@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O13C4_HUMAN: (2016-01-11 )
MDKINQTFVREFILLGLSGYPKLEIIFFALILVMYVVILIGNGVLIIASILDSRLHMPMYFFLGNLSFLDICYTTSSIPSTLVSLISKKRNISFSGCAVQMFFGFAMGSTECFLLGMMAFDRYVAICNPLRYPIIMNKVVYVLLTSVSWLSGGINSTVQTSLAMRWPFCGNNIINHFLCEILAVLKLACSDISVNIVTLAVSNIAFLVLPLLVIFFSYMFILYTILRTNSATGRHKAFSTCSAHLTVVIIFYGTIFFMYAKPKSQDLLGKDNLQATEGLVSMFYGVVTPMLNPIIYSLRNKDVKAAIKYLLSRKAINQ
Atome Classification :
(20 SA)
----------------.........10..---......20--------------..-------------......30........---40---.....-----------...50.-.---..---------------------....-60........70......----------..--80........90.....---...100.......110.......--------------120.......--------------130........140......--.150.......160....-..--.170....-----...180.....----..-------190-----.........200.....--------..210....----...220......--.230--------------------.--------.--------.....240.......250.......260....------...270.-----.....-..280----..-.....290.----......300.......310---------------.-......-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MDK
I
N
Q
T
F
V
R
E
F
I
---
L
LGLSGYP--------------
K
L
-------------
E
I
I
F
F
A
L
I
L
V
M
Y
V
V
I
L
---IG---N
G
V
L
I
-----------
I
A
S
I
L
D-S---RL---------------------H
M
P
M
-
Y
F
FLGN
L
S
F
L
D
I
CYTTSS----------
I
P
--
S
T
L
V
S
L
I
S
KKRNISFS
G
---
C
A
V
Q
M
F
F
G
FAMGS
T
E
C
F
L
L
G
M
M
A
--------------
F
D
R
Y
V
A
I
CNP--------------L-RY
P
I
I
M
N
K
V
V
Y
V
L
L
T
S
V
S
--
W
L
SGGIN
S
T
V
Q
T
S
L
A
M
RW-PF--C
G
N
N
I
I
N
H
-----
F
L
C
E
I
L
A
V
L
K
L
----AC-------S-------DI
S
V
N
I
V
T
L
A
V
S
N
I
A
F
L
--------
V
L
P
L
L
V
I
F
F
----
S
Y
M
F
I
L
Y
T
I
L
RT--NSAT--------------------G--------R--------
H
K
A
F
S
TCS
A
H
L
T
V
V
I
I
F
YG
T
I
F
F
M
YAKPKSQD------LLGK-DN-----
L
Q
A
T
E
-
G
L
V
S
M
----
F
Y
-
G
V
V
T
P
M
L
N
P
----
I
I
Y
S
LRNK
D
V
K
A
A
I
K
Y
L
L
----------------
S
-
R
KAINQ-----------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.74
20%
-141
- C1 -
4GBR
1
ADRB2_HUMAN
A:
[2-284]
------------------------------------------------------
E
V
-------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
---
V
F
---
G
N
V
L
V
-----------
I
T
A
I
A
K
F
E
---
R
L
---------------------
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
----------
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
V
D
R
Y
F
A
I
T
S
P
--------------
F
-
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
-----
Y
A
E
E
-----------
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--------
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
Q
K
I
--------------------
D
--------
K
FC
L
K
E
---
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
------
N
L
I
R
-
K
E
-----
V
Y
-----
I
L
L
N
----
W
I
-
G
Y
V
N
S
G
F
N
P
----
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
----------------
C
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.48
22%
-135
- C1 -
4LDE
3
A:
[173-461]
------------------------------------
D
A
Y
A
--------------
A
D
-------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
-----------
T
A
I
A
K
F
-
E
---
R
L
---------------------
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
----------
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
V
D
R
Y
F
A
I
T
S
P
--------------
F
-
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
-----
Y
A
E
E
-----------
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--------
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
--------------------
K
--------
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
N
-----
L
I
R
K
E
-
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
----
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
----------------
C
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.82
22%
-138
- C1 -
4LDL
3
ADRB2_HUMAN
A:
[173-461]
------------------------------------
D
A
Y
A
--------------
A
D
-------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
-----------
T
A
I
A
K
F
-
E
---
R
L
---------------------
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
----------
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
V
D
R
Y
F
A
I
T
S
P
--------------
F
-
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
-----
Y
A
E
E
-----------
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--------
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
--------------------
K
--------
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
N
-----
L
I
R
K
E
-
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
----
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
----------------
C
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.44
22%
-137
- C1 -
4QKX
2
ADRB2_HUMAN
A:
[173-461]
------------------------------------
D
A
Y
A
--------------
A
D
-------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
-----------
T
A
I
A
K
F
-
E
---
R
L
---------------------
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
----------
V
P
--
F
G
A
A
C
I
L
T
K
T
W
T
F
G
N
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
V
D
R
Y
F
A
I
T
S
P
--------------
F
-
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
-----
Y
A
E
E
-----------
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--------
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
--------------------
K
--------
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
N
-----
L
I
R
K
E
-
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
----
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
----------------
C
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.91
22%
-137
- C1 -
4LDO
3
A:
[173-461]
------------------------------------
D
A
Y
A
--------------
A
D
-------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
-----------
T
A
I
A
K
F
-
E
---
R
L
---------------------
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
----------
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
V
D
R
Y
F
A
I
T
S
P
--------------
F
-
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
-----
Y
A
E
E
-----------
T
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--------
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
--------------------
K
--------
E
--------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
N
-----
L
I
R
K
E
-
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
----
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
----------------
C
-
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.12
23%
-135
- C1 -
2YCY
6
ADRB1_MELGA
A:
[15-299]
--------------------------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
---
V
A
---
G
N
V
L
V
-----------
I
A
A
I
G
S
-
T
Q--
R
L
---------------------
Q
T
L
T
-
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
----------
V
P
F
G
A
T
L
V
V
-----
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
I
D
R
Y
L
A
I
T
S
P
--------------
F
-
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
--
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
------------------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
--------
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----
D
R
A
S
--------------------
K
--------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
----
N
I
V
N
------
V
F
N
R
-
D
L
-----
V
P
D
W
L
-
F
V
A
F
N
----
W
L
-
G
Y
A
N
S
A
M
N
P
----
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----------------
A
F-----------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.73
23%
-135
- C1 -
2VT4
8
ADRB1_MELGA
A:
[15-298]
--------------------------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
---
V
A
---
G
N
V
L
V
-----------
I
A
A
I
G
S
-
T
Q--
R
L
---------------------
Q
T
L
T
-
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
----------
V
P
F
G
A
T
L
V
V
-----
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
I
D
R
Y
L
A
I
T
S
P
--------------
F
-
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
--
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
------------------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
--------
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--------------------------------------
E
-------
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
----
N
I
V
N
------
V
F
N
R
-
D
L
-----
V
P
D
W
L
-
F
V
A
F
N
----
W
L
-
G
Y
A
N
S
A
M
N
P
----
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
86.47
23%
-136
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[15-299]
--------------------------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
---
V
A
---
G
N
V
L
V
-----------
I
A
A
I
G
S
-
T
Q--
R
L
---------------------
Q
T
L
T
-
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
----------
V
P
F
G
A
T
L
V
V
-----
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
I
D
R
Y
L
A
I
T
S
P
--------------
F
-
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
--
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
------------------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
--------
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
--
D
R
A
S
--------------------
K
--------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
----
N
I
V
N
------
V
F
N
R
-
D
L
-----
V
P
D
W
L
-
F
V
A
F
N
----
W
L
-
G
Y
A
N
S
A
M
N
P
----
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----------------
A
F-----------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
86.09
23%
-136
- C1 -
2YCW
7
ADRB1_MELGA
A:
[15-299]
--------------------------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
---
V
A
---
G
N
V
L
V
-----------
I
A
A
I
G
S
-
T
Q--
R
L
---------------------
Q
T
L
T
-
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
----------
V
P
F
G
A
T
L
V
V
-----
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
I
D
R
Y
L
A
I
T
S
P
--------------
F
-
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
--
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
------------------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
--------
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
--
D
R
A
S
--------------------
K
--------
R
KR
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
----
N
I
V
N
------
V
F
N
R
-
D
L
-----
V
P
D
W
L
-
F
V
A
F
N
----
W
L
-
G
Y
A
N
S
A
M
N
P
----
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----------------
A
F-----------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
83.49
19%
-123
- C1 -
2KS9
1
NK1R_HUMAN
A:
[35-325]
------------------------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
---
V
G
---
N
V
V
V
M
-----------
W
I
I
L
A
H
-
K
---
R
M
---------------------
R
T
V
T
-
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
----------
T
V
--
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
---
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
--------------
F
D
R
Y
M
A
I
I
H
P
--------------
L
-
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
--
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
--
S
--
T
T
---
E
-
T
M
P
S
R
-----
V
V
C
M
I
E
W
P
E
H
P
----
N
K
-------
I
----------
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
--------
F
L
P
L
L
V
I
G
Y
----
A
Y
T
V
V
G
I
T
L
W
A
S
--
E
I
P
G
DSSDRYH
E
Q
V
S
---------
A
--------
K
--------
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
------
D
L
Y
L
-
K
K
-----
F
I
Q
Q
V
-
Y
L
A
I
M
----
W
L
-
A
M
S
S
T
M
Y
N
P
----
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
----------------
R
-
C
C
P
F
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
82.20
23%
-129
- C1 -
2YCX
3
ADRB1_MELGA
A:
[15-294]
--------------------------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
---
V
A
---
G
N
V
L
V
-----------
I
A
A
I
G
S
-
T
Q--
R
L
---------------------
Q
T
L
T
-
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
----------
V
P
F
G
A
T
L
V
V
-----
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
I
D
R
Y
L
A
I
T
S
P
--------------
F
-
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
--
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
------------------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
--------
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
--
D
R
A
S
--------------------
K
--------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
----
N
I
V
N
------
V
F
N
R
-
D
L
-----
V
P
D
W
L
-
F
V
A
F
N
----
W
L
-
G
Y
A
N
S
A
M
N
P
----
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
81.07
18%
-124
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------
M
N
G
T
E
G
P
N
F
Y
---
V
P
F
S
N
K
T
G
--------------
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
---
L
G
---
F
P
I
N
F
-----------
L
T
L
Y
V
T
-
V
Q
H
K
K
L
---------------------
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
----------
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
--------------
I
E
R
Y
V
V
V
C
K
P
--------------
M
-
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
--
W
V
M
A
L
A
C
A
A
---
P
P
L
V
G
W
-----------
S
R
-----
Y
I
P
E
G
M
---
Q
C
----
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--------
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
--------------------
Q
--------
E
--------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
------
A
F
Y
I
-
F
T
H
QGSD
F
G
P
I
F
-
M
T
I
P
A
----
F
F
-
A
K
T
S
A
V
Y
N
P
----
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
-
K
T
E
T
S
Q
VAPA-------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
79.98
17%
-122
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNK
T
G
V
V
R
S
P
F
E
A
P
Q
Y
---
Y
L
A
---
E
P
--------------
W
Q
-------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
---
N
F
L
T
L
-----------
Y
V
T
V
Q
H
-
K
---
K
L
---------------------
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
----------
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
--------------
I
E
R
Y
V
V
V
C
K
P
--------------
M
-
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
--
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
--
E
G
-------------------
M
Q
C
----
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--------
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
S
A
--------------------
T
--------
T
--------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
------
F
T
H
Q
G
S
D
-----
F
G
P
I
F
-
M
T
I
P
A
----
F
F
-
A
K
T
S
A
V
Y
N
P
----
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
-
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
79.94
17%
-124
- C1 -
2Z73
5
OPSD_TODPA
A:
[34-333]
---------------------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
---
G
G
---
N
G
I
V
I
-----------
Y
L
F
T
K
T
-
K
---
S
L
---------------------
Q
T
P
A
-
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
---------
F
P
--
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
---
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
--------------
I
D
R
Y
N
V
I
G
R
P
--------------
M
-
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
--
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
-
G
---
A
--
Y
T
-
L
E
G
V
L
-----
C
N
C
S
F
D
Y
I
S
R
-----------------------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
--------
F
G
P
I
L
I
I
F
F
----
C
Y
F
N
I
V
M
S
V
S
N
H
--
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--------
E
--------
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
---------
L
-
E
W
-----
V
T
P
Y
A
-
A
Q
L
P
V
----
M
F
-
A
K
A
S
A
I
H
N
P
----
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
----------------
P
-
W
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
78.96
20%
-155
- C1 -
4MGR
3
GABR_BACSU
A:
[2-469]
-D
I
T
I
T
L
DRSEQADY
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
RN
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
KVS
V
N
S
V
-------------
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
---
E
R
---
K
G
F
F
V
E
ELDMFSA
E
E
H
P
P
F
A
L
P
-
D
---
D
L
KE
I
H
I
D
Q
S
DWISFSHMSSDTD
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
S
Y
R
T
L
G
DMSHPQGI
Y
E
V
R
--
A
A
I
T
R
L
I
S
L
T
R
G
V
K
C
R
-----
P
E
Q
M
I
I
G
---
A
G
T
Q
V
L
M
Q
L
L
T
E
L
L
PKE
A
V
Y
A
M
E
EPG
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
EKG
M
-
S
I
A
E
I
T
R
Q
Q
P
D
V
L
V
T
T
P
S
HQ
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
-
A
A
EE
P
R
R
Y
I
I
E
D
D
Y
DSE
F
T
Y
D
V
D
S
I
P
A
L
----
Q
S
-------
L
-------
D
R
F
Q
N
V
I
Y
M
G
T
F
S
K
S
L
L
----------
P
G
L
R
I
------
S
Y
M
V
L
P
P
E
L
L
R
A
--
Y
K
Q
R
--------------------
G
--------
Y
--------
D
L
Q
T
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
Y
Q
K
H
I
K
K
M
K
Q
H
------
Y
K
E
K
-
R
E
------
R
L
I
T
-
A
L
E
A
E
----
F
S
-
G
E
V
T
V
K
G
A
N
AGL
H
F
V
T
E
F
D
T
R
R
T
E
Q
D
I
L
S
H
A
----------------
A
-
G
L
Q
L
E
I
F
G
MSRFNLKENKRQTGR
P
A
L
I
I
G
F
ARLKEED
I
Q
E
G
V
Q
R
L
FKAVY---------------------------------------------------------------------------------------------------------------
43
Fugue
75.93
16%
-108
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------
D
E
--------------
V
W
-------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
---
F
G
---
N
V
L
V
I
-----------
T
A
I
A
K
F
-
E
---
R
L
---------------------
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
----------
V
P
--
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
--------------
V
D
R
Y
F
A
I
T
S
P
--------------
F
-
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
----------
H
W
Y
R
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
E
T
----
C
C
---------------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--------
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
--------------------------------
N
--------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
------
K
S
P
S
-
L
N
-----
A
A
K
S
E
-
L
D
K
A
I
----
G
R
-
N
T
N
G
V
I
T
K
D
----
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
----------------
R
-
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
8
PsiBlast_PDB
74.65
20%
-126
- C1 -
4A4M
4
OPSD_BOVIN
A:
[40-315]
------------------------------------------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
---
L
G
F
P
I
N
F
L
T
L
-----------
Y
V
T
V
Q
H
-
K
---
K
L
---------------------
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
----------
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
--------------
I
E
R
Y
V
V
V
C
K
P
--------------
M
S
N
F
R
F
G
E
N
H
A
I
M
-------------
G
V
A
F
T
W
V
M
A
L
A
--------
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
E
G
M
Q
C
----
S
C
-------
G
--------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
--------------------
Q
--------
E
--------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
Y
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
------
A
F
Y
I
-
F
T
-----
H
Q
G
S
C
F
G
P
I
F
M
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
----
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
-
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
73.15
16%
-125
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-327]
----------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
---
N
F
L
T
L
-----------
Y
V
T
V
Q
H
-
K
---
K
L
---------------------
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
----------
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
--------------
I
E
R
Y
V
V
V
C
K
P
--------------
M
-
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
--
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
---
I
P
-
E
G
M
Q
-----
C
S
C
G
I
D
Y
Y
T
P
H
---------------------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--------
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
--------------------
Q
ESA
T
T
Q
K
A
E
--------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--------
G
S
-
D
------
F
G
P
I
F
-
M
T
I
P
A
----
F
F
-
A
K
T
S
A
V
Y
N
P
----
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
-
C
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
70.01
16%
-124
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
----------------------------------------------------------------------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
---
L
G
---
N
S
L
V
M
-----------
L
V
I
L
Y
S
-
R
---
V
G
---------------------
R
S
V
T
-
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
----------
L
P
--
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
---
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
--------------
V
D
R
Y
L
A
I
V
H
A
--------------
T
-
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
--
W
G
L
S
M
N
L
S
L
P
F
F
L
F
--
R
--
Q
A
--
Y
H
-
P
N
N
S
S
-----
P
V
C
Y
E
V
L
G
N
D
--------------
T
-------
A
-
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
--------
I
V
P
L
F
V
M
L
F
----
C
Y
G
F
T
L
R
T
L
F
K
A
--
H
-
M
G
--------------------
Q
--------
K
--------
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
TQVIQE
S
C
E
R
-
R
N
-----
N
I
G
R
A
-
L
D
A
T
E
----
I
L
-
G
F
L
H
S
C
L
N
P
----
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
----------------
A
-
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.48
20%
-113
- C1 -
1LN6
1
OPSD_BOVIN
A:
[40-312]
---------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
---
L
G
FPI
N
F
L
T
L
-----------
Y
V
T
V
Q
H
-
K
---
K
L
---------------------
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
----------
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
--------------
I
E
R
Y
V
V
V
C
K
P
--------------
M
S
N
F
R
F
G
E
N
H
A
I
M
-------------
G
V
A
F
T
W
V
M
A
L
A
--------
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
E
G
M
Q
C
----
S
C
-------
G
--------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
IYMFVVHF
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
--------------------
Q
--------
E
--------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
------
A
F
Y
I
-
F
T
-----
H
Q
G
S
D
F
G
P
I
F
M
TIPA
F
F
-
A
K
T
S
A
V
Y
N
P
----
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
A
T
----------------
T
-
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------