@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O2A12_HUMAN: (2016-01-11 )
MESNQTWITEVILLGFQVDPALELFLFGFFLLFYSLTLMGNGIILGLIYLDSRLHTPMYVFLSHLAIVDMSYASSTVPKMLANLVMHKKVISFAPCILQTFLYLAFAITECLILVMMCYDRYVAICHPLQYTLIMNWRVCTVLASTCWIFSFLLALVHITLILRLPFCGPQKINHFFCQIMSVFKLACADTRLNQVVLFAGSAFILVGPLCLVLVSYLHILVAILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSSHSQERRKILSLFYSLFNPILNPLIYSLRNAEVKGALKRVLWKQRSM
Atome Classification :
(20 SA)
.........10..--------------......20........30........40........50........60........70..-...-...80........-90........100.......110.......120.......130-.......140.......150.......160.......170.......180......--.-------190........200.......210.......220..-----------..----...----230-------------------...----.....240.....------..250.......-------260---.-----------..---...---------.270------........280........--.290.......300.......310----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MES
N
Q
T
W
I
T
E
V
I
L
--------------LGFQV
D
P
A
L
E
L
F
L
F
G
F
F
L
L
F
Y
S
L
T
LMGN
G
I
I
L
G
L
I
Y
LDSRLH
T
P
M
Y
V
F
L
S
H
L
A
I
V
DM
S
Y
A
-
S
S
T
-
V
P
K
M
L
A
N
L
V
M
H
K
K
-
V
I
S
F
A
P
C
I
L
Q
T
F
L
Y
L
A
F
A
I
T
E
C
L
I
L
V
M
M
C
Y
D
R
Y
V
A
I
CHP
L
Q
Y
T
-
L
I
MNW
R
V
C
T
V
L
A
S
T
C
W
I
F
S
F
L
L
A
L
V
H
I
T
L
I
LRLPFC
G
P
Q
K
I
N
H
F
F
C
Q
I
M
S
V
F
K
L
AC--A-------D-TRL
N
Q
V
V
L
FAG
S
A
F
I
L
V
G
P
L
C
L
V
L
V
S
Y
L
H
I
L
V
A
I
-----------
L
R
----IQS----GE--------------------G
R
R
----
K
A
F
S
T
C
S
S
H
L
C
V
V
------
G
L
F
F
G
S
A
I
V
M
Y
M-------APK---S-----------S
H
---
S
Q
E
---------
R
R
K
-------
I
L
S
L
F
Y
S
L
F
--
N
P
I
L
N
P
L
I
--
Y
S
LRN
A
E
V
K
G
A
L
K
R
V
L
W
KQRSM------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.40
26%
-182
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
92.35
25%
-175
- C3 -
4UG2
3
?
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L--------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.24
25%
-181
- C3 -
3VG9
8
?
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
-
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
Q
PLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.92
25%
-180
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
-
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
Q
PLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.89
26%
-181
- C3 -
3REY
1
AA2AR_HUMAN
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
91.82
25%
-171
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
------------
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.68
26%
-178
- C3 -
3PWH
1
?
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.65
26%
-181
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.52
26%
-183
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----------
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
--------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.18
25%
-169
- C3 -
2YDO
3
?
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
-----------------------------T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.98
25%
-173
- C3 -
2YDV
6
?
A:
[19-303]
-------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
-
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
-
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
L
K
Q
M
E
S
Q----------------------------S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
------
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
---
C
-----------
S
H
---
A
P
L
---------
W
L
M
-------
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
--
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
85.67
18%
-155
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-----------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
-
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
-
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
---
L
-
E
G
V
L
C
N
C
S
F
D
Y
I
S
--------------
R
-
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----------
S
N
----
H
E
K
----
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
----
R
L
A
K
I
S
I
V
I
V
S
Q
F
------
L
L
S
W
S
P
Y
A
V
V
A
L
-------
L
A
Q
---
F
GPL--------
E
W
---
V
T
P
---------
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
--
S
A
I
H
N
P
M
I
--
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
84.61
17%
-154
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
-
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
-
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
---
E
T
-
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
------------
N
-
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-----------
W
A
----
S
E
I
----
P
G
DSSDRYH
E
Q
V
S
---------
A
K
R
----
K
V
V
K
M
M
I
V
V
V
C
T
F
------
A
I
C
W
L
P
F
H
I
F
F
L
-------
L
P
Y
I
NP
D
-----------
L
Y
LKK
F
I
Q
---------
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
--
S
T
M
Y
N
P
I
I
--
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
83.26
18%
-143
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
-
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
-
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
----------
D
-
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
----
Q
L
N
----
I
F
--------------------
E
M
L
----
R
I
D
E
G
L
R
L
K
I
Y
K
D
------
T
E
G
Y
Y
T
I
G
I
G
H
L
-------
L
T
K
---
S
-----------
P
S
---
L
N
A
---------
A
K
S
-------
E
L
D
K
A
I
G
R
N
TN
G
V
I
T
K
D
E
A
--
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
39
Fugue
81.25
15%
-150
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAP
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
-
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
--------------
M
Q
C
S
C
--
G
I
DYYTPH
E
-
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
----
A
A
A
----
S
A
--------------------
T
T
Q
----
K
A
E
K
E
V
T
R
M
V
I
I
M
------
V
I
A
F
L
I
C
W
L
P
Y
A
-------
G
V
A
---
F
-----------
Y
I
---
F
T
H
---------
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
79.29
18%
-180
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----
S
F
K
C
A
L
T
K
--------------
T
G
F
-----
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
-
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
----
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
--------
S
-------
D
-
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
-----------
V
R
----
A
L
I
----
Y
K
--------------------
M
K
K
----
Y
T
C
T
V
C
G
Y
I
Y
N
P
E
DGDPDN
G
V
N
P
G
T
D
F
K
D
I
V
-------
C
P
L
---
C
-----------
G
V
---
G
K
D
Q
F
E
E
V
EE
P
L
R
R
K
-------
S
I
Y
L
V
I
I
V
L
--
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
---
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR---------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.64
19%
-130
- C3 -
2ZIY
2
OPSD_TODPA
A:
[64-329]
-------------------------------------------------------------------
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
-
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
--
S
-------
T
-
T
R
S
N
I
L
C
M
F
I
L
G
F
F
---
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
----
L
N
A
----
K
E
--------------------
L
R
K
A
---
Q
A
G
A
N
A
E
M
R
L
A
K
I
------
S
I
V
I
V
S
Q
F
L
L
S
W
-------
S
P
Y
---
A
V
V
A
L
L
A
Q
FGPL
E
W
---
V
T
P
---------
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
--
S
A
I
H
N
P
M
I
--
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.40
19%
-129
- C3 -
2Z73
5
OPSD_TODPA
A:
[65-330]
-------------------------------------------------------------------
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
-
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
--
S
-------
T
-
T
R
S
N
I
L
C
M
F
I
L
G
F
F
---
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
----
L
N
A
----
K
E
--------------------
L
R
K
A
---
Q
A
G
A
N
A
E
M
R
L
A
K
I
------
S
I
V
I
V
S
Q
F
L
L
S
W
-------
S
P
Y
---
A
V
V
A
L
L
A
Q
FGPL
E
W
---
V
T
P
---------
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
--
S
A
I
H
N
P
M
I
--
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.40
19%
-130
- C3 -
4WW3
5
OPSD_TODPA
A:
[57-322]
-------------------------------------------------------------------
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
-
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
--
S
-------
T
-
T
R
S
N
I
L
C
M
F
I
L
G
F
F
---
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
----
L
N
A
----
K
E
--------------------
L
R
K
A
---
Q
A
G
A
N
A
E
M
R
L
A
K
I
------
S
I
V
I
V
S
Q
F
L
L
S
W
-------
S
P
Y
---
A
V
V
A
L
L
A
Q
FGPL
E
W
---
V
T
P
---------
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
--
S
A
I
H
N
P
M
I
--
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
75.33
19%
-128
- C3 -
3AYM
3
OPSD_TODPA
A:
[65-330]
-------------------------------------------------------------------
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
-
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
--
S
-------
T
-
T
R
S
N
I
L
C
M
F
I
L
G
F
F
---
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
----
L
N
A
----
K
E
--------------------
L
R
K
A
---
Q
A
G
A
N
A
E
M
R
L
A
K
I
------
S
I
V
I
V
S
Q
F
L
L
S
W
-------
S
P
Y
---
A
V
V
A
L
L
A
Q
FGPL
E
W
---
V
T
P
---------
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
--
S
A
I
H
N
P
M
I
--
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------