@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O5AU1_HUMAN: (2016-01-12 )
MTEFHLQSQMPSIRLIFRRLSLGRIKPSQSPRCSTSFMVVPSFSIAEHWRRMKGANLSQGMEFELLGLTTDPQLQRLLFVVFLGMYTATLLGNLVMFLLIHVSATLHTPMYSLLKSLSFLDFCYSSTVVPQTLVNFLAKRKVISYFGCMTQMFFYAGFATSECYLIAAMAYDRYAAICNPLLYSTIMSPEVCASLIVGSYSAGFLNSLIHTGCIFSLKFCGAHVVTHFFCDGPPILSLSCVDTSLCEILLFIFAGFNLLSCTLTILISYFLILNTILKMSSAQGRFKAFSTCASHLTAICLFFGTTLFMYLRPRSSYSLTQDRTVAVIYTVVIPVLNPLMYSLRNKDVKKALIKVWGRKTME
Atome Classification :
(20 SA)
-----------------------------.........10........20........30........40........50........60........70........80........90........100.......110.......120...-...-.130.....-..140.......150......--.160.......170.......-------------180..--------..---...190.......200.......210.....-..220.......230.......240----.-------...--.....-250.......260.......270.-----......280-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------......----.290.......300.-----.......310....------------.------------.------.320.-----------......330.......340--.......350....--...360-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------MT
E
F
H
L
Q
SQM
P
S
I
R
L
I
F
R
R
LSLGRIKPSQSPRCS
T
S
F
M
V
VPS
F
S
I
A
E
H
W
R
R
MKGANLSQG
M
E
F
E
L
L
GLTT
D
P
Q
L
Q
R
L
L
F
V
V
F
L
G
M
Y
T
A
T
L
L
G
N
L
V
M
F
L
L
I
H
V
S
A
TLH
T
P
M
Y
S
L
L
K
S
L
S
F
L
D
F
C
YS-STV-
V
P
Q
T
L
V
N
F
L
-
A
K
R
K
V
I
S
Y
F
G
C
M
T
Q
M
F
F
YAGF--ATS
E
C
Y
L
I
A
A
M
A
Y
D
R
Y
A
A
I
C
N
-------------
P
L
L
Y
S
--------TI---M
S
P
E
V
C
A
S
L
I
VGSY
S
A
G
F
L
N
S
L
I
HTG
C
I
F
S
L
-
K
F
C
G
A
H
V
V
T
H
FFCDGP
P
I
L
S
L
SC------V-------
D
T
S
--
L
C
E
I
L
-
L
F
I
F
A
G
F
N
L
L
S
C
T
L
T
I
L
I
S
Y
F
L
I
L
-----
N
T
I
L
K
MSS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------Q
G
R
F
K
A
----
F
S
T
C
A
S
H
L
T
A
I
C
L
-
F
-----
F
G
T
T
L
F
M
Y
LRPRSS------------Y------------S------LTQD
R
-----------
T
V
A
V
I
Y
T
V
V
I
P
V
L
N
P
L
M
Y
S
--
L
RN
K
D
V
K
K
A
L
I
K
V
W--GRKTME-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
87.79
16%
-132
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
--
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------------
P
M
S
N
F
--------
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-------------
W
S
R
Y
I
P
E
G
---
M
Q
C
S
C
------
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
-----
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
-
A
-----
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
------------
I
------------
F
------
T
H
Q
G
S
DFGPIFM----
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
--
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
86.59
16%
-141
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
-
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
--
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-------------
P
F
K
Y
Q
--------
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
-
A
T
----
H
Q
E
A
I
N
C
Y
A
E
----
E
T
C
------
C
-------
D
F
F
--
T
N
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
-----
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
----
L
K
T
L
G
I
I
M
G
T
F
T
L
-
C
-----
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
DN----------
L
------------
I
------
R
K
E
V
Y
-----------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
---
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
83.16
16%
-140
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-333]
-----------------------------------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
-
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
--
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------
P
M
A
A
S
--------
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
-
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------------
R
D
S
--
T
T
R
S
N
-
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
-----
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
----
A
K
I
S
I
V
I
V
S
Q
F
L
L
-
S
-----
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
------------
P
LEW---------
V
------
T
P
Y
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
--
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
82.58
16%
-154
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-470]
-------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
-
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
--
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-------------
P
L
R
Y
N
--------
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
------
L
-------
F
E
D
VV
P
M
N
Y
M
-
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
-----
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
----
A
K
S
L
A
I
I
V
G
L
F
A
L
-
C
-----
W
L
P
L
H
I
I
N
C
F
T
F
F
C
PDCS--------
H
------------
A
------
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
--
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
81.93
16%
-140
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
-
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
--
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
-------------
P
V
H
Y
Q
--------
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
--------
T
G
D
P
T
V
C
S
I
S
N
-------------------------
P
D
--
F
-
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
-----
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
----
T
Q
M
V
A
I
V
L
G
A
F
I
V
-
C
-----
W
L
P
F
F
L
T
H
V
L
N
T
H
C
QTC---------
H
------------
V
------
S
P
E
L
Y
-----------
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
--
T
F
N
I
E
F
R
K
A
F
L
K
I
L
--
S
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
81.79
19%
-144
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
-
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
--
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
-------------
P
L
R
Y
L
--------
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
---------
R
R
E
D
K
C
E
T
D
F
Y
D
------------------------
V
T
W
F
-
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
-----
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
----
A
K
Q
L
G
F
I
M
A
A
F
I
L
-
C
-----
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
------------
K
NC----------
C
------
N
E
H
L
H
-----------
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
--
L
C
N
E
N
F
K
K
T
F
K
R
I
L
--
H
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
81.52
15%
-102
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
---------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
--
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------------
P
M
S
N
F
--------
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-------------
W
S
R
Y
I
P
E
G
---
M
Q
C
S
C
------
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
-----
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
-
I
-----
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
------------
V
------------
A
------
F
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
--
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
DDEA
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
77.36
15%
-141
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
-
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
--
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
-------------
P
L
T
Y
P
--------
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
-
V
G
--
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
------------------------
S
N
A
A
V
-
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
-----
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
----
T
R
T
I
L
A
I
L
L
A
F
I
I
-
T
-----
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
AP----------
C
------------
I
------
P
N
T
V
W
-----------
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
--
L
C
N
A
T
F
K
K
T
F
K
H
L
L
--
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
74.61
14%
-147
- C4 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
--------------------------------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
-
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
--
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
-------------
P
L
Q
P
R
--------
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
------
E
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------------
N
K
I
--
Y
E
K
V
Y
-
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
-----
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
----
V
K
M
M
I
V
V
V
C
T
F
A
I
-
C
-----
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
------------
P
------------
D
LYLKKF
I
Q
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
--
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
C
C
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
74.59
16%
-138
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
-----------------------------------------------------------------------------------------------------
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
-
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
--
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------------------------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
--------
I
S
A
L
S
S
C
S
T
V
L
P
L
------------------------
Y
H
K
H
-
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
-----
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
----
L
K
T
V
I
I
V
L
S
V
F
I
A
-
C
-----
W
A
P
L
F
I
L
L
L
L
D
V
G
C
------------
K
VKTC--------
D
------
I
L
F
R
A
-----------
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
--
L
T
N
K
E
M
R
R
A
F
I
R
I
M
--
G
R
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
71.54
12%
-107
- C4 -
1U19
14
OPSD_BOVIN
A:
[38-327]
-----------------------------------------------------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
--
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------------
P
M
S
N
F
--------
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
----
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
----------------
E
E
T
--
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
-----
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
----
T
R
M
V
I
I
M
V
I
A
F
L
I
-
C
-----
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS---------
D
------------
F
------
G
P
I
F
M
-----------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
--
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
71.18
16%
-125
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
------------------------------------------------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
-
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
--
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
-------------
A
T
R
T
L
--------
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
---
Y
--
H
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
-----------------
T
A
K
--
W
R
M
V
L
-
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
-----
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
----
M
R
V
I
F
A
V
V
L
I
F
L
L
-
C
-----
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
------------
R
TQVIQE
S
C
E
R
R
N
N
------
I
G
R
A
L
-----------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
--
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
--
A
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
71.18
15%
-133
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-496]
-----------------------------------------------------------------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
--
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
--
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
-------------
A
T
N
S
Q
--------
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
------
E
A
D
D
R
Y
I
C
D
R
F
Y
P
N
-------------------
D
L
--
W
V
V
V
F
-
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
-----
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
----
L
K
T
T
V
I
L
I
L
A
F
F
A
-
C
-----
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
------
V
H
K
W
I
-----------
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
--
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
--
T
S
G
R
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
69.19
12%
-124
- C4 -
4KPP
4
?
A:
[2-396]
--------------------------DF
T
K
E
K
F
Q
L
L
A
I
S
S
L
T
L
P
W
L
I
S
L
A
F
N
Y
H
H
P
A
L
T
Q
T
L
L
S
G
L
A
V
V
S
A
S
F
L
I
S
W
A
A
E
T
A
E
M
D
V
P
R
--
S
F
S
L
A
I
V
A
L
L
A
V
L
P
E
Y
A
V
D
G
Y
F
A
W
K
A
G
S
V
G
G
E
Y
V
H
Y
A
T
A
N
M
T
G
A
N
R
L
L
I
G
I
G
W
S
L
V
A
F
I
A
F
R
T
L
-
K
S
K
-
E
V
E
L
D
D
G
I
R
-
L
E
I
F
F
L
F
L
A
T
L
Y
A
F
T
L
P
L
K
G
H
--
I
S
P
F
D
A
L
V
F
V
S
L
Y
A
I
Y
I
Y
L
S
T
K
AER
E
E
V
E
V
G
G
V
P
A
Y
L
C
S
LK
T
E
T
R
R
L
S
V
---
V
V
L
F
L
F
A
G
F
T
I
L
M
S
V
E
A
F
S
E
G
L
L
E
T
A
R
I
A
G
I
D
E
F
L
A
V
Q
W
I
A
P
L
A
S
E
S
P
E
L
I
V
A
I
Y
F
V
R
R
FR
V
-------
S
A
S
--
M
N
A
L
I
-
S
S
K
V
N
Q
W
T
L
L
I
G
T
I
A
I
I
Y
S
I
S
A
F
K
-----
L
Q
S
L
P
L
D
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
E
E
V
L
----
L
T
A
A
Q
S
L
F
A
V
A
I
L
-
L
DLKIS
W
K
E
A
S
A
L
F
L
L
F
I
V
Q
------------
L
------------
L
------
F
P
G
V
E
-----------
V
R
Y
I
I
S
A
I
Y
I
I
L
S
L
P
I
L
F
A
---
K
R
K
E
I
V
E
S
F
R
T
V
K
--
R
L
I
S
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.39
23%
-116
- C4 -
4WW3
3
OPSD_TODPA
A:
[54-230]
-----------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
--
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------
P
M
A
A
S
--------
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---
L
W
S
V
L
W
A
I
G
P
I
F
G
W
----
G
A
Y
T
L
E
G
V
L
C
N
C
-
S
F
D
Y
I
S
R
------
D
-------
S
T
T
--
R
S
N
I
L
C
M
F
I
L
G
F
F
G
------
P
I
L
I
I
F
F
C
Y
F
-----
N
I
V
M
S
V
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
E
M
A
A
----
M
A
K
R
L
N
A
K
E
L
R
K
A
-
Q
-----
A
G
A
N
A
E
M
R
L
A
K
I
S
I
------------
V
------------
I
------
V
S
Q
F
L
-----------
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
--
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
--
K
A
S
A
I
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
64.80
14%
-141
- C3 -
4IUW
16
?
A:
[4-633]
LPRIQDD
L
Y
L
A
V
N
G
E
W
Q
A
K
TPIPPDKSVV
S
A
D
S
N
L
T
D
D
I
R
--
Q
K
L
V
A
D
L
S
T
M
T
-
K
T
A
K
T
L
P
L
Q
Y
A
A
R
L
F
A
K
A
N
D
Q
T
R
R
Q
Q
L
G
I
E
P
V
R
D
R
I
S
F
-
L
M
A
L
T
T
L
D
Q
F
R
S
A
M
P
K
L
V
A
D
Q
Y
--------
V
L
P
I
S
P
Y
V
D
A
D
M
H
D
A
E
H
N
I
L
N
L
G
G
P
D
T
I
L
P
D
-
A
A
M
-
Y
N
Q
E
--
D
A
E
-
N
A
A
D
L
A
A
W
S
Q
M
A
A
A
M
L
A
A
V
G
F
S
Q
T
D
Q
T
A
Y
V
E
A
A
K
R
F
D
R
R
L
A
D
Y
V
-------------
P
------------------------
A
N
V
D
L
A
V
D
S
T
Y
D
N
P
L
S
W
Q
A
F
E
D
A
A
-
G
Y
L
G
I
P
Q
A
F
A
T
Y
M
P
Q
T
P
A
-
K
V
N
A
------
V
-------
V
P
A
--
Y
L
P
H
L
-
S
K
L
L
T
P
D
N
Y
S
E
W
H
A
W
M
V
I
N
E
L
L
T
C
A
T
Y
L
S
D
D
L
R
Q
L
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
R
F
L
A
GQPE
A
S
S
W
T
K
H
A
F
G
I
A
N
E
Y
-----
F
D
D
V
I
G
Q
Y
Y
G
Q
T
Y
F
------------
G
------------
A
------
D
A
K
A
D
-----------
V
T
A
M
V
K
Q
I
L
A
Q
Y
R
V
Q
L
E
N
N
TW
L
S
P
A
T
K
Q
K
A
M
R
K
L
A
--
T
M
Q
V
K
M
GYPARLFSLYDH
L
S
V
D
VDDD
L
L
T
A
I
L
K
L
S
A
Q
T
Q
A
F
W
F
K
Q
L
GQTVDRNQWNMPGHLV
N
A
S
Y
D
PLKN
D
I
T
F
P
AGILQPPYYSLKWT
R
A
E
N
L
G
G
T
G
A
T
I
G
H
E
I
S
H
S
F
D
N
N
G
A
L
Y
DEYGNLHNWWT
P
A
D
K
Q
A
F
D
Q
L
V
K
A
M
A
A
Q
F
DGRDYEG
V
K
V
N
GTLT
V
S
E
N
M
A
D
N
A
G
M
D
V
A
L
A
L
L
GDQPD
V
K
D
L
Q
A
F
F
I
T
Y
A
R
S
W
A
T
K
M
R
P
E
R
A
K
T
V
L
R
QDVHAP
A
T
L
R
V
N
V
P
V
Q
N
F
P
A
W
Y
Q
A
F
NVQPQDGMYRQPQK
R
L
T
I
WHQ
13
PsiBlast_PDB
61.10
23%
-114
- C4 -
2ZIY
1
OPSD_TODPA
A:
[61-242]
-----------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
--
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------
P
M
A
A
S
--------
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---
L
W
S
V
L
W
A
I
G
P
I
F
G
W
----
G
A
Y
T
L
E
G
V
L
C
N
C
-
S
F
D
Y
I
S
R
------
D
-------
S
T
T
--
R
S
N
I
L
C
M
F
I
L
G
F
F
G
------
P
I
L
I
I
F
F
C
Y
F
-----
N
I
V
M
S
V
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
E
----
M
A
A
M
A
K
R
L
N
A
K
E
L
-
R
-----
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
------------
I
------------
S
------
I
V
I
V
S
-----------
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
--
M
F
A
K
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.71
23%
-114
- C4 -
3AYN
3
OPSD_TODPA
A:
[62-243]
-----------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
--
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------
P
M
A
A
S
--------
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---
L
W
S
V
L
W
A
I
G
P
I
F
G
W
----
G
A
Y
T
L
E
G
V
L
C
N
C
-
S
F
D
Y
I
S
R
------
D
-------
S
T
T
--
R
S
N
I
L
C
M
F
I
L
G
F
F
G
------
P
I
L
I
I
F
F
C
Y
F
-----
N
I
V
M
S
V
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
E
----
M
A
A
M
A
K
R
L
N
A
K
E
L
-
R
-----
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
------------
I
------------
S
------
I
V
I
V
S
-----------
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
--
M
F
A
K
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.37
23%
-114
- C4 -
2Z73
3
OPSD_TODPA
A:
[62-243]
-----------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
--
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------
P
M
A
A
S
--------
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---
L
W
S
V
L
W
A
I
G
P
I
F
G
W
----
G
A
Y
T
L
E
G
V
L
C
N
C
-
S
F
D
Y
I
S
R
------
D
-------
S
T
T
--
R
S
N
I
L
C
M
F
I
L
G
F
F
G
------
P
I
L
I
I
F
F
C
Y
F
-----
N
I
V
M
S
V
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
E
----
M
A
A
M
A
K
R
L
N
A
K
E
L
-
R
-----
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
------------
I
------------
S
------
I
V
I
V
S
-----------
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
--
M
F
A
K
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.16
23%
-117
- C4 -
3AYM
3
OPSD_TODPA
A:
[62-243]
-----------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
--
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------
P
M
A
A
S
--------
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---
L
W
S
V
L
W
A
I
G
P
I
F
G
W
----
G
A
Y
T
L
E
G
V
L
C
N
C
-
S
F
D
Y
I
S
R
------
D
-------
S
T
T
--
R
S
N
I
L
C
M
F
I
L
G
F
F
G
------
P
I
L
I
I
F
F
C
Y
F
-----
N
I
V
M
S
V
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
E
----
M
A
A
M
A
K
R
L
N
A
K
E
L
-
R
-----
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
------------
I
------------
S
------
I
V
I
V
S
-----------
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
--
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
--
M
F
A
K
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------