@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O56A4_HUMAN: (2016-01-12 )
MASPSNDSTAPVSEFLLICFPNFQSWQHWLSLPLSLLFLLAMGANTTLLITIQLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLAIFWFDLRSISFPACFLQMFIMNSFLTMESCTFMVMAYDRYVAICHPLRYPSIITDQFVARAVVFVIARNAFVSLPVPMLSARLRYCAGNIIKNCICSNLSVSKLSCDDITFNQLYQFVAGWTLLGSDLILIVISYSFILKVVLRIKAEGAVAKALSTCGSHFILILFFSTVLLVLVITNLARKRIPPDVPILLNILHHLIPPALNPIVYGVRTKEIKQGIQNLLKRL
Atome Classification :
(20 SA)
--------.........10........20........30........40........50.....--...60........70........80..----.......-90........100-.......110....--...120.......130.-.....---.140.......150.......-160.......170.......180.......190..--.....200--.......210.......220.......230-------....-------------------------------------------------------------------------------------------------------------------------------------------------------------------....-------------------.240...---....250--.......260.......270--------.------........280.......290.......300.......310.---------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MASPSNDSTA
P
V
S
E
F
L
L
I
CFP
N
F
Q
S
W
Q
H
W
L
S
L
P
L
S
L
L
F
L
L
AMGAN
T
T
L
L
I
T
I
Q
L
E
A
--
S
LH
Q
P
L
Y
Y
L
L
S
L
L
S
L
L
D
I
V
L
C
L
T
V
-
I
P
----
K
V
L
A
I
F
W
-
F
D
L
RSIS
F
P
A
C
F
L
-
Q
M
F
I
M
N
S
F
LTMES
C
--
T
F
M
V
M
A
YD
R
Y
V
A
I
CHPL-RYP
S
I
---
I
T
D
Q
F
V
A
R
A
V
V
F
V
I
ARNAFVS-L
P
V
P
M
L
S
A
R
L
R
Y
C
A
G
N
I
I
K
N
C
I
CSNL
S
V
SKLSCDD--I
T
F
N
Q
L
Y
Q
--
F
V
A
G
W
TLLGS
D
L
I
L
I
V
I
S
Y
S
F
I
L
K
V
V
L
R
---------IKAE-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
V
A
-------------------
K
A
L
S
TCG---
S
H
F
I
L
I
L
--
F
F
S
T
V
L
L
V
L
V
I
T
N
L
A
RKR----------I------PPD
V
P
I
L
L
N
I
L
H
H
LIPP
A
L
N
P
I
V
YGV
R
T
K
E
I
K
Q
G
I
Q
N
L
L
K
RL---------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.04
23%
-156
- C4 -
2YCW
7
ADRB1_MELGA
A:
[8-297]
-------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
----
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
-------
C
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
---------
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
---------
V
Y
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
Q
I
R
K
IDRASKRKR
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
--
I
M
G
V
F
T
L
--
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
----------
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.00
23%
-155
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
--------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
----
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
-------
C
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
---------
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
---------
V
Y
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
Q
I
R
K
IDRASK
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
--
I
M
G
V
F
T
L
--
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
----------
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
88.44
23%
-155
- C4 -
2YCY
6
ADRB1_MELGA
A:
[10-297]
---------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
----
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
-------
C
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
---------
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
---------
V
Y
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
Q
I
RDRASKR
K
R
V
M
L
M
R
E
H
--
K
A
L
K
T
L
G
I
--
I
M
G
V
F
T
L
--
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
----------
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.39
23%
-158
- C4 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
----
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
-------
C
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
---------
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
---------
V
Y
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
Q
I
R
K
I
DRAS
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
--
I
M
G
V
F
T
L
--
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
----------
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
86.85
23%
-157
- C4 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
---------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
----
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
-------
C
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
---------
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
---------
V
Y
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
Q
IR
E
H
---------------
K
A
L
K
T
L
G
I
--
I
M
G
V
F
T
L
--
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
----------
V
------
P
D
W
L
F
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.07
24%
-157
- C4 -
4QKX
2
ADRB2_HUMAN
A:
[179-461]
-------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
G
A
A
C
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
E
E
------
T
C
C
D
--
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQ-------
K
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
-------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
--------------------
E
V
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
84.75
21%
-151
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
---------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
----
E
A
I
N
C
Y
A
E
----
E
T
C
C
D
--
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
-------------------
K
A
L
K
T
L
G
---
I
I
M
G
T
F
T
--
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----------
L
------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.42
24%
-152
- C4 -
4GBR
1
ADRB2_HUMAN
A:
[2-284]
-------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-------
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
------
Y
A
E
E
T
C
C
D
--
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
KIDKFC
L
K
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
--------------------
E
V
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.43
24%
-162
- C4 -
4LDE
3
A:
[179-461]
-------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-------
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
E
E
------
T
C
C
D
--
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQ-------
K
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
-------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
--------------------
E
V
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.42
24%
-161
- C4 -
4LDL
3
ADRB2_HUMAN
A:
[179-461]
-------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-------
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
E
E
------
T
C
C
D
--
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQ-------
K
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
-------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
--------------------
E
V
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.29
24%
-158
- C4 -
4LDO
3
A:
[179-461]
-------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-------
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
E
E
------
T
C
C
D
--
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
QLQ-------
K
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
-------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
--------------------
E
V
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
77.13
15%
-155
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
--
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
----
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
-
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
--
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
F
W
Q
F
I
V
G
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------
S
N
A
A
V
T
--
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
---------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
R
E
K
-------------------
K
V
T
R
T
I
L
---
A
I
L
L
A
F
I
--
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
----------
C
------
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.87
17%
-160
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
-------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
--
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
----
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
-
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
--
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
L
G
W
N
-
H
--------
R
R
E
D
K
C
E
T
D
F
Y
D
-----------
V
T
W
F
K
--
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
---------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
E
R
-------------------
K
A
A
K
Q
L
G
---
F
I
M
A
A
F
I
--
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
----------
C
------
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
75.48
15%
-157
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-332]
--------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
--
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
----
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
-
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
--
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
P
I
F
G
W
G
A
Y
T
L
E
----
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
--
D
S
T
T
R
S
N
I
--
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
-------------------
R
L
A
K
I
S
I
---
V
I
V
S
Q
F
L
--
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E---------
W
------
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
75.39
15%
-129
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
I
A
L
W
--
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-----
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
--
N
E
S
F
V
I
Y
M
--
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
---------
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
-------------------
Q
K
A
E
K
E
V
---
T
R
M
V
I
I
M
--
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
----------
F
T
H
QGSD
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
KNPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
75.15
17%
-152
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
--
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
----
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
-
F
V
T
L
D
V
M
M
C
T
A
S
I
W
--
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
G
F
N
T
T
G
-------
D
P
T
V
C
S
I
S
------------
N
--
P
D
F
V
--
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
---------
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
-------------------
K
A
T
Q
M
V
A
---
I
V
L
G
A
F
I
--
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C---------
H
------
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
75.14
16%
-162
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-467]
-----------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
--
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
-
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
--
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
F
ED
V
V
P
M
N
Y
M
V
--
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
E
V
-------------------
H
A
A
K
S
L
A
---
I
I
V
G
L
F
A
--
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
CS--------
H
------
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
73.46
14%
-141
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
I
A
L
W
--
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
W
S
---
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
VH
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
T
---------
Q
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
-------------------
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
--
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--
Q
G
S
----------
D
------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
KNPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
69.57
15%
-128
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
-------
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
---
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
-------------------
R
I
D
E
G
L
R
---
L
K
I
Y
K
D
T
--
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
----------
N
------
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
36
HHSearch
68.99
16%
-147
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-493]
-------------------------------
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
--
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
----
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
-
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
--
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
-
I
P
D
F
I
F
A
N
V
S
E
-----
A
D
D
R
Y
I
C
D
R
F
Y
P
N
--------
D
L
W
V
V
V
F
Q
--
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
---------
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
-------------------
K
A
L
K
T
T
V
---
I
L
I
L
A
F
F
--
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------