Atome 2 Filter

@TOME V2.3
(Nov 2016)

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Sequence color : MutatedHelixStrandConserved

Query sequence : O5AC1_HUMAN: (2016-01-12 )
MAEENKILVTHFVLTGLTDHPGLQAPLFLVFLVIYLITLVGNLGLMALIWKDPHLHTPIYLFLGSLAFADACTSSSVTSKMLINFLSKNHMLSMAKCATQFYFFGSNATTECFLLVVMAYDRYVAICNPLLYPVVMSNSLCTQFIGISYFIGFLHSAIHVGLLFRLTFCRSNIIHYFYCEILQLFKISCTNPTVNILLIFIFSAFIQVFTFMTLIVSYSYILSAILKKKSEKGRSKAFSTCSAHLLSVSLFYGTLFFMYVSSRSGSAADQAKMYSLFYTIIIPLLNPFIYSLRNKEVIDALRRIMKK

Atome Classification :

	(20 SA)									-----------------------.........10.......-.20....---....30....-----....40........50........60........70-...-..-.-..80.....--------...90.......--.----------------100----.-..-....110.......120-.......130...---....-----140....-...150.....-..-----160.......170.......180-........-------190----------..---..-.---------....--200.......210.--..----------....220...-----------....230----------.--------------------..---.....240....-----...250-----.-----......260.--.--.---.-----...-270-.----------..-.------....-----280.......290.......300.....-------------------------
		(Atome)	(Ident)	(Tito)	(Num)		(Ligand)	(Uniprot)		-----------------------MAEENKILVTHFVLTGLT-DHPGLQA---PLFLVFLVIY-----LITLVGNLGLMALIWKDPHLHTPIYLFLGSLAFADA-CTS-SS-V-TSKMLINFL--------SKNHMLSMAKCA--T----------------QFY----F-FG-SNATTECFLLVVMAYDR-YVAICNPLLYPVV---MSNS-----LCTQFIG-ISYFIGFLHSA-IH-----VGLLFRLTFCRSNIIHYFYCE-I-LQLFKISC-------T------------NP---TV-N---------ILLI--FIFSAFIQVFTFMT--LI----------VSYSYILSAI-----------LKKKSE-----------K--------------------GR---SKAFSTCSAHLL-----SVSLFY-----G-----TLFFMYVSSR--S--G---S-----AAD-QA--K----------MY-S------LFYT-----IIIPLLNPFIYSLRNKEVIDALRRIMKK-------------------------
33	HHSearch	88.26	16%	-144	- C3 -	2Z73		OPSD_TODPA	A:[34-331]	-----------------------------------------------YY---SLGIFIGICG-----IIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDF-TFS-LV-NGFPLMTISCF--------LKKWIFGFAACK--V----------------YGF----I-GG-IFGFMSIMTMAMISIDR-YNVIGRPMAASKK---MSHR-----RAFIMII-FVWLWSVLWAI-GP-----IFG-WG--AYT-LEGVLCNCS-F-DYIS------------------------RD---ST-T---------RSNI--LCMFILGFFGPILI--IF----------FCYFNIVMSV-----------SNHEKE-----------MAAMAKRLNAKELRKAQAGANAE---MRLAKISIVIVS-----QFLLSW-----S-----PYAVVALLAQ--F--G---PLEW--VTP-YA--A----------QL-P------VMFA-----KASAIHNPMIYSVSHPKFREAISQTFPW-------------------------
38	Fugue	84.94	16%	-116	- C3 -	1F88		OPSD_BOVIN	A:[1-348]	----------MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYL-AEPWQFS---MLAAYMFLLI-----MLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADL-FMV-FG-G-FTTTLYTSL--------HGYFVFGPTGCN--L----------------EGF----F-AT-LGGEIALWSLVVLAIER-YVVVCKPM-SNFR---FGEN-----HAIMGVA-FTWVMALACAA--------------------PPLVGWSRY-I-PEGMQCSC-------GIDYYTPHEETNNES---FV-I---------YMFVVHFIIPLIVIFFCYGQ--LV----------FTVKEAAASA-----------TTQKAE-----------K--------------------EV---TRMVIIMVIAFL-----ICWLPY-----A-----GVAFYIFTHQ--G--S---D-----FGP-IF--M----------TI-P------AFFA-----KTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPSTTVSKTETSQVAPA------
28	HHSearch	80.37	15%	-141	- C3 -	2KS9		NK1R_HUMAN	A:[34-322]	----------------------------------------------------LWAAAYTVIV-----VTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEA-SMA-AF-N-TVVNFTYAV--------HNEWYYGLFYCK--F----------------HNF----F-PI-AAVFASIYSMTAVAFDR-YMAIIHPLQPRL-----SAT-----ATKVVIC-VIWVLALLLAF-PQ-----GYY--S-TT-E-TMPSRVVCM-I-EWPEHPN----------------------K---IY-E---------KVYH--ICVTVLIYFLPLLV--IG----------YAYTVVGITL-----------WASEIPGDSSDRYHEQVS--------------------AK---RKVVKMMIVVVC-----TFAICW-----L-----PFHIFFLLPY--INPD---LY----LKKFIQQVY----------LA-I------MWLA-----MSSTMYNPIIYCCLNDRFRLGFKHAFRC-------------------------
39	Fugue	78.99	16%	-119	- C3 -	1U19		OPSD_BOVIN	A:[4-349]	-----------MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFS---MLAAYMFLLI-----MLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADL-FMV-FG-G-FTTTLYTSL--------HGYFVFGPTGCN--L----------------EGF----F-AT-LGGEIALWSLVVLAIER-YVVVCKPMS-------------------------NFRFGENHAI-MG-----VAFTWVMALACAAPPLVGWSRYI-PEGMQCSCGIDYYTPH------------EE---TN-N---------ESFV--IYMFVVHFIIPLIV--IF----------FCYGQLVFTVKEAAAQQQESATTQKAE-----------K--------------------EV---TRMVIIMVIAFL-----ICWLPY-----A-----GVAFYIFTHQ--G--S---D-----FGP-IF--M----------TI-P------AFFA-----KTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA
44	Fugue	75.67	15%	-163	- C3 -	4IIK		SIDD_LEGPH	A:[1-314]	---------------------------MRSIITQICN-GVL-HGQSYQSGSNDLDKGNSEIF-----ASSLFVHLNEQGKEIKDSDDKIVIGYTKDGMAFQIV-VDGFYG-C-ERQAVFSFI--------DNYVLPLIDNFS--L----------------DLT----R-YPDSKKVTESLIHTIYSLRS-KHAPLAEFTMSLC---VTYQ-----KDEQLFC-AGFGIG-------D-----TGIAIKRN--EGTIEQLVCHT-E-VDGFKDAF-------D------------NY---SS-A---------NIDL--VIERNSVFNTKVMPGDEL----------VGYTYVPPML-----------EMTEKE-----------F--------------------EV---EK--RIVRHLNL-----DPGNFD-----DKDPLFSQLLQVVKSK--Q--K---Q-----LVE-QA--K----------ET-G------QIQRFGDDFTVGRLVIP------DQLLINQLRIHALS-------------------------
27	HHSearch	74.04	15%	-131	- C3 -	2LNL	-	CXCR1_HUMAN	A:[40-322]	------------------------------------------------Y---VVIIAYALVF-----LLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADL-LFA-L--T-LPIWAASKV---------NGWIFGTFLCK--V----------------VSL----L-KE-VNFYSGILLLACISVDR-YLAIVHATRTLT----QKRH-----LVKFVCL-GCWGLSMNLSL-PF-----FLF--R-QAYH-PNNSSPVCY-E-VLGND----------T------------A----KW-R---------MVLR--ILPHTFGFIVPLFV--ML----------FCYGFTLRTL-----------FKAH-M-----------G--------------------QK---HRAMRVIFAVVL-----IFLLCW-----L-----PYNLVLLADTLMR--TQVIQESCERRNN-IGRAL----------DA-T------EILG-----FLHSCLNPIIYAFIGQNFRHGFLKILAM-------------------------
45	Fugue	73.69	20%	-164	- C3 -	3WI3		SLD3_YEAST	A:[8-275]	-----------------------YSDPKEYIESKYYDALFS---------------------------------------------IHTP----------------------------LAYF--------VKSNLVRLKNTC--R----------------TKY-------G-S--------------DS-YKIAYQAMLQKFL---LS-------------------IVQFKDR-HD-----NRLLLEPF--SSPIADEKRKN-C-LTKFVIQD-------E------------NKNSSTI-A---------DLCV--VLKSREIKLQILLL--LE----------IIGLNDLDWN-----------FRDFD---------------------------------------------YCEQL-----DLYLDR-----A-----CILDILLSSE--T--G---T-----IQE-HK--KNILDKSKEASLV-G------FINY-----VLIPYFN--------KKVPHAVEFIIQKLKGPS--------------------
31	HHSearch	72.08	14%	-132	- C3 -	1U19		OPSD_BOVIN	A:[42-324]	----------------------------------------------------MLAAYMFLLI-----MLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADL-FMV-FG-G-FTTTLYTSL--------HGYFVFGPTGCN--L----------------EGF----F-AT-LGGEIALWSLVVLAIER-YVVVCKPMSNFR----FGEN-----HAIMGVA-FTWVMALACAA-PP-----LVG-WS--RYI-PEGMQCSCG-I-DYYTP----------H------------EE---TN-N---------ESFV--IYMFVVHFIIPLIV--IF----------FCYGQLVFTV-----------KEAAAQ-----------QQESATTQK------------AE---KEVTRMVIIMVI-----AFLICW-----L-----PYAGVAFYIFTHQ--GS--D-----FGP-IF--M----------TI-P------AFFA-----KTSAVYNPVIYIMMNKQFRNCMVTTLCC-------------------------
23	HHSearch	70.16	20%	-139	- C3 -	2RH1		ADRB2_HUMAN (first)	A:[40-235]	-----------------------------------------------VV---GMGIVMSLIV-----LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADL-VMG-LA-V-VPFGAAHIL--------MKMWTFGNFWCE--F----------------WTS----I-DV-LCVTASIETLCVIAVDR-YFAITSPFKYQSL---LTKN-----KARVIIL-MVWIVSGLTSF-LP-----IQMHWY----RATHQEAINCY-A-E----ETC-------C------------DF---FT-N---------QAYA--IASSIVSFYVPLVI--MV----------FVYSRVFQEA-----------KRQLNI-----------F--------------------EM---LRIDEGLRLKIY-----KDTEGY-----Y-----TIGIGHLLTK--S--P---S-----LNA-AK--S----------EL-D------KAIG-----RNTNGVITKDEAEKLFNQDVDAAVRGIL-------------------------
26	HHSearch	67.03	20%	-153	- C3 -	3EML		ENLYS_BPT4	A:[23-221]	----------------------------------------------------VYITVELAIA-----VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADI-AVG-VL-A-IPFAITIST----------GFCAACHGCL--F----------------IAC----F-VL-VLTQSSIFSLLAIAIDR-YIAIRIPLRYNGL---VTGT-----RAKGIIA-ICWVLSFAIGL-TP-----MLG-WN--NCGQ----SQGCG-E-GQ---VAC-------L------------FE---DVVPM--------NYMV--YFNFFACVLVPLLL--ML----------GVYLRIFLAA-----------RRQLNI-----------F--------------------EM---LRIDEGLRLKIY-----KDTEGY-----Y-----TIGIGHLLTK--S--P---S-----LNA-AK--S----------EL-D------KAIG-----RNTNGVITKDEAEKLFNQDVDAAVRGIL-------------------------
47	Fugue	66.59	15%	-99	- C2 -	4MVD		PCY1A_RAT	A:[60-315]	-----------------------GLRQPAPFSDEIEVDFSK-PYVRVT-----------------------------MEEACRGTPCERPVRVYADGIF--DL-FHS-GH-A-RALMQAKNL--------FPNTYLIVGVCS--D----------------ELT----H-NF-KGFT------VMNENER-YDAVQHCRYVDEV---VRNA-----------P-WTLTPEFLAE-------------HRIDFVAHDDIPY----------------------S------------SA---GS-D---------DVYK--HIKEAGMFAPTQRT--EG----------ISTSDIITRI-----------VRDYDV-----------Y--------------------AR---RNLQRTAKELNV-----SFINEK-----K-----YHLQERVDKV--K--K---K-----VKD-VE--E----------KS-K------EFVQ-----KVEEKSIDLIWEEKSREFIGSFLEMFGP-------------------------
21	HHSearch	65.28	21%	-159	- C3 -	3UON		ACM2_HUMAN (first)	A:[25-215]	----------------------------------------------------FIVLVAGSLS-----LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADL-IIG-VF-S-MNLYTLYTV--------IGYWPLGPVVCD--L----------------WLA----L-DY-VVSNASVMNLLIISFDR-YFCVTKPLTYPVK---RTTK-----MAGMMIA-AAWVLSFILWA-PA-----ILF-WQ-FIVGVRTVEDGECY-I-QFF-------------------------------S-N---------AAVT--FGTAIAAFYLPVII--MT----------VLYWHISRAS-----------KSRINI-----------F--------------------EM---LRIDEGLRLKIY-----KDTEGY-----Y-----TIGIGHLLTK--S--P---S-----LNA-AK--S----------EL-D------KAIG-----RNTNGVITKDEAEKLFNQDVDAAVRGIL-------------------------
22	HHSearch	65.22	20%	-146	- C3 -	3RZE		ENLYS_BPT4 (first)	A:[11-200]	-----------------------------------------------------LVVVLSTIC-----LVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADL-IVG-AV-V-MPMNILYLL--------MSKWSLGRPLCL--F----------------WLS----M-DY-VASTASIFSVFILCIDR-YRSVQQPLRYLKY---RTKT-----RASATIL-GAWFLSFLWVI-PI-----LG--WN-H------RREDKCE-T-DFY-------------------------------D-V---------TWFK--VMTAIINFYLPTLL--ML----------WFYAKIYKAV-----------RQHCNI-----------F--------------------EM---LRIDEGLRLKIY-----KDTEGY-----Y-----TIGIGHLLTK--S--P---S-----LNA-AK--S----------EL-D------KAIG-----RNTNGVITKDEAEKLFNQDVDAAVRGIL-------------------------
19	PsiBlast_PDB	62.71	27%	-140	- C3 -	4BVN		ADRB1_MELGA	A:[11-150]	-----------------------------------------------EA---GMSLLMALVV-----LLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADL-VVG-LL-V-VPFGATLVV--------RGTWLWGSFLCELWT----------------SLD----V-LC-VTASVET--LCVIAIDR-YLAITSPFRYQSL---MTRARAKVIICTVW-A-ISALVSFLPIM-MH-----WWRDEDPQALKCYQDPGCCDF-V-TNRAYAIA-------S------------SI---IS-F---------YIPL--LIMIFVALRVYREA--KE----------QIRKRKTSRV-----------MLMREH-----------K--------------------AL---KTLGIIMGVFTL-----CWLPFF-----L-----VNIVNVFNRD--L--V---P-----KWL-FV--A----------FN-W------LGYA-----NSAMNPIILCRSPDFRKAFKRLLA-----------------------------
20	PsiBlast_PDB	62.03	27%	-134	- C3 -	2VT4		ADRB1_MELGA	A:[11-150]	-----------------------------------------------EA---GMSLLMALVV-----LLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADL-VVG-LL-V-VPFGATLVV--------RGTWLWGSFLCELWT----------------SLD----V-LC-VTASIET--LCVIAIDR-YLAITSPFRYQSL---MTRARAKVIICTVW-A-ISALVSFLPIM-MH-----WWRDEDPQALKCYQDPGCCDF-V-TNRAYAIA-------S------------SI---IS-F---------YIPL--LIMIFVALRVYREA--KE----------QIREHKALKT-----------LGIIMG-----------V--------------------FT---LCWLPFFLVNIV-----NVFNRD-----L-----VPDWLFVAFN--W--L---G-----YAN-SA--M----------NP-I------IYCR-----SPDFRKAFKRLLA----------------------------------------
32	HHSearch	61.11	19%	-134	- C3 -	3V2Y		ENLYS_BPT4	A:[63-249]	-----------------------------------------------IK---LTSVVFILIC-----CFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDL-LAG-VA-Y-TANLLLSGA---------TTYKLTPAQWF--L----------------REG----S-MF-VALSASVFSLLAIAIER-YITMLK-----------NNF-----RLFLLIS-ACWVISLILGG-LP-----IMG-W-----NC-ISALSSCS-T-VLPL-----------------------------Y--H---------KHYI---LFCTTVFTLLLLS--IV----------ILYCRIYSLV-----------RTRNIF-----------E--------------------ML---RIDEGLRLKIYK-----DTEGYY-----T-----IGIGHLLTKS--P--S---L-----NAA-KS--E----------LD-K------AIGR-----NTNGVITKDEAEKLFNQDVDAAVRGILR-------------------------
30	HHSearch	60.40	18%	-142	- C3 -	3PBL		DRD3_HUMAN (first)	A:[41-226]	-----------------------------------------------------YALSYCALI-----LAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADL-LVA-TL-V-MPWVVYLEVT-------GGVWNFSRICCD--V----------------FVT----L-DV-MMCTASIWNLCAISIDR-YTAVVMPVHYQHGTGQSSCR-----RVALMIT-AVWVLAFAVSC-PL-----LFG-FN--TT----GDPTVCS-------------------------------IS---NP-D-----------FV--IYSSVVSFYLPFGV--TV----------LVYARIYVVL-----------KQRRRK-----------N--------------------IF---EMLRIDEGLRLK-----IYKDTE-----G-----YYTIGIGHLL--T--K---S-----PSL-NA--A----------KS-E------LDKA-----IGRNTNGVITKDEAEKLFNQDVDAAVRG-------------------------
15	PsiBlast_PDB	60.01	24%	-134	- C3 -	3RZE		ENLYS_BPT4 (first)	A:[10-138]	----------------------------------------------------PLVVVLSTIC-----LVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADL-IVG-AV-V-MPMNILYLL--------MSKWSLGRPLCL--F----------------WLS----M-DY-VASTASIFSVFILCIDR-YRSVQQPLRYLKY---RTKT-----RASATIL-GAWFLSFLWVI-PI-----LGWNHRREDKCETDFYDVTWF-K-VMTAIINF-------Y------------LP---TL-L---------MLWF--YAKIYKAVRQHCNI--FE----------MLRIDEGLRL-----------KIYKDT-----------E--------------------GY---YTIGIGHLLTKS-----PSLNAA-----K-----SELDKAIGRN--T--N---G-----VIT-KD--E----------AE-K------LFNQ-----DVDAAVRGILRNAKLKPVYDSLDAVRRA-------------------------
42	Fugue	58.95	16%	-142	- C1 -	4DN7		?	A:[24-428]	QTEQVSLKKRAESAAEKKAAFGEDFELEKYEEGSKVSKPIE-DLQSLDE---ESKKTLLQVG-----VIPSEEGRSGSFLVLDNAVSHSTLKD-----KNVELMSTH-KAME-KYEWLKDYSWKLVQVDADKYTAKTYLEDA--DGYFIRVPAGKKTSMPVQTC----LMLG-SKKAAQTVHNIIIVEEGATLDIITGCTTKKG---VEEG-----LHLGISEMYIKKGGTLNFTMIHNWAEQIGVRPRTVVSVEEGGTYVSNY-ICLKPVRSVQ-------T------------YP---TV-RLEGEGAVTRLNTI--AIAHPGSELDLGSK--AIFNAPGTRAELISRTITIGGR-----------LIARGEM----------I--------------------GNAKGAKGHLECKGLVLTDKGSQLAIPILEANVD-----DIELTHEAAV--G--K---I-----AKD-QV--E----------YLMARGLTEDEAVGM----IIRGFLDVGIRGIP-EELKEEIENTIAQTALG---------------------
10	PsiBlast_PDB	58.46	26%	-163	- C3 -	4MQT		ACM2_HUMAN	A:[36-170]	------------------------------------------------K---TFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADL-IIG----V-FSMNLYTLY--------TVIGYWPLGPVV--C----------------DLWLALDY-VV-SNASV--MNLLIISFDR-YFCVTKPLTYPVK---RTTK-----MAGMMIA-AAWVLSFILWA-PA-----ILFWQFIVGVRTVEDGECYIQ-F-FSNAAVTF-------G------------TA---IA-A---------FYLP--VIIMTVLYWHISRA--SK----------PSREKKVTRT-----------ILAILL-----------A--------------------FI---ITWAPYNVMVLI-----NTFCAP-----C-----IPNTVWTIGY--W--L---C-----YIN-ST--I----------NP-A------CYAL-----CNATFKKTFKHLLMC--------------------------------------