@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O2T33_HUMAN: (2016-01-11 )
MEMRNTTPDFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFLLSQLSLMDMMLVSTTVPKMAADYLTGSKAISRAGCGVQIFFLPTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMTMSCWLLGAADGLLQAVVTLSFPYCGAHEIDHFFCETPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCSSHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALKRWLGTCVNIKHQQNEAHRSR
Atome Classification :
(20 SA)
---.........10...----------------.---------------....20........30....--------------....40-------------........50........60........70---------------------------.....-....80.......-.90........100--------......----------.110.......120.......130...---------....140---.......150---------.........160.......170-------.....--...180..----...--.-----.190.......200..--.--..---------..210------......-...220----...------------..-.------------...--------------------230------..-----------.....---------------..240..--------------.....-------250....------...260-----------.-.-----.---.---..---.---.270-----......----...280------........290......--------..300.......310--.........320----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MEMRNTTP
D
F
I
L
L
G----------------L---------------FNH
T
R
A
H
Q
V
L
F
M
M
V
L
S
I
V
L
T
--------------
S
LFGN
S
-------------
L
M
I
L
L
I
HWDHRLH
T
P
M
Y
F
L
L
S
Q
L
S
L
M
D
M
M
----------------------------
L
V
STT-
V
P
K
M
A
A
D
Y
LTG
S
K
-
A
I
SRAGC
G
V
Q
I
F
F
L
--------
P
TLGGG----------E
C
F
L
L
A
A
M
A
Y
D
R
Y
A
A
V
CHPLRYP
T
L
M
S
---------
W
Q
L
C
L
R
M
---
T
M
S
C
W
L
L
G
-----------
A
A
D
G
L
L
Q
A
V
V
T
LSFPYCG
A
H
E
--------
I
D
H
F
F--CET
P
V
L
V
R
----
L
AC--A-----D
T
S
V
F
E
N
A
M
Y
I
C
C
V
L
M
--
L
--
L
V
---------
P
F
S
--------
L
I
L
S
S
Y
-
G
L
I
L
------
A
A
V
------------
L
H
-M------------RS
T
--------------------
E
--------
A
R
-----------
K
K
A
F
A
---------------
T
C
S
S
H
V
A
--------------
V
V
G
L
F
-------
Y
G
A
A
I
F
T
------YMRPK------------S-H-----R---S---T
N
---
H
---
D
K
-------
V
V
S
A
F
Y
----
T
M
F
T
P
-------
L
L
N
P
L
I
Y
SVK-N
S
E
V
K
G
--------
A
L
K
R
W
L
G
T
C
VNIK----HQQ
N
E
AHRSR------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
97.05
22%
-137
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
A
Q
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
A
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
------------------
G
C
G
E
G
Q
----
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
------------
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
--------------------
S
--------
T
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
--------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
A
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
96.02
22%
-139
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
A
Q
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
A
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
------------------
G
C
G
E
G
Q
----
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
------------
R
R
-
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
--------------------
S
--------
T
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
--------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
A
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
95.83
22%
-137
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
A
Q
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
A
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
------------------
G
C
G
E
G
Q
----
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
------------
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
--------------------
S
--------
T
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
--------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
A
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.35
22%
-139
- C3 -
3PWH
1
?
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
A
Q
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
A
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
------------------
G
C
G
E
G
Q
----
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
------------
R
R
-
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
--------------------
S
--------
T
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
--------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
A
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.22
22%
-137
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
A
Q
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
A
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
------------------
G
C
G
E
G
Q
----
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
-
L
R
I
F
------
A
A
A
------------
R
R
-
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
--------------------
S
--------
T
L
-----------
Q
K
E
V
H
---------------
A
A
K
S
A
A
I
--------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
A
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
95.04
22%
-127
- C3 -
2YDO
3
?
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
T
A
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
K
--------
E
G
K
A
H
--
S
Q
G
C
G
E
G
Q
----
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
------------
R
Q
-
L
------------
K
Q
M
--------------------
E
--------
S
-T
L
---------
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
--------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
S
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
R
Q
----
Q
E
P
F
K
A
A
A
A
E
------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
93.95
22%
-130
- C3 -
2YDV
6
?
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
T
A
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
K
--------
E
G
K
A
H
--
S
Q
G
C
G
E
G
Q
----
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
------------
R
Q
-
L
------------
K
Q
M
--------------------
E
--------
S
Q
S
T
L
--------
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
--------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
S
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
R
Q
----
Q
E
P
F
K
A
A
A
A
E
------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
93.52
22%
-136
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
T
Q
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
-----------------
S
Q
G
C
G
E
G
Q
----
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
------------
R
Q
-
L
------------
K
Q
M
--------------------
E
--------
S
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
--------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
S
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.28
22%
-141
- C3 -
3VG9
8
?
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
T
Q
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
-----------------
S
Q
G
C
G
E
G
Q
----
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
------------
R
Q
-
L
------------
K
Q
M
--------------------
E
--------
S
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
--------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
S
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
R
---------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
92.29
22%
-134
- C3 -
4UG2
3
?
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
T
A
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
K
--------
E
G
K
A
H
--
S
Q
G
C
G
E
G
Q
----
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
------------
R
Q
-
L
----------------------------------------------A
R
S
T
L
------
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
--------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-
S
-----
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
S
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
R
---------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
90.79
22%
-130
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[14-301]
---------------------------------------------------------------
L
A
I
A
V
L
--------------
A
I
L
G
N
V
-------------
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
----------------------------
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
--------
L
V
L
T
A
S
----------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
---
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
K
--------
E
G
K
A
-----
G
C
G
E
G
Q
----
V
A
C
LF
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
--
L
V
---------
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
------------
R
Q
-
L
------------
K
Q
M
--------------------
E
--------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
---------------
A
A
K
S
L
A
I
--------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
P
D
------------
C
-------
H
---
A
---
P
L
---
W
---
L
M
-------
Y
L
A
I
V
L
----
S
H
T
N
S
-------
V
V
N
P
F
I
Y
A
Y
R
-
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
R
Q
----
Q
E
P
F
K
A
A
A
A
-------------------------------------------------------------------------------------------------------------------
31
HHSearch
87.05
16%
-130
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-325]
----------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
--------------
S
V
V
G
N
V
-------------
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
----------------------------
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
--------
I
A
A
V
F
A
----------
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
---------
A
T
A
T
K
V
V
---
I
C
V
I
W
V
L
A
-----------
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
----
E
-
T
M
--------
P
S
R
V
V
--
C
M
I
E
W
P
E
H
----
P
----------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
--
Y
--
F
L
---------
P
L
L
--------
V
I
G
Y
A
Y
-
T
V
V
G
------
I
T
L
------------
W
A
-
S
------------
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
-----------
R
K
V
V
K
---------------
M
M
I
V
V
V
C
--------------
T
F
A
I
C
-------
W
L
P
F
H
I
F
------
F
L
L
P
Y
------------
I
-
N
-----
P
---
D
LYL
K
K
---
F
I
Q
Q
V
Y
-------
L
A
I
M
W
L
----
A
M
S
S
T
-------
M
Y
N
P
I
I
Y
C
C
L
-
N
D
R
F
R
L
--------
G
F
K
H
A
F
R
C
C
P
F
I
S
----
A
G
D
Y
E
G
L
E
M
K
------------------------------------------------------------------------------------------------------------------
40
Fugue
87.04
18%
-108
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
---------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
--------------
G
F
P
I
N
F
-------------
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
----------------------------
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
--------
T
L
G
G
E
I
----------
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
------------------
F
R
F
---
G
E
N
H
A
I
M
G
-----------
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
----------------
Y
I
P
E
G
M
Q
----
C
S
C
--
G
I
DYYT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VH
F
--
I
I
---------
P
L
I
--------
V
I
F
F
C
Y
-
G
Q
L
V
------
F
T
V
------------
K
E
-
A
------------
A
A
S
--------------------
A
--------
T
T
-----------
Q
K
A
E
K
---------------
E
V
T
R
M
V
I
--------------
I
M
V
I
A
-------
F
L
I
C
W
L
P
------
Y
A
G
V
A
------------
F
-
Y
-----
I
---
F
---
T
H
---
Q
---
G
S
DFGPIFM
T
I
P
A
F
F
----
A
K
T
S
A
-------
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
--------
C
M
V
T
T
L
C
C
G
K
N
P
S
----
T
T
V
S
K
T
E
T
S
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------
33
HHSearch
85.32
17%
-134
- C3 -
2Z73
5
OPSD_TODPA
A:
[35-334]
--------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
--------------
G
C
G
G
N
G
-------------
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
----------------------------
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
--------
G
I
F
G
F
M
----------
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
---------
H
R
R
A
F
I
M
---
I
I
F
V
W
L
W
S
-----------
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
----
L
E
--------
G
V
L
C
N
--
C
S
F
D
Y
I
S
R
----------------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
--
F
--
F
G
---------
P
I
L
--------
I
I
F
F
C
Y
-
F
N
I
V
------
M
S
V
------------
S
N
-
H
------------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
-----------
M
R
L
A
K
---------------
I
S
I
V
I
V
S
--------------
Q
F
L
L
S
-------
W
S
P
Y
A
V
V
------
A
L
L
A
Q
------------
F
-
G
-----
P
LEW
V
---
T
P
---
Y
---
A
A
-------
Q
L
P
V
M
F
----
A
K
A
S
A
-------
I
H
N
P
M
I
Y
S
V
S
-
H
P
K
F
R
E
--------
A
I
S
Q
T
F
P
W
V
L
T
C
C
----
Q
F
D
D
K
E
T
E
D
D
------------------------------------------------------------------------------------------------------------------
39
Fugue
82.27
17%
-103
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
----------------
N
KTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
--------------
G
F
P
I
N
F
-------------
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
----------------------------
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
--------
T
L
G
G
E
I
----------
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
------------------
F
R
F
---
G
E
N
H
A
I
M
G
-----------
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-----------
W
S
R
Y
I
--
P
E
G
---
M
Q
----
C
S
C
--
G
I
DYYT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
--
V
HF
I
I
---------
P
L
I
--------
V
I
F
F
C
Y
-
G
Q
L
V
FTVKEA
A
A
Q
------------
Q
Q
-
E
------------
S
A
T
--------------------
T
--------
Q
K
-----------
A
E
K
E
V
---------------
T
R
M
V
I
I
M
--------------
V
I
A
F
L
I
C
W
L
P
--
Y
A
G
V
A
F
Y
------
I
F
T
H
Q
------------
G
-
S
-----
D
---
F
---
G
P
---
I
---
F
M
-------
T
I
P
A
F
F
----
A
K
T
S
A
-------
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
--------
C
M
V
T
T
L
C
C
G
K
N
P
L
----
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA--------------------------------------------------------------------------------------------------------
42
Fugue
81.47
17%
-118
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--S
F
K
C
A
L
T
K
T
G
F
-----------------------------------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
--------------
G
F
L
G
N
S
-------------
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
----------------------------
Y
V
-
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
--------
H
V
N
L
Y
G
----------
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
---------
K
K
N
A
I
C
I
---
S
V
L
V
W
L
I
V
-----------
V
V
A
I
----
S
P
I
L
F
Y
S
G
T
G
V
R
K
--------
N
K
T
I
T
--
C
Y
D
T
T
--------
S
D
--
E
-----
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
--
C
V
---------
P
L
V
--------
L
I
L
G
C
Y
-
G
L
I
V
------
R
A
L
------------
I
Y
K
M
------------
K
K
Y
--------------------
T
--------
C
T
-----------
V
C
G
Y
I
Y
N
PEDGDPDNGVNPG
T
D
F
K
D
I
V
--------------
C
P
L
C
G
-------
V
G
K
D
Q
F
E
------
E
V
E
E
P
------------
L
-
R
-----
R
---
K
---
S
I
---
Y
L
V
-
I
I
-------
V
L
T
V
F
A
----
V
S
Y
I
P
-------
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
--------
P
A
M
C
A
F
N
D
R
V
Y
A
T
----
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-----------------------------------------------------------------------------------------------
30
HHSearch
79.93
18%
-108
- C3 -
1U19
14
OPSD_BOVIN
A:
[42-328]
---------------------------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
--------------
G
F
P
I
N
F
-------------
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
----------------------------
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
--------
T
L
G
G
E
I
----------
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
---------
E
N
H
A
I
M
G
---
V
A
F
T
W
V
M
A
-----------
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
I
--
P
E
--------
G
M
Q
C
S
--
C
G
I
D
Y
Y
T
P
---------
H
-----
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
--
I
I
---------
P
L
I
--------
V
I
F
F
C
Y
-
G
Q
L
V
------
F
T
V
------------
K
E
-
A
------------
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
-----------
K
E
V
T
R
---------------
M
V
I
I
M
V
I
--------------
A
F
L
I
C
-------
W
L
P
Y
A
G
V
------
A
F
Y
I
F
------------
T
H
Q
G----
S
---
D
F--
G
P
---
I
---
F
M
-------
T
I
P
A
F
F
----
A
K
T
S
A
-------
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
--------
C
M
V
T
T
L
C
C
G
K
N
P
L
----
G
D
D
E
A
S
T
T
V
S
------------------------------------------------------------------------------------------------------------------
28
HHSearch
78.35
19%
-117
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
--------------
S
L
L
G
N
S
-------------
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
----------------------------
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
--------
E
V
N
F
Y
S
----------
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
---------
R
H
L
V
K
F
V
---
C
L
G
C
W
G
L
S
-----------
M
N
L
S
L
P
F
F
L
F
R
Q
A
--
Y
H
P
--
N
--------
N
S
S
P
V
--
C
Y
E
V
L
G
N
D
---------
T
------
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
--
F
--
I
V
---------
P
L
F
--------
V
M
L
F
C
Y
-
G
F
T
L
------
R
T
L
------------
F
K
-
A
------------
H
-
M
--------------------
G
--------
Q
K
-----------
H
R
A
M
R
---------------
V
I
F
A
V
V
L
--------------
I
F
L
L
C
-------
W
L
P
Y
N
L
V
------
L
L
A
D
T
------------
L
-
M
RTQVI
Q
E
S
C
E
R
--
R
N
N
I
G
R
---
A
L
-------
D
A
T
E
I
L
----
G
F
L
H
S
-------
C
L
N
P
I
I
Y
A
F
I
-
G
Q
N
F
R
H
--------
G
F
L
K
I
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------
43
Fugue
78.08
17%
-158
- C1 -
3KMQ
-
?
A:
[1-476]
GLI
V
D
T
R
D
V
E
E
R
V
H
V
M
R
----------------
K
TK-------------
L
A
P
T
V
A
H
G
V
F
N
P
E
F
G
P
A
A
L
S
NKDPRLNEGVV
L
D
E
V
I
F
S
K
H
KSD
T
K
M
S
A
E
D
K
A
L
F
R
R
C
A
A
D
Y
A
S
R
L
H
S
V
L
G
T
A
N
A
P
L
S
I
Y
E
A
I
K
GVDG
L
D
A
M
EPDTAPGL
P
W
A
L
Q
GKR
R
G
A
L
I
D
F
E
-
N
G
T
V
G
P
E
V
E
A
A
L
K
-
L
M
E
K
R
E
Y
K
F
A
C
Q
T
F
L
K
DEIRP
M
E
K
V
R
A
G
K
T
R
I
V
DVLP
V
E
H
I
L
Y
T
R
M
M
I
G
R
F
C
A
Q
M
H
S
N
N
G
P
Q
I
G
S
AVGCNPDVD
W
Q
R
F
G
T
H
F
A
Q
Y
R
N
V
W
D
V
D
Y
S
AFDANHC
S
D
A
M
N
I
M
F
E
E
V
F
R
T
E
F
G
F
H
P
N
A
E
W
I
L
K
T
L
V
N
T
E
H
A
Y
--
E
N
K
R
I
T
V
E
G
GMP
S
G
C
--
S
-----
A
T
S
I
I
N
T
I
L
N
N
I
Y
V
L
Y
--
A
--
L
R
---------
R
H
Y
EGVELDT
Y
T
M
I
S
Y
G
-
D
D
I
V
------
V
A
S
------------
D
Y
-
D
------------
L
D
F
--------------------
E
--------
A
L
-----------
K
P
H
F
K
---------------
S
L
G
Q
T
I
T
P
ADKSDKGFVLGHS
I
T
D
V
T
-------
F
L
K
R
H
F
H
M
DYGTG
F
Y
K
P
V
M
A
S
K
T
L
E
A
I
L
S
F
A
-
R
-----
R
---
G
---
T
I
---
Q
---
E
K
-------
L
I
S
V
A
G
----
L
A
V
H
S
G
P
D
E
Y
R
R
L
F
E
P
F
Q
G
L
F
E
-
I
P
S
Y
R
S
--------
L
Y
L
R
W
V
N
A
V
C
--------
G
D
A
A
A
L
E
H
H
------------------------------------------------------------------------------------------------------------------
45
Fugue
75.29
16%
-115
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---
P
C
F
R
E
E
N
A
N
F
-----------------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
--------------
G
I
V
G
N
G
-------------
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
----------------------------
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
N
W
Y
-
F
-
G
N
F
L
C
K
A
V
H
V
I
Y
--------
T
V
N
L
Y
S
----------
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
---------
L
L
A
E
K
V
V
---
Y
V
G
V
W
I
P
A
-----------
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
D
D
R
Y
I
--------
C
D
R
F
Y
PN
D
L
W
V
V
V
F
Q
----
F
Q
H
--
I
-----
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
--
I
--
I
I
S
K
LSHSGSN
I
F
E
--------
M
L
R
I
D
E
-
G
L
R
L
------
K
I
Y
K
D
TEG
Y
Y
T
I
GIG
H
L
-
L
------------
T
K
S
--------------------
P
--------
S
L
-----------
N
A
A
K
S
---------------
E
L
D
K
A
I
G
RNTNG---------
V
I
T
K
D
-------
E
A
E
K
L
F
N
------
Q
D
V
D
A
------------
A
-
V
-----
R
---
G
---
I
L
---
R
---
N
A
-------
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
-------
A
L
I
N
M
V
F
Q
M
G
-
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ