@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52A5_HUMAN: (2016-01-12 )
MPTFNGSVFMPSAFILIGIPGLESVQCWIGIPFSAMYLIGVIGNSLILVIIKYENSLHIPMYIFLAMLAATDIALNTCILPKMLGIFWFHLPEISFDACLFQMWLIHSFQAIESGILLAMALDRYVAICIPLRHATIFSQQFLTHIGLGVTLRAAILIIPSLGLIKCCLKHYRTTVISHSYCEHMAIVKLATEDIRVNKIYGLFVAFAILGFDIIFITLSYVQIFITVFQLPQKEARFKAFNTCIAHICVFLQFYLLAFFSFFTHRFGSHIPPYIHILLSNLYLLVPPFLNPIVYGVKTKQIRDHIVKVFFFKKVT
Atome Classification :
(20 SA)
----------------------------------------------------......--------...10---------------......-...20.----------.......30........40...-------.....---------------------50........60......--..70.---------.......-80........90.-......----.100........110-..--....--...120.......130.......140...-....150.......-----160-...----------...----------..170----........180...---------.-...190.......-200.......210----------------.........220......-.230-------..---------..-----------.--------------------..----..240......--------------.250.-------------.--------.....260....---------...---------270--.---.-----......280--......------...290.....---..300.......310....---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------MPTFNG--------
S
V
FM----------------P
S
A
F
I
L
-
I
GIPGL----------ES
V
Q
C
W
IGI
P
F
S
A
M
Y
L
I
G
VIGN-------
S
L
I
L
V
---------------------
I
I
K
YENSLH
I
P
M
Y
I
F
L
A
M
--
L
A
A
T
D
---------
I
A
L
N
T
C
I
-
L
P
K
M
L
G
I
F
W
FHLP-EI
S
F
D
A
----
C
L
-
F
Q
M
W
L
I
H
S
F
Q
---
A
I
--
E
S
G
I
--
L
L
A
M
A
L
D
R
Y
V
A
I
C
I
PL
R
H
A
T
I
F
S
Q
Q
F
L
T
H
-IGL
G
V
T
L
R
A
A
I
L
I
I-----P
S
--
L
G
L
----------
I
K
C
----------
C
L
K
H
-----
Y
R
T
T
V
I
S
H
S
Y
C
E
H
M
---------
A
-
I
V
K
LATED
I
R
V
N
K
-
I
Y
G
L
F
V
A
F
A
I
L
------------------
G
F
D
I
I
F
I
T
L
S
Y
V
Q
I
F
I
T
V
-
F
Q---------LP---------
Q
K
-----------
E
--------------------
A
R
----
F
K
A
F
N
T
C
I
A
H
I
--------------
C
V
F
L
Q
-------------
F
--------
Y
L
L
A
F
F
S
F
F
T
H
R
---------FGS---------H-I--
P
---
P
-----
Y
I
H
I
L
L
S
----
N
L
Y
L
LV------PP
F
L
N
P
I
V
YGV---
K
T
K
Q
I
R
D
H
I
V
K
V
F
F
F
KKVT---------------------
2
PsiBlast_PDB
88.79
24%
-162
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
---------
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
-------
S
T
G
F
C
A
----
A
C
-
H
G
C
L
F
I
A
C
F
V
---
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
---------------
S
Q
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
K
---------
Q
M
-----------
E
--------------------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
4
PsiBlast_PDB
87.93
24%
-152
- C4 -
2YDV
6
?
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
A
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
-------
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
T
---
A
S
--
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
K
-----
E
G
K
---
A
H
S
Q
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
K
---------
Q
M
-----------
E
--------------------
S
Q
--------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
7
PsiBlast_PDB
86.95
24%
-164
- C4 -
3PWH
1
?
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
-------
S
T
G
F
C
A
----
A
C
-
H
G
C
L
F
I
A
C
F
V
---
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
----------------
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-
R
R
Q
L
K
Q
M
E
S
QP
L
P
GE
R
A
R
S
T
L
-
Q
K
-----------
E
V
H
A
-----------------
A
K
----
S
A
A
I
I
A
G
L
F
A
L
--------------
C
-
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
8
PsiBlast_PDB
86.77
24%
-160
- C4 -
3REY
1
AA2AR_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
-------
S
T
G
F
C
A
----
A
C
-
H
G
C
L
F
I
A
C
F
V
---
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
----------------
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-
R
R
Q
L
K
Q
M
E
S
QP
L
P
GE
R
A
R
S
T
L
-
Q
K
-----------
E
V
H
A
-----------------
A
K
----
S
A
A
I
I
A
G
L
F
A
L
--------------
C
-
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
1
PsiBlast_PDB
86.67
24%
-163
- C4 -
3VG9
8
?
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
---------
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
-------
S
T
G
F
C
A
----
A
C
-
H
G
C
L
F
I
A
C
F
V
---
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
---------------
S
Q
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
K
---------
Q
M
-----------
E
--------------------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
9
PsiBlast_PDB
86.40
24%
-166
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
-------
S
T
G
F
C
A
----
A
C
-
H
G
C
L
F
I
A
C
F
V
---
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
----------------
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
S
T
L
-
Q
K
-----------
E
V
H
A
-----------------
A
K
----
S
A
A
I
I
A
G
L
F
A
L
--------------
C
-
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
10
PsiBlast_PDB
86.38
24%
-165
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
-------
S
T
G
F
C
A
----
A
C
-
H
G
C
L
F
I
A
C
F
V
---
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
----------------
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
S
T
L
-
Q
K
-----------
E
V
H
A
-----------------
A
K
----
S
A
A
I
I
A
G
L
F
A
L
--------------
C
-
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
11
PsiBlast_PDB
85.95
24%
-166
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
L
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
-------
S
T
G
F
C
A
----
A
C
-
H
G
C
L
F
I
A
C
F
V
---
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
----------------
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
S
T
L
-
Q
K
-----------
E
V
H
A
-----------------
A
K
----
S
A
A
I
I
A
G
L
F
A
L
--------------
C
-
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
5
PsiBlast_PDB
85.90
24%
-156
- C4 -
4UG2
3
?
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
A
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
-------
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
T
---
A
S
--
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
K
-----
E
G
K
---
A
H
S
Q
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
----------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
3
PsiBlast_PDB
85.78
24%
-152
- C4 -
2YDO
3
?
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
A
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
-------
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
T
---
A
S
--
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
K
-----
E
G
K
---
A
H
S
Q
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
K
---------
Q
M
-----------
E
--------------------
S
----------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-
S
---------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
6
PsiBlast_PDB
85.39
24%
-157
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[15-302]
-------------------------------------------------------------------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
-------
V
L
V
C
W
---------------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
--
A
A
A
A
D
---------
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
-------
S
T
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
T
---
A
S
--
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
M
--
L
G
W
----------
N
N
C
----------
G
Q
P
K
-----
E
G
K
---
A
---
G
C
G
E
---------
G
-
Q
V
A
C
L
F
E
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
V
------------------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
K
---------
Q
M
-----------
E
--------------------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-------------
L
--------
H
I
I
N
C
F
T
F
F
C
P
D
---------
C
-----------
H
-
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
----
H
T
N
S
V
V
----------
N
P
F
I
Y
A
Y
---
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
35
HHSearch
82.16
18%
-155
- C4 -
2Z73
5
OPSD_TODPA
A:
[33-332]
---------------------------------------------------------------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
-------
G
I
V
I
Y
---------------------
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
--
L
A
F
S
D
---------
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
----
C
K
-
V
Y
G
F
I
G
G
I
F
G
---
F
M
--
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
-
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-----
G
P
--
I
F
G
----------
W
G
A
-----------
Y
T
L
---------
E
G
V
L
C
N
C
S
F
D
---------
Y
-
I
S
-----
R
D
S
T
T
R
-
S
N
I
L
C
M
F
I
L
G
F
------------------
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
---------
H
E
---------
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
----
M
R
L
A
K
I
S
I
V
I
V
--------------
S
Q
F
L
L
-------------
S
--------
W
S
P
Y
A
V
V
A
L
L
A
Q
---------
F
G
P
---------
L
E
W
--
V
---
T
-----
P
Y
A
A
Q
L
P
----
V
M
F
A
K
A
------
S
A
I
H
N
P
M
I
Y
S
V
---
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
---------------------
44
Fugue
81.02
21%
-190
- C2 -
4XR7
-
PAN3_YEAST
B:
[1-456]
MH
S
L
L
Q
YRSADQLFIPNN
I
R
E
D
L
T
K
K
N
L
S
I
L
QVFPSSGKVIPSIVQDYFNLV
P
L
N
F
N
N
KT
T
L
F
K
V
F
S
N
Y
D
----------------
G
K
A
Y
V
L
-
K
R
L
P
N
I
DKSMNP
N
K
I
S
K
I
Y
Q
I
W
S
K
I
N
C
T
N
L
I
K
F
R
D
I
F
Q
T
TKFG
D
L
S
I
C
L
V
---------------------
F
D
Y
Y
P
N
S
L
S
L
Y
D
Y
H
F
V
N
F
PK
F
P
I
T
N
---------
N
Y
L
W
I
Y
L
-
V
Q
L
T
N
V
I
N
S
I
H
S
Q
-
N
L
S
I
G
N
----
T
L
N
W
R
K
V
L
I
T
G
D
P
GR
I
K
L
--
S
H
C
N
--
F
M
D
L
L
F
N
D
D
T
D
---
T
V
V
S
S
T
I
E
G
Q
Q
Q
L
D
Y
-
K
Y
L
G
E
L
L
F
N
L
S
I
N
I
-----
E
N
--
S
N
N
-----------
N
T
----------
A
P
K
E
-----
Y
R
L
E
E
I
T
P
Q
S
I
D
D
M
RQIDDKF
K
D
V
-
L
K
Y
L
I
S
D
N
G
D
S
K
K
S
I
H
D
L
T
S
H
F
Y
D
K
------------------
M
F
M
V
L
E
S
S
Q
T
Y
T
E
Y
M
E
S
V
-
L
S
---------
R
E
---------
L
E
-----------
N
--------------------
G
R
----
L
F
R
L
V
N
K
L
N
C
I
--------------
F
G
R
I
E
SRIDINWSESGTK
F
--------
P
I
I
L
F
Y
D
Y
V
F
H
Q
---------
V
D
S
N
G
K
P
I
M
D
L
T
H
-
V
--
L
---
R
-----
C
L
N
K
L
D
A
GIQ
E
K
L
M
L
V
T
------
P
D
E
L
N
C
I
I
I
S
-----
Y
K
E
L
K
D
L
I
E
S
T
F
R
S
I
T
Q
H
---------------------
42
Fugue
79.78
16%
-150
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------------------------------------MN
G
T
E
G
PNFY
V
P
F
S
N
K
--------
T
G
V
V
----------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
----------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-------
F
L
T
L
Y
---------------------
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
---------
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
----
C
N
-
L
E
G
F
F
A
T
L
G
G
---
E
I
--
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-----
P
L
--
V
G
W
----------
S
R
Y
----------
I
P
E
G
-----
M
Q
C
S
C
G
I
D
Y
Y
T
-------------------
P
H
E
E
T
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
------------------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
---------
A
A
AQQQESA
T
T
Q
K
-----------
A
--------------------
E
K
----
E
V
T
R
M
V
I
I
M
V
I
--------------
A
F
L
I
C
-------------
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
---------
H
Q
G
---------
S
-
D
--
F
---
G
-----
P
I
F
M
T
I
P
----
A
F
F
A
K
T
------
S
A
V
Y
N
P
V
I
Y
I
M
---
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA
31
HHSearch
78.88
17%
-154
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
------------------------------------------------------------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
-------
V
V
V
M
W
---------------------
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
--
L
A
F
A
E
---------
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
----
C
K
-
F
H
N
F
F
P
I
A
A
V
---
F
A
--
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
-
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-----
P
Q
--
G
Y
Y
----------
S
T
T
-----------
E
T
----------
M
P
S
R
V
V
C
M
I
E
---------
W
-
P
E
H
P
---
N
K
I
Y
E
K
-
V
Y
H
I
C
V
T
V
L
I
Y
------------------
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-
W
A
---------
S
E
---------
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
----
R
K
V
V
K
M
M
I
V
V
V
--------------
C
T
F
A
I
-------------
C
--------
W
L
P
F
H
I
F
F
L
L
P
Y
---------
I
N
P
---------
D
-
L
YL
K
KF-
I
-----
Q
Q
V
Y
L
A
I
----
M
W
L
A
M
S
------
S
T
M
Y
N
P
I
I
Y
C
C
---
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
---------------------
41
Fugue
77.87
16%
-146
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------------------------------
M
N
G
T
E
G
--------
P
N
F
Y
VPFSNKTGVVRSPFEA
P
Q
Y
Y
L
------
A
E
----------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-------
F
L
T
L
Y
---------------------
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
---------
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
----
C
N
-
L
E
G
F
F
A
T
L
G
G
---
E
I
--
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-----
P
L
--
V
G
W
----------------------------------
S
R
Y
I
P
E
G
M
Q
C
S
C
---------
G
-
I
D
Y
Y
T
P
H
E
E
T
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
------------------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
---------
A
A
---------
A
S
-----------
A
--------------------
T
T
----
Q
K
A
E
K
E
V
T
R
M
V
--------------
I
I
M
V
I
-------------
A
--------
F
L
I
C
W
L
P
Y
A
G
V
A
---------
F
Y
I
---------
F
-
T
--
H
---
Q
GSDFG
P
I
F
M
T
I
P
----
A
F
F
A
K
T
------
S
A
V
Y
N
P
V
I
Y
I
M
---
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A------
47
Fugue
75.27
17%
-142
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------------------------------------
S
F
K
C
--------
A
----------------------------
L
T
K
T
----------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
-------
S
V
A
I
W
---------------------
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
--
L
A
L
A
D
---------
F
-
L
Y
V
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
----
C
K
-
L
Q
R
F
I
F
H
V
N
L
---
Y
G
--
S
I
L
F
--
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
-
I
S
V
L
V
W
L
I
V
V
V
A
I
S
-----
P
I
--
L
F
Y
S
G
T
G
V
R
KNKT
I
T
C
YDTTSDEY
L
R
S
Y
F
I
-----
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
---------
V
-
L
I
L
G
C
Y
G
L
I
V
R
A
L
-
I
Y
K
M
K
K
Y
T
C
T
V
CG
Y
I
Y
N
PEDGDPDNGVNP
G
T
D
F
K
D
I
V
C
P
L
C
G
V
G
K
D
Q
-
F
E
---------
E
V
---------
E
E
-----------
P
--------------------
L
R
----
R
K
S
I
Y
L
V
I
I
V
L
--------------
T
V
F
A
V
S
Y
I
P
---------
F
--------
H
V
M
K
T
M
N
L
R
A
R
L
DFQTPAM
C
A
F
N
D
---------
R
-
V
--
Y
---
A
-----
T
Y
Q
V
T
R
G
----
L
A
S
L
N
S
--------
C
V
N
P
I
L
Y
F
L
---
A
G
D
T
F
R
R
R
--------------------------------
46
Fugue
71.51
14%
-178
- C1 -
1U7L
1
VATC_YEAST
A:
[5-392]
-------------------------------------------------------------------
L
Y
T
----------------
A
N
D
F
I
L
-
I
S
L
P
Q
N
----------
A
Q
P
V
T
A
P
G
S
K
T
D
S
W
F
N
E
T
L
I
G
G
-------
R
A
F
V
S
D
F
K
I
P
EFKIGSLDT
L
I
V
E
S
E
E
L
S
K
V
D
N
Q
I
G
A
S
I
G
K
I
I
E
I
--
L
Q
G
L
N
ETSTNAYRT
L
P
I
N
N
M
P
-
V
P
E
Y
L
E
N
F
Q
W
Q
T
R
-
K
F
K
L
D
K
----
S
I
-
K
D
L
I
T
L
I
S
N
E
---
S
S
--
Q
L
D
A
--
D
V
R
A
T
Y
A
N
Y
N
S
A
K
T
N
L
A
A
A
E
R
K
K
T
G
D
L
S
V
-
R
S
L
H
D
I
V
K
P
E
D
F
V
L
-----
N
S
EH
L
T
T
----------
V
L
V
----------
A
V
P
K
-----
S
L
K
S
D
F
E
K
S
Y
E
T
L
S
---------
K
N
V
V
P
A
S
A
S
V
I
A
E
D
A
-
E
Y
V
L
F
N
V
H
L
F
K
------------------
K
N
V
Q
E
F
T
T
A
A
R
E
K
K
F
-
I
P
-
R
E
---------
F
N
---------
Y
S
-----------
E
--------------------
E
L
----
I
D
Q
L
K
K
E
H
D
S
A
--------------
A
S
L
E
Q
-------------
S
--------
L
R
V
Q
L
V
R
L
A
K
T
A
---------
Y
V
D
---------
V
-
F
--
I
---
N
-----
W
F
H
I
K
A
L
----
R
V
Y
V
E
S
V
L
R
YGL
P
P
H
F
N
I
K
I
I
A
V
PPK
N
L
S
K
C
K
S
E
L
I
D
A
F
G
F
L
G
G
N
AFMYEP
F
V
M
Y
I
I
N
L-------
33
HHSearch
70.76
16%
-147
- C4 -
1U19
14
OPSD_BOVIN
A:
[41-326]
-----------------------------------------------------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-------
F
L
T
L
Y
---------------------
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
--
L
A
V
A
D
---------
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
----
C
N
-
L
E
G
F
F
A
T
L
G
G
---
E
I
--
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-----
P
P
--
L
V
G
----------
W
S
R
-----------
Y
I
---------
P
E
G
M
Q
C
S
C
G
I
D
---------
Y
-
Y
T
P
---
H
E
E
T
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
------------------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
---------
A
A
---------
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
----
K
E
V
T
R
M
V
I
I
M
V
--------------
I
A
F
L
I
-------------
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
---------
T
H
Q
---------
G
S
D
--
F
---
G
-----
P
I
F
M
T
I
P
----
A
F
F
A
K
T
------
S
A
V
Y
N
P
V
I
Y
I
M
---
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
---------------------
48
Fugue
69.93
12%
-171
- C3 -
1QLM
3
MCH_METKA
A:
[1-316]
----------------------------------------------------
M
V
S
V
N
E
--------
N
A
L
P
----------------
L
V
E
R
M
I
-
E
R
A
E
L
L
----------
N
-------------
V
E
V
Q
E
L
E
N
-------
G
T
T
V
I
---------------------
D
C
G
V
E
A
A
G
G
F
E
A
G
L
L
F
S
E
--
V
C
M
G
G
---------
L
A
T
V
E
L
T
-
E
F
E
H
D
G
L
C
L
P
A
V
Q
-
V
T
T
D
H
P
----
A
V
-
S
T
L
A
A
Q
K
A
G
W
---
Q
V
--
Q
V
G
D
--
Y
F
A
M
G
S
G
-------
P
A
R
A
L
A
L
K
P
K
E
T
Y
E
E
-
I
D
Y
E
D
D
A
D
V
A
I
L
C
L
ESS
E
L
P
D
--
E
D
V
----------
A
E
H
----------
V
A
D
E
C
GVDP
E
N
L
Y
L
L
V
A
P
T
A
S
I
V
---------
G
-
S
V
Q
V
S
A
---
R
V
V
E
-
T
-
G
L
Y
K
L
L
E
V
L
------------------
E
Y
D
V
T
R
V
K
Y
A
T
G
T
A
P
I
A
P
-
V
A
---------
D
D
---------
D
G
-----------
E
--------------------
A
M
----
G
R
T
N
D
C
I
L
Y
G
G
--------------
T
V
Y
L
Y
-------------
V
EGDDE
L
P
E
V
V
E
E
L
P
S
E
A
S
E
D
---------
Y
G
K
---------
P
-
F
--
M
---
K
-----
I
F
E
E
A
D
Y
----
D
F
Y
K
I
D
------
P
G
V
F
A
P
A
R
V
V
V
---
N
D
L
S
T
G
K
T
Y
T
A
G
E
I
N
V
D
V
L
K
E
S
F
SL---------------