@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O2T12_HUMAN: (2016-01-11 )
MEMRNTTPDFILLGLFNHTRAHQVLFMMLLATVLTSLFSNALMILLIHWDHRLHRPMYFLLSQLSLMDMMLVSTTVPKMAADYLTGNKAISRAGCGVQIFFLPTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMTMSSWLLGAADGLLQAVATLSFPYCGAHEIDHFFCEAPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLLMRSTEARKKAFATCSSHVAVVGLFYGAGIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVRNSEVKEALKRWLGTCVNLKHQQNEAHRSR
Atome Classification :
(20 SA)
-.........10...----------------.---------------....20........30........40........50........60........70....-....80.......-.90..------------......100......-.110.......120.......130.......140.......150.......160.......170--.......180.....--.-----.190.......200..--.--....210....-...220--.....-.------------..------.-----------230------------------..-----------.....-------------..240.......-------250----.........260-.-----.-----.---..--.--.270-----.---........280....-...290.......300.......310.......320----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MEMRNTTP
D
F
I
L
L
G----------------L---------------FNH
T
R
A
H
Q
V
L
F
M
M
L
L
A
T
V
L
T
S
L
F
SN
A
L
M
I
L
L
I
HWDHRL
H
R
P
M
Y
F
L
L
S
Q
L
S
L
M
D
M
M
L
V
STT-
V
P
K
M
A
A
D
Y
LTGNK-AISRA------------GC
G
V
Q
I
F
F
L
P
TLGGG-E
C
F
L
L
A
A
M
A
Y
D
R
Y
A
A
V
CHPLRYP
T
L
M
S
W
Q
L
C
L
R
M
T
M
S
S
W
L
L
G
A
A
D
G
L
L
Q
A
V
A
T
LSFPYCG
A
H
E
I
--
D
H
F
FCEA
P
V
L
V
R
L
AC--A-----D
T
S
V
F
E
N
A
M
Y
I
C
C
V
L
M
--
L
--
L
V
P
F
S
L
I
L
S
S
Y
-
G
L
I
L
----
A
A
V
L
L
-M------------RS------
T
-----------
E
--------------------
A
R
-----------
K
K
A
F
A
-------------
T
C
S
S
H
V
A
V
V
G
L
F
-------Y------GA
G
I
F
T
Y
MRPKS-H-----R-----S---T
N
--
H
--
D
K
-------
V
---
V
S
A
F
Y
T
M
F
T
P
L
L
N
P
L
-
I
Y
SVR
N
S
E
V
K
E
A
L
K
R
W
L
G
T
C
VNLKHQ
Q
N
E
AHRSR------------------------
4
PsiBlast_PDB
92.05
22%
-135
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
----
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
------
R
-----------
S
--------------------
T
L
-----------
Q
K
E
V
H
-------------
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
1
PsiBlast_PDB
91.71
22%
-135
- C2 -
3PWH
1
?
A:
[14-305]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
----
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPGE
R
A
------
R
-----------
S
--------------------
T
L
-----------
Q
K
E
V
H
-------------
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
3
PsiBlast_PDB
91.36
22%
-135
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
----
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
------
R
-----------
S
--------------------
T
L
-----------
Q
K
E
V
H
-------------
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
2
PsiBlast_PDB
91.31
22%
-136
- C2 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
----
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPGE
R
A
------
R
-----------
S
--------------------
T
L
-----------
Q
K
E
V
H
-------------
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
5
PsiBlast_PDB
91.21
22%
-134
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-------------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
----
A
A
A
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
------
R
-----------
S
--------------------
T
L
-----------
Q
K
E
V
H
-------------
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------
11
PsiBlast_PDB
90.55
22%
-137
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[14-308]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
---------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
----
A
A
R
R
Q
-
L
------------
K
Q
------
M
-----------
E
--------------------
S
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
-------------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-
L
-----------------------------------
10
PsiBlast_PDB
89.91
22%
-140
- C2 -
3VG9
8
?
A:
[14-309]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
---------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
----
A
A
R
R
Q
-
L
------------
K
Q
------
M
-----------
E
--------------------
S
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
-------------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-
L
R
----------------------------------
39
Fugue
83.05
18%
-110
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
---------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
---
W
--
S
R
Y
I
P
E
G
---
M
Q
C
S
C
--
G
I
DYYT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VH
F
--
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
----
F
T
V
K
E
-
A
------------
A
A
------
S
-----------
A
--------------------
T
T
-----------
Q
K
A
E
K
-------------
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
------
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
-----
I
-----
F
---
T
H
--
Q
--
G
S
DFGPIFM
T
---
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A--------------------
33
HHSearch
78.88
17%
-129
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-334]
----------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
------------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
-
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
-
L
E
G
--
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
--
F
--
F
G
P
I
L
I
I
F
F
C
Y
-
F
N
I
V
----
M
S
V
S
N
-
H
------------
E
K
------
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
-----------
M
R
L
A
K
-------------
I
S
I
V
I
V
S
Q
F
L
L
S
-------
W
------
S
P
Y
A
V
V
A
L
L
A
Q
F
-
G
-----
P
LEW--
V
---
T
P
--
Y
--
A
A
-------
Q
---
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
-
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
------------------------
13
PsiBlast_PDB
78.69
24%
-106
- C2 -
2YDV
6
?
A:
[45-312]
----------------------------------------------------------------------------------------------------------
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
GFCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
--
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
----
A
A
R
R
Q
-
L
------------
K
Q
------
M
-----------
E
--------------------
S
Q
S
T
L
--------
Q
K
E
V
H
-------------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-
L
R
Q
Q
E
P
F
K
A
A
A
A
------------------------
12
PsiBlast_PDB
78.67
24%
-102
- C2 -
2YDO
3
?
A:
[45-312]
----------------------------------------------------------------------------------------------------------
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
GFCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
--
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
----
A
A
R
R
Q
-
L
------------
K
Q
------
M
-----------
E
--------------------
S
-T
L
---------
Q
K
E
V
H
-------------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-
L
R
Q
Q
E
P
F
K
A
A
A
A
------------------------
20
PsiBlast_PDB
78.24
19%
-121
- C2 -
3C9L
12
OPSD_BOVIN
A:
[55-317]
-----------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
---------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
--
E
-----
E
T
N
N
E
S
F
V
I
Y
M
-
F
V
V
H
--
F
--
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
------------
Q
E
------
S
-----------
A
--------------------
T
T
-----------
Q
K
A
E
K
-------------
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
--
T
-
H
-----
Q
-----
G
---
S
D
--
F
--
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
---------------------------------
19
PsiBlast_PDB
78.00
19%
-123
- C2 -
3CAP
4
OPSD_BOVIN
A:
[55-317]
-----------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
---------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
--
E
-----
E
T
N
N
E
S
F
V
I
Y
M
-
F
V
V
H
--
F
--
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
F
T
V
K
E
A
A
A
Q
-
Q
------------
Q
E
------
S
-----------
A
--------------------
T
T
-----------
Q
K
A
E
K
-------------
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
--
T
-
H
-----
Q
-----
G
---
S
D
--
F
--
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------------------------------------
40
Fugue
77.78
17%
-103
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
----------------
N
KTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
---
W
--
S
R
Y
I
P
E
G
---
M
Q
C
S
C
--
G
I
DYYT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
--
V
HF
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
----
F
T
V
K
E
-
A
------------
A
A
QQQESA
T
-----------
T
--------------------
Q
K
-----------
A
E
K
E
V
-------------
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
--
Y
------
A
G
V
A
F
Y
I
F
T
H
Q
G
-
S
-----
D
-----
F
---
G
P
--
I
--
F
M
-------
T
---
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA--------------
29
HHSearch
77.25
15%
-126
* C2 *
2KS9
1
NK1R_HUMAN
A:
[34-327]
-------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
------------
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
-
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
----
E
-
T
M
P
--
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
--
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
-
T
V
V
G
----
I
T
L
W
A
-
S
------------
E
I
------
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
-----------
R
K
V
V
K
-------------
M
M
I
V
V
V
C
T
F
A
I
C
-------
W
------
L
P
F
H
I
F
F
L
L
P
Y
I
-
N
-----
P
-----
D
LYL
K
K
F-
I
Q
Q
V
Y
-------
L
---
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
-
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
------------------------
15
PsiBlast_PDB
77.25
24%
-109
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[45-312]
----------------------------------------------------------------------------------------------------------
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
TGFCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
--
G
K
A
---
G
C
G
E
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
----
A
A
R
R
Q
-
L
------------
K
Q
------
M
-----------
E
--------------------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
-------------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-------
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-
L
R
Q
Q
E
P
F
K
A
A
A
A
------------------------
14
PsiBlast_PDB
77.13
24%
-108
- C2 -
4UG2
3
?
A:
[45-309]
----------------------------------------------------------------------------------------------------------
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
--
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
----
A
A
R
R
Q
-
L
-------------------------------------------------------A
R
S
T
L
------
Q
K
E
V
H
-------------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
------
I
I
N
C
F
T
F
F
C
P
D
C
-
S
-----
H
-----
A
---
P
L
--
W
--
L
M
-------
Y
---
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-
L
R
----------------------------------
42
Fugue
75.56
16%
-108
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
S
F
K
C
A
L
T
K
T
G
F
-----------------------------------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
------------
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
-
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
----
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
--
K
T
I
T
C
Y
D
T
T
----
S
D
--
E
-----
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
--
C
V
P
L
V
L
I
L
G
C
Y
-
G
L
I
V
----
R
A
L
I
Y
K
M
------------
K
K
------
Y
-----------
T
--------------------
C
T
-----------
V
C
G
Y
I
Y
N
PEDGDPDNGVN
P
G
T
D
F
K
D
I
V
C
P
L
-------
C
------
G
V
G
K
D
Q
F
E
E
V
E
E
-
P
-----
L
-----
R
---
R
K
--
S
--
I
Y
-------
L
---
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
-
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
31
HHSearch
73.20
17%
-101
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
------------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
-
I
-
P
E
G
--
M
Q
C
S
C
G
I
D
Y
Y
T
P
-----
H
-----
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
--
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
----
F
T
V
K
E
-
A
------------
A
A
------
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
-----------
K
E
V
T
R
-------------
M
V
I
I
M
V
I
A
F
L
I
C
-------
W
------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
SD---
F
---
G
P
--
I
--
F
M
-------
T
---
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
------------------------
30
HHSearch
72.30
18%
-115
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
------------------------------------------------------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
------------
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
-
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
--
Y
-
H
-
P
N
N
--
S
S
P
V
C
Y
E
V
L
G
N
D
-----
T
------
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
--
F
--
I
V
P
L
F
V
M
L
F
C
Y
-
G
F
T
L
----
R
T
L
F
K
-
A
------------
H
-------
M
-----------
G
--------------------
Q
K
-----------
H
R
A
M
R
-------------
V
I
F
A
V
V
L
I
F
L
L
C
-------
W
------
L
P
Y
N
L
V
L
L
A
D
T
L
-
M
RTQVI
Q
E
S
C
E
R
R
---
N
N
I
G
R
--
A
L
-------
D
---
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
-
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-------------------------------------