@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52D1_HUMAN: (2016-01-12 )
MSDSNLSDNHLPDTFFLTGIPGLEAAHFWIAIPFCAMYLVALVGNAALILVIAMDNALHAPMYLFLCLLSLTDLALSSTTVPKMLAILWLHAGEISFGGCLAQMFCVHSIYALESSILLAMAFDRYVAICNPLRYTTILNHAVIGRIGFVGLFRSVAIVSPFIFLLRRLPYCGHRVMTHTYCEHMGIARLACANITVNIVYGLTVALLAMGLDSILIAISYGFILHAVFHLPSHDAQHKALSTCGSHIGIILVFYIPAFFSFLTHRFGHHEVPKHVHIFLANLYVLVPPVLNPILYGARTKEIRSRLLKLLHLGKTSI
Atome Classification :
(20 SA)
.........10..------......20----------.....-...30........40..---......50........60........70........80.----.......90........100.......110.....--..120.......130.......--140.......150.......160.......170.......180......-----.190.-------......200.......210.-......220....-..-------------.230...-----------.----...240.......250.......260.......270...----....280.......290.......300.......310......--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDSNLSDNHLPD------
T
F
F
LTGIP----------GLEA
A
-
H
F
W
I
A
I
P
F
C
A
M
Y
L
V
A
L
V---GN
A
A
L
I
L
V
I
AMDNA
L
H
A
P
M
Y
L
F
L
C
L
L
S
L
T
D
L
ALSST
T
V
P
----
K
M
L
A
I
L
WLHAGEI
S
F
G
G
C
L
A
Q
M
F
C
V
H
S
I
Y
A
L
E
S
S
I
--
L
L
A
M
A
F
D
R
Y
V
A
I
CNP
L
R
Y
T
T
I
L
--
N
H
A
V
I
G
R
I
G
F
V
G
L
F
R
S
V
A
I
V
S
P
F
I
F
L
L
R
RLPYCG
H
R
V
M
T
H
T
Y
C
E
HMG
I
A
-----
R
L
A
CA-------
N
I
T
V
N
I
V
Y
G
L
T
V
A
L
L
A
M
G
L
D
-
S
I
L
I
A
I
S
Y
G
F
I
L
H
-
A
V
-------------
F
HLPSH
D
-----------
A
----
Q
H
K
A
L
S
T
CGSH
I
G
I
I
L
V
F
Y
I
P
A
F
F
S
F
L
T
H
R
FGHHEV
P
K
H
----
V
H
I
F
L
A
N
L
Y
VLVP
P
V
L
N
P
I
LYGA
R
T
K
E
I
R
S
R
L
L
K
L
L
HLGKTSI--------------
2
PsiBlast_PDB
88.49
23%
-174
- C3 -
4LDL
3
ADRB2_HUMAN (first)
A:
[154-463]
--------
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
----------
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
----
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
-----------
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------------
R
Q
L
Q
--------------
K
FA
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
----
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
4
PsiBlast_PDB
88.37
23%
-173
- C3 -
4QKX
2
ADRB2_HUMAN
A:
[154-463]
--------
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
----------
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
C
I
L
T
K
T
W
------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
----
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
-----------
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------------
R
Q
L
Q
--------------
K
FAL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
----
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
1
PsiBlast_PDB
88.26
23%
-170
- C3 -
4LDE
3
ENLYS_BPT4
A:
[154-463]
--------
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
----------
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
----
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
-----------
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------------
R
Q
L
Q
--------------
K
FAL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
----
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
3
PsiBlast_PDB
88.20
23%
-172
- C3 -
4LDO
3
ENLYS_BPT4
A:
[154-463]
--------
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
----------
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
----
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
-----------
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------------
R
Q
L
Q
--------------
K
FAL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
----
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
5
PsiBlast_PDB
85.20
23%
-165
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[17-286]
-------------------------------------------------------
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
----
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
-----------
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------------
R
Q
L
Q
K
I
D
-----------
K
FC
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
----
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
11
PsiBlast_PDB
84.12
21%
-173
- C3 -
3SN6
1
ENLYS_BPT4
R:
[154-490]
--------
N
Q
T
P
N
RAKRVI
T
T
F
R
T
G
T
W
----------
D
A
----
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
IVF
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
FGAA
H
I
L
T
K
T
W
------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
ET
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
TK
N
K
A
R
V
----
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
---
Q
E
A
I
N
C
Y
A
E
E
-----------
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
-
E
A
KRQLQKIDKSEGR-------------------CLK-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
----
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
--------------------
20
PsiBlast_PDB
83.66
21%
-156
- C3 -
4BVN
11
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
I
R
---KRKTS
R
V
M
L
M
-
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
K
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
9
PsiBlast_PDB
83.19
21%
-156
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[23-299]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
I
R
K
I
D
RASK
R
K
R
V
M
L
M
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
6
PsiBlast_PDB
82.54
21%
-156
- C3 -
2VT4
8
ADRB1_MELGA
A:
[23-298]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
I
R
-------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
10
PsiBlast_PDB
82.39
21%
-155
- C3 -
2YCY
6
ADRB1_MELGA
A:
[23-299]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
I
R
--
D
RASKR
K
R
V
M
L
M
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
18
PsiBlast_PDB
82.35
21%
-156
- C3 -
3ZPQ
11
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
-----S
R
V
M
L
M
-----
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
14
PsiBlast_PDB
82.28
21%
-158
- C3 -
2Y02
13
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
-----S
R
V
M
L
M
-----
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
13
PsiBlast_PDB
81.85
21%
-153
- C3 -
2Y01
12
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
-----S
R
V
M
L
M
-----
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
12
PsiBlast_PDB
81.82
21%
-158
- C3 -
2Y00
13
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
-----S
R
V
M
L
M
-----
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
7
PsiBlast_PDB
81.67
21%
-156
- C3 -
2YCW
7
ADRB1_MELGA
A:
[23-299]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
I
R
K
I
D
RASKRKR
V
M
L
M
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
17
PsiBlast_PDB
81.65
21%
-155
- C3 -
4AMJ
12
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
-----S
R
V
M
L
M
-----
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
15
PsiBlast_PDB
81.20
21%
-157
- C3 -
2Y03
9
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
I
R
---S
R
V
M
L
M
-----
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
8
PsiBlast_PDB
81.09
21%
-157
- C3 -
2YCX
3
ADRB1_MELGA
A:
[23-294]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
I
R
K
I
D
RAS
K
R
K
R
V
M
L
M
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
------------------------
16
PsiBlast_PDB
80.71
21%
-155
- C3 -
2Y04
13
ADRB1_MELGA
A:
[23-300]
-------------------------------------------------------
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
----
F
G
A
T
L
V
--
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
--
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-------
F
L
P
-----
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
-
A
K
-------------
E
Q
-----S
R
V
M
L
M
-----
R
----
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
----
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
42
Fugue
78.53
16%
-141
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
------
S
N
K
T
G
V
V
R
SPFEAPQYYL
A
E
P
W
Q
-
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
----
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
--
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
--------------
G
M
------
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-
T
V
-------------
K
E
A
A
A
S
A
-----------
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
DFGP
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A