@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O5AP2_HUMAN: (2016-01-12 )
MRLMKEVRGRNQTEVTEFLLLGLSDNPDLQGVLFALFLLIYMANMVGNLGMIVLIKIDLCLHTPMYFFLSSLSFVDASYSSSVTPKMLVNLMAENKAISFHGCAAQFYFFGSFLGTECFLLAMMAYDRYAAIWNPLLYPVLVSGRICFLLIATSFLAGCGNAAIHTGMTFRLSFCGSNRINHFYCDTPPLLKLSCSDTHFNGIVIMAFSSFIVISCVMIVLISYLCIFIAVLKMPSLEGRHKAFSTCASYLMAVTIFFGTILFMYLRPTSSYSMEQDKVVSVFYTVIIPVLNPLIYSLKNKDVKKALKKILWKHIL
Atome Classification :
(20 SA)
--------........-.10........20........30--........40........50........60........-70........---80..-..-....90........100------.........-------------110.......120........---------------130.......140...-------------------------.-.-..150-.........160.......170.......180-....-...190...------.-.--..--200.......210.......220-.....---....230.---------...------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------.-----.-240-..-------.......250---------------.........260-------.......270----...--------...-----------.280.------------------------...-...290......--.300.......310....----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------M
R
L
M
K
E
V
R-GR
N
Q
T
E
V
T
E
F
L
LLGLSDNP
D
L
Q
G
--
V
L
F
A
L
F
L
L
I
Y
M
A
N
M
VGNL
G
M
I
V
L
I
K
I
D
L
C
LH
T
P
M
Y
F
F
L
-
S
S
L
S
F
VDASY---SSSV-
T
P
-
K
M
L
V
N
L
M
AENK
A
I
S
F--------HG
C
A
A
Q
F
Y
F
-------------
F
G
S
F
L
G
T
E
C
F
L
-
L
A
M
M
A
Y
D
R
Y
---------------
A
A
I
W
N
P
L
L
Y
P
V
LVSG
R
-------------------------
I
-
C
-
F
L
L
---
I
A
T
S
F
L
AGCGNA
A
I
HT
G
M
T
F
R
L
S
FCGSNRI
N
H
-
F
YCD-TP
P
L
L
K
L
SC------S-D--TH--FN
G
I
V
I
M
A
F
S
S
F
I
V
I
S
C
V
M
I
V
---
L
I
S
Y
L
---
C
I
F
I
A
V
LK---------MPS------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------E-----
G
-
R
---
H
K
-------
A
F
S
T
C
A
S
Y
-----------------
L
M
A
V
T
I
F
F
G
T
I
L
-------
F
M
YLRPTSSY----SM
E
--------
Q
D
K
-----------
V
V
S
V
F
------------------------
Y
T
V
-
I
I
P
V
L
N
P
L
I
Y
S
L--K
N
K
D
V
K
K
A
L
K
K
I
L
W
K
HIL----------------------
6
PsiBlast_PDB
83.59
21%
-161
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[14-308]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
---
G
V
L
A
-
I
P
-
F
A
I
T
--
I
S
T
G
F
C
A
A
C
--------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
R
-----
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
L
-----------------
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
5
PsiBlast_PDB
81.43
21%
-161
- C5 -
3VG9
8
?
A:
[14-308]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
---
G
V
L
A
-
I
P
-
F
A
I
T
--
I
S
T
G
F
C
A
A
C
--------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
R
-----
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
L
-----------------
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
21
HHSearch
77.98
19%
-143
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------
V
--
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
-
F
S
L
A
C
A
D
L
I
I
---
G
V
F
S
-
M
N
-
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
--------
V
V
C
D
L
W
L
A
L
-------------
D
Y
V
V
S
N
A
S
V
M
N
-
L
L
I
I
S
F
D
R
Y
---------------
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
-------------------------
M
-
A
-
G
M
M
---
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
V
E
D
-
G
E
C
Y
-
I
Q
F
F
S
--------------------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
---
T
V
L
Y
W
---
H
I
S
R
A
S
K
S
---------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------
S
-----
R
-
E
---
K
K
-------
V
T
R
T
I
L
A
I
-----------------
L
L
A
F
I
I
T
W
A
P
Y
N
-------
V
M
V
L
I
N
T
F
C
A
PC--
I
P
N
--------
T
V
W
-----------
T
I
G
Y
W
------------------------
L
C
Y
-
I
N
S
T
I
N
P
A
C
Y
A
L
--
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------
27
HHSearch
77.33
18%
-154
* C5 *
3EML
13
ENLYS_BPT4
A:
[21-469]
--------------------------------------
S
S
--
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
---
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
--
G
F
C
A
A
C
--------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
-------------------------
R
-
A
-
K
G
I
---
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
-
Q
G
C
G
-
E
G
Q
V
---
A
C
------
L
-
F
--
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------
Q
-----
K
-
E
---
V
H
-------
A
A
K
S
L
A
I
I
-----------------
V
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
T
F
F
C
P
DCSH
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
23
HHSearch
74.36
18%
-147
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------
V
V
--
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
-
T
S
L
A
C
A
D
L
V
M
---
G
L
A
V
-
V
P
-
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
--------
F
W
C
E
F
W
T
S
I
-------------
D
V
L
C
V
T
A
S
I
E
T
-
L
C
V
I
A
V
D
R
Y
---------------
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
-------------------------
K
-
A
-
R
V
I
---
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
----
T
H
Q
E
A
-
I
N
C
Y
-
A
E
E
----
T
C
------
C
-
D
--
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
---
V
F
V
Y
S
---
R
V
F
Q
E
A
K
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
-------
L
-----
K
-
E
---
H
K
-------
A
L
K
T
L
G
I
I
-----------------
M
G
T
F
T
L
C
W
L
P
F
F
-------
I
V
N
I
V
H
V
I
Q
D
NL--
I
R
K
--------
E
V
Y
-----------
I
L
L
N
W
------------------------
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
C
---
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------
17
PsiBlast_PDB
74.05
23%
-142
- C5 -
3EML
9
ENLYS_BPT4
A:
[18-301]
-------------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
---
G
V
L
A
-
I
P
-
F
A
I
T
--
I
S
T
G
F
C
A
A
C
--------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
---------
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
-----
G
L
R
---
L
K
-------
I
Y
K
D
T
E
G
Y
-----------------
Y
---
T
I
G
I
G
H
L
L
-------
T
K
S
P
S
L
N
A
A
K
----
S
-
E
--------
L
D
K
-----------
A
I
G
R
N
------------------------
T
N
G
-
V
I
--
T
K
D
E
A
E
K
L
--
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
----------------------
18
PsiBlast_PDB
73.85
23%
-133
- C5 -
3QAK
2
ENLYS_BPT4
A:
[18-301]
-------------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
---
G
V
L
A
-
I
P
-
F
A
I
T
--
I
S
T
G
F
C
A
A
C
--------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
---------
Q
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
---------
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
-----
G
L
R
---
L
K
-------
I
Y
K
D
T
E
G
Y
-----------------
Y
---
T
I
G
I
G
H
L
L
-------
T
K
S
P
S
L
N
A
A
K
----
S
-
E
--------
L
D
K
-----------
A
I
G
R
N
------------------------
T
N
G
-
V
I
--
T
K
D
E
A
E
K
L
--
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
----------------------
47
Fugue
73.61
21%
-180
- C2 -
4QT9
2
?
A:
[19-432]
----------
L
S
D
D
A
L
M
D
T
V
Q
R
R
T
F
L
Y
F
W
E
G
A
E
P
N
S
G
L
--------
A
P
E
R
Y
H
V
D
G
V
Y
P
Q
N
D
A
N
V
V
T
------
S
G
G
S
G
F
G
I
M
A
I
L
A
G
I
D
R
G
Y
VT
R
E
E
G
L
-
A
R
M
E
R
I
V
S
F
L
E
K
--
A
D
R
F
--------
H
G
A
Y
P
H
W
W
Y
GDTGKVKPFGQKD
N
G
G
D
L
V
E
T
A
F
L
M
Q
G
L
L
A
V
H
Q
Y
Y
A
NGN
D
K
E
K
A
I
A
Q
R
I
D
R
L
W
R
E
V
D
W
D
W
Y
R
K
G
G
QNVLYWHWSPTYGWEMD
F
P
I
H
G
YNE
C
M
I
M
Y
I
L
---
A
A
A
S
P
T
H
G
V
P
A
A
V
Y
H
D
G
------
W
A
Q
N
G
A
I
V
S
-
P
H
K
V
-
E
G
I
E
L
H
L
R
Y
------
Q
-
G
--
T
E
--
A
-
G
P
L
F
W
A
Q
Y
S
F
L
G
L
D
P
V
G
L
K
DEY
C
P
S
Y
F
H
E
M
R
N
L
T
L
V
N
R
---------
A
Y
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
R
-----
N
-
P
---
K
H
YKGFGPD
C
W
G
L
T
A
S
Y
SVDGYAAHSPNEQDDKG
V
I
S
P
T
A
A
L
S
S
I
V
-------
Y
-----
T
P
E
Y
----
S
L
Q
V
M
R
H
L
Y
N
M
G
D
K
-----------
V
F
G
P
F
GFYDAFSETDNWYPQRYL
A
I
D
Q
G
P
I
A
V
M
I
E
N
Y
R
T
G
L
L
W
K
L
F
M
S
H
P
D
V
Q
A
G
L
T
K
L
G
F
N
T
N
-----------------------
3
PsiBlast_PDB
71.65
22%
-154
- C5 -
4UG2
3
?
A:
[47-308]
-----------------------------------------------------------------------------------------------
S
A
A
-
A
A
-
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
A
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
Q
L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
L
-----------------
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
24
HHSearch
71.31
18%
-150
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
-
V
S
L
S
V
A
D
L
I
V
---
G
A
V
V
-
M
P
-
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
--------
P
L
C
L
F
W
L
S
M
-------------
D
Y
V
A
S
T
A
S
I
F
S
-
V
F
I
L
C
I
D
R
Y
---------------
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
-------------------------
R
-
A
-
S
A
T
---
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
--------
R
R
E
-
D
K
C
E
-
T
D
F
Y
D
V
--------------------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
---
L
W
F
Y
A
---
K
I
Y
K
A
V
R
Q
---------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------
N
-----
R
-
E
---
R
K
-------
A
A
K
Q
L
G
F
I
-----------------
M
A
A
F
I
L
C
W
I
P
Y
F
-------
I
F
F
M
V
I
A
F
C
K
NC--
C
N
E
--------
H
L
H
-----------
M
F
T
I
W
------------------------
L
G
Y
-
I
N
S
T
L
N
P
L
I
Y
P
L
--
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------
2
PsiBlast_PDB
71.24
22%
-152
- C5 -
2YDV
6
?
A:
[47-308]
-----------------------------------------------------------------------------------------------
S
A
A
-
A
A
-
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
GFCAA
C
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
A
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
T
L
Q
K
-------
E
V
H
A
A
K
S
L
-----------------
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
40
Fugue
71.14
15%
-122
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
-
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
--
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
---
V
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--------
T
G
C
N
L
E
G
F
F
-------------
A
T
L
G
G
E
I
A
L
W
S
-
L
V
V
L
A
I
E
R
Y
---------------
V
V
V
C
K
P
M
----------------------------------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
------
G
I
D
YY
T
P
--
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
---
L
I
V
I
F
---
F
C
Y
G
Q
L
V
F
---------
T
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
A
-----
A
-
A
---
S
A
-------
T
T
Q
K
A
E
K
E
-----------------
V
T
R
M
V
I
I
M
V
I
A
F
-------
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
--------
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
------------------------
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
--
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A------
28
HHSearch
70.54
17%
-139
- C5 -
2Z73
5
OPSD_TODPA
A:
[31-332]
-----------------------------------
D
A
V
Y
Y
--
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
-
I
N
L
A
F
S
D
F
T
F
---
S
L
V
N
G
F
P
-
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
--------
A
A
C
K
V
Y
G
F
I
-------------
G
G
I
F
G
F
M
S
I
M
T
-
M
A
M
I
S
I
D
R
Y
---------------
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
-------------------------
R
-
A
-
F
I
M
---
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
----
T
L
E
G
V
L
-
C
N
C
S
-
F
D
Y
I
S
R
--------------
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
---
F
F
C
Y
F
---
N
I
V
M
S
V
S
N
---------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------
N
-----
A
-
E
---
M
R
-------
L
A
K
I
S
I
V
I
-----------------
V
S
Q
F
L
L
S
W
S
P
Y
A
-------
V
V
A
L
L
A
Q
F
G
P
LEW-
V
T
P
--------
Y
A
A
-----------
Q
L
P
V
M
------------------------
F
A
K
-
A
S
A
I
H
N
P
M
I
Y
S
V
--
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
----------------------
1
PsiBlast_PDB
70.11
22%
-150
- C5 -
2YDO
3
?
A:
[47-308]
-----------------------------------------------------------------------------------------------
S
A
A
-
A
A
-
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
GFCAA
C
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
T
A
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
L
-
Q
K
-------
E
V
H
A
A
K
S
L
-----------------
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
7
PsiBlast_PDB
69.33
22%
-169
- C5 -
3PWH
1
?
A:
[75-305]
-----------------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
R
-----
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
A
-----------------
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
A
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
9
PsiBlast_PDB
69.30
22%
-171
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[75-305]
-----------------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
R
-----
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
A
-----------------
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
A
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
41
Fugue
69.17
16%
-105
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
-
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
--
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
---
V
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--------
T
G
C
N
L
E
G
F
F
-------------
A
T
L
G
G
E
I
A
L
W
S
-
L
V
V
L
A
I
E
R
Y
---------------
V
V
V
C
K
P
M
----------------------------------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYT
P
-
H
--
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
---
I
F
F
C
Y
---
G
Q
L
V
F
T
V
K
---------
E
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
Q
QQESA
T
-
T
---
Q
K
-------
A
E
K
E
V
T
R
M
-----------------
V
I
I
M
V
I
A
F
L
I
C
W
-------
L
P
Y
A
G
V
A
F
Y
I
----
F
T
H
--------
Q
G
S
DFGPIFM----
T
I
P
A
F
------------------------
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
--
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA
11
PsiBlast_PDB
68.93
22%
-171
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[75-305]
-----------------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
R
-----
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
A
-----------------
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
A
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
10
PsiBlast_PDB
68.68
22%
-172
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[75-305]
-----------------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
R
-----
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
A
-----------------
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
A
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
8
PsiBlast_PDB
68.47
22%
-170
- C5 -
3REY
1
AA2AR_HUMAN
A:
[75-305]
-----------------------------------------------------------------------------------------------------------------------------
H
G
C
L
F
I
A
C
F
-------------
V
L
V
L
A
Q
S
S
I
F
S
-
L
L
A
I
A
I
D
R
Y
---------------
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
------------------
I
-
C
-
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
-
L
F
E
D
-
V
V
P
M
---------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
---
L
G
V
Y
L
---
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
R
-----
A
-
R
S
T
L
Q
K
-------
E
V
H
A
A
K
S
A
-----------------
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
--------
W
L
M
-----------
Y
L
A
I
V
------------------------
L
A
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------