@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O13G1_HUMAN: (2016-01-11 )
MNHSVVTEFIILGLTKKPELQGIIFLFFLIVYLVAFLGNMLIIIAKIYNNTLHTPMYVFLLTLAVVDIICTTSIIPKMLGTMLTSENTISYAGCMSQLFLFTWSLGAEMVLFTTMAYDRYVAICFPLHYSTIMNHHMCVALLSMVMAIAVTNSWVHTALIMRLTFCGPNTIDHFFCEIPPLLALSCSPVRINEVMVYVADITLAIGDFILTCISYGFIIVAILRIRTVEGKRKAFSTCSSHLTVVTLYYSPVIYTYIRPASSYTFERDKVVAALYTLVTPTLNPMVYSFQNREMQAGIRKVFAFLKH
Atome Classification :
(20 SA)
.........----10......----------------..20----.----------------....-...30........40........------50........60........70------------------...-.....80..-.----.....90........100.......110.--......-120....--.-..130---.......140.......150.....-----..160.---......170.......180--------...---.....-------.190....--------.....200.......-----210.....--..----------------220......--------------------.--------230--.........240.......250.......260-.-------.------..---....-------270....-...-280.......290.......300-----.....-------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
H
S
V
V
T
E
F
----
I
I
LGLTKK----------------PEL
Q
----
G
----------------
I
I
F
L
-
F
F
L
I
V
Y
L
V
A
F
L
G
N
M
L
I
I
I
A
K
I
YN------NTLH
T
P
M
Y
V
F
L
L
T
L
A
V
V
D
I
I
C
T
------------------
T
S
I
-
I
P
K
M
L
G
T
M
L-T----SENT
I
S
Y
A
G
C
M
S
Q
L
F
L
F
T
WSLGA
E
M
V
L
F
T
--
T
MAYD
R
-
Y
V
A
I
C
F
P--
L
-
H
Y
S
T
I
---
M
N
H
H
M
C
V
A
L
L
S
M
V
M
A
I
A
VTN
S
W
V
H
T
-----
A
L
I
M
R
L---TFCGPN
T
I
D
H
F
F
CEIP
P
----------
L
L
A
---LSCSP-------
V
R
--
I
N
E
V
--------
M
V
Y
V
A
D
I
T
L
A
I
G
D
F
I
-----
L
T
C
I
S
Y
G
F
--
I
I
----------------
V
A
I
L
R
I
RTV--------------------E--------G----
K
R
K
A
F
S
T
CSS
H
L
T
V
V
T
L
Y
YS
P
V
I
Y
T
Y
IRPAS--S-------Y------T
F
---
E
R
D
K
-------
V
V
A
A
L
Y
T
-
L
VT-PTLN
P
M
V
Y
SFQN
R
E
M
Q
A
G
I
R
K
V
F
-----
A
F
LKH-------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
92.73
18%
-131
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
----
Y
V
P
F
S
N
K
T
----------------
G
V
V
R
----
S
PFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
--
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
-
S
N
F
R
------------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-----
L
A
C
A
A
P
---
P
L
V
G
------
W
S
R
Y
I
P
E
----------
G
M
Q
---
C
S
C
G
I
DYYTPHE
E
T
--
N
N
E
S
--------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
-----
V
I
F
F
C
Y
G
Q
--
L
V
----------------
F
T
V
K
E
A
A
A
S
--------------------
A
--------
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
--
Y
-------
I
------
F
T
---
H
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
-
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
88.26
18%
-118
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
----
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLAE
P
W
Q
F
----
S
----------------
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
--
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
-------------------
I
P
E
----------
G
M
Q
---
C
S
C
G
I
DYYTP--
H
E
--
E
T
N
N
--------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
----------------
F
T
V
K
E
A
A
A
Q
--------------------
Q
--------
Q
ESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
--
Y
-------
I
------
F
T
---
H
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
-
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
86.21
16%
-144
- C2 -
2Z73
5
OPSD_TODPA
A:
[30-332]
--------------------
P
----------------
D
A
V
Y
----
Y
----------------
S
L
G
I
-
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
------
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
------------------
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
----
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
--
M
I
S
I
D
R
-
Y
N
V
I
G
R
P
--
M
-
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
-----
F
G
W
G
A
Y
---
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
----------
I
--------
S
R
-------
D
S
--
T
T
R
S
--------
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
-----
I
I
F
F
C
Y
F
N
--
I
V
----------------
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
----
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
--
G
PLE----
W
------
V
T
---
P
Y
A
A
-------
Q
L
P
V
M
F
A
-
K
A
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-----
P
W
V
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
81.47
16%
-130
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-326]
---------------------------------------------
S
----------------
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
--
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
-
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
G
W
S
R
Y
---
I
P
----
E
G
M
Q
C
S
C
G
I
D
Y
----------
Y
T
P
------
H
E
-------
E
T
--
N
N
E
S
--------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
-----
V
I
F
F
C
Y
G
Q
--
L
V
----------------
F
T
V
K
E
A
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S------
D
------
F
G
---
P
I
F
M
-------
T
I
P
A
F
F
A
-
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
76.93
15%
-127
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------
D
----------------
E
V
W
V
----
V
----------------
G
M
G
I
-
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
------
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
------------------
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
----
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
--
V
I
A
V
D
R
-
Y
F
A
I
T
S
P
--
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-----
Q
M
----------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
----------
A
E
E
---
T
C
C
D
F
-------
F
T
--
N
Q
A
Y
--------
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
-----
M
V
F
V
Y
S
R
V
--
F
Q
----------------
E
A
K
R
Q
L
N
I
F
--------------------
E
--------
M
----
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
--
S
-------
L
------
N
A
---
A
K
S
E
-------
L
D
K
A
I
G
R
-
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-----
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
42
HHSearch
76.53
13%
-143
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------------------------------
L
W
A
A
-
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
------
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
------------------
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
----
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
--
A
V
A
F
D
R
-
Y
M
A
I
I
H
P
--
L
-
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
-----
Y
Y
S
T
T
----
E
T
----
M
P
S
R
V
V
C
M
I
E
W
----------
P
E
H
------
P
N
-------
K
I
--
Y
E
K
V
--------
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
-----
V
I
G
Y
A
Y
T
V
--
V
G
----------------
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
----
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
--
N
-------
P
DLYLKK
F
I
---
Q
Q
V
Y
-------
L
A
I
M
W
L
A
-
M
S
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-----
R
C
C
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
76.36
17%
-143
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------
S
----
F
K
C
A
L
T
K
T
----------------
G
F
Q
F
----
Y
----------------
Y
L
P
A
-
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
------
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
------------------
L
T
L
-
P
A
L
I
F
Y
Y
F
N
-
K
----
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
--
C
I
S
A
H
R
-
Y
S
G
V
V
Y
P
KS
L
-
G
R
L
K
K
---
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
-----
G
T
G
V
R
K
NKT
I
T
C
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
----------
Y
S
M
---
C
T
T
V
A
-------
M
F
--
C
V
P
L
--------
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
--
I
Y
N
PEDGDPDNGVNPGTD
F
K
D
I
V
C
P
L
C
--------------------
G
--------
V
----
G
K
D
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
-----------------------------------
Y
I
P
F
H
V
-
M
K
T
-
M
N
L
R
A
R
L
D
-
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
-----
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-----------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
73.56
16%
-121
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
---------------------------------------
N
K
----
Y
----------------
V
V
I
I
-
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
------
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
------------------
L
-
T
-
L
P
I
W
A
A
S
K
--
V
----
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
--
C
I
S
V
D
R
-
Y
L
A
I
V
H
A
--
T
-
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
-----
L
F
R
Q
A
Y
---
H
P
----
N
N
S
S
P
V
C
Y
E
V
L
----------
G
N
-------
D
T
-------
A
K
--
W
R
M
V
--------
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
-----
V
M
L
F
C
Y
G
F
--
T
L
----------------
R
T
L
F
K
A
H
-
M
--------------------
G
--------
Q
----
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
--
M
RTQVIQE
S
C
E
R
---
R
N
N
I
-
G
R
A
L
-------
D
A
T
E
I
L
G
-
F
L
H
-
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
-----
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
66.01
15%
-157
- C3 -
3ES5
-
?
A:
[42-420]
M
R
L
G
W
I
D
P
L
P
Q
V
D
T
I
F
P
L
G
L
E
----------------
P
N
V
E
SIPA
G
----------------
E
V
E
L
D
F
N
L
P
E
T
I
A
K
P
F
A
D
T
V
T
S
V
G
D
R
I
Q
LV
D
D
D
K
E
N
I
A
T
S
I
Y
G
L
S
F
F
K
A
A
R
Q
L
Y
S
T
ML
D
H
E
K
A
V
N
QPLKAVYYD
E
T
P
-
I
P
A
H
M
S
G
A
L
-
G
II
G
H
M
K
T
K
V
G
D
V
L
V
K
D
A
G
V
L
F
K
R
G
T
A
A
G
V
T
K
F
S
--
E
I
D
N
D
K
T
W
N
L
D
C
S
K
--
L
-
V
W
A
D
H
---
S
S
L
S
M
I
K
R
L
A
S
E
K
I
S
Q
L
V
K
Q
R
Y
R
V
T
D
AQGH
V
Y
S
V
S
M
---
P
Q
L
T
D
Q
A
L
P
D
Y
Y
D
S
I
P
D
VAPN
S
D
Q
L
R
V
L
T
A
A
L
Q
M
S
L
A
Q
-------
F
R
--
N
D
E
L
PHDED
R
S
D
L
L
T
T
L
D
L
L
Y
A
D
G
A
Y
E
-----
I
S
A
L
R
D
Q
F
--
E
L
----------------
L
M
A
R
Y
T
T
D
F
--------------------
K
--------
W
----
R
V
E
S
I
F
K
V
G
P
P
P
A
G
T
T
G
Y
G
A
Q
T
V
S
S
T
-
G
N
T
A
--
R
-------
W
------
Q
F
PLS
D
A
D
I
-------
N
I
G
Y
L
F
S
P
S
K
S
-
F
S
L
F
P
K
M
V
G
Y
S
K
R
A
R
E
D
A
S
A
S
F
A
N
S
DAK
K
F
Y
A
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
65.88
19%
-174
- C2 -
3EML
8
ENLYS_BPT4
A:
[22-221]
---------------------------------------------
S
----------------
V
Y
I
T
-
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
------
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
------------------
V
L
A
-
I
P
F
A
I
T
I
S
T
-------
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
--
A
I
A
I
D
R
-
Y
I
A
I
R
I
P
--
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
W
N
N
C
---
G
Q
-------
S
Q
G
C
G
E
G
Q
----------------
V
A
C
L
F
-------
E
D
VV
P
M
N
Y
--------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
-----
L
M
L
G
V
Y
L
R
--
I
F
----------------
L
A
A
R
R
Q
L
N
I
--------------------
F
--------
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
-------
S
------
L
N
---
A
A
K
S
-------
E
L
D
K
A
I
G
-
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----
I
L
R
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
64.86
20%
-166
- C2 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-226]
---------------------------------------------------------------
Y
A
L
-
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
------
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
------------------
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
----
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
--
A
I
S
I
D
R
-
Y
T
A
V
V
M
P
--
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
-----
F
G
F
N
T
T
----------
G
D
P
T
V
C
S
I
S
------------------------------
N
--
P
D
----------
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
-----
V
T
V
L
V
Y
A
R
--
I
Y
----------------
V
V
L
K
Q
R
R
R
K
--------------------
N
--------
I
----
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
--
K
-------
S
------
P
S
---
L
N
A
A
-------
K
S
E
L
D
K
A
-
I
G
R
-
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
-----
R
G
I
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
64.78
17%
-153
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-235]
----------------------------------------
V
----
V
----------------
G
M
G
I
-
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
------
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
------------------
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
----
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
--
V
I
A
V
D
R
-
Y
F
A
I
T
S
P
--
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-----
Q
M
H
W
Y
R
---
A
T
H
Q
----
E
A
I
N
C
Y
A
E
-----------------
E
T
C
C
D
-------
F
F
--
T
N
Q
A
--------
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
-----
I
M
V
F
V
Y
S
R
--
V
F
----------------
Q
E
A
K
R
Q
L
N
I
--------------------
F
--------
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
-------
S
------
L
N
---
A
A
K
S
-------
E
L
D
K
A
I
G
-
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----
I
L
R
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
62.08
19%
-162
* C2 *
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
---------------------------------------------
V
----------------
F
I
V
L
-
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
------
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
------------------
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
----
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
--
I
I
S
F
D
R
-
Y
F
C
V
T
K
P
--
L
-
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
-----
L
F
W
Q
F
I
---
V
G
V
R
--
T
V
E
D
G
E
C
Y
I
Q
F
-----------------------------
F
--
S
N
A
A
--------
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
-----
I
M
T
V
L
Y
W
H
--
I
S
----------------
R
A
S
K
S
R
I
N
I
--------------------
F
--------
E
----
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
-------
S
------
L
N
---
A
A
K
S
-------
E
L
D
K
A
I
G
-
R
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----
I
L
R
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.24
29%
-172
- C2 -
1F88
2
OPSD_BOVIN
A:
[43-166]
----------------------------------------------------------------
Y
M
-
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
----------
T
N
N
---
E
S
F
V
I
-------
Y
M
--
F
V
V
H
--------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----
V
F
T
V
K
E
A
A
--
A
S
----------------
A
T
T
Q
K
A
E
K
E
--------------------
V
--------
T
----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
--
F
-------
G
------
P
I
---
F
M
T
I
-------
P
A
F
F
A
K
T
-
S
A
V
-
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
-----
G
K
N
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.21
29%
-181
- C2 -
4J4Q
5
GNAT1_BOVIN (first)
A:
[43-166]
----------------------------------------------------------------
Y
M
-
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
----------
T
N
N
---
E
S
F
V
I
-------
Y
M
--
F
V
V
H
--------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----
V
F
T
V
K
E
A
A
--
A
Q
----------------
Q
Q
E
S
A
T
T
Q
K
--------------------
A
--------
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--
Q
-------
G
------
S
D
---
F
G
P
I
-------
F
M
T
I
P
A
F
-
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-----
T
L
C
C
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.99
29%
-161
- C2 -
1HZX
3
OPSD_BOVIN
A:
[46-167]
----------------------------------------------------------------
Y
M
-
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
----------
T
N
N
---
E
S
F
V
I
-------
Y
M
--
F
V
V
H
--------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----
V
F
T
V
K
E
A
A
--
A
A
----------------
T
T
Q
K
A
E
K
E
V
--------------------
T
--------
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
--
G
-------
P
------
I
F
---
M
T
I
P
-------
A
F
F
A
K
T
S
-
A
V
Y
-
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
-----
K
N
P
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.98
29%
-185
- C2 -
3DQB
2
GNAT1_BOVIN (first)
A:
[43-166]
----------------------------------------------------------------
Y
M
-
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
----------
T
N
N
---
E
S
F
V
I
-------
Y
M
--
F
V
V
H
--------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----
V
F
T
V
K
E
A
A
--
A
Q
----------------
Q
Q
E
S
A
T
T
Q
K
--------------------
A
--------
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--
Q
-------
G
------
S
D
---
F
G
P
I
-------
F
M
T
I
P
A
F
-
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-----
T
L
C
C
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.97
29%
-184
- C2 -
3PQR
5
OPSD_BOVIN
A:
[43-166]
----------------------------------------------------------------
Y
M
-
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
----------
T
N
N
---
E
S
F
V
I
-------
Y
M
--
F
V
V
H
--------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----
V
F
T
V
K
E
A
A
--
A
Q
----------------
Q
Q
E
S
A
T
T
Q
K
--------------------
A
--------
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--
Q
-------
G
------
S
D
---
F
G
P
I
-------
F
M
T
I
P
A
F
-
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-----
T
L
C
C
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.56
29%
-178
- C2 -
3PXO
2
OPSD_BOVIN
A:
[43-166]
----------------------------------------------------------------
Y
M
-
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
----------
T
N
N
---
E
S
F
V
I
-------
Y
M
--
F
V
V
H
--------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----
V
F
T
V
K
E
A
A
--
A
Q
----------------
Q
Q
E
S
A
T
T
Q
K
--------------------
A
--------
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--
Q
-------
G
------
S
D
---
F
G
P
I
-------
F
M
T
I
P
A
F
-
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-----
T
L
C
C
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
60.31
29%
-182
- C2 -
3CAP
1
OPSD_BOVIN
A:
[43-166]
----------------------------------------------------------------
Y
M
-
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
------------------
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-
Y
V
V
V
C
K
P
--
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----
W
S
R
Y
I
P
---
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
----------
T
N
N
---
E
S
F
V
I
-------
Y
M
--
F
V
V
H
--------
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----
V
F
T
V
K
E
A
A
--
A
Q
----------------
Q
Q
E
S
A
T
T
Q
K
--------------------
A
--------
E
----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--
Q
-------
G
------
S
D
---
F
G
P
I
-------
F
M
T
I
P
A
F
-
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
-----
T
L
C
C
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------