@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O13C3_HUMAN: (2016-01-11 )
MIVQLICTVCFLAVNTFHVRSSFDFLKADDMGEINQTLVSEFLLLGLSGYPKIEIVYFALILVMYLVILIGNGVLIIASIFDSHFHTPMYFFLGNLSFLDICYTSSSVPSTLVSLISKKRNISFSGCAVQMFFGFAMGSTECLLLGMMAFDRYVAICNPLRYPIILSKVAYVLMASVSWLSGGINSAVQTLLAMRLPFCGNNIINHFACEILAVLKLACADISLNIITMVISNMAFLVLPLMVIFFSYMFILYTILQMNSATGRRKAFSTCSAHLTVVIIFYGTIFFMYAKPKSQDLIGEEKLQALDKLISLFYGVVTPMLNPILYSLRNKDVKAAVKYLLNKKPIH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70---........80........90........100.....-..110....-...120.......130.......140.......150.......160...---....170.......180.......190-.......200.......210.......220----.--........230....-..--------.240.......250...-----....260----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------........270.......280------........290.......300-----........310.......320.......330.......340-......-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
V
Q
L
I
C
T
V
C
F
L
A
V
N
T
F
H
VRSSFDFLKADDM
G
E
I
N
Q
T
L
V
S
E
F
L
L
LGLSGYPK
I
E
I
V
Y
F
A
L
I
L
V
M
Y
L
V
I
L
IG---N
G
V
L
I
I
A
S
I
F
DSHFH
T
P
M
Y
F
F
LGN
L
S
F
L
D
I
CYTSSS-
V
P
S
T
L
V
S
L
I
-
S
KKRNISFS
G
C
A
V
Q
M
F
F
G
FAMG
S
T
E
C
L
L
L
G
M
M
A
F
D
R
Y
V
A
I
CNPLR
Y
P
I
I
---
L
S
K
V
A
Y
V
L
M
A
S
V
S
W
L
SG
G
I
N
S
A
V
Q
T
L
L
-
A
M
RLPFCG
N
N
I
I
N
H
F
A
C
E
I
L
A
V
L
K
L
A
C
A------D--
I
S
L
N
I
I
T
M
V
I
S
N
M
A
F
-
L
V
--------
L
P
L
M
V
I
F
F
S
Y
M
F
I
L
Y
T
I
-----
L
QMNS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------TGR
R
K
A
F
S
TCS
A
H
L
T
V
V
I
I
F
-------YG
T
I
F
F
M
YAKPKSQDL
I
G
E
-
E
-----
K
L
Q
A
L
D
K
L
I
S
L
F
Y
G
V
V
T
P
M
L
N
P
I
L
Y
S
LRNK
D
V
K
A
A
V
K
Y
L
L--NKKPIH-------------------
29
HHSearch
92.85
19%
-139
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
----------------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
----
T
C
C
------
D
--
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
-
F
Y
--------
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
-------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-----------------------
46
Fugue
85.08
17%
-116
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
---
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
--------------
M
Q
C
S
C
G
I
DYYTP
H
--
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
--------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A----
34
HHSearch
85.02
15%
-140
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-469]
-----------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
------
F
ED
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
-------
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
-
S
-----
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
-------------------
31
HHSearch
84.58
18%
-128
* C3 *
2KS9
1
NK1R_HUMAN
A:
[31-324]
----------------------------------------------------
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
---
P
------
N
--
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
-
Y
F
--------
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-----
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
-------
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
Y
L
-
K
-----
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
C
C
P
F
I
-------------------
47
Fugue
83.49
17%
-108
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
---
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
--------------
M
Q
C
S
C
G
I
DYYTP
H
--
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
--------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
-------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-
F
T
H
QGS
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
DDEA
S
T
T
V
S
K
TETSQVAPA
3
PsiBlast_PDB
81.63
20%
-137
- C3 -
3C9L
13
OPSD_BOVIN
A:
[44-314]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EAAA
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
D
-------------------
12
PsiBlast_PDB
80.87
20%
-143
- C3 -
1HZX
14
OPSD_BOVIN
A:
[47-315]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------
32
HHSearch
80.83
17%
-130
- C3 -
2Z73
5
OPSD_TODPA
A:
[31-333]
--------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----------
R
--
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
-
F
F
--------
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
-------
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
----
E
-----
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
-------------------
26
HHSearch
79.80
19%
-140
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------------
S
N
A
A
V
T
F
G
T
A
I
A
A
-
F
Y
--------
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
-----
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
-------
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
----------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
--
M
------------------------
27
HHSearch
79.71
16%
-132
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
---
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
N
H
--------
R
R
E
D
K
C
E
T
D
F
Y
D
-----------------
V
T
W
F
K
V
M
T
A
I
I
N
-
F
Y
--------
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
-----
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
-------
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
----------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
--
H
I
-----------------------
16
PsiBlast_PDB
79.65
20%
-140
- C3 -
2PED
13
OPSD_BOVIN
A:
[47-315]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAA
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------
14
PsiBlast_PDB
79.43
20%
-135
- C3 -
2I35
4
OPSD_BOVIN
A:
[44-314]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EAAA
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
D
-------------------
18
PsiBlast_PDB
79.34
20%
-145
- C3 -
1L9H
14
OPSD_BOVIN
A:
[47-315]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------
36
HHSearch
79.28
19%
-132
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
---
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
-------
G
D
P
T
V
C
S
I
S
N
--------------------
P
D
F
V
I
Y
S
S
V
V
S
-
F
Y
--------
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
-----
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
-------
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
----
C
-----
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
--
S
C
-----------------------
17
PsiBlast_PDB
79.23
20%
-140
- C3 -
2G87
13
OPSD_BOVIN
A:
[47-315]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAA
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------
4
PsiBlast_PDB
79.07
20%
-133
- C3 -
1F88
7
OPSD_BOVIN
A:
[44-314]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAA----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------
5
PsiBlast_PDB
79.05
20%
-135
- C3 -
3DQB
4
GNAT1_BOVIN (first)
A:
[44-314]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
--------------------
19
PsiBlast_PDB
79.04
20%
-139
- C3 -
1U19
13
OPSD_BOVIN
A:
[47-315]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAA
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------
6
PsiBlast_PDB
79.01
20%
-137
- C3 -
3PQR
9
OPSD_BOVIN
A:
[44-314]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
--------------------
10
PsiBlast_PDB
78.70
20%
-142
- C3 -
3OAX
16
OPSD_BOVIN
A:
[47-315]
---------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-
C
A
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
---------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
-
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAA
Q
Q
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------