@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52E8_HUMAN: (2016-01-12 )
MAGRMSTSNHTQFHPSSFLLLGIPGLEDVHIWIGVPFFFVYLVALLGNTALLFVIQTEQSLHEPMYYFLAMLDSIDLGLSTATIPKMLGIFWFNTKEISFGGCLSHMFFIHFFTAMESIVLVAMAFDRYIAICKPLRYTMILTSKIISLIAGIAVLRSLYMVVPLVFLLLRLPFCGHRIIPHTYCEHMGIARLACASIKVNIRFGLGNISLLLLDVILIILSYVRILYAVFCLPSWEARLKALNTCGSHIGVILAFFTPAFFSFLTHRFGHNIPQYIHIILANLYVVVPPALNPVIYGVRTKQIRERVLRIFLKTNH
Atome Classification :
(20 SA)
.........10----.........20........30-------.--.---......40----........50........60..--......70........80..-......90........100-----........110.......120.-------......130.......140.-...------------------...150.......160.......170.-----..-----------------------------------.-------...180.......190...---....200........-.210..-----....--------..220.......230-------.---------......--------------------..--240....----------...250.......260-------........270-..---.-----....280.......290.......300.......310----.....----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGRMSTSNH-----TQFHPS
S
F
L
L
L
GIPGL
E
D
V
H
I
-------
W
--
I
---
G
V
P
F
F
F
V
Y
----
L
V
A
L
LGN
T
A
L
L
F
V
IQT
E
Q
S
LH
E
--
P
M
Y
Y
F
L
A
M
L
D
S
IDLGLS
T
A
T
-
I
P
K
M
L
G
I
F
W
FNTKEIS
F
G
------
G
C
L
S
H
M
F
F
I
H
F
F
T
A
M
E
S
I
V
L
V
A
-------
M
A
F
D
R
Y
I
A
I
C
K
P
L
R
Y
T
M
I
L
T
-
S
K
I
------------------
I
S
L
I
A
G
I
A
V
L
R
S
L
Y
M
V
V
P
L
V
F
L
L
L
RLP-----FC-----------------------------------G-------HRII
P
H
T
Y
C
E
HMG
I
A
R
L
A
C
---
A
S
I
K
V
--
N
I
R
FGL
G
N
-
I
S
-
L
L
L
-----
L
D
V
I
--------
L
I
I
L
S
Y
V
R
I
L
Y
A
V
---------F---------CLP
S
W
E
--------------------
A
R
--
L
K
A
L
N
T
C
----------
G
S
H
I
G
V
I
L
A
F
F
T
P
A
F
--------
F
S
F
L
T
H
R
FGHN-
I
P
---
Q
-----
Y
I
H
I
I
L
A
N
L
Y
V
VVPPAL
N
P
V
IYG
V
R
T
K
Q
I
R
E
R
V
L
R
I
F
----LKTNH----------------------
11
PsiBlast_PDB
88.41
24%
-167
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
--
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
LFE
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
--
A
P
L
W
L
M
-----
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
H
V
L
----------------------
8
PsiBlast_PDB
87.52
24%
-163
- C5 -
2YDO
3
?
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
--
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LFE
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
A
A
---------
R
R
Q
L
K
Q
M
E
S-----------------------------T-
L
Q
K
E
V
H
A
----------
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
-----
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
H
V
L
----------------------
9
PsiBlast_PDB
87.28
24%
-166
- C5 -
2YDV
6
?
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
--
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LFE
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
A
A
---------
R
R
Q
L
K
Q
M
ESQ----------------------------S
T
L
Q
K
E
V
H
A
----------
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
-----
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
H
V
L
----------------------
15
PsiBlast_PDB
85.35
24%
-167
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
-------------------------
16
PsiBlast_PDB
85.10
24%
-166
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
-------------------------
14
PsiBlast_PDB
85.09
24%
-165
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
-------------------------
12
PsiBlast_PDB
85.09
24%
-161
- C5 -
3PWH
1
?
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
--------
G
C
G
E
G
Q
V
A
C
LFE
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
-------------------------
13
PsiBlast_PDB
85.04
24%
-164
- C5 -
3REY
1
AA2AR_HUMAN
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
A
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
-------------------------
3
PsiBlast_PDB
84.54
24%
-162
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
FCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
H
V
L
----------------------
2
PsiBlast_PDB
84.30
24%
-161
- C5 -
3VG9
8
?
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
FCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
A
A
---------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
--
P
L
W
L
M
-----
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
H
V
L
----------------------
10
PsiBlast_PDB
83.87
24%
-164
- C5 -
4UG2
3
?
A:
[16-302]
--------------------------------------------------------
I
A
----
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
--
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
------------------
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
-----
N
C
-----------------------------------
G
-------
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LFE
D
V
V
P
M
--
N
Y
M
V
Y
F
N
F
-
F
A
-
C
V
L
-----
V
P
L
L
--------
L
M
L
G
V
Y
L
R
I
F
L
A
A
---------
R
R
Q
L--------------------------------
A
R
S
T
L
Q
K
E
V
H
A
----------
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
--
A
P
L
W
L
M
-----
Y
L
A
I
V
L
S
H
T
N
S
V
V
----
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----
R
S
H
V
L
----------------------
50
Fugue
82.77
18%
-132
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
-----
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
--
L
---
A
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
--
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
-
N
H
A
------------------
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-------------
V
G
-----------------------------------
W
-------
S
R
Y
I
P
E
------
G
M
-
Q
C
S
C
---
G
I
D
Y
Y
--
T
P
H
E
E
T
N
N
-
E
S
-
F
V
I
-----
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
---------
K
---------
E
A
A
A
S
A
--------------------
T
T
--
Q
K
A
E
K
E
V
----------
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
-
T
H
---
Q
GSDFG
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A------
7
PsiBlast_PDB
81.66
22%
-161
- C5 -
4LDO
3
A:
[179-447]
----------------------------------
E
V
-------
W
--
V
V
G
M
G
I
V
M
S
L
I
V
----
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
--
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
------
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
------------------
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--------------------------------------------------
H
Q
E
A
I
N
C
Y
A
E
E
------
T
C
---
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
-
S
F
Y
-----
V
P
L
V
--------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQK---
F
---------
A
L
K
E
--------------------------
H
K
A
L
K
T
L
----------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
--------
I
V
N
I
V
H
V
I
Q
D
N
-
L
I
---
R
-----
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
----
L
--------------------------
6
PsiBlast_PDB
81.47
22%
-165
- C5 -
4LDL
3
ADRB2_HUMAN
A:
[179-447]
----------------------------------
E
V
-------
W
--
V
V
G
M
G
I
V
M
S
L
I
V
----
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
--
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
------
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
------------------
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--------------------------------------------------
H
Q
E
A
I
N
C
Y
A
E
E
------
T
C
---
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
-
S
F
Y
-----
V
P
L
V
--------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQK---
F
---------
A
L
K
E
--------------------------
H
K
A
L
K
T
L
----------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
--------
I
V
N
I
V
H
V
I
Q
D
N
-
L
I
---
R
-----
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
----
L
--------------------------
5
PsiBlast_PDB
81.16
22%
-162
- C5 -
4LDE
3
A:
[179-447]
----------------------------------
E
V
-------
W
--
V
V
G
M
G
I
V
M
S
L
I
V
----
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
--
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
------
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
------------------
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--------------------------------------------------
H
Q
E
A
I
N
C
Y
A
E
E
------
T
C
---
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
-
S
F
Y
-----
V
P
L
V
--------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQK---
F
---------
A
L
K
E
--------------------------
H
K
A
L
K
T
L
----------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
--------
I
V
N
I
V
H
V
I
Q
D
N
-
L
I
---
R
-----
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
----
L
--------------------------
4
PsiBlast_PDB
80.86
22%
-163
- C5 -
4QKX
2
ADRB2_HUMAN
A:
[179-447]
----------------------------------
E
V
-------
W
--
V
V
G
M
G
I
V
M
S
L
I
V
----
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
--
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
C
I
L
T
K
T
W
T
F
G
------
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
------------------
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--------------------------------------------------
H
Q
E
A
I
N
C
Y
A
E
E
------
T
C
---
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
-
S
F
Y
-----
V
P
L
V
--------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQK---
F
---------
A
L
K
E
--------------------------
H
K
A
L
K
T
L
----------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
--------
I
V
N
I
V
H
V
I
Q
D
N
-
L
I
---
R
-----
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
----
L
--------------------------
43
HHSearch
78.57
17%
-152
- C5 -
2Z73
5
OPSD_TODPA
A:
[32-332]
--------------------------------
A
V
Y
Y
-------
S
--
L
---
G
I
F
I
G
I
C
G
----
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
--
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-------
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
-
H
R
R
------------------
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
-----
L
----------------------------------------------
E
G
V
L
C
N
C
S
F
D
Y
I
S
--------
R
D
S
T
--
T
R
S
N
I
L
C
M
-
F
I
L
G
F
F
-----
G
P
I
L
--------
I
I
F
F
C
Y
F
N
I
V
M
S
V
---------
S
---------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
--
M
R
L
A
K
I
S
----------
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
--------
V
V
A
L
L
A
Q
F
G
P
L
E
W
V
---
T
-----
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
----
P
W
V
L
T
----------------------
1
PsiBlast_PDB
78.48
23%
-167
- C5 -
4GBR
1
ADRB2_HUMAN
A:
[2-270]
----------------------------------
E
V
-------
W
--
V
V
G
M
G
I
V
M
S
L
I
V
----
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
--
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
------
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
------------------
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--------------------------------------------------
H
Q
E
A
I
N
C
Y
A
E
E
------
T
C
---
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
-
S
F
Y
-----
V
P
L
V
--------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
KIDK
F
---------
C
L
K
------------------------
E
--
H
K
A
L
K
T
L
----------
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
--------
I
V
N
I
V
H
V
I
Q
D
N
-
L
I
---
R
-----
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
----
L
--------------------------
51
Fugue
76.43
16%
-127
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
VPFSN
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
-------
F
S
M
L
---
A
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
--
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
-
N
H
A
------------------
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
-----------------------------------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
--
F
F
C
Y
G
Q
-----------------
L
--------
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
---------
S
---------
A
T
T
Q
K
A
--------------------
E
K
--
E
V
T
R
M
V
I
----------
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--------
V
A
F
Y
I
F
T
H
Q
G
S
-
D
F
---
G
-----
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA
55
Fugue
73.82
17%
-145
- C5 -
4CI0
4
?
A:
[2-386]
-
S
E
R
I
V
I
S
P
T
-----
S
R
Q
E
G
H
A
E
L
V
M
E
V
---
D
D
E
G
I
-------
V
--
T
---
K
G
R
Y
F
S
I
T
PVRG
L
E
K
M
V
T
G
K
A
P
E
T
A
P
V
M
V
Q
R
I
C
G
VC
P
I
P
H
T
L
A
S
V
E
A
I
D
D
S
L
D
-
I
E
-
V
P
K
A
G
R
L
L
----
R
E
L
T
L
A
------
A
H
H
V
N
S
H
A
I
H
H
F
L
I
A
P
D
F
V
P
E
N
-------
L
M
A
D
A
I
N
S
V
S
E
I
R
K
N
A
Q
Y
V
V
-
D
M
V
A
GEGIHPSDVRIGGMA
D
N
I
T
E
L
A
R
K
R
L
Y
A
R
L
K
Q
L
K
P
K
V
N
E
H
V
E
L
M
-----
I
G
L
I
E
D
K
GLPEGLGVHN
Q
P
T
L
A
SHQIYGDRTKFDLDR
F
-------
T
E
I
M
P
E
S
W
Y
D
D
P
E
I
A
K
R
A
C
---
S
T
I
P
L
Y
D
G
R
N
V
E
V
G
P
-
R
A
-
R
M
V
E
FQGF
K
E
R
G
--------
V
V
A
Q
H
V
A
R
A
L
E
M
K
---------
T
---------
A
L
S
R
A
I
--------------------
E
I
--
L
D
E
L
D
T
S
APV
R
A
D
F
D
ER
G
T
G
K
L
G
I
G
A
I
E
A
P
R
G
--------
L
D
V
H
M
A
K
V
E
N
G
-
K
I
---
Q
-----
F
Y
S
A
L
V
P
T
T
W
N
I
--
P
T
M
G
P
A
T
E
G
F
H
-
H
E
Y
G
P
H
V
I
R
A
Y
DPCL
S
C
A
T
H
----------------------