@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O56A3_HUMAN: (2016-01-12 )
MTTHRNDTLSTEASDFLLNCFVRSPSWQHWLSLPLSLLFLLAVGANTTLLMTIWLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLTIFWFDLRPISFPACFLQMYIMNCFLAMESCTFMVMAYDRYVAICHPLRYPSIITDHFVVKAAMFILTRNVLMTLPIPILSAQLRYCGRNVIENCICANMSVSRLSCDDVTINHLYQFAGGWTLLGSDLILIFLSYTFILRAVLRLKAEGAVAKALSTCGSHFMLILFFSTILLVFVLTHVAKKKVSPDVPVLLNVLHHVIPAALNPIIYGVRTQEIKQGMQRLLKKGC
Atome Classification :
(20 SA)
-------------------------------.........10--.........20------........30........40........50........60-.........70........80-..----.----.....90.....--------....100.-----......110....------..--..120.......130------------.......---140.......150.......160--.......170...-------....----------180.......190.....--..200.....-..210.......220...------....230--------....-------------------------------------------------------------------------------------------------------------------------------------------------------------------....-----240.......250.......----260.---.....---.270-..------..-....280.......290.........300..--.....310...--------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------MTTHRNDTLS---
T
E
A
S
D
F
L
L
N
C
F------VRSP
S
W
Q
H
W
L
S
L
P
L
S
L
L
F
L
L
AVGAN
T
T
L
L
M
T
I
W
LEASLH--
Q
P
L
Y
Y
L
L
S
L
L
S
L
L
D
I
V
L
C
L
T
V
-
I
P
----
K
----
V
L
T
I
F
W-FDLRP--------IS
F
P
A
C
F
L
-----
Q
M
Y
I
M
N
C
F
-
L
A
M
E
------S
C
--
T
F
M
V
M
A
YD
R
Y
V
A
I
CH------------PLRYP
S
I
---
I
T
D
H
F
V
V
K
A
A
M
F
I
L
T
R
N
V
L
M
TL
P
--
I
P
I
L
S
A
Q
L
R
Y
C
G
R
-------
N
V
I
E
----------
N
C
I
CANM
S
V
SRLSCDD
V
T
--
I
N
H
L
Y
Q
FAG
G
-
W
T
L
LG
S
D
L
I
L
I
F
L
S
Y
T
F
I
------
L
R
A
V
L
R
---------LKAE-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
V
A
-----
K
A
L
S
T
C
G
S
H
F
M
L
I
L
F
F
S
T
I
L
----
L
V
F
V
---
L
T
H
V
A
---KKK--VS------P
D
-
V
P
V
L
L
N
V
L
H
H
V
I
P
A
A
--
L
N
P
I
I
YGV
R
T
Q
E
I
K
--
Q
G
M
Q
R
L
L
KKGC--------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.92
25%
-166
- C1 -
4LDL
3
ADRB2_HUMAN
A:
[164-461]
-------------------------------
I
T
T
F
R
T
G
T
W
D
---
A
Y
A
A
D
---------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
--
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
----
I
L
T
K
T
W
---------------
T
F
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
-
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
------------
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
-------
E
A
I
-----------
N
C
Y
A
E
E
------
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
R
Q--------
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
E
H
-
K
A
L
K
T
L
G
---
I
I
M
G
T
F
T
L
C
W
----
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
D
N
L-
I
R
------
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
--
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
--
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.51
25%
-166
- C1 -
4LDE
3
A:
[164-461]
-------------------------------
I
T
T
F
R
T
G
T
W
D
---
A
Y
A
A
D
---------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
--
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
----
I
L
T
K
T
W
---------------
T
F
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
-
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
------------
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
-------
E
A
I
-----------
N
C
Y
A
E
E
------
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
R
Q--------
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
E
H
-
K
A
L
K
T
L
G
---
I
I
M
G
T
F
T
L
C
W
----
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
D
N
L-
I
R
------
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
--
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
--
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.49
25%
-166
- C1 -
4LDO
3
A:
[164-461]
-------------------------------
I
T
T
F
R
T
G
T
W
D
---
A
Y
A
A
D
---------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
--
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
----
I
L
T
K
T
W
---------------
T
F
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
-
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
------------
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
-------
E
A
I
-----------
N
C
Y
A
E
E
------
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
R
Q--------
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
E
H
-
K
A
L
K
T
L
G
---
I
I
M
G
T
F
T
L
C
W
----
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
D
N
L-
I
R
------
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
--
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
--
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.07
24%
-162
- C1 -
2YCW
7
ADRB1_MELGA
A:
[7-297]
---------------------------------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
--
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
----
G
A
T
L
V
----
V
R
G
--------
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
----------
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
------------
P
F
R
Y
Q
S
L
---
M
T
R
---
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
---
V
S
F
L
P
I
M
M
H
W
W
R
D
-------
E
D
P
Q
----------
A
L
K
C
Y
Q
D
P
----
G
C
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
---------
A
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
---
I
I
M
G
V
F
T
L
C
W
----
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
--
L
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
-
N
S
A
--
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
--
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
85.32
24%
-166
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
-----------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
--
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
----
G
A
T
L
V
----
V
R
G
--------
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
----------
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
------------
P
F
R
Y
Q
S
L
---
M
T
R
---
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
---
V
S
F
L
P
I
M
M
H
W
W
R
D
-------
E
D
P
Q
----------
A
L
K
C
Y
Q
D
P
----
G
C
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
---------
A
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
---
I
I
M
G
V
F
T
L
C
W
----
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
--
L
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
-
N
S
A
--
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
--
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.17
24%
-167
- C1 -
4GBR
1
ADRB2_HUMAN
A:
[4-284]
------------------------------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
--
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
----
I
L
T
K
T
W
---------------
T
F
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
-
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
------------
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
-------
E
A
I
-----------
N
C
------
Y
A
E
E
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
R
Q
L
Q
KIDKFC
L
K
E
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
---
I
I
M
G
T
F
T
L
C
W
----
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
D
N
L-
I
R
------
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
--
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
--
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.02
25%
-164
- C1 -
4QKX
2
ADRB2_HUMAN
A:
[164-461]
-------------------------------
I
T
T
F
R
T
G
T
W
D
---
A
Y
A
A
D
---------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
--
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
G
A
A
C
I
L
T
K
T
W
---------------
T
F
G
N
F
W
C
-----
E
F
W
T
S
I
D
V
-
L
C
V
T
------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
------------
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
-------
E
A
I
-----------
N
C
Y
A
E
E
------
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
R
Q--------
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
E
H
-
K
A
L
K
T
L
G
---
I
I
M
G
T
F
T
L
C
W
----
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
D
N
L-
I
R
------
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
-
N
S
G
--
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
--
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
84.74
20%
-158
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
--------------------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
--
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
----
G
A
A
H
I
L
-
M
K
M
W
T
--------
F
G
N
F
W
C
E
F
-----
W
T
S
I
D
V
L
C
-
V
T
A
S
------
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
------------
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
T
H
Q
-----------
E
----------
A
I
N
C
Y
A
E
----
E
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
----
F
I
V
N
---
I
V
H
V
I
---
Q
D
N
--
L
I
------
R
K
-
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
--
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
--
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.27
24%
-162
- C1 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
-----------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
--
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
----
G
A
T
L
V
----
V
R
G
--------
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
----------
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
------------
P
F
R
Y
Q
S
L
---
M
T
R
---
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
---
V
S
F
L
P
I
M
M
H
W
W
R
D
-------
E
D
P
Q
----------
A
L
K
C
Y
Q
D
P
----
G
C
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
---------
A
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
---
I
I
M
G
V
F
T
L
C
W
----
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
--
L
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
-
N
S
A
--
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
--
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
83.34
24%
-162
- C1 -
2YCY
6
ADRB1_MELGA
A:
[10-297]
------------------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
--
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
----
G
A
T
L
V
----
V
R
G
--------
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
----------
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
------------
P
F
R
Y
Q
S
L
---
M
T
R
---
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
---
V
S
F
L
P
I
M
M
H
W
W
R
D
-------
E
D
P
Q
----------
A
L
K
C
Y
Q
D
P
----
G
C
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
R
---------
A
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
---
I
I
M
G
V
F
T
L
C
W
----
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
--
L
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
-
N
S
A
--
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
--
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
82.89
24%
-163
- C1 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
------------------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
--
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
----
G
A
T
L
V
----
V
R
G
--------
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
-
A
S
I
E
----------
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
------------
P
F
R
Y
Q
S
L
---
M
T
R
---
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
---
V
S
F
L
P
I
M
M
H
W
W
R
D
-------
E
D
P
Q
----------
A
L
K
C
Y
Q
D
P
----
G
C
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
---
K
A
L
K
T
L
G
---
I
I
M
G
V
F
T
L
C
W
----
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
--
L
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
-
N
S
A
--
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
--
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
79.91
16%
-159
* C1 *
2Z73
5
OPSD_TODPA
A:
[32-332]
-----------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
--
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
----
L
----
M
T
I
S
C
F
-
L
K
K
W
I
--------
F
G
F
A
A
C
K
V
-----
Y
G
F
I
G
G
I
F
-
G
F
M
S
------
I
M
--
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
------------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
--
P
I
F
G
W
G
A
Y
T
L
E
-----------
G
V
----------
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
--
T
T
R
S
N
I
L
C
M
F
-
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
------
V
M
S
V
S
N
---------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
-----
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
----
A
V
V
A
---
L
L
A
Q
F
---
G
P
L
E-
W
V
------
T
P
-
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
--
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
--
E
A
I
S
Q
T
F
P
W
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
75.82
17%
-164
- C1 -
3EML
13
ENLYS_BPT4
A:
[22-468]
--------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
--
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
----
F
----
A
I
T
I
S
---
T
G
F
C
--------
A
A
C
H
G
C
L
F
-----
I
A
C
F
V
L
V
L
-
T
Q
S
S
------
I
F
--
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
------------
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
--
P
M
L
G
W
N
N
C
G
Q
------------------------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
E
V
-----
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
----
H
I
I
N
---
C
F
T
F
F
---
C
P
D
CS
H
A
------
P
L
-
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
--
Q
T
F
R
K
I
I
R
S
H
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
75.43
18%
-164
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
----------------------------------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
--
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
----
M
----
N
I
L
Y
L
L
-
M
S
K
W
S
--------
L
G
R
P
L
C
L
F
-----
W
L
S
M
D
Y
V
A
-
S
T
A
S
------
I
F
--
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
------------
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
--
I
L
G
W
N
-
H
---------------
R
R
----------
E
D
K
C
E
T
D
F
---------
Y
--
D
V
T
W
F
K
V
M
T
A
-
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
------
Y
K
A
V
R
Q
---------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
E
R
-----
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
----
F
I
F
F
---
M
V
I
A
F
---
C
K
N
--
C
C
------
N
E
-
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
--
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
--
K
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
75.13
16%
-160
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
---------------------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
--
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
----
L
----
Y
T
L
Y
T
V
-
I
G
Y
W
P
--------
L
G
P
V
V
C
D
L
-----
W
L
A
L
D
Y
V
V
-
S
N
A
S
------
V
M
--
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
------------
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
--
A
I
L
F
W
Q
F
I
V
G
V
R
---------
T
V
E
----------
D
G
E
C
Y
I
Q
F
---------
F
--
S
N
A
A
V
T
F
G
T
A
-
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
------
S
R
A
S
K
S
---------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
R
E
K
-----
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
----
N
V
M
V
---
L
I
N
T
F
---
C
A
P
--
C
I
------
P
N
-
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
--
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
--
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
74.94
14%
-141
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------MN
G
T
E
G
PNF
Y
V
P
F
S
N
K
T
G
V
---
V
R
S
P
F
E
A
P
Q
Y
Y
------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
--
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
----
T
L
Y
T
S
L
-
H
G
Y
F
V
--------
F
G
P
T
G
C
N
L
-----
E
G
F
F
A
T
L
G
-
G
E
I
A
------
L
W
--
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
------------
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
--
L
V
G
W
S
---
R
Y
I
P
E
-------
G
M
Q
C
----------
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
--
V
I
Y
M
F
V
V
H
---
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
------
V
K
E
A
A
A
---------
S
A
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
----
Y
A
G
V
---
A
F
Y
I
F
---
T
H
Q
--
G
S
------
D
F
-
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
--
N
C
M
V
T
T
L
C
C
G
K
NPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
73.86
15%
-162
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
--
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
----
W
----
V
V
Y
L
E
V
T
G
G
V
W
N
--------
F
S
R
I
C
C
D
V
-----
F
V
T
L
D
V
M
M
-
C
T
A
S
------
I
W
--
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
------------
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
--
L
L
F
G
F
N
T
T
G
--------------
D
----------
P
T
V
C
S
I
----------
S
N
----
P
D
F
V
I
Y
S
S
-
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
------
Y
V
V
L
K
Q
---------
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
-----
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
----
F
L
T
H
---
V
L
N
T
H
---
C
Q
T
C-
H
V
------
S
P
-
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
--
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
--
K
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
73.19
16%
-127
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------------------
M
N
G
T
E
G
P
N
F
Y
VPF
S
N
K
T
G
V
V
R
S
P
F
EAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
--
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
----
T
L
Y
T
S
L
-
H
G
Y
F
V
--------
F
G
P
T
G
C
N
L
-----
E
G
F
F
A
T
L
G
-
G
E
I
A
------
L
W
--
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
------------
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
--
L
V
G
W
S
---
R
Y
-----------
I
P
E
GM--------
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
------
V
K
E
A
A
A
---------
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
-----
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
----
C
W
L
P
---
Y
A
G
V
A
---
F
Y
I
--
F
T
H
QGSDF
G
P
-
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
--
N
C
M
V
T
T
L
C
C
G
K
NPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
73.12
14%
-134
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
--
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
----
G
A
A
H
I
L
-
M
K
M
W
T
--------
F
G
N
F
W
C
E
F
-----
W
T
S
I
D
V
L
C
-
V
T
A
S
------
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
------------
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
-------
H
W
-------
Y
R
A
T
----------
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
-
F
F
--
T
N
Q
A
Y
A
I
A
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
R
---------
Q
L
N
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
-----
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
I
G
H
---
L
L
T
K
S
---
P
S
L
--
N
A
------
A
K
-
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
--
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
51
Fugue
72.00
18%
-152
- C1 -
4KPP
4
?
A:
[2-396]
DF
T
K
E
K
F
Q
L
L
A
I
S
S
L
T
L
P
W
L
I
S
L
A
F
N
Y
H
H
P
A
L
T
Q
T
L
L
S
G
L
A
---
V
V
S
A
S
F
L
I
S
W
A
------
A
E
T
A
E
M
D
V
P
R
S
F
S
L
A
I
V
A
L
L
A
V
L
P
E
Y
A
V
D
G
Y
F
A
W
K
A
G
S
V
GG
E
Y
V
H
Y
A
T
A
N
M
T
G
A
N
R
L
L
I
G
I
G
-
W
S
----
L
----
V
A
F
I
A
F
-
R
T
L
K
S
K
E
V
E
L
D
DG
I
R
L
E
I
F
F
L
-----
F
L
A
T
L
Y
A
F
T
L
P
L
K
GHIS
P
F
D
A
--
L
V
F
V
S
L
Y
A
I
Y
I
Y
L
S
T
K
AER
E
E
V
E
V
G
G
V
P
A
Y
L
C
S
L
---
K
T
E
T
R
R
L
S
V
V
V
L
F
L
F
A
G
F
T
I
L
M
S
--
V
E
A
F
S
E
G
L
L
E
T
A
R
I
A
GID
E
F
L
A
V
Q
W
I
A
P
L
A
S
E
S
P
E
L
I
V
A
I
Y
F
V
R
R
F
R
V
S
A
S
M
--
N
A
L
I
S
S
K
V
N
Q
-
W
T
L
L
I
G
T
I
A
I
I
Y
S
I
S
A
F
K
------
L
Q
S
-
L
P
---------
L
D
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
E
E
-----
V
L
L
T
A
A
Q
S
L
F
A
V
A
I
L
L
D
L
K
I
S
W
K
E
A
S
A
L
---
F
L
L
F
I
---
V
Q
L
--
L
F
------
P
G
-
V
E
V
R
Y
I
I
S
A
I
Y
I
I
L
S
--
L
-
P
I
L
F
A
K
R
K
E
I
V
E
S
F
R
T
V
K
R
L
I
S
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------