@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52L2_HUMAN: (2016-01-12 )
MNLDSFFSFLLKSLIMALSNSSWRLPQPSFFLVGIPGLEESQHWIALPLGILYLLALVGNVTILFIIWMDPSLHQSMYLFLSMLAAIDLVVASSTAPKALAVLLVRAQEIGYTVCLIQMFFTHAFSSMESGVLVAMALDRYVAICHPLHHSTILHPGVIGHIGMVVLVRGLLLLIPFLILLRKLIFCQATIIGHAYCEHMAVVKLACSETTVNRAYGLTVALLVVGLDVLAIGVSYAHILQAVLKVPGNEARLKAFSTCGSHVCVILVFYIPGMFSFLTHRFGHHVPHHVHVLLAILYRLVPPALNPLVYRVKTQKIHQ
Atome Classification :
(20 SA)
---------.........----------10........20-------------...--...-.----..30........40...---.....50...------....-.60...-----.....70..-......80..-......-90..----------..-.-...100...-.-..-----..110-------...--....120.-----......130......----------------.140----....------------....150.---...---------.---..160.--......170--------------.--........180...-----.-.------------..----190.-----------......----200..-----...----------------.-------.210......----...220.......230....---...240------.......-------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------250.-----.-..-.----------..-260..-...----..270.....-..280...-.----------.----.--------..290...------....300.......310.......---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------M
N
L
D
S
F
F
S
F
----------
L
L
K
S
L
I
M
A
LSN--------------SSW--RLP-Q----P
S
F
F
L
V
GIPGLEESQ
H
W
---
I
A
L
P
L
G
I
L
Y
L
------
L
A
L
V-GN
V
T
I
L
-----
F
I
I
WMDP
S
L
-
H
Q
S
M
Y
L
F
L
S
M
-
L
A
A
I
D
L
-VVAS----------ST-A-
P
K
A
L
A
-
V
L
L
-
V
-
R
A
-----
Q
EI
G
Y
-------
T
V
C
--
L
I
Q
M
F
F
T
H
-----
A
F
S
S
MES
G
V
L
V
A
M
A
L
----------------
D
R
Y
-----
V
A
I
C
------------HPLHHSTI---LHP---------G---
V
I
G
H
I
G
--
M
V
V
L
V
R
G
----------------
L
--
L
L
L
I
P
F
L
I
L
L
R
K
L
I
-----
F
-
C
------------
Q
A
----
T
I
I
G
-----------
H
A
Y
C
E
H
----
M
A
V
V
K-----LAC----------------S-------ET--TVNRAY----
G
L
T
V
A
L
L
V
V
G
L
D
V
L
A
I
G
V
S
Y
---
A
H
I
L
Q
-------
A
V
L
KVPG-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
L
-----
K
-
A
F
-
S
----------TC-GS
H
V
C
-
V
I
L
----
V
F
Y
I
P
G
M
F
S
F
-
L
T
H
-
R
FGH-H----------V----
P
--------
H
H
V
H
V
L
L
A
------
I
L
Y
R
LVPPAL
N
P
L
V
Y
R
V
K
TQKIHQ---------------------------
24
HHSearch
94.52
18%
-147
- C2 -
2RH1
15
ADRB2_HUMAN (first)
A:
[40-469]
---------------------------------------------------------------------------------
V
V
G
---
M
G
I
V
M
S
L
I
V
L
------
A
I
V
F
-
G
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
L
-
Q
T
V
T
N
Y
F
I
T
S
-
L
A
C
A
D
L
-
V
M
G
L
----------
A
V
-
V
-
P
F
G
A
A
-
H
I
L
-
M
-
K
M
-----
W
T
F
G
N
-------
F
W
C
--
E
F
W
T
S
I
D
V
-----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
----------------
D
R
Y
-----
F
A
I
T
------------
S
P
F
K
Y
Q
S
L
---
L
T
K
---------
N
---
K
A
R
V
I
I
--
L
M
V
W
I
V
S
----------------
G
--
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-----
T
---------------------
H
Q
E
-----------
A
I
N
C
Y
A
----
E
E
---------
T
C
----------------
C
-------
D
F
--
F
T
N
Q
A
Y
----
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
---
S
R
V
F
Q
-------
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF--
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
-----
K
-
A
L
-
K
----------
T
L
-
G
I
I
M
G
-
T
F
T
----
L
C
W
L
P
F
F
I
V
N
-
I
V
H
-
V
I
Q
D
-
N
----------
L
----
I
--------
R
K
E
V
Y
I
L
L
------
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
---------------------------
21
HHSearch
91.96
18%
-156
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-450]
----------------------------------------------------------------------------------
V
F
---
I
V
L
V
A
G
S
L
S
L
------
V
T
I
I
-
G
N
I
L
V
M
-----
V
S
I
K
V
N
R
H
L
-
Q
T
V
N
N
Y
F
L
F
S
-
L
A
C
A
D
L
-
I
I
G
V
----------
F
S
-
M
-
N
L
Y
T
L
-
Y
T
V
-
I
-
G
Y
-----
W
P
L
G
P
-------
V
V
C
--
D
L
W
L
A
L
D
Y
-----
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
----------------
D
R
Y
-----
F
C
V
T
------------
K
P
L
T
Y
P
V
K
---
R
T
T
---------
K
---
M
A
G
M
M
I
--
A
A
A
W
V
L
S
----------------
F
--
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
-----
G
-
V
------------
R
------
T
V
E
-----------
D
G
E
C
Y
I
----
Q
F
F
---------------------------------------
S
N
A
A
V
----
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
---
W
H
I
S
R
-------
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP--
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
-----
K
-
V
T
-
R
----------
T
I
-
L
A
I
L
L
-
A
F
I
----
I
T
W
A
P
Y
N
V
M
V
-
L
I
N
-
T
F
C
A
-
P
----------
C
----
I
--------
P
N
T
V
W
T
I
G
------
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
---------------------------
29
HHSearch
87.50
20%
-145
- C2 -
2KS9
1
NK1R_HUMAN
A:
[32-314]
---------------------------------------------------------------------------------
I
V
L
---
W
A
A
A
Y
T
V
I
V
V
------
T
S
V
V
-
G
N
V
V
V
M
-----
W
I
I
L
A
H
K
R
M
-
R
T
V
T
N
Y
F
L
V
N
-
L
A
F
A
E
A
-
S
M
A
A
----------
F
N
-
T
-
V
V
N
F
T
-
Y
A
V
-
H
-
N
E
-----
W
Y
Y
G
L
-------
F
Y
C
--
K
F
H
N
F
F
P
I
-----
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
----------------
D
R
Y
-----
M
A
I
I
------------
H
P
L
Q
P
R
L
-----
S
A
---------
T
---
A
T
K
V
V
I
--
C
V
I
W
V
L
A
----------------
L
--
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
---------------------------
M
P
S
-----------
R
V
V
C
M
I
----
E
W
P
E
H
------------------------
P
-------
N
K
--
I
Y
E
K
V
Y
----
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
---
T
V
V
G
I
-------
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
-----
K
-
V
V
-
K
----------
M
M
-
I
V
V
V
C
-
T
F
A
----
I
C
W
L
P
F
H
I
F
F
-
L
L
P
-
Y
I
N
P
-
D
----------
L
YLKK
F
--------
I
Q
Q
V
Y
L
A
I
------
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
---------------------------
27
HHSearch
87.12
18%
-147
* C2 *
2Z73
5
OPSD_TODPA
A:
[29-324]
----------------------------------------------------------------------------
V
P
D
A
V
Y
Y
S
---
L
G
I
F
I
G
I
C
G
I
------
I
G
C
G
-
G
N
G
I
V
I
-----
Y
L
F
T
K
T
K
S
L
-
Q
T
P
A
N
M
F
I
I
N
-
L
A
F
S
D
F
-
T
F
S
L
----------
V
N
G
F
-
P
L
M
T
I
-
S
C
F
-
L
-
K
K
-----
W
I
F
G
F
-------
A
A
C
--
K
V
Y
G
F
I
G
G
-----
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
----------------
D
R
Y
-----
N
V
I
G
------------
R
P
M
A
A
S
K
K
---
M
S
H
---------
R
---
R
A
F
I
M
I
--
I
F
V
W
L
W
S
----------------
V
--
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
-----
L
---------------------
E
G
V
-----------
L
C
N
C
S
F
----
D
Y
I
--------------------------
S
-------
R
D
--
S
T
T
R
S
N
----
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
---
F
N
I
V
M
-------
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
-----
R
-
L
A
-
K
----------
I
S
-
I
V
I
V
S
-
Q
F
L
----
L
S
W
S
P
Y
A
V
V
A
-
L
L
A
-
Q
F
G
P
-
L
E---------
W
----
V
--------
T
P
Y
A
A
Q
L
P
------
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
---------------------------
39
Fugue
86.48
17%
-131
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------
M
N
G
T
E
G
P
N
F
----------
Y
V
-----
P
F
S
N
--------------
K
T
G
--
V
V
R
-
S
----
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
---
L
A
A
Y
M
F
L
L
I
M
------
L
G
F
P
-
I
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
L
-
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
-
F
M
V
F
----------
G
G
-
F
-
T
T
T
L
Y
-
T
S
L
-
H
-
G
Y
-----
F
V
F
G
P
-------
T
G
C
--
N
L
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
----------------
E
R
Y
-----
V
V
V
C
------------
K
P
M
S
N
F
R
F
---
G
E
N
---------
H
---
A
I
M
G
V
A
--
F
T
W
V
M
A
L
----------------
A
--
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
-
C
G
I
DYYTPHEETN
N
E
----
S
F
V
I
-----------
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
-----
F
C
Y
G
Q
L
VFTVKEAAAQQQE
S
-------
A
T
--
T
Q
K
A
E
K
----
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
G
------
P
-
I
F
-
M
----------
T
I
-
P
A
F
F
A
-
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
-
M
N
K
-
Q
F
R
N
-
C
----------
M
----
V
--------
T
T
L
C
C
G
K
N
------
P
L
G
D
--
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------
40
Fugue
85.60
16%
-140
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------
M
N
-----
G
T
----------
E
G
P
N
F
Y
V
P
F
S
N
--------------
K
T
G
--
V
V
R
-
S
----
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
---
L
A
A
Y
M
F
L
L
I
M
------
L
G
F
P
-
I
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
L
-
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
-
F
M
V
F
----------
G
G
-
F
-
T
T
T
L
Y
-
T
S
L
-
H
-
G
Y
-----
F
V
F
G
P
-------
T
G
C
--
N
L
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
----------------
E
R
Y
-----
V
V
V
C
------------
K
P
M
S
N
F
R
F
---
G
E
N
---------
H
---
A
I
M
G
V
A
--
F
T
W
V
M
A
L
----------------
A
--
C
A
A
P
P
L
V
G
W
S
R
----------------------------------------------
Y
I
P
E
----
G
--
M
Q
-----
C
S
C
----------------
G
I
DYYTPH
E
E
--
T
N
N
E
S
F
----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
-------
T
V
K
E
A
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
-----
K
-
A
E
-
K
----------
E
V
-
T
R
M
V
I
-
I
M
V
----
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
-
A
F
Y
I
-
F
----------
T
----
H
QGSDF---
G
P
I
F
M
T
I
P
------
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTETS
Q
V
A
P
A
23
HHSearch
85.25
19%
-149
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-435]
-----------------------------------------------------------------------------------
P
---
L
V
V
V
L
S
T
I
C
L
------
V
T
V
G
-
L
N
L
L
V
L
-----
Y
A
V
R
S
E
R
K
L
-
H
T
V
G
N
L
Y
I
V
S
-
L
S
V
A
D
L
-
I
V
G
A
----------
V
V
-
M
-
P
M
N
I
L
-
Y
L
L
-
M
-
S
K
-----
W
S
L
G
R
-------
P
L
C
--
L
F
W
L
S
M
D
Y
-----
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
----------------
D
R
Y
-----
R
S
V
Q
------------
Q
P
L
R
Y
L
K
Y
---
R
T
K
---------
T
---
R
A
S
A
T
I
--
L
G
A
W
F
L
S
----------------
F
--
L
W
V
I
P
I
L
G
W
N
H
-------------------------------
R
R
-----------
E
D
K
C
E
T
----
D
F
Y
---------------------------------------
D
V
T
W
F
----
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
---
A
K
I
Y
K
-------
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH--
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
-----
K
-
A
A
-
K
----------
Q
L
-
G
F
I
M
A
-
A
F
I
----
L
C
W
I
P
Y
F
I
F
F
-
M
V
I
-
A
F
C
K
-
N
----------
C
----
C
--------
N
E
H
L
H
M
F
T
------
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
---------------------------
20
PsiBlast_PDB
84.71
23%
-166
- C2 -
4QKX
2
ADRB2_HUMAN
A:
[191-447]
----------------------------------------------------------------------------------------------
L
I
V
------
L
A
I
V
F
G
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
L
-
Q
T
V
T
N
Y
F
I
T
S
-
L
A
C
A
D
L
-
V
M
G
L
----------
A
V
-
V
-
P
F
G
A
A
-
C
I
L
-
T
-
K
T
-----
W
T
F
G
N
-------
F
W
C
-----
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
----------------
D
R
Y
-----
F
A
I
T
------------
S
P
F
K
Y
Q
S
L
---
L
T
K
---------
N
K
A
R
V
I
--
I
L
--
M
V
W
I
V
S
G
----------------
L
--
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-----
H
-
Q
------------
E
A
----
I
--------------
N
C
Y
A
E
E
---------------
T
C
----------------
C
-------
D
F
--
F
T
N
Q
A
Y
----
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
---
S
R
V
F
Q
-------
E
A
K
R
Q
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
AL
K
E
H
K
-
A
L
-
K
----------
T
L
-
G
I
I
M
G
-
T
F
T
----
L
C
W
L
P
F
F
I
V
N
-
I
V
H
-
V
I
Q
D
-
N
L---------
I
----
R
--------
K
E
V
Y
I
L
L
N
------
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
---------------------------
30
HHSearch
81.84
18%
-156
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-459]
----------------------------------------------------------------------------------
S
V
---
Y
I
T
V
E
L
A
I
A
V
------
L
A
I
L
-
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
-
A
V
G
V
----------
L
A
-
I
-
P
F
A
I
T
-
I
S
T
----
G
-----
F
C
A
A
C
-------
H
G
C
--
L
F
I
A
C
F
V
L
-----
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
----------------
D
R
Y
-----
I
A
I
R
------------
I
P
L
R
Y
N
G
L
---
V
T
G
---------
T
---
R
A
K
G
I
I
--
A
I
C
W
V
L
S
----------------
F
--
A
I
G
L
T
P
M
L
G
W
N
N
C
G
-----
Q
-----------------------------------
S
Q
G
C
G
E
----
G
Q
V
--------
A
C
----------------
L
-------
F
E
DV
V
P
M
N
Y
M
----
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
---
L
R
I
F
L
-------
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
-
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
-----
H
-
A
A
-
K
----------
S
L
-
A
I
I
V
G
-
L
F
A
----
L
C
W
L
P
L
H
I
I
N
-
C
F
T
-
F
F
C
P
-
D
CS--------
H
----
A
--------
P
L
W
L
M
Y
L
A
------
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------------------------
22
HHSearch
80.50
16%
-141
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-485]
------------------------------------------------------------------------------
N
F
N
K
I
F
---
L
P
T
I
Y
S
I
I
F
L
------
T
G
I
V
-
G
N
G
L
V
I
-----
L
V
M
G
Y
Q
K
K
L
-
R
S
M
T
D
K
Y
R
L
H
-
L
S
V
A
D
L
-
L
F
V
-----------
I
T
-
L
-
P
F
W
A
V
-
D
A
V
---
A
N
-----
W
Y
F
G
N
-------
F
L
C
--
K
A
V
H
V
I
Y
T
-----
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
----------------
D
R
Y
-----
L
A
I
V
------------
H
A
T
N
S
Q
R
P
---
R
K
L
---------
L
---
A
E
K
V
V
Y
--
V
G
V
W
I
P
A
----------------
L
--
L
L
T
I
P
D
F
I
F
A
N
V
S
E
---------------------------
A
D
D
-----------
R
Y
I
C
D
R
----
F
Y
P
----------------------------------
N
D
--
L
W
V
V
V
F
----
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
---
C
I
I
I
S
-------
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
K
R
-----
K
-
A
L
-
K
----------
T
T
-
V
I
L
I
L
-
A
F
F
----
A
C
W
L
P
Y
Y
I
G
I
-
S
I
D
-
S
F
I
L
-
L
EI
I
K
Q
G
C
E
F
E
N
----
T
--------
V
H
K
W
I
S
I
T
------
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
---------------------------
47
Fugue
78.51
20%
-163
* C4 *
4UY5
2
EGTD_MYCS2
A:
[2-327]
--T
L
S
L
A
N
Y
L
A
A
D
S
A
A
E
A
----------
L
R
R
D
V
R
A
G
L
T
A
--------------
A
P
K
--
S
L
P
--------------------
P
K
W
---
F
Y
D
A
V
G
S
D
L
F
------
D
Q
I
T
-
R
L
P
E
Y
Y
-----
P
T
R
T
E
A
Q
I
L
-
R
T
R
S
A
E
I
I
A
A
-
A
G
A
D
T
L
-
V
E
L
G
----------
S
G
-
T
-
S
E
K
T
R
M
L
L
D
-
A
M
R
D
-----
A
E
---------------
L
L
R
R
F
I
P
F
-----
D
V
D
A
G
V
L
R
S
A
G
A
A
I
G
----------------
A
E
Y
PGIEI
D
A
V
C
------------
G
D
F
E
E
-------
H
L
---------
G
---
K
I
P
H
V
G
R
R
L
V
V
F
L
G
S
----------------
T
--
I
G
N
L
T
P
A
P
R
A
E
F
L
S
-----
T
-
L
------------
A
D
----
T
L
Q
P
-----------
G
D
--
S
L
----
L
L
G
T
D
-----
L
V
K
----------------
D
-------
T
G
--
R
L
V
R
A
Y
D
DAA
G
V
T
A
A
F
N
R
N
V
L
A
V
V
N
R
E
L
S
A
DFD
L
D
A
F
E
-------
H
V
A
K
W
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
R
I
-----
E
M
W
L
-
R
----------
A
R
T
A
Q
H
V
R
-
V
A
A
LD
L
E
V
D
F
A
A
G
--
E
E
M
L
T
E
-
V
S
C
K
-
F
----------
R
----
P
--------
E
N
V
V
A
E
L
A
E
A
GLRQ
T
H
W
W
T
D
P
A
G
D
F
G
L
S
L
A
V
R
L
E
H
H
H
H
---------------------------
33
HHSearch
78.24
16%
-147
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-314]
--------------------------------------------------------------------------------
N
K
Y
V
---
V
I
I
A
Y
A
L
V
F
L
------
L
S
L
L
-
G
N
S
L
V
M
-----
L
V
I
L
Y
S
R
V
G
-
R
S
V
T
D
V
Y
L
L
N
-
L
A
L
A
D
L
-
L
F
A
L
----------
T
--
L
-
P
I
W
A
A
-
S
K
--
V
-
N
G
-----
W
I
F
G
T
-------
F
L
C
--
K
V
V
S
L
L
K
E
-----
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
----------------
D
R
Y
-----
L
A
I
V
------------
H
A
T
R
T
L
T
Q
----
K
R
---------
H
---
L
V
K
F
V
C
--
L
G
C
W
G
L
S
----------------
M
--
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
-----
P
---------------------
N
N
S
-----------
S
P
V
C
Y
E
----
V
L
G
N
-------------------------
D
-------
T
A
--
K
W
R
M
V
L
----
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
---
G
F
T
L
R
-------
T
L
F
K
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
-----
R
-
A
M
-
R
----------
V
I
-
F
A
V
V
L
-
I
F
L
----
L
C
W
L
P
Y
N
L
V
L
-
L
A
D
-
T
L
M
R
-
T
QVIQE
S
C
E
R
R
N
----
N
--------
I
G
R
A
L
D
A
T
------
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
---------------------------
32
HHSearch
76.12
16%
-150
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-464]
---------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
------
A
I
V
F
-
G
N
G
L
V
C
-----
M
A
V
L
K
E
R
A
L
-
Q
T
T
T
N
Y
L
V
V
S
-
L
A
V
A
D
L
-
L
V
A
T
----------
L
V
-
M
-
P
W
V
V
Y
-
L
E
V
T
G
-
G
V
-----
W
N
F
S
R
-------
I
C
C
--
D
V
F
V
T
L
D
V
-----
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
----------------
D
R
Y
-----
T
A
V
V
------------
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
---------
R
---
R
V
A
L
M
I
--
T
A
V
W
V
L
A
----------------
F
--
A
V
S
C
P
L
L
F
G
F
N
T
T
-----------------------------
G
D
-----------
P
T
V
C
S
I
----
S
N
------------------------------------------
P
D
F
----
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
---
A
R
I
Y
V
-------
V
L
K
Q
R
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
-----
K
-
A
T
-
Q
----------
M
V
-
A
I
V
L
G
-
A
F
I
----
V
C
W
L
P
F
F
L
T
H
-
V
L
N
-
T
H
C
Q
-
T
C---------
H
----
V
--------
S
P
E
L
Y
S
A
T
------
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
---------------------------
31
HHSearch
75.87
17%
-136
- C2 -
1U19
13
OPSD_BOVIN
A:
[39-316]
--------------------------------------------------------------------------------
Q
F
S
M
---
L
A
A
Y
M
F
L
L
I
M
------
L
G
F
P
-
I
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
L
-
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
-
F
M
V
F
----------
G
G
-
F
-
T
T
T
L
Y
-
T
S
L
-
H
-
G
Y
-----
F
V
F
G
P
-------
T
G
C
--
N
L
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
----------------
E
R
Y
-----
V
V
V
C
------------
K
P
M
S
N
F
R
F
----
G
E
---------
N
---
H
A
I
M
G
V
--
A
F
T
W
V
M
A
----------------
L
--
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-----
P
---------------------
E
G
M
-----------
Q
C
S
C
G
I
----
D
Y
Y
T
P
------------------------
H
-------
E
E
--
T
N
N
E
S
F
----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---
G
Q
L
V
F
-------
T
V
K
E
A
A
A
QQQESA
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
-----
E
-
V
T
-
R
----------
M
V
-
I
I
M
V
I
-
A
F
L
----
I
C
W
L
P
Y
A
G
V
A
-
F
Y
I
-
F
T
H
Q
-
G
S---------
D
----
F
--------
G
P
I
F
M
T
I
P
------
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
---------------------------
28
HHSearch
75.14
15%
-134
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[59-485]
-----------------------------------------------------------------------------
K
E
N
S
I
K
L
---
T
S
V
V
F
I
L
I
C
C
------
F
I
I
L
-
E
N
I
F
V
L
-----
L
T
I
W
K
T
K
K
F
-
H
R
P
M
Y
Y
F
I
G
N
-
L
A
L
S
D
L
-
L
A
G
V
----------
A
Y
-
T
-
A
N
L
L
L
-
S
G
A
---
T
T
-----
Y
K
L
T
P
-------
A
Q
W
--
F
L
R
E
G
S
M
F
-----
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
----------------
E
R
Y
-----
I
T
M
L
------------
K
-----------
N
N
---------
F
---
R
L
F
L
L
I
--
S
A
C
W
V
I
S
----------------
L
--
I
L
G
G
L
P
I
M
G
W
N
C
I
-----------------------------
S
A
-----------
L
S
S
C
S
T
----
V
L
P
L
---------------------------------------
Y
H
K
H
----
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
---
C
R
I
Y
S
-------
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
--
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
-----
A
-
L
L
-
K
----------
T
V
-
I
I
V
L
S
-
V
F
I
----
A
C
W
A
P
L
F
I
L
L
-
L
L
D
-
V
G
C
K
-
V
KT--------
C
----
D
--------
I
L
F
R
A
E
Y
F
------
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
---------------------------
44
Fugue
71.96
19%
-164
- C3 -
4TR2
8
?
A:
[54-627]
DD
V
H
K
I
I
S
E
L
R
F
L
Q
K
V
E
T
----------
I
L
E
S
S
N
M
S
V
S
D
VEADANAYNPDRDA
P
K
E
--
E
L
Q
-
K
L
QDK
K
S
L
R
L
I
V
S
E
N
H
A
T
S
P
S
F
FEE
S
L
L
Q
E
D
V
V
S
F
------
I
Q
S
K
-
G
K
L
S
N
L
KNLK
S
M
I
I
D
L
N
S
D
M
T
D
E
E
L
A
E
Y
I
S
L
-
L
E
R
K
G
A
-
L
I
E
S
D
K
L
V
G
A
DYKF
N
D
-
E
-
Y
R
N
L
Q
-
W
G
L
-
D
-
L
A
RLDET
Q
D
L
I
N
A
N
RV
S
V
T
K
I
C
--
V
I
D
S
G
I
D
Y
-----
N
H
P
D
L
R
N
N
I
D
V
N
V
K
E
L
H
GRKGVDDDSNGVVD
D
V
Y
-----
G
A
N
F
VNNSGDPMDDNY
H
G
T
H
V
S
G
I
---
I
S
A
VGNNGIGIV
G
---
V
D
G
H
-
S
--
K
L
V
I
C
K
A
----------------
L
DQ
H
K
L
G
R
L
G
D
M
F
K
C
I
D
-----
Y
-
C
------------
I
S
R
QAH
M
I
N
G
S
F
S
F
D
E
YS
N
I
F
N
A
S
V
E
H
----
L
R
S
L
G
-----
I
L
F
----------------
F
-------
V
S
--
A
S
N
C
A
H
----
D
K
L
S
K
P
D
I
A
K
C
D
-
L
A
V
N
H
R
Y
---
P
P
I
L
S
KTHNN
V
I
A
V
A
N
L
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
E
S
-----
Y
-
S
L
-
S
----------
V
N
-
S
F
Y
S
N
-
I
Y
C
----
Q
L
A
A
P
G
T
N
I
Y
-
S
T
T
-
P
M
N
N
-
Y
----------
R
----
K
L
N
G
T
S
M
A
S
P
H
V
A
A
I
A
S
------
I
V
R
S
I
N
P
N
L
T
Y
L
Q
I
V
E
I
L
R
N
A
I
V
K
L
PSLTERVSWG
G
Y
V
D
I
L
R
A
V
N
L
A
I
D
S
K
48
Fugue
70.05
16%
-167
- C4 -
4Y5J
-
?
A:
[15-241]
-----------------
I
----------
L
P
A
E
I
L
N
G
L
V
D
--------------
S
N
W
K
N
R
L
A
-
A
----
V
E
Q
L
L
G
E
I
S
G
F
D
A
K
Q
----------------------
A
G
I
-
S
Q
I
L
I
R
-----
T
I
S
G
R
K
P
G
L
-
K
E
M
N
F
Q
V
L
K
F
-
K
L
D
I
I
R
-
S
V
A
E
----------
N
Y
-------------------------
P
L
-------
T
T
T
--
T
V
D
L
V
I
N
E
-----
I
I
E
K
L
A
D
A
K
N
G
A
A
A
A
----------------
D
V
L
-----
S
A
F
A
------------
E
A
T
---------------------------------------------------------------------
K
L
E
-----
Y
-
V
------------
V
G
----
K
V
L
S
-----------
F
A
F
E
--------------------------------------------
Q
--
K
S
P
K
V
Q
----
S
E
A
F
N
W
V
N
R
S
I
I
E
F
G
F
Q
L
Q
P
---
K
T
L
I
E
-------
D
V
R
K
G
V
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
-------
P
-
T
V
-
R
----------
A
S
-
A
I
Q
M
V
-
G
T
M
----
S
M
Y
M
G
---
K
A
-
L
M
M
-
F
F
D
S
-
E
----------
K
----
P
--------
A
L
K
S
Q
I
Q
V
------
E
F
D
K
N
V
G
E
K
P
P
K
P
V
R
G
V
----------------------------------
45
Fugue
67.37
18%
-106
- C3 -
4PE6
1
?
A:
[18-339]
-------------------------------
K
P
F
I
A
L
S
N
GFIG----------
N
G
W
--
R
Q
T
M
I
----
A
K
F
E
E
A
A
K
Q
A
Q
A
D
G
------------------------
L
I
-
G
K
Y
K
V
V
-----
N
A
P
G
N
N
S
A
T
-
E
Q
V
A
Q
I
K
S
L
L
-
L
Q
K
P
D
A
-
L
L
I
N
----------
P
A
-
S
-
P
T
A
L
Q
-
P
V
I
-
Q
-
Q
A
-----
C
D
A
G
V
-------
K
V
V
--
V
F
D
----
S
-----
A
I
D
A
P
C
A
Y
I
L
Q
N
S
F
V
----------------
D
W
A
-----
T
Y
A
A
------------
K
P
V
L
E
S
----------------------
I
G
G
K
G
--
N
V
I
V
V
R
G
VVGS
Q
P
E
A
E
M
Y
E
T
T
K
K
I
--
L
A
E
Y
P
Q
V
K
T
V
A
T
V
T
-----
G
M
C
------------
D
G
----
A
T
A
Q
-----------
K
A
V
L
G
V
----
L
P
S
V
S
TVD
A
V
I
G
C
----------------
G
-------
D
-------
G
Y
----
G
V
A
Q
A
F
A
T
A
G
K
P
I
P
A
V
T
F
E
T
---
N
G
R
A
L
-------
S
Y
W
K
D
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
G
S
-----
V
-
A
V
M
S
D
---------
P
A
-
Q
S
V
A
A
-
L
W
A
----
A
L
D
L
L
E
G
R
D
L
-
P
K
Q
M
T
F
P
I
V
L
----------
I
----
E
--------
E
K
D
R
D
T
W
A
------
S
V
L
K
P
D
E
Y
A
A
W
P
W
T
R
E
L
F
R
Q
Q
V
E
A
I
K
T
GGEPVQPPIPST------------
6
PsiBlast_PDB
62.61
25%
-148
- C2 -
4N6H
15
C562_ECOLX (first)
A:
[112-262]
-------------------------------------------------------------------------
G
S
P
G
A
R
S
A
S
S
----
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
-
G
N
V
L
V
M
-----
F
G
I
V
R
Y
T
K
M
-
K
T
A
T
N
I
Y
I
F
N
-
L
A
L
A
D
--
A
L
A
T
----------
S
T
-
L
-
P
F
Q
S
A
-
K
Y
L
-
M
-
E
T
-----
W
P
F
G
E
-------
L
L
C
K
A
V
L
S
I
D
Y
Y
N
-----
M
F
T
S
I
F
T
--
L
T
M
M
S
V
----------------
D
R
Y
-----
I
A
V
C
------------
H
P
V
K
A
L
D
F
---
R
T
P
---------
A
---
K
A
K
L
I
N
--
I
C
I
W
V
L
A
----------------
S
--
G
V
G
V
P
I
M
V
M
A
V
T
R
P
-----
R
-
D
------------
G
A
----
V
V
C
M
-----------
L
Q
F
P
S
P
----
S
W
Y
W
D
-----
T
V
T
----------------
K
-------
I
C
--
V
F
L
F
A
F
----
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
---
V
R
L
L
S
-------
G
S
K
E
K
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
I
-----
T
-
R
M
-
V
----------
L
V
-
V
V
G
A
F
-
V
V
C
----
W
A
P
I
H
I
F
V
I
V
-
W
T
L
-
V
D
I
D
-
R
----------
R
----
D
--------
P
L
V
V
A
A
L
H
------
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
---------------------------
41
Fugue
61.93
13%
-164
- C3 -
1L8Q
2
DNAA_AQUAE
A:
[2-324]
---------
D
F
L
N
P
K
Y
T
L
EN
F
I
V
G
EGN
R
L
A
Y
E
V
V
K
E
A
L
E
--------------
N
L
G
--
S
L
Y
-
N
----
P
-
I
F
I
Y
G
S
V
G
T
--------------
G
K
T
H
L
------
L
Q
A
A
-
G
N
E
A
K
K
--------
R
G
Y
R
V
I
-
Y
S
S
A
D
D
F
A
Q
A
M
V
E
H
L
K
K
G
T
I
N
E
----------
F
R
-
N
M
Y
K
S
V
D
-
L
L
L
-
L
D
D
V
-----
Q
F
L
S
G
-------
K
E
R
--
T
Q
I
E
F
F
H
I
-----
F
N
T
L
Y
L
L
E
K
Q
I
I
L
A
S
----------------
D
R
H
-----
P
Q
K
L
------------
D
G
V
S
--------------------------
D
R
L
--
V
S
R
F
E
G
G
----------------
I
--
L
V
E
I
E
L
D
N
K
T
R
F
K
I
-----
I
-
K
------------
E
K
----
L
K
E
F
-----------
N
L
E
L
R
K
----
E
V
I
D
Y
-----
L
L
E
----------------
N
-------
T
K
--
N
V
R
E
I
E
----
G
K
I
K
L
I
K
L
K
G
F
E
G
L
E
R
K
E
R
K
---
E
R
D
K
L
M
------
Q
I
V
E
F
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
A
V
-----
K
-
V
E
-
D
I
L
SDKRNKR
T
S
E
-
A
R
K
I
A
M
Y
L
C
----
R
K
V
C
S
A
S
L
I
E
-
I
A
R
-
A
F
K
R
-
K
----------
D
----
H
--------
T
T
V
I
H
A
I
R
------
S
V
E
E
E
K
K
R
K
F
K
H
L
V
G
F
L
E
K
Q
A
F
D
K
IC-------------------------