@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O2AK2_HUMAN: (2016-01-11 )
MNISDVISFDILVSAMKTGNQSFGTDFLLVGLFQYGWINSLLFVVIATLFTVALTGNIMLIHLIRLNTRLHTPMYFLLSQLSIVDLMYISTTVPKMAVSFLSQSKTIRFLGCEIQTYVFLALGGTEALLLGFMSYDRYVAICHPLHYPMLMSKKICCLMVACAWASGSINAFIHTLYVFQLPFCRSRLINHFFCEVPALLSLVCQDTSQYEYTVLLSGLIILLLPFLAILASYARVLIVVFQMSSGKGQAKAVSTCSSHLIVASLFYATTLFTYTRPHSLRSPSRDKAVAVFYTIVTPLLNPFIYSLRNKEVTGAVRRLLGYWICCRKYDFRSLY
Atome Classification :
(20 SA)
---------------------.........10........20.-.......30..---......40......------..50.......-----.60.....------------...70........80........90.-..---...--------..100.....----...110.......120---------.......130.......140...------....150-.........160.......----170.......--180-----.......190......---.200..-------.-------...--.210.......220...-----...-.230.......----240---------..-------------...------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------...------250.......260----.....-------...----------270......-----.280----------.------------.------.......290......-.300.......310.......320.......330...------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------M
N
I
S
D
V
I
S
F
D
I
L
V
S
A
M
K
TGNQS-F
G
T
D
F
L
L
V
G
L
F
---
Q
Y
G
W
I
N
S
L
L
F
V
V
I
A
------
T
L
F
T
V
A
LTG
N
I
-----
M
L
I
H
L
I
R
L------------NTRLH
T
P
M
Y
F
L
L
S
Q
L
S
I
V
D
L
M
Y
ISTT-
V
P
---
K
M
A
--------
V
S
F
L
-SQS
K
T
----
I
R
F
L
G
C
E
I
Q
T
Y
V
F
L
A
L---------GG
T
E
A
L
L
L
G
F
MSYD
R
Y
V
A
I
CHPL------H
Y
P
M
L
---
M
SK
K
I
C
C
L
M
V
A
C
AWASG
S
I
----
N
A
F
I
H
T
L
Y
VF--QLP-----
F
C
R
S
R
L
I
N
H
F
F
C
E
V
P
A
---
L
L
S
L
V
C-------Q-------DTS--Q
Y
E
Y
T
V
L
L
S
G
L
I
I
L
L
L
P
-----
F
L
A
-
I
L
A
S
Y
A
R
V
L
I
V
----
V
-----------
F
Q-------------MSS------------------------------------------------------------------------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------KGQ------
A
K
A
V
S
T
C
S
S
H
L
I
-----
V
A
S
L
F
-------
Y
A
T
----------
T
L
F
TYTRPH-----SL------------R------------S------PSRD
K
A
V
A
V
F
Y
T
I
V
T
P
-
L
L
N
P
F
I
Y
S
LRN
K
E
V
T
G
A
V
R
R
L
L
G
Y
W
I
C
CRKYDFRSLY------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
88.92
18%
-98
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
------
L
L
I
M
L
G
F
P
I
N
F
-----
L
T
L
Y
V
T
V
Q
------------
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
--------
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
---------
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
----
C
A
---------------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
---
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
-
I
F
F
C
Y
G
Q
L
V
F
T
----
V
KEAAAQQQESA
T
T
-------------
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
------
T
R
M
V
I
I
M
V
I
A
F
L
-----
I
C
W
L
P
-------
Y
A
G
----------
V
A
F
Y
I
F
T
H
Q
-----
G
S
------------
D
------------
F
------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA--------------------------------------------------------------------------------------------------------------------
29
HHSearch
88.16
18%
-137
- C5 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
------
A
I
A
V
L
A
I
L
G
N
V
-----
L
V
C
W
A
V
W
L
------------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
--------
T
I
S
T
---
G
F
C
----
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---------
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
----
I
G
L
T
P
M
L
G
W
N
--
N
C
G
-----
Q
-------
S
Q
G
C
G
E
G
Q
---
V
---
A
C
-------
L
-------
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
-
M
L
G
V
Y
L
R
I
F
L
A
----
A
-----------
R
R
-------------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
------
V
H
A
A
K
S
L
A
I
I
V
G
-----
L
F
A
L
C
-------
W
L
P
----------
L
H
I
I
N
C
F
T
F
-----
F
C
PDCS--------
H
------------
A
------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
86.66
19%
-127
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
--------------------------------------------------------------
W
V
V
G
M
G
I
V
M
S
------
L
I
V
L
A
I
V
F
G
N
V
-----
L
V
I
T
A
I
A
K
------------
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
--------
A
H
I
L
-
M
K
M
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
------
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
----
T
S
F
L
P
I
Q
M
H
W
--
Y
R
A
-----
T
----
H
Q
E
A
I
N
C
Y
A
E
E
-------
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-----
L
V
I
-
M
V
F
V
Y
S
R
V
F
Q
E
----
A
-----------
K
R
-------------
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
------
H
K
A
L
K
T
L
G
I
I
M
G
-----
T
F
T
L
C
-------
W
L
P
----------
F
F
I
V
N
I
V
H
V
-----
I
Q
------------
D
NL----------
I
------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
-
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.64
21%
-132
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[19-303]
----------------------------------------------------------------------------------
L
A
I
L
G
N
V
-----
L
V
C
W
A
V
W
L
------------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
--------
T
G
F
C
-
A
A
C
H
G
----
C
L
F
I
A
C
F
V
-----
L
V
L
---------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
-
S
F
----
A
I
G
L
T
P
M
L
G
W
--
N
N
C
-----
G
Q
P
--------
G
C
G
E
G
---
Q
V
A
C
L
F
-------
E
-------
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
-
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
-----------
K
Q
-------------
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PL-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
-----
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
----------
N
C
F
T
F
F
C
P
D
-----
C
S
------------
H
------------
A
------
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.63
21%
-133
- C5 -
3PWH
1
?
A:
[19-303]
----------------------------------------------------------------------------------
L
A
I
L
G
N
V
-----
L
V
C
W
A
V
W
L
------------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
--------
T
G
F
C
-
A
A
C
H
G
----
C
L
F
I
A
C
F
V
-----
L
V
L
---------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
-
S
F
----
A
I
G
L
T
P
M
L
G
W
--
N
N
C
-----
G
Q
P
--------
G
C
G
E
G
---
Q
V
A
C
L
F
-------
E
-------
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
-
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
-----------
K
Q
-------------
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PL-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
-----
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
----------
N
C
F
T
F
F
C
P
D
-----
C
S
------------
H
------------
A
------
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.52
21%
-133
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[19-303]
----------------------------------------------------------------------------------
L
A
I
L
G
N
V
-----
L
V
C
W
A
V
W
L
------------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
--------
T
G
F
C
-
A
A
C
H
G
----
C
L
F
I
A
C
F
V
-----
L
V
L
---------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
-
S
F
----
A
I
G
L
T
P
M
L
G
W
--
N
N
C
-----
G
Q
P
--------
G
C
G
E
G
---
Q
V
A
C
L
F
-------
E
-------
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
-
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
-----------
K
Q
-------------
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PL-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
-----
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
----------
N
C
F
T
F
F
C
P
D
-----
C
S
------------
H
------------
A
------
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.07
21%
-133
- C5 -
3REY
1
AA2AR_HUMAN
A:
[19-303]
----------------------------------------------------------------------------------
L
A
I
L
G
N
V
-----
L
V
C
W
A
V
W
L
------------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
--------
T
G
F
C
-
A
A
C
H
G
----
C
L
F
I
A
C
F
V
-----
L
V
L
---------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
-
S
F
----
A
I
G
L
T
P
M
L
G
W
--
N
N
C
-----
G
Q
P
--------
G
C
G
E
G
---
Q
V
A
C
L
F
-------
E
-------
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
-
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
-----------
K
Q
-------------
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PL-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
-----
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
----------
N
C
F
T
F
F
C
P
D
-----
C
S
------------
H
------------
A
------
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
85.06
18%
-136
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
------------------------------------------------------------------
L
V
V
V
L
S
------
T
I
C
L
V
T
V
G
L
N
L
-----
L
V
L
Y
A
V
R
S
------------
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
---
M
N
I
--------
L
Y
L
L
-
M
S
K
W
S
----
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
---------
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
------
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
----
W
V
I
P
I
L
G
W
N
H
----------------
R
R
E
D
K
C
E
T
D
F
---
Y
D
-------------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
-----
T
L
L
-
M
L
W
F
Y
A
K
I
Y
K
A
----
V
-----------
R
Q
-------------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
------
R
K
A
A
K
Q
L
G
F
I
M
A
-----
A
F
I
L
C
-------
W
I
P
----------
Y
F
I
F
F
M
V
I
A
-----
F
C
------------
K
NC----------
C
------
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
-
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
84.92
17%
-119
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
------
L
L
I
M
L
G
F
P
I
N
F
-----
L
T
L
Y
V
T
V
Q
------------
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
--------
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
---------
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
----
C
A
---------------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
---
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
-
I
F
F
C
Y
G
Q
L
V
F
T
----
V
KEAAASA----
T
T
-------------
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
------
T
R
M
V
I
I
M
V
I
A
F
L
-----
I
C
W
L
P
-------
Y
A
G
----------
V
A
F
Y
I
F
T
H
Q
-----
G
S
------------
D
------------
F
------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
----
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.89
21%
-132
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[19-303]
----------------------------------------------------------------------------------
L
A
I
L
G
N
V
-----
L
V
C
W
A
V
W
L
------------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
--------
T
G
F
C
-
A
A
C
H
G
----
C
L
F
I
A
C
F
V
-----
L
V
L
---------
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
-
S
F
----
A
I
G
L
T
P
M
L
G
W
--
N
N
C
-----
G
Q
P
--------
G
C
G
E
G
---
Q
V
A
C
L
F
-------
E
-------
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
-
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
-----------
K
Q
-------------
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PL-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
-----
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
----------
N
C
F
T
F
F
C
P
D
-----
C
S
------------
H
------------
A
------
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
83.10
17%
-136
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------
V
F
I
V
L
V
A
G
------
S
L
S
L
V
T
I
I
G
N
I
-----
L
V
M
V
S
I
K
V
------------
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
---
L
Y
T
--------
L
Y
T
V
-
I
G
Y
W
P
----
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
---------
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
------
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
----
L
W
A
P
A
I
L
F
W
Q
--
F
I
V
-------
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
---
F
S
-------------------------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
-----
V
I
I
-
M
T
V
L
Y
W
H
I
S
R
A
----
S
-----------
K
S
-------------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
------
K
K
V
T
R
T
I
L
A
I
L
L
-----
A
F
I
I
T
-------
W
A
P
----------
Y
N
V
M
V
L
I
N
T
-----
F
C
------------
A
PC----------
I
------
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
-
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
81.80
18%
-131
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------
Y
A
L
S
Y
C
------
A
L
I
L
A
I
V
F
G
N
G
-----
L
V
C
M
A
V
L
K
------------
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
---
W
V
V
--------
Y
L
E
V
T
G
G
V
W
N
----
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
---------
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
------
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
----
V
S
C
P
L
L
F
G
F
N
--
T
------------
T
G
D
P
T
V
C
S
I
S
N
-------------------------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
-----
F
G
V
-
T
V
L
V
Y
A
R
I
Y
V
V
----
L
-----------
K
Q
-------------
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
------
K
K
A
T
Q
M
V
A
I
V
L
G
-----
A
F
I
V
C
-------
W
L
P
----------
F
F
L
T
H
V
L
N
T
-----
H
C
------------
Q
TCH---------
V
------
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
-
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
80.04
16%
-128
* C5 *
2Z73
5
OPSD_TODPA
A:
[31-336]
------------------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
------
I
C
G
I
I
G
C
G
G
N
G
-----
I
V
I
Y
L
F
T
K
------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
--------
I
S
C
F
-
L
K
K
W
I
----
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
---------
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
------
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
----
W
A
I
G
P
I
F
G
W
G
--
A
---------
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
---
I
S
R
-------------------
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
-----
I
L
I
-
I
F
F
C
Y
F
N
I
V
M
S
----
V
-----------
S
N
-------------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
------
M
R
L
A
K
I
S
I
V
I
V
S
-----
Q
F
L
L
S
-------
W
S
P
----------
Y
A
V
V
A
L
L
A
Q
-----
F
G
------------
P
LEW---------
V
------
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
-
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
78.58
15%
-124
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-498]
-------------------------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
------
I
I
F
L
T
G
I
V
G
N
G
-----
L
V
I
L
V
M
G
Y
------------
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
---
F
W
A
--------
V
D
A
V
--
A
N
W
Y
----
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
---------
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
------
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
----
L
T
I
P
D
F
I
F
A
N
--
V
----------
S
E
A
D
D
R
Y
I
C
D
R
F
Y
---
P
N
D
--------------------
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
-----
G
I
V
-
I
L
S
C
Y
C
I
I
I
S
K
----
L
-----------
S
H
-------------
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
------
R
K
A
L
K
T
T
V
I
L
I
L
-----
A
F
F
A
C
-------
W
L
P
----------
Y
Y
I
G
I
S
I
D
S
-----
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
------
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
-
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
----------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
77.47
14%
-128
- C5 -
2KS9
1
NK1R_HUMAN
A:
[31-325]
--------------------------------------------------------------
Q
I
V
L
W
A
A
A
Y
T
------
V
I
V
V
T
S
V
V
G
N
V
-----
V
V
M
W
I
I
L
A
------------
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
---
V
N
F
--------
T
Y
A
V
-
H
N
E
W
Y
----
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
---------
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
------
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
----
L
A
F
P
Q
G
Y
Y
S
T
--
T
----------
E
T
M
P
S
R
V
V
C
M
I
E
W
---
P
E
H
P
-----------------
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
-----
L
L
V
-
I
G
Y
A
Y
T
V
V
G
I
T
----
L
-----------
W
A
-------------
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
------
R
K
V
V
K
M
M
I
V
V
V
C
-----
T
F
A
I
C
-------
W
L
P
----------
F
H
I
F
F
L
L
P
Y
-----
I
N
------------
P
------------
D
LYLKKF
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
-
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
76.71
15%
-110
- C5 -
1U19
14
OPSD_BOVIN
A:
[36-329]
-----------------------------------------------------------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
------
L
L
I
M
L
G
F
P
I
N
F
-----
L
T
L
Y
V
T
V
Q
------------
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
--------
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
---------
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
----
C
A
A
P
P
L
V
G
W
S
--
R
-------
Y
--
I
P
E
G
M
Q
C
S
C
G
I
D
Y
---
Y
T
P
H
-----------------
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
-
I
F
F
C
Y
G
Q
L
V
F
T
----
V
-----------
K
E
-------------
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
------
K
E
V
T
R
M
V
I
I
M
V
I
-----
A
F
L
I
C
-------
W
L
P
----------
Y
A
G
V
A
F
Y
I
F
-----
T
H
QGS---------
D
------------
F
------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
73.52
14%
-125
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----------------------------------
P
C
F
R
E
E
N
A
N
-
F
-----------------
N
K
I
F
L
P
T
I
Y
S
------
I
I
F
L
T
G
I
V
G
N
G
-----
L
V
I
L
V
M
G
Y
------------
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
---
F
W
A
--------
V
D
A
V
-
A
N
W
-
Y
----
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
---------
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
------
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
----
L
T
I
P
D
F
I
F
A
N
--
V
S
E
A
DD
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
---
F
Q
H
I
M
V
-------
G
-------
L
I
L
--
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
HSGSN
I
F
E
-
M
L
R
I
D
E
G
L
R
L
K
----
I
-----------
Y
K
D
TEG
Y
Y
T
I
GIGHL
L
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
------
N
A
A
K
S
E
L
D
K
A
I
G
RNTNG
V
I
T
K
D
-------
E
A
E
----------
K
L
F
N
Q
D
V
D
A
-----
A
V
------------
R
------------
G
------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
-
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
33
HHSearch
72.09
16%
-111
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
--------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
------
L
V
F
L
L
S
L
L
G
N
S
-----
L
V
M
L
V
I
L
Y
------------
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
---
I
W
A
--------
A
S
K
--
V
N
G
W
I
----
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
---------
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
------
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
----
L
S
L
P
F
F
L
F
R
Q
--
A
-------
Y
--
H
P
N
N
S
S
P
V
C
Y
E
V
L
---
G
N
D
------------------
T
A
K
--
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
-----
L
F
V
-
M
L
F
C
Y
G
F
T
L
R
T
----
L
-----------
F
K
-------------
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
------
H
R
A
M
R
V
I
F
A
V
V
L
-----
I
F
L
L
C
-------
W
L
P
----------
Y
N
L
V
L
L
A
D
T
-----
L
M
------------
R
TQVIQE
S
C
E
R
R
N
N
------
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
-
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
72.00
16%
-125
- C5 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
------------------------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
------
L
I
C
C
F
I
I
L
E
N
I
-----
F
V
L
L
T
I
W
K
------------
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
---
N
L
L
--------
L
S
G
A
--
T
T
Y
K
----
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
---------
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
----
L
G
G
L
P
I
M
G
W
N
--
C
------------
I
S
A
L
S
S
C
S
T
V
L
---
P
L
-------------------------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
L
-----
L
L
S
-
I
V
I
L
Y
C
R
I
Y
S
L
----
V
-----------
R
T
-------------
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
------
V
A
L
L
K
T
V
I
I
V
L
S
-----
V
F
I
A
C
-------
W
A
P
----------
L
F
I
L
L
L
L
D
V
-----
G
C
------------
K
------------
V
KTC
D
--
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
-
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
68.80
19%
-149
- C2 -
4XGC
-
?
D:
[5-457]
D
R
E
L
V
S
I
R
R
F
L
K
E
R
L
Q
RDYTT
L
R
G
Y
A
K
E
R
S
N
V
R
L
L
L
Q
R
T
A
E
M
G
-
E
S
N
S
L
L
L
L
G
P
R
GSG
K
T
T
L
I
N
S
V
L
A
D
L
L
P
NK
S
F
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QSS----------------------------------------------------------------------------------------------------------------------------