@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51B2_HUMAN: (2016-01-12 )
MWPNITAAPFLLTGFPGLEAAHHWISIPFFAVYVCILLGNGMLLYLIKHDHSLHEPMYYFLTMLAGTDLMVTLTTMPTVMGILWVNHREISSVGCFLQAYFIHSLSVVESGSLLAMAYDCFIAIRNPLRYASILTNTRVIALGVGVFLRGFVSILPVILRLFSFSYCKSHVITRAFCLHQEIMRLACADITFNRLYPVILISLTIFLDCLIILFSYILILNTVIGIASGEERAKALNTCISHISCVLIFYVTVMGLTFIYRFGKNVPEVVHIIMSYIYFLFPPLMNPVIYSIKTKQIQYGIIRLLSKHRFSS
Atome Classification :
(20 SA)
---------------------------------------------..---.......10.....---------------...20........------30......-----..40........50........60.---.......70...--.-..-----..80.-.......90........100-........110........120.......130.......140.....-..150.......160-........170.--....------..180-.......-------.190..-....--..200...-------------....210.....-----..-220------.------......------------------------------------------------------------------------------------------------------------------------------------------------------------------230.------......240--....--...------..250...-----....260...--.--------.--.--.270.......-.280.......290.......300-----....----------------....310-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------MW---PNITAA
P
F
L
L
TGFP---------------
G
L
E
A
A
H
H
W
IS
I
P
F
------
F
A
V
Y
V
C
I
L
-----LGN
G
M
L
L
Y
L
I
KHDHSLH
E
P
M
Y
Y
F
L
T
---
M
LAGT
D
L
M
V
T
L
T--T-M
P
-----
T
V
M
G
I
-
L
W
VN
H
R
E
I
S
S
V
G
C
F
L
Q
A
Y
F
--
I
H
S
L
S
VVES-G
S
L
L
A
M
A
Y
D
C
F
I
A
IRN
P
L
R
Y
A
S
I
LTN
T
R
V
I
A
L
G
V
G
V
F
-
L
R
G
F
V
S
I
L
P
V
I
L
R
-
L
-
F
S
F
S
Y
C
K
S
H
V
I
T
--
R
A
F
C
------
L
H
Q
E
--
I
M
R
L
A
C
A-------DI
T
-
F
N
-R
L
Y
P
--
V
I
L
I
S
L
T
I
-------------
F
L
D
C
L
I
I
L
F
S
Y
I
-----
L
I
-
L
N
T
------
V
------
I
GIAS
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
R
A
------
K
A
L
N
T
C
I
----
S
H
I
S
--
C
V
L
------
I
F
Y
V
T
V
M
G
-----
L
T
F
I
Y
R
FGKN--
V
--------
P
--
E
--
V
V
-
H
I
I
M
S
Y
I
Y
-
F
LF
P
P
LM
N
P
V
I
Y
S
I
K
T
K
Q
I
Q
Y
G
I
------
I
R
L
L
----------------
S
K
HRFSS-----------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
91.21
19%
-176
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-470]
-------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
------
L
A
I
A
V
L
A
I
-----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
---
S
L
A
A
A
D
I
A
V
G
V
L
--
A
-
I
P
-----
F
A
I
T
I
-
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
S
I
-
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
-
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
N
C
G
Q
---------
S
Q
G
C
------
G
E
G
Q
--
V
---
A
C
L
-------
F
E
D
V
V
P
M
N
Y
M
V
--
Y
F
N
F
F
A
C
V
-------------
L
V
P
L
L
L
M
L
G
V
Y
L
-----
R
I
-
F
L
A
------
A
------
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
Q
K
E
V
------
H
A
A
K
S
L
A
----
I
I
V
G
--
L
F
A
------
L
C
W
L
P
L
H
I
-----
I
N
C
F
T
F
F
C
P
D
CS
H
--------
A
--
P
--
L
W
-
L
M
Y
L
A
I
V
L
-
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
------
R
K
I
I
----------------
R
S
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
91.09
23%
-163
- C2 -
2YCY
6
ADRB1_MELGA
A:
[21-299]
----------------------------------------------------------------------------------------------------
V
V
L
L
I
V
-----
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
---
S
L
A
C
A
D
L
V
V
G
L
L
--
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
---------
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
-
W
------
R
D
E
D
P
--
Q
A
L
K
------
C
Y
Q
D
--
P
---
G
C
C
-------
D
F
V
-
T
N
-
R
A
Y
A
--
I
A
S
S
I
I
S
F
-------------
Y
I
P
L
L
I
M
I
F
V
A
L
-----
R
V
-
Y
R
E
------
A
K
E
Q
I
R--
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
--
V
F
T
------
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
R
D
L-
V
--------
P
--
D
--
W
L
-
F
V
A
F
N
W
L
G
-
Y
A
-
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
------
K
R
L
L
----------------
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
90.21
23%
-165
- C2 -
2YCW
7
ADRB1_MELGA
A:
[21-299]
----------------------------------------------------------------------------------------------------
V
V
L
L
I
V
-----
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
---
S
L
A
C
A
D
L
V
V
G
L
L
--
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
---------
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
-
W
------
R
D
E
D
P
--
Q
A
L
K
------
C
Y
Q
D
--
P
---
G
C
C
-------
D
F
V
-
T
N
-
R
A
Y
A
--
I
A
S
S
I
I
S
F
-------------
Y
I
P
L
L
I
M
I
F
V
A
L
-----
R
V
-
Y
R
E
------
A
K
E
Q
I
R
K
I
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
--
V
F
T
------
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
R
D
L-
V
--------
P
--
D
--
W
L
-
F
V
A
F
N
W
L
G
-
Y
A
-
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
------
K
R
L
L
----------------
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
89.87
23%
-167
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[21-299]
----------------------------------------------------------------------------------------------------
V
V
L
L
I
V
-----
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
---
S
L
A
C
A
D
L
V
V
G
L
L
--
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
---------
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
-
W
------
R
D
E
D
P
--
Q
A
L
K
------
C
Y
Q
D
--
P
---
G
C
C
-------
D
F
V
-
T
N
-
R
A
Y
A
--
I
A
S
S
I
I
S
F
-------------
Y
I
P
L
L
I
M
I
F
V
A
L
-----
R
V
-
Y
R
E
------
A
K
E
Q
I
R
K
I
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
--
V
F
T
------
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
R
D
L-
V
--------
P
--
D
--
W
L
-
F
V
A
F
N
W
L
G
-
Y
A
-
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
------
K
R
L
L
----------------
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
89.54
16%
-159
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------------------
M
N
---
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
TGVVRSPFEAPQYYL
A
E
P
W
Q
F
S
M
L
A
A
Y
M
------
F
L
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
---
N
L
A
V
A
D
L
F
M
V
F
G
--
G
-
F
T
-----
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
--------
S
R
Y
I
P
--
E
G
---------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
-
N
N
-
E
S
F
V
--
I
Y
M
F
V
V
H
F
-------------
I
I
P
L
I
V
I
F
F
C
Y
G
-----
Q
L
-
V
F
T
------
V
------
K
E
A
A
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
------
K
A
E
K
E
V
T
----
R
M
V
I
--
I
M
V
------
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
--------
F
--
G
--
P
I
-
F
M
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
------
V
T
T
L
----------------
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
88.96
23%
-172
- C2 -
2VT4
8
ADRB1_MELGA
A:
[21-298]
----------------------------------------------------------------------------------------------------
V
V
L
L
I
V
-----
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
---
S
L
A
C
A
D
L
V
V
G
L
L
--
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
---------
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
-
W
------
R
D
E
D
P
--
Q
A
L
K
------
C
Y
Q
D
--
P
---
G
C
C
-------
D
F
V
-
T
N
-
R
A
Y
A
--
I
A
S
S
I
I
S
F
-------------
Y
I
P
L
L
I
M
I
F
V
A
L
-----
R
V
-
Y
R
E
------
A
K
E
Q
IR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
----
K
A
L
K
T
L
G
----
I
I
M
G
--
V
F
T
------
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
R
D
L-
V
--------
P
--
D
--
W
L
-
F
V
A
F
N
W
L
G
-
Y
A
-
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
------
K
R
L
L
----------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
88.28
23%
-162
- C2 -
2YCX
3
ADRB1_MELGA
A:
[21-294]
----------------------------------------------------------------------------------------------------
V
V
L
L
I
V
-----
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
---
S
L
A
C
A
D
L
V
V
G
L
L
--
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
---------
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
-
W
------
R
D
E
D
P
--
Q
A
L
K
------
C
Y
Q
D
--
P
---
G
C
C
-------
D
F
V
-
T
N
-
R
A
Y
A
--
I
A
S
S
I
I
S
F
-------------
Y
I
P
L
L
I
M
I
F
V
A
L
-----
R
V
-
Y
R
E
------
A
K
E
Q
I
R
K
I
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
----
I
I
M
G
--
V
F
T
------
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
R
D
L-
V
--------
P
--
D
--
W
L
-
F
V
A
F
N
W
L
G
-
Y
A
-
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
87.23
18%
-167
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
-------------------------------------------------------------------------------------
V
G
M
G
I
V
M
------
S
L
I
V
L
A
I
V
-----
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
---
S
L
A
C
A
D
L
V
M
G
L
A
--
V
-
V
P
-----
F
G
A
A
H
-
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
--
D
V
L
C
V
T
A
S
I
-
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
-
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
A
T
H
Q
-----
E
--
A
I
N
C
------
Y
A
E
------
E
T
C
C
-------
D
F
F
-
T
N
-
Q
A
Y
A
--
I
A
S
S
I
V
S
F
-------------
Y
V
P
L
V
I
M
V
F
V
Y
S
-----
R
V
-
F
Q
E
------
A
------
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC-
L
K
E
H
------
K
A
L
K
T
L
G
----
I
I
M
G
--
T
F
T
------
L
C
W
L
P
F
F
I
-----
V
N
I
V
H
V
I
Q
D
N
--
L
--------
I
--
R
--
K
E
-
V
Y
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
------
Q
E
L
L
----------------
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
86.52
17%
-160
- C2 -
2Z73
5
OPSD_TODPA
A:
[32-333]
----------------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
------
G
I
C
G
I
I
G
C
-----
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
---
N
L
A
F
S
D
F
T
F
S
L
V
--
N
G
F
P
-----
L
M
T
I
S
-
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
--
G
G
I
F
G
F
M
S
I
-
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
-
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
-
G
A
Y
T
L
----
E
G
V
--
L
C
N
C
------
S
F
D
Y
--
I
S
R
------------
D
S
-
T
T
-
R
S
N
I
--
L
C
M
F
I
L
G
F
-------------
F
G
P
I
L
I
I
F
F
C
Y
F
-----
N
I
-
V
M
S
------
V
------
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
------
R
L
A
K
I
S
I
----
V
I
V
S
--
Q
F
L
------
L
S
W
S
P
Y
A
V
-----
V
A
L
L
A
Q
F
G
P
L
E-
W
--------
V
--
T
--
P
Y
-
A
A
Q
L
P
V
M
F
-
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
------
S
Q
T
F
----------------
P
W
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
83.61
17%
-156
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
---------------------------------------------------------------------------------------
L
V
V
V
L
------
S
T
I
C
L
V
T
V
-----
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
---
S
L
S
V
A
D
L
I
V
G
A
V
--
V
-
M
P
-----
M
N
I
L
Y
-
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
--
D
Y
V
A
S
T
A
S
I
-
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
-
F
L
S
F
L
W
V
I
P
I
L
-
G
-
W
-
N
H
--------
R
R
--
E
D
K
C
------
E
T
D
F
--
Y
-----------------
D
V
-
T
W
F
K
--
V
M
T
A
I
I
N
F
-------------
Y
L
P
T
L
L
M
L
W
F
Y
A
-----
K
I
-
Y
K
A
------
V
------
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM-
N
R
E
R
------
K
A
A
K
Q
L
G
----
F
I
M
A
--
A
F
I
------
L
C
W
I
P
Y
F
I
-----
F
F
M
V
I
A
F
C
K
N
--
C
--------
C
--
N
--
E
H
-
L
H
M
F
T
I
W
L
-
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
------
K
R
I
L
----------------
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
83.41
19%
-159
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
----------------------------------------------------------------------------------
N
S
I
K
L
T
S
V
V
F
------
I
L
I
C
C
F
I
I
-----
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
---
N
L
A
L
S
D
L
L
A
G
V
A
--
Y
-
T
A
-----
N
L
L
L
S
-
G
A
-
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
--
M
F
V
A
L
S
A
S
V
-
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------
N
N
F
R
L
F
L
L
I
S
A
C
W
-
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
-
N
C
I
-------
S
A
--
L
S
S
C
------
S
T
V
L
--
P
L
----------------
Y
H
-
K
H
Y
I
--
L
F
-
C
T
T
V
F
-------------
T
L
L
L
L
S
I
V
I
L
Y
C
-----
R
I
-
Y
S
L
------
V
------
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
-
S
E
N
V
------
A
L
L
K
T
V
I
----
I
V
L
S
--
V
F
I
------
A
C
W
A
P
L
F
I
-----
L
L
L
L
D
V
G
C
K
V
--
K
--------
T
--
C
D
I
L
F
-
R
A
E
Y
F
L
V
L
-
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
------
I
R
I
M
----------------
G
R
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
81.35
17%
-162
* C2 *
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-------------------------------------------------------------------------------------
V
F
I
V
L
V
A
------
G
S
L
S
L
V
T
I
-----
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
---
S
L
A
C
A
D
L
I
I
G
V
F
--
S
-
M
N
-----
L
Y
T
L
Y
-
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
--
D
Y
V
V
S
N
A
S
V
-
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
-
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
-
Q
F
I
V
G
V
--
R
T
V
E
--
D
G
E
C
------
Y
I
Q
F
--
F
-----------------
S
N
-
A
A
V
T
--
F
G
T
A
I
A
A
F
-------------
Y
L
P
V
I
I
M
T
V
L
Y
W
-----
H
I
-
S
R
A
------
S
------
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP-
S
R
E
K
------
K
V
T
R
T
I
L
----
A
I
L
L
--
A
F
I
------
I
T
W
A
P
Y
N
V
-----
M
V
L
I
N
T
F
C
A
P
--
C
--------
I
--
P
--
N
T
-
V
W
T
I
G
Y
W
L
-
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
------
K
H
L
L
----------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
81.15
16%
-144
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-327]
-------------------------------------------------------------------------------------
S
M
L
A
A
Y
M
------
F
L
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
---
N
L
A
V
A
D
L
F
M
V
F
G
--
G
-
F
T
-----
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
R
Y
I
P
----
E
G
M
--
Q
C
S
C
------
G
I
D
Y
--
Y
T
P
---
H
-------
E
E
T
-
N
N
-
E
S
F
V
--
I
Y
M
F
V
V
H
F
-------------
I
I
P
L
I
V
I
F
F
C
Y
G
-----
Q
L
-
V
F
T
------
V
------
K
E
A
A
A
Q
QQESA
T
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
------
E
V
T
R
M
V
I
----
I
M
V
I
--
A
F
L
------
I
C
W
L
P
Y
A
G
-----
V
A
F
Y
I
F
T
H
Q
G
S-
D
--------
F
--
G
--
P
I
-
F
M
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
------
V
T
T
L
----------------
C
C
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
80.46
15%
-165
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
--------------------------------------------------------------------------------------
L
W
A
A
A
Y
------
T
V
I
V
V
T
S
V
-----
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
---
N
L
A
F
A
E
A
S
M
A
A
F
--
N
-
T
V
-----
V
N
F
T
Y
-
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
--
P
I
A
A
V
F
A
S
I
-
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
-
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
-
T
T
-
E
T
----
M
P
S
--
R
V
V
C
------
M
I
E
W
--
P
E
H
---
P
-------
N
K
I
-
Y
E
-
K
V
Y
H
--
I
C
V
T
V
L
I
Y
-------------
F
L
P
L
L
V
I
G
Y
A
Y
T
-----
V
V
-
G
I
T
------
L
------
W
A
S
E
I
P
GDSSDRYH
E
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
------
K
V
V
K
M
M
I
----
V
V
V
C
--
T
F
A
------
I
C
W
L
P
F
H
I
-----
F
F
L
L
P
Y
I
N
P
D
--
L
YL------
K
KF
I
--
Q
Q
-
V
Y
L
A
I
M
W
L
-
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
------
K
H
A
F
----------------
R
C
C
P
F
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
79.14
15%
-131
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------------------------------MN
G
T
E
G
PNF
Y
V
---
P
F
S
N
K
T
G
V
V
R
S
P
F
E
APQYYL---------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
------
F
L
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
---
N
L
A
V
A
D
L
F
M
V
F
G
--
G
-
F
T
-----
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
-
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
L
A
C
A
A
P
P
L
------
V
G
W
S
---
R
Y
I
P
E
GM
Q
C
S
C
G
I
DYYT
P
H
E
E
--
T
N
N
E
S
F
V
-------
I
Y
M
-
F
V
-
V
H
F
I
--
I
P
L
I
V
I
F
F
-------------
C
Y
G
Q
L
V
F
T
V
K
E
A
-----
A
A
-
Q
Q
Q
------
E
------
S
A
T
T
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
E
------
V
T
R
M
V
I
I
----
M
V
I
A
--
F
L
I
------
C
W
L
P
Y
A
G
V
-----
A
F
Y
I
F
T
H
Q
G
S
--
D
--------
F
--
G
--
P
I
-
F
M
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
------
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
VAPA-------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
78.91
14%
-135
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
------
S
L
I
V
L
A
I
V
-----
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
---
S
L
A
C
A
D
L
V
M
G
L
A
--
V
-
V
P
-----
F
G
A
A
H
-
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
--
D
V
L
C
V
T
A
S
I
-
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
-
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
-
W
Y
R
A
T
H
Q
E
A
I
N
C
--
Y
A
---------------
E
E
T
C
C
--------
D
F
F
-
T
N
-
Q
A
Y
A
--
I
A
S
S
I
V
S
F
-------------
Y
V
P
L
V
I
M
V
F
V
Y
S
-----
R
V
-
F
Q
E
------
A
------
K
R
Q
L
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
------
R
I
D
E
G
L
R
----
L
K
I
Y
--
K
D
T
------
E
G
Y
Y
T
I
G
I
-----
G
H
L
L
T
K
S
P
S
L
--
N
--------
A
--
A
--
K
S
-
E
L
D
K
A
I
G
R
-
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
------
R
G
I
L
----------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
49
Fugue
77.53
20%
-165
- C3 -
3WL8
2
OPH_PSESP
A:
[23-358]
--------------------------------------------V
K
W
E
C
P
A
G
Y
E
V
K
E
G
L
N
V
D
F
P
---------------
H
K
G
M
K
R
A
F
I
V
Y
P
A
KNVS
G
P
A
P
V
W
V
P
M
T
G
SVES
T
N
D
N
L
T
V
A
R
S
G
A
N
S
I
L
A
D
H
G
Y
T
V
I
A
P
V
R
A
C
A
N
Q
D
P
N
I
R
G
E
RC
N
-
G
P
-----
G
S
N
G
W
-
N
W
-
N
P
W
F
E
G
R
A
A
D
P
S
G
E
H
W
--
K
N
D
E
G
--
P
D
-
S
S
F
F
V
A
M
V
Q
C
V
-----
G
T
K
Y
K
---
L
D
A
R
R
L
F
L
G
-
G
I
A
-
S
G
G
T
M
T
N
R
A
L
L
F
R
----------
S
N
F
W
A
--
G
G
L
P
------
I
S
G
E
WY
V
T
S
D
D
G
T
-------
P
L
S
-
F
D
-
D
A
R
A
--
A
V
A
A
A
P
T
K
-------------
I
H
Q
G
R
V
G
P
Y
P
L
P
AKV
G
P
L
I
-
V
M
T
------
V
------
W
G
---
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------
K
D
L
W
N
C
T
R
PDG
S
R
F
L
--
C
A
D
------
Y
R
P
S
T
Q
A
G
-----
S
N
F
F
S
A
Q
--------------
P
--
D
--
V
V
-
H
V
A
C
S
S
T
H
G
H
M
W
P
Q
L
--------
N
T
Q
E
F
N
R
W
A
------
L
D
T
L
----------------
A
S
H
P
K
G
S
DPRS
F
K
L
T
Q
PPEG
Y
T
C
H
V
G
PFTGLYASAWS-----------------------------------------------------------------------------------------------------------------------------
47
Fugue
75.62
17%
-158
* C3 *
4ONQ
1
?
A:
[7-353]
RLPKPMIGFGVPTEPLPAMV
R
R
T
L
PSQAVGPP
F
F
Y
Y
E
N
VALAP
K
G
V
W
---
D
T
I
S
S
S
L
Y
D
I
E
--
P
---------------
E
F
V
D
S
K
Y
F
C
A
A
A
R
------
K
R
G
Y
I
H
N
L
-----
P
V
E
N
R
F
P
L
F
P
L
A
P
R
T
I
H
E
A
L
P
L
S
K
K
---
W
W
P
S
W
D
P
R
T
K
L
N
--
C
-
L
Q
-----
T
A
I
G
S
-
A
Q
L
T
N
R
I
R
K
A
V
E
D
F
D
G
E
P
-----
P
M
R
V
Q
K
F
-
V
L
D
Q
C
R
K
W
N
L
V
W
V
G
R
N
K
V
A
P
L
E
P
D
E
V
E
M
L
L
G
F
P
K
N
H
T
-
R
G
G
G
I
S
R
T
D
R
Y
K
S
-
L
G
N
S
F
Q
-------
V
--
D
T
V
A
------
Y
H
L
S
--
V
L
K
------------------
D
L
F
P
G
G
I
N
V
L
S
L
F
S
-------------
G
I
G
G
G
E
V
A
L
Y
R
L
-----
G
I
P
L
N
T
------
V
------
V
S
V
E
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
N
R
------
D
I
V
R
S
W
W
----
E
Q
T
N
QR
G
N
L
------
I
H
F
N
D
V
Q
Q
-----
L
--------
N
--
G
--------
D
--
R
--
L
E
-
Q
L
I
E
S
F
G
G
-
F
------
D
L
V
I
G
G
S
P
S
L
F
S
S
Y
V
R
------
I
L
D
L
----------------
V
K
S
I
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
67.86
16%
-143
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
---------------------------------------------------------------------------------
T
L
N
K
Y
V
V
I
I
A
Y
------
A
L
V
F
L
L
S
L
-----
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
---
N
L
A
L
A
D
L
L
F
A
L
---
T
-
L
P
-----
I
W
A
A
S
-
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
--
K
E
V
N
F
Y
S
G
I
-
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
-
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
-
Q
A
Y
H
P
----
N
N
S
--
S
P
V
C
------
Y
E
V
L
--
G
N
D
---
T
--------
A
K
-
W
R
-
M
V
L
R
--
I
L
P
H
T
F
G
F
-------------
I
V
P
L
F
V
M
L
F
C
Y
G
-----
F
T
-
L
R
T
------
L
------
F
K
A
H
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
------
R
A
M
R
V
I
F
----
A
V
V
L
--
I
F
L
------
L
C
W
L
P
Y
N
L
-----
V
L
L
A
D
T
L
M
R
T
--
Q
VIQE
S
C
E
R
R
--
N
N
I
G
R
-
A
L
D
A
T
E
I
L
-
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
------
L
K
I
L
----------------
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
62.72
13%
-144
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
--------------------------------------------------
P
C
F
R
E
--------
E
---------------
N
A
N
F
N
K
I
F
L
P
T
I
Y
------
S
I
I
F
L
T
G
I
-----
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
---
H
L
S
V
A
D
L
L
F
V
I
T
----
L
P
-----
F
W
A
V
D
-
A
V
A
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
--
Y
T
V
N
L
Y
S
S
V
-
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
-
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
-
N
V
S
E
A
D
D
R
Y
I
C
D
--
R
F
Y
P
------
N
D
L
W
--
V
V
V
F
Q
F
Q
-------
H
I
M
-
V
G
-
L
I
L
P
--
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
LSHSGSN
I
F
E
M
L
R
I
D
E
G
L
R
-----
L
K
-
I
Y
K
D
TEG
Y
Y
T
------
I
G
I
G
H
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
K
S
------
P
S
L
N
A
A
K
----
S
E
L
D
--
K
A
I
GRNTNG
V
I
T
K
D
E
A
E
-----
K
L
F
N
Q
D
V
D
A
A
--
V
--------
R
--
G
--
I
L
R
N
A
K
L
K
P
V
Y
-
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
----------------
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
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A
L
A
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FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ---------------------