@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51T1_HUMAN: (2016-01-12 )
MAIFNNTTSSSSNFLLTAFPGLECAHVWISIPVCCLYTIALLGNSMIFLVIITKRRLHKPMYYFLSMLAAVDLCLTITTLPTVLGVLWFHAREISFKACFIQMFFVHAFSLLESSVLVAMAFDRFVAICNPLNYATILTDRMVLVIGLVICIRPAVFLLPLLVAINTVSFHGGHELSHPFCYHPEVIKYTYSKPWISSFWGLFLQLYLNGTDVLFILFSYVLILRTVLGIVARKKQQKALSTCVCHICAVTIFYVPLISLSLAHRLFHSTPRVLCSTLANIYLLLPPVLNPIIYSLKTKTIRQAMFQLLQSKGSWGFNVRGLRGRWD
Atome Classification :
(20 SA)
----------------------.-.....-...10........20-----....----.....30--..------......----40........50-----........60-........70........-80...-------.-----------..-.-.-90-------.........100.......110--....--...-120.......130-.......---..140........150----------...--......160..-.....170.......------180......-------.190...-..------------------------..----------200.......210.......220-......--------..230----.------------------------------------------------------------------------------------------------------------------------------------------------------------------......-------------240.----......250..---------------.....260..-.....--.----------270.---...---.....280...-----....290.......300-------.---......---310.......320...----...------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------M-
A
I
FNN-TTSSSS
N
F
L
L
T
AFP------G
L
E
C
----
A
H
V
W
I
SI--
P
V
------
C
C
L
Y
T
I
----
A
L
LGN
S
M
I
F
L
V
I
-----
I
T
K
R
RLH
K
P
M
-
Y
Y
F
L
S
M
L
A
A
V
D
L
C
L
T
I
T
T
-
L
P
T
V
L
-------
G
-----------
V
L
-
W
-
F
-
H
--------
A
REI
S
F
K
A
C
F
I
Q
M
F
F
V
H
A
F
S
L
L
--
E
S
S
V
--
L
V
A
-
M
A
F
D
R
F
V
A
I
CN---PLN
Y
A
T
I
---
L
T
D
-
R
M
V
L
V
I
G
L
V
I
------------
C
I
R
--
P
A
V
F
L
L
P
L
L
V
A
-
I
N
T
V
S
FHGGHELSHP------FCYHP
E
V
I
K
-------
Y
TYSK
P
W
-
I
S
------------------------
S
F
----------
W
G
L
F
L
Q
L
Y
LNG
T
D
V
L
F
I
L
F
S
Y
V
--
L
I
L
R
T
V
--------
L
G
I
V
A
----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
Q
Q
K
A
-------------
L
S
T
C
----
V
C
H
I
C
A
V
T
I
F
Y
---------------
V
P
L
I
S
L
-
S
L
A
-
H
R
L
F
H--S----------
T
--
P
---
R
V
L
---
C
S
T
L
A
N
I
Y
LLL-----P
P
V
L
N
P
I
I
Y
S
L
K
T
K
T
I
R
-------
Q
---
A
M
F
Q
L
L
---
Q
SKGSWGFNVRG-LRG----RWD------
41
Fugue
87.38
17%
-139
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------MN
G
T
E
G
-
P
N
F
Y
V
-
P
F
S
N
K
T
G
V
V
R
S
P
F
E
APQYYL
A
E
P
W
----
Q
F
S
M
L
A
A
--
Y
M
------
F
L
L
I
M
L
----
G
F
P
I
N
F
L
T
L
Y
V
T
-----
V
Q
H
K
K
L
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-------
Y
-----------
T
S
-
L
-
H
-
G
--------
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
--
A
L
W
S
--
L
V
V
-
L
A
I
E
R
Y
V
V
V
C
K
---
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
------------
V
M
A
--
L
A
C
A
A
P
P
L
-------------
V
G
W
S
R
---------
Y
I
P
E
G
M
Q
C
S
C
G
I
DY
Y
T
P
H
E
E
T
-
N
N
------------------------
E
S
----------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
--
Q
L
V
F
T
V
--------
K
E
A
A
A
SATT
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
-------------
T
R
M
V
----
I
I
M
V
I
A
F
L
I
C
W
---------------
L
P
Y
A
G
V
-
A
F
Y
-
I
F
T
H
Q
--
G
----------
S
--
D
F--
G
P
I
---
F
M
T
I
P
A
F
F
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
-------
N
---
C
M
V
T
T
L
---
C
C
G
K
N
P
S
T
T
V
S
K
-
T
E
T
----
S
Q
V
A
P
A---
4
PsiBlast_PDB
87.28
22%
-156
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[19-305]
--------------------------------------------------------------------------------
L
----
A
I
L
G
N
V
L
V
C
W
A
V
-----
W
L
N
S
N
L
Q
N
V
T
-
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-------
T
-----------
I
-----------------
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------
V
L
S
--
F
A
I
G
L
T
P
M
L
G
W
-
N
N
C
G
Q
-------
S
Q
G
CGEGQ
V
A
C
L
F
E
D
V
V
P
-------
M
N
Y
M
V
-
Y
-
F
N
------------------------
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-------
Q
P
L
--------
P
G
E
R
A
----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
-------------
V
H
A
A
----
K
S
L
A
I
I
V
G
L
F
A
---------------
L
C
W
L
P
L
-
H
I
I
-
N
C
F
T
F
--
F
----------
C
--
P
---
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
-------
Q
---
T
F
R
K
I
I
---
R
S
H
V
L
------------------------
3
PsiBlast_PDB
85.67
22%
-155
- C2 -
3VG9
8
?
A:
[19-305]
--------------------------------------------------------------------------------
L
----
A
I
L
G
N
V
L
V
C
W
A
V
-----
W
L
N
S
N
L
Q
N
V
T
-
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-------
T
-----------
I
-----------------
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------
V
L
S
--
F
A
I
G
L
T
P
M
L
G
W
-
N
N
C
G
Q
-------
S
Q
G
CGEGQV
A
C
L
F
E
D
V
V
P
-------
M
N
Y
M
V
-
Y
-
F
N
------------------------
F
F
ACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-------
Q
P
L
--------
P
G
E
R
A
----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
-------------
V
H
A
A
----
K
S
L
A
I
I
V
G
L
F
A
---------------
L
C
W
L
P
L
-
H
I
I
-
N
C
F
T
F
--
F
----------
C
--
P
---
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
-------
Q
---
T
F
R
K
I
I
---
R
S
H
V
L
R
-----------------------
21
HHSearch
84.42
17%
-160
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
-------------------------------------------------------------
F
I
V
L
--
V
A
------
G
S
L
S
L
V
----
T
I
I
G
N
I
L
V
M
V
S
I
-----
K
V
N
R
H
L
Q
T
V
N
-
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
-------
L
-----------
Y
T
-
V
-
I
-
G
--------
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
--
S
V
M
N
--
L
L
I
-
I
S
F
D
R
Y
F
C
V
T
K
---
P
L
T
Y
P
V
K
---
R
T
T
-
K
M
A
G
M
M
I
A
A
A
------------
W
V
L
--
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
V
R
--
T
V
E
D
G
------
E
C
Y
I
Q
F
----------------
F
-
S
N
------------------------
A
A
----------
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
--
H
I
S
R
A
S
--------
K
S
R
I
N
----
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP-
S
R
E
K
K
V
-------------
T
R
T
I
----
L
A
I
L
L
A
F
I
I
T
W
---------------
A
P
Y
N
V
M
-
V
L
I
-
N
T
F
C
A
--
P
----------
C
--
I
---
P
N
T
---
V
W
T
I
G
Y
W
L
C
Y
I
-----
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
-------
K
---
T
F
K
H
L
L
---
M
----------------------------
40
Fugue
79.80
17%
-124
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------MN
G
T
E
G
PNF
Y
-
V
P
F
S
N
-
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
------
Y
L
A
E
----
P
W
Q
F
S
M
L
A
A
Y
M
------
F
L
L
I
M
L
----
G
F
P
I
N
F
L
T
L
Y
V
T
-----
V
Q
H
K
K
L
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-------
Y
-----------
T
S
-
L
-
H
-
G
--------
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
--
A
L
W
S
--
L
V
V
-
L
A
I
E
R
Y
V
V
V
C
K
---
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
------------
V
M
A
--
L
A
C
A
A
P
P
L
-------------
V
G
W
S
R
---------
Y
I
P
E
G
M
Q
C
S
C
G
I
DY
Y
T
P
H
E
E
T
-
N
N
------------------------
E
S
----------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
--
Q
L
V
F
T
V
KEAAAQQQ
E
S
A
T
T
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
-------------
T
R
M
V
----
I
I
M
V
I
A
F
L
I
C
W
---------------
L
P
Y
A
G
V
-
A
F
Y
-
I
F
T
H
Q
--
G
----------
S
--
D
F--
G
P
I
---
F
M
T
I
P
A
F
F
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
-------
N
---
C
M
V
T
T
L
C
CG
K
N
P
L
G
D
D
E
A
S
T
T
-
V
S
K
----
T
E
T
SQVAPA
25
HHSearch
79.64
17%
-165
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-472]
------------------------------------------------------------
S
V
Y
I
T
--
V
E
------
L
A
I
A
V
L
----
A
I
L
G
N
V
L
V
C
W
A
V
-----
W
L
N
S
N
L
Q
N
V
T
-
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-------
T
-----------
I
S
-
T
------------
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
--
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
---
V
T
G
-
T
R
A
K
G
I
I
A
I
C
------------
W
V
L
--
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
-------
S
Q
------
G
C
G
E
G
Q
----------
V
A
C
L
F
E
D
V
V
P
M
-----------------------
N
Y
----------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
--
R
I
F
L
A
A
--------
R
R
Q
L
N
----
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
Q
K
E
V
H
A
-------------
A
K
S
L
----
A
I
I
V
G
L
F
A
L
C
W
---------------
L
P
L
H
I
I
-
N
C
F
-
T
F
F
C
P
DC
S
----------
H
--
A
---
P
L
W
---
L
M
Y
L
A
I
V
L
S
H
T
-----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
-------
Q
---
T
F
R
K
I
I
---
R
S
H
V
L
R
Q
----------------------
30
HHSearch
74.43
17%
-146
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-329]
------------------------------------------------------------
S
M
L
A
A
--
Y
M
------
F
L
L
I
M
L
----
G
F
P
I
N
F
L
T
L
Y
V
T
-----
V
Q
H
K
K
L
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
-------
Y
-----------
T
S
-
L
-
H
-
G
--------
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
--
A
L
W
S
--
L
V
V
-
L
A
I
E
R
Y
V
V
V
C
K
---
P
M
S
N
F
R
F
----
G
E
-
N
H
A
I
M
G
V
A
F
T
------------
W
V
M
--
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
----
G
M
Q
C
------
S
C
G
I
D
Y
Y
T
P
----------
H
E
E
T
-
N
N
------------------------
E
S
----------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
--
Q
L
V
F
T
V
--------
K
E
A
A
A
----
Q
QQESA
T
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
-------------
T
R
M
V
----
I
I
M
V
I
A
F
L
I
C
W
---------------
L
P
Y
A
G
V
-
A
F
Y
-
I
F
T
H
Q
G-
S
----------
D
--
F
---
G
P
I
---
F
M
T
I
P
A
F
F
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
-------
N
---
C
M
V
T
T
L
---
C
C
G
K
N
P
L
G
D
D
E
A
-
S
T
T
----
V
S
K
------
27
HHSearch
74.03
16%
-160
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-326]
-------------------------------------------------------------
L
W
A
A
--
A
Y
------
T
V
I
V
V
T
----
S
V
V
G
N
V
V
V
M
W
I
I
-----
L
A
H
K
R
M
R
T
V
T
-
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
-------
T
-----------
Y
A
-
V
-
H
-
N
--------
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
--
S
I
Y
S
--
M
T
A
-
V
A
F
D
R
Y
M
A
I
I
H
---
P
L
Q
P
R
L
-----
S
A
-
T
A
T
K
V
V
I
C
V
I
------------
W
V
L
--
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
T
M
-----
P
S
R
V
------
V
C
M
I
E
W
P
E
H
----------
P
N
K
I
-
Y
E
------------------------
K
V
----------
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
--
V
V
G
I
T
L
--------
W
A
S
E
I
----
P
GDSSDRYH
E
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
-------------
V
K
M
M
----
I
V
V
V
C
T
F
A
I
C
W
---------------
L
P
F
H
I
F
-
F
L
L
-
P
Y
I
N
P
--
D
----------
L
YL
K
KF-
I
Q
Q
---
V
Y
L
A
I
M
W
L
A
M
S
-----
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
-------
L
---
G
F
K
H
A
F
---
R
C
C
P
F
I
S
A
G
D
Y
E
-
G
L
E
----
M
K
S
------
31
HHSearch
73.19
20%
-138
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
----------------------------------------------------------
N
K
Y
V
V
I
I
--
A
Y
------
A
L
V
F
L
L
----
S
L
L
G
N
S
L
V
M
L
V
I
-----
L
Y
S
R
V
G
R
S
V
T
-
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
-------
A
-----------
S
K
---
V
-
N
--------
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
--
G
I
L
L
--
L
A
C
-
I
S
V
D
R
Y
L
A
I
V
H
---
A
T
R
T
L
T
----
Q
K
R
-
H
L
V
K
F
V
C
L
G
C
------------
W
G
L
--
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
H
P
----
N
N
S
S
P
------
V
C
Y
E
V
L
G
N
-----------
D
T
A
K
-
W
R
------------------------
M
V
----------
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
--
F
T
L
R
T
L
--------
F
K
A
H
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
-------------
M
R
V
I
----
F
A
V
V
L
I
F
L
L
C
W
---------------
L
P
Y
N
L
V
-
L
L
A
-
D
T
L
M
R
--
T
QVIQE
S
C
E
R
R
N
--
N
---
I
G
R
---
A
L
D
A
T
E
I
L
G
F
L
-----
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
-------
H
---
G
F
L
K
I
L
---
A
M
H
G
-------------------------
22
HHSearch
72.78
14%
-156
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
--------------------------------------------------------------
L
V
V
--
V
L
------
S
T
I
C
L
V
----
T
V
G
L
N
L
L
V
L
Y
A
V
-----
R
S
E
R
K
L
H
T
V
G
-
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
-------
L
-----------
Y
L
-
L
-
M
-
S
--------
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
--
S
I
F
S
--
V
F
I
-
L
C
I
D
R
Y
R
S
V
Q
Q
---
P
L
R
Y
L
K
Y
---
R
T
K
-
T
R
A
S
A
T
I
L
G
A
------------
W
F
L
--
S
F
L
W
V
I
P
I
L
G
--
W
N
H
--------
R
R
E
D
------
K
C
E
T
D
F
Y
-----------------
D
V
------------------------
T
W
----------
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
--
K
I
Y
K
A
V
--------
R
Q
H
C
N
----
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM-
N
R
E
R
K
A
-------------
A
K
Q
L
----
G
F
I
M
A
A
F
I
L
C
W
---------------
I
P
Y
F
I
F
-
F
M
V
-
I
A
F
C
K
--
N
----------
C
--
C
---
N
E
H
---
L
H
M
F
T
I
W
L
G
Y
I
-----
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
-------
K
---
T
F
K
R
I
L
---
H
I
---------------------------
32
HHSearch
71.76
14%
-157
* C2 *
2Z73
5
OPSD_TODPA
A:
[33-335]
----------------------------------------------------------
V
Y
Y
S
L
G
I
--
F
I
------
G
I
C
G
I
I
----
G
C
G
G
N
G
I
V
I
Y
L
F
-----
T
K
T
K
S
L
Q
T
P
A
-
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
-------
I
-----------
S
C
-
F
-
L
-
K
--------
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
--
S
I
M
T
--
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
---
P
M
A
A
S
K
K
---
M
S
H
-
R
R
A
F
I
M
I
I
F
V
------------
W
L
W
--
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
E
----
G
V
L
C
------
N
C
S
F
D
Y
I
S
------------
R
D
S
-
T
T
------------------------
R
S
----------
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
--
N
I
V
M
S
V
--------
S
N
H
E
K
----
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
-------------
A
K
I
S
----
I
V
I
V
S
Q
F
L
L
S
W
---------------
S
P
Y
A
V
V
-
A
L
L
-
A
Q
F
G
P
--
L
E---------
W
--
V
---
T
P
Y
---
A
A
Q
L
P
V
M
F
A
K
A
-----
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
-------
E
---
A
I
S
Q
T
F
---
P
W
V
L
T
C
C
Q
F
D
D
K
-
E
T
E
----
D
D
K
------
33
HHSearch
69.63
16%
-158
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[62-495]
----------------------------------------------------------
S
I
K
L
T
S
V
--
V
F
------
I
L
I
C
C
F
----
I
I
L
E
N
I
F
V
L
L
T
I
-----
W
K
T
K
K
F
H
R
P
M
-
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
-------
L
-----------
S
G
-
A
---
T
--------
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
--
S
V
F
S
--
L
L
A
-
I
A
I
E
R
Y
I
T
M
L
K
--------------
N
N
-
F
R
L
F
L
L
I
S
A
C
------------
W
V
I
--
S
L
I
L
G
G
L
P
I
M
G
-
W
N
C
I
S
-------
A
L
S
------
S
C
S
T
V
L
P
---------------
L
-
Y
H
------------------------
K
H
----------
Y
I
-
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
--
R
I
Y
S
L
V
--------
R
T
R
N
I
----
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
-
S
E
N
V
A
L
-------------
L
K
T
V
----
I
I
V
L
S
V
F
I
A
C
W
---------------
A
P
L
F
I
L
-
L
L
L
-
D
V
G
C
K
--
V
----------
K
TC
D
---
I
L
F
---
R
A
E
Y
F
L
V
L
A
V
L
-----
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
-------
R
---
A
F
I
R
I
M
---
G
R
P
L
-------------------------
45
Fugue
64.26
17%
-116
- C1 -
3WL8
2
OPH_PSESP
A:
[23-358]
-------V
K
W
E
C
PAG
Y
E
V
K
E
G
L
N
-
V
D
F
P
H
-
K
G
M
K
R
A
F
I
V
Y
P
A
K
N
------
V
S
G
P
----
A
P
V
W
V
P
M
--
T
----------
G
S
V
----
E
S
T
N
D
N
L
T
V
A
R
S
-----
G
A
N
S
I
L
A
D
H
G
-
Y
---
T
V
I
A
P
V
R
A
C
A
N
Q
D
P
-
N
I
R
G
E
-------
R
CNGPGSNGWNW
N
P
-
W
-
F
-
E
--------
G
R
A
A
D
P
S
G
E
H
W
K
-----
N
D
E
G
P
--
D
S
S
F
--
F
V
A
-
M
V
------
Q
C
V
---
G
T
K
Y
K
-----
L
D
A
-
R
R
L
F
L
G
G
----------------
I
A
--
S
G
G
T
M
T
N
R
A
L
L
-
F
R
S
N
F
W
A
G
G
L
P
I
S
G
E
------
W
Y
V
T
S
D
D
G
T
-------
P
L
S
F
D
D
A
-
R
A
------------------------
A
V
----------
A
A
A
P
T
K
I
H
-
Q
G
R
V
G
P
Y
P
L
P
A
K
V
G
P
L
I
V
M
T
V
--------
W
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
D
-------------
L
W
N
C
----
T
R
P
D
G
S
R
F
L
C
A
---------------
D
Y
R
P
S
T
-
Q
A
G
-
S
N
F
F
S
--
A
----------
Q
--
P
D
V
V
H
V
A
---
C
S
S
T
H
G
H
--
M
W
-----
P
Q
L
N
T
Q
E
F
N
R
W
A
L
D
T
L
A
S
H
PKGSD
P
---
R
S
F
K
L
T
---
Q
P
P
E
G
Y
T
C
H
V
G
P
-
F
T
G
LYAS
A
W
S
------
48
Fugue
63.73
19%
-100
- C2 -
4OWT
-
INT3_HUMAN
A:
[1-466]
GGRL
L
L
S
T
SLDAKD
E
L
E
E
R
L
E
R
C
M
S
I
V
T
S
M
T
A
G
V
S
E
R
E
A
N
D
A
L
N
------
A
Y
V
C
KG
L
P
Q
H
E
E
I
C
L
--
G
L
------
F
T
L
I
L
T
E
PAQ
A
Q
K
C
Y
R
D
L
A
L
V
S
RDGM
N
I
V
L
N
K
I
N
Q
I
L
M
E
K
Y
L
K
L
Q
D
T
C
R
T
Q
L
V
W
L
V
-
R
E
L
V
K
S
GVLG
A
D
G
-----------
V
C
M
T
-
F
M
K
Q
IAGGDVT
A
K
N
I
W
L
A
E
S
V
L
D
I
L
T
E
Q
R
E
W
V
L
--
K
S
S
I
--
L
I
A
M
A
V
Y
T
Y
L
R
L
I
V
D
HHG
T
A
Q
L
Q
A
L
---
R
Q
K
-
E
V
D
F
C
I
S
L
L
R
E
R
F
M
E
C
L
MIG
R
D
L
V
R
L
L
Q
N
V
A
R
I
P
E
F
E
L
-
L
W
K
D
I
I
H
N
P
Q
A
L
S
P
Q
------
F
T
G
I
L
Q
L
L
Q
-------
S
R
T
S
R
K
F
-
L
A
C
R
L
T
P
D
M
E
T
K
L
L
F
M
T
S
RVRFGQQ
K
R
Y
----------
Q
D
W
F
Q
R
Q
Y
L
S
T
P
D
S
Q
S
L
R
---
C
--
D
L
I
R
Y
I
--------
C
G
V
V
H
----
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
E
V
L
S
SDILP
R
W
A
I
I
G
W
L
L
T
T
C
TS
N
V
A
A
S
N
A
K
L
A
L
F
Y
DWLFFSPDKDSIMNI
E
P
A
I
L
V
M
H
H
S
M
K
P
H
P
A
--
I
----------
T
--
A
---
T
L
L
D
F
M
C
R
I
I
P
N
F
Y
P
P
L
-----
E
G
H
V
R
Q
G
V
F
S
S
L
N
H
I
V
E
-------
K
RVL
A
H
L
A
P
L
---
F
D
N
P
K
L
D
K
E
L
R
A
M
L
R
E
----
K
F
P
EFCS--
12
PsiBlast_PDB
59.53
26%
-171
- C2 -
4EIY
19
AA2AR_HUMAN (first)
A:
[26-166]
-------------------------------------------
P
------
P
I
M
G
----
S
S
V
Y
I
T
V
--
E
L
------
A
-
I
A
V
L
----
A
I
L
G
N
V
L
V
C
W
A
V
-----
W
L
N
S
N
L
Q
N
V
T
-
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-------
T
-----------
I
-----------------
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------
V
L
S
--
F
A
I
G
L
T
P
M
L
G
W
-
N
N
C
G
Q
P
K
E
G
K
N
H
S
Q
G
------
C
G
E
G
Q
V
A
C
L
-------
F
E
D
V
V
P
M
-
N
Y
------------------------
M
V
----------
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
R
R
--------
Q
L
A
D
L
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
W
E
T
L
-------------
N
D
N
L
----
K
V
I
E
K
A
D
N
A
A
Q
---------------
V
K
D
A
L
T
-
K
M
R
-
A
A
A
L
D
--
A
----------
Q
--
K
---
M
K
D
---
F
R
H
G
F
D
I
L
V
G
Q
-----
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
-------
A
---
A
A
E
Q
L
K
---
T
T
R
N
A
Y
I
Q
K
Y
L
E
-
R
A
R
----
S
T
L
------
23
HHSearch
59.30
17%
-165
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
------------------------------------------------------------
V
G
M
G
I
--
V
M
------
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
-----
A
K
F
E
R
L
Q
T
V
T
-
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
-------
A
-----------
H
I
-
L
-
M
-
K
--------
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--
S
I
E
T
--
L
C
V
-
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
Q
S
L
---
L
T
K
-
N
K
A
R
V
I
I
L
M
V
------------
W
I
V
--
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
-----
E
A
I
------
N
C
Y
A
E
-----------
E
T
C
C
D
F
F
-
T
N
------------------------
Q
A
----------
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--
R
V
F
Q
E
A
--------
K
R
Q
L
N
----
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
-------------
D
E
G
L
----
R
L
K
I
Y
K
D
T
E
G
Y
---------------
Y
T
I
G
I
G
-
H
L
L
-
T
K
S
P
S
--
L
----------
N
--
A
---
A
K
S
---
E
L
D
K
A
I
G
R
N
T
N
-----
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
-------
A
---
A
V
R
G
I
L
---
R
N
A
K
L
K
P
V
Y
D
S
L
-
D
A
V
----
R
R
A
------
1
PsiBlast_PDB
58.23
25%
-160
- C2 -
4DJH
1
ENLYS_BPT4 (first)
A:
[18-191]
-------------------------------------------------------------
S
P
A
I
--
P
V
I
I
T
A
V
Y
S
V
V
F
V
V
----
G
L
V
G
N
S
L
V
M
F
V
I
-----
I
R
Y
T
K
M
K
T
A
T
-
N
I
Y
I
F
N
L
A
L
A
D
A
L
V
T
-
T
T
-
M
P
F
Q
S
-------
T
-----------
V
Y
-
L
-
M
-
N
--------
S
W
P
F
G
D
V
L
C
K
I
V
L
S
I
D
Y
Y
N
M
F
T
--
S
I
F
T
--
L
T
M
-
M
S
V
D
R
Y
I
A
V
C
H
---
P
V
K
A
L
D
F
---
R
T
P
-
L
K
A
K
I
I
N
--
I
------------
C
I
------
W
L
L
S
S
S
V
G
-
I
S
A
I
V
L
-
G
G
T
K
V
R
E
D
------
V
----
D
V
I
E
-------
C
S
L
Q
F
P
D
-
D
D
Y
-----------------------
S
W
----------
W
D
L
F
M
K
I
C
V
F
I
F
A
F
V
I
P
V
L
I
I
I
--
V
C
Y
T
L
M
--------
I
L
R
L
K
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
L
S
G
-------------
N
I
F
E
----
M
L
R
I
D
E
G
L
R
L
K
---------------
I
Y
K
D
T
E
-
G
Y
Y
-
T
I
G
I
G
--
H
----------
L
--
L
---
T
K
S
---
P
S
L
N
A
A
K
S
E
L
D
-----
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
-------
K
---
L
F
N
Q
D
V
---
D
A
A
V
R
G
I
L
R
N
A
K
-
L
K
P
----
V
Y
D
------
29
HHSearch
58.20
17%
-176
- C2 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-226]
--------------------------------------------------------------
Y
A
L
--
S
Y
------
C
A
L
I
L
A
----
I
V
F
G
N
G
L
V
C
M
A
V
-----
L
K
E
R
A
L
Q
T
T
T
-
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
-------
Y
-----------
L
E
-
V
T
G
-
G
--------
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
--
S
I
W
N
--
L
C
A
-
I
S
I
D
R
Y
T
A
V
V
M
---
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
-
R
R
V
A
L
M
I
T
A
V
------------
W
V
L
--
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
-------
G
D
P
T
------
V
C
S
I
S
--------------------
N
------------------------
P
D
----------
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
--
R
I
Y
V
V
L
--------
K
Q
R
R
R
----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
-------------
R
I
D
E
----
G
L
R
L
K
I
Y
K
D
T
E
---------------
G
Y
Y
T
I
G
-
I
G
H
-
L
L
T
K
S
--
P
----------
S
--
L
---
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
-----
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
-------
V
---
D
A
A
V
R
G
---
I
L
R
N
A
K
L
K
P
V
Y
D
-
S
L
D
----
A
V
R
------
11
PsiBlast_PDB
55.44
26%
-174
- C2 -
3QAK
2
ENLYS_BPT4
A:
[18-156]
---------------------------------------------------
I
M
G
----
S
S
V
Y
I
T
V
--
E
L
------
A
-
I
A
V
L
----
A
I
L
G
N
V
L
V
C
W
A
V
-----
W
L
N
S
N
L
Q
N
V
T
-
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-------
T
-----------
I
-----------------
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------
V
L
S
--
F
A
I
G
L
T
P
M
L
G
W
-
N
N
C
G
Q
G
C
G
E
G
Q
V
A
C
L
------
F
E
D
V
V
P
M
N
Y
-------
M
V
Y
F
N
F
F
-
A
C
------------------------
V
L
----------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
--
I
F
E
M
L
R
--------
I
D
E
G
L
----
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
Y
K
D
-------------
T
E
G
Y
----
Y
T
I
G
I
G
H
L
L
T
K
---------------
S
P
S
L
N
A
-
A
K
S
-
E
L
D
K
A
--
I
----------
G
--
R
---
N
T
N
---
G
V
I
T
K
D
E
A
E
K
L
-----
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-------
L
---
K
P
V
Y
D
S
---
L
D
A
V
R
R
A
A
L
I
N
M
-
V
F
Q
----
M
G
E
------
10
PsiBlast_PDB
55.35
26%
-179
- C2 -
3EML
8
ENLYS_BPT4
A:
[18-156]
---------------------------------------------------
I
M
G
----
S
S
V
Y
I
T
V
--
E
L
------
A
-
I
A
V
L
----
A
I
L
G
N
V
L
V
C
W
A
V
-----
W
L
N
S
N
L
Q
N
V
T
-
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
-------
T
-----------
I
-----------------
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------------
V
L
S
--
F
A
I
G
L
T
P
M
L
G
W
-
N
N
C
G
Q
S
Q
G
C
G
E
G
Q
V
A
------
C
L
F
E
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
-
F
F
------------------------
A
C
----------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
--
L
N
I
F
E
M
--------
L
R
I
D
E
----
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
K
I
Y
-------------
K
D
T
E
----
G
Y
Y
T
I
G
I
G
H
L
L
---------------
T
K
S
P
S
L
-
N
A
A
-
K
S
E
L
D
--
K
----------
A
--
I
---
G
R
N
---
T
N
G
V
I
T
K
D
E
A
E
-----
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-------
A
---
K
L
K
P
V
Y
---
D
S
L
D
A
V
R
R
A
A
L
I
-
N
M
V
----
F
Q
M
------