P
E
Y
R
K
K
-
L
M
D
G
L
T
N
Q
C
-
K
M
I
N
E
Q
F
E
P
L
V
P
E
G
R
D
I
F
D
V
W
G
N
D
S
N
Y
T
K
I
V
A
A
V
D
M
F
F
H
M
F
K
K
H
E
C
A
S
F
---
R
Y
G
T
I
V
S
R
F
K
-
D
C
A
A
L
A
T
F
G
H
L
C
K
I
T
G
-
M
S
T
------
E
D
V
T
T
W
IL
N
---
R
E
V
A
D
E
M
V
Q
M
M
L
P
G
Q
E
I
D
K
A
--
D
S
--
Y
-----
M
P
Y
L
I
DFG
L
S
S
K
S
P
-----
Y
SSVKN
P
A
F
H
F
W
G
Q
L
T
A
L
L
L
R
S
T
R
A
R
N
A
R
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
E
Y
--------
T
S
L
T
T
A
----
G
L
L
Y
A
Y
A
V
G
S
S
A
DLAQQFCVGDNKYTPDDSTGGLTTNAPPQGR
D
-
V
V
E
W
L
G
W
F
E
D
Q
N
------------
R
------------
K
P
-------
T
P
D
M
M
Q
Y
-
A
K
R
A
V
M
S
L
Q
G
-----
L
R
E
K
T
I
G
K
Y
A
K
S
E
F
D
K
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