@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52J3_HUMAN: (2016-01-12 )
MFYHNKSIFHPVTFFLIGIPGLEDFHMWISGPFCSVYLVALLGNATILLVIKVEQTLREPMFYFLAILSTIDLALSTTSVPRMLGIFWFDAHEINYGACVAQMFLIHAFTGMEAEVLLAMAFDRYVAVCAPLHYATILTSQVLVGISMCIVIRPVLLTLPMVYLIYRLPFCQAHIIAHSYCEHMGIAKLSCGNIRINGIYGLFVVSFFVLNLVLIGISYVYILRAVFRLPSHDAQLKALSTCGAHVGVICVFYIPSVFSFLTHRFGHQIPGYIHILVANLYLIIPPSLNPIIYGVRTKQIRERVLYVFTKK
Atome Classification :
(20 SA)
------------.........10........20........30........40---.---.......50........60........70........-80........90........100.......110..-------.....120.......130.......-140.......150.......160.......170.......180.......190--------.......200--.--....-..210......-.220-------........230-----------------------------------------------------------------------------------------------------------------------------------------------------------------.----...-----...240.......250.......260......-.--270---.--........280.......290.......300--.......310-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MFYHNKSIFH
P
V
T
F
F
L
I
GIPG
L
E
D
F
H
M
WISG
P
F
C
S
V
Y
L
V
A
L
---L---GN
A
T
I
L
L
V
I
K
V
E
Q
T
L
R
E
P
M
F
Y
F
L
A
I
L
S
T
I
D
L
A
LSTTS-VP
R
M
L
G
I
F
W
F
DAHEI
N
Y
G
A
C
V
A
Q
M
F
L
I
H
A
FTGM
E
A
-------
E
V
L
L
A
M
A
F
D
R
Y
V
A
V
C
A
P
L
H
Y
A
T
I
L
T
-
S
Q
V
L
V
G
I
S
M
C
I
V
I
R
P
V
L
L
T
L
P
M
V
Y
L
I
Y
RLP
F
C
Q
A
H
I
I
A
H
S
Y
C
E
HMG
I
A
K
LSCG--------
N
I
R
I
N
G
I
Y
G
L
--
F
--
V
V
S
F
-
F
V
L
N
L
V
L
I
G
I
S
-
Y
V
Y
--------
I
L
R
A
V
F
RLPSH-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
A
Q
L
-----
K
A
L
S
TCGAH
V
G
V
I
C
V
F
Y
I
P
S
V
F
S
F
L
T
H
R
FGHQ-I--
P
-----
G
--
Y
I
H
I
L
VA
N
L
Y
L
I
IPPSL
N
P
I
I
Y
G
V
R
T
K
Q
I
R
E
--
R
V
L
Y
V
F
TKK------------------
1
PsiBlast_PDB
87.90
24%
-146
- C4 -
2Y00
13
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
8
PsiBlast_PDB
87.83
24%
-147
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[8-299]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-------------M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------------------
3
PsiBlast_PDB
87.69
24%
-147
- C4 -
2Y02
13
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
12
PsiBlast_PDB
87.07
23%
-148
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
--------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
A
S
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------
6
PsiBlast_PDB
86.99
24%
-144
- C4 -
4AMJ
12
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
7
PsiBlast_PDB
86.92
24%
-148
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
9
PsiBlast_PDB
86.78
23%
-150
- C4 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
---------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
---
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
20
PsiBlast_PDB
86.36
24%
-141
- C4 -
4BVN
11
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----
K
R
K
T
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
K
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
11
PsiBlast_PDB
86.31
23%
-144
- C4 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
A
S
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
--------------------------
2
PsiBlast_PDB
86.29
24%
-145
- C4 -
2Y01
12
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q-----------
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
5
PsiBlast_PDB
86.00
24%
-145
- C4 -
2Y04
13
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
EQ-----------
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
22
HHSearch
85.63
18%
-157
* C4 *
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
---
I
---
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
-------
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
-
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------------
S
N
A
A
V
T
F
--
G
--
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
-
Y
W
H
--------
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP
S
----
R
E
K
-----
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-
C
--
I
-----
P
--
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
--
T
F
K
H
L
L
M
--------------------
4
PsiBlast_PDB
85.48
24%
-148
- C4 -
2Y03
9
ADRB1_MELGA
A:
[8-300]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
IR---------
S
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----
R
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------
41
Fugue
84.96
17%
-148
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
-
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
--------
V
G
W
S
R
Y
I
P
E
G
M
-------
Q
C
S
C
G
I
DYYTPHE
E
T
N
N
E
S
F
V
I
Y
--
M
--
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
-
Y
G
Q
--------
L
V
F
T
V
K
E
A
A
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
T
T
Q
-----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-
T
--
H
QGSDF
G
--
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
--
C
M
V
T
T
L
C
C
G
KNPSTTVSKTETS
Q
V
A
P
A
10
PsiBlast_PDB
84.90
23%
-146
- C4 -
2YCW
7
ADRB1_MELGA
A:
[8-299]
-------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
K
I
D
R
A
S
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------
34
HHSearch
83.70
15%
-153
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-332]
-----------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
---
G
---
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
-------
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
-
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------------
R
D
S
T
T
R
S
N
I
L
--
C
--
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
-
Y
F
N
--------
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
---------------------------------------------------------------------------------------------------------------------------------------------
N
----
A
E
M
-----
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
--
V
-----
T
--
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
--
A
I
S
Q
T
F
P
W
V
------------------
13
PsiBlast_PDB
83.43
23%
-148
- C4 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
---------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
---
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
C
--------
D
F
V
T
N
R
A
Y
A
I
--
A
S
S
I
I
S
F
-
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
---
Q
I
R
--
D
R
A
S
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
--
P
-----
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------
14
PsiBlast_PDB
81.97
23%
-150
- C4 -
4GBR
1
ADRB2_HUMAN
A:
[15-270]
-----------------------------------------------
I
V
L
A
I
V
---
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-------
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
E
E
------
T
C
C
--------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
--
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
--------
F
Q
E
A
K
R
Q
L
Q
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
KFC
L
K
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
--
R
-----
K
--
E
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
--
F
Q
E
L
L
C
L
--------------------
30
HHSearch
81.43
18%
-152
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-322]
---------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
---
V
---
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
-------
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
-
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------
N
K
I
Y
E
K
V
Y
H
I
--
C
--
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
-
Y
T
V
--------
V
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
A
K
R
-----
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
-
L
YL
K
-----
K
FI
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
--
G
F
K
H
A
F
R
C
C
------------------
19
PsiBlast_PDB
80.51
23%
-152
- C4 -
4LDO
3
A:
[179-447]
-------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-------
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
E
E
------
T
C
C
--------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
--
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
--------
F
Q
E
A
K
R
Q
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------KFAL
K
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
--
R
-----
K
--
E
V
Y
I
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
--
F
Q
E
L
L
C
L
--------------------