@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O6C70_HUMAN: (2016-01-12 )
MKNHTRQIEFILLGLTDNSQLQIVIFLFLLLNCVLSMIGNFTIIALILLDSQLKTPMYFFLRNFSFLEISFTTACIPRFLITIVTREKTISCNGCISQLFFYIFLGVTEFFLLAALSYDRYVAICKPLRYMSIMSNKVCYQLVFSSWVTGFLIIFTPLILGLNLDFCASNIIDHFICDISLILQLSCSDTHLLELIAFLLAVMTLIVTLFLVILSYSYIIKTILKFPSAQQKKKAFSTCSSHMIVVSITYGSCMFIYIKPSANERVALSKGVTVLNTSVAPLLNPFIYTLRNQQVKQAFKAVFRKIFSASDK
Atome Classification :
(20 SA)
---.........10--....--------...---------------..20.----------------.......30........40....-----....50........60...--..------.-..70..--------..-....80........90........---------------------100.......-----110...--....120.......130.......140.......150..---.....160.......170.-......180.....-------.-------.-190.-....---------------------..200---.......---.210.......220..------.---....230---------.----------------.----...-....240.......-------250.----------.....----.260-..-----.---..-------...---270.......280....---...290.......300..------------------......310----------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MKNH
T
R
Q
I
E
F
---
I
L
L
G--------LTD---------------NSQ
L
Q
----------------
I
V
I
F
L
F
L
L
L
N
C
V
L
S
M
IGN
F
T
I
I
A
-----
L
I
L
LDSQLK
T
P
M
Y
F
F
L
RNF--
S
F
------
L
-
E
I
S
F
T
T
--------
A
C
-
I
P
R
F
L
I
T
I
V
TREKTIS
C
N
G
C
I
S
Q
L
---------------------
F
F
Y
I
F
L
G
V
T
E
-----
F
F
L
L
A
A
--LSYD
R
Y
V
A
I
C
K
P
L
R
Y
M
S
I
M
SN
K
V
C
Y
Q
L
V
F
S
S
W
V
T
G
F
L
I
I
---
F
T
P
L
I
LGL
N
L
D
F
C
A
S
N
I
I
D
-
H
F
I
C
D
I
S
L
I
L
Q
LSC-------S-------D-
T
H
L
L
-
E
L
I
A
---------------------
F
L
L
A
----
V
M
T
L
I
V
T
---
L
F
L
V
I
L
S
Y
S
Y
I
I
K
T
I
L
------K---FP
S
A
Q
-----------
Q
----------------
K
----
K
K
A
-
F
S
TCSS
H
M
I
V
V
S
I
T-------YG
S
C
----------
M
F
I
Y
I----KPS--AN-----
E
---
R
V
-------
A
LS---KG
V
T
V
LNT
S
V
A
P
L
L
N
P
F
---
I
Y
T
L
R
N
Q
Q
V
K
Q
A
F
K
-
A
V
F
------------------
R
K
I
FSASDK----------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
86.18
16%
-153
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-334]
-------------------------------------------------
V
Y
----------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-----
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
--
A
F
------
S
-
D
F
T
F
S
L
--------
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
---------------------
F
I
G
G
I
F
G
F
M
S
-----
I
M
T
M
A
M
--
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
---
I
G
P
I
F
G
W
G
A
Y
T
L
E
----
G
V
-
L
C
N
C
S
F
D
Y
I
S
-------------------
R
-
D
S
T
T
-
R
S
N
I
---------------------
L
C
M
F
----
I
L
G
F
F
G
P
---
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
------
N
---
H
E
K
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----
A
N
A
-
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
-------
F
L
L
S
----------
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
G
-----
P
LEW
V
T
-------
P
Y
A
---
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
---
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
-
Q
T
F
------------------
P
W
V
L
T
C
C
Q
F
----------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.02
18%
-160
- C2 -
1F88
7
OPSD_BOVIN
A:
[40-315]
-------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
-
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-------
E
-------
E
-
T
N
N
E
-
S
F
V
I
---------------------
Y
M
F
-----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
---
A
A
A
-------------------------------SATT
Q
K
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
----------
A
F
Y
I
F
----
T
H
Q
--
G
S
-----
D
---
F
G
-------
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
---
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-
T
T
L
------------------
C
C
G
K
N
P
S
T
T
----------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
84.81
18%
-157
- C2 -
3C9L
13
OPSD_BOVIN
A:
[40-315]
-------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
-
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-------
E
-------
E
-
T
N
N
E
-
S
F
V
I
---------------------
Y
M
F
-----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
---
A
A
A
Q
Q
-----------
Q
----------------
E
S
A
T
T
Q
K
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
----------
A
F
Y
I
F
----
T
H
Q
--
G
S
-----
D
---
F
G
-------
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
---
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-
T
T
L
------------------
C
C
G
K
N
D
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.64
18%
-156
- C2 -
3CAP
4
OPSD_BOVIN
A:
[40-315]
-------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
-
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-------
E
-------
E
-
T
N
N
E
-
S
F
V
I
---------------------
Y
M
F
-----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
---
A
A
A
Q
Q
-----------
Q
----------------
E
S
A
T
T
Q
K
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
----------
A
F
Y
I
F
----
T
H
Q
--
G
S
-----
D
---
F
G
-------
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
---
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-
T
T
L
------------------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
82.53
18%
-132
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----
M
N
G
T
E
G
P
N
F
---
Y
V
P
F
--------
S
N
K
---------------
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
-------
V
G
W
S
R
Y
I
P
-
E
G
-------
M
Q
C
S
C
-------
G
I
DYYTPH
E
-
E
T
N
N
-
E
S
F
V
---------------------
I
Y
M
F
----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
---
A
A
A
S
A
-----------
T
----------------
T
----
Q
K
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
----------
W
L
P
Y
A
----
G
V
A
--
F
Y
-----
I
---
F
T
H
QGSDFG
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
---
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-
T
T
L
------------------
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A----------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.38
21%
-154
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[124-405]
-------------------------------------------------
L
K
----------------
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
-----
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
--
A
L
A
D
T
L
V
L
L
-
T
L
P
F
Q
G
--------
T
D
-
I
---
L
L
G
F
W
P
F
G
N
A
L
-
C
K
T
V
I
A
I
D
---------------------
Y
Y
N
M
F
---
T
S
-----
T
F
T
L
T
A
--
M
S
V
D
R
Y
V
A
I
C
H
P
-------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
---
V
P
V
A
I
M
G
------
S
A
Q
V
E
D
-
E
---
E
I
E
C
L
V
E
I
P
T
-------
P
-------
Q
-
D
Y
W
G
-
P
V
F
A
---------------------
I
C
I
F
----
L
F
S
F
I
V
P
---
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
R
------
G
VRL
L
S
G
S
R
-----------
E
----------------
K
----
D
R
N
-
L
R
R
I
T
R
L
V
L
V
V
V
A
V
-------
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
----
Q
P
S
--
S
E
-----
T
---
A
V
-------
A
I
L
---
R
F
C
T
A
L
G
Y
-
V
N
S
C
L
N
P
I
---
L
Y
A
F
L
D
E
N
----
F
K
-
A
C
F
------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
81.16
19%
-147
* C2 *
2KS9
1
NK1R_HUMAN
A:
[33-324]
-------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
-----
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
--
A
F
------
A
-
E
A
S
M
A
A
--------
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
---------------------
F
F
P
I
A
A
V
F
A
S
-----
I
Y
S
M
T
A
--
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
---
F
P
Q
G
Y
Y
S
T
T
E
T
M
-----
P
S
-
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
-
K
I
Y
E
-
K
V
Y
H
---------------------
I
C
V
T
----
V
L
I
Y
F
L
P
---
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
------
A
---
S
E
I
P
G
DSSDRYH
E
Q
V
S
A
----------------
K
----
R
K
V
-
V
K
M
M
I
V
V
V
C
T
F
A
I
C
-------
W
L
P
F
----------
H
I
F
F
L
----
L
P
Y
--
I
N
-----
P
---
D
L
YLK----
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
---
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
-
H
A
F
------------------
R
C
C
P
F
I
S
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
80.69
18%
-127
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---
M
N
G
T
E
G
P
N
F
Y
---
V
P
F
S
--------
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
----------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
-----------
W
S
-
R
Y
I
P
E
G
---
M
Q
C
S
C
G
I
DYYTP
H
-------
E
-
E
T
N
N
-
E
S
F
V
---------------------
I
Y
M
F
----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
---
A
A
A
Q
Q
-----------
Q
ESA
T
------------
T
----
Q
K
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
----------
W
L
P
Y
A
----
G
V
A
--
F
Y
-----
I
---
F
T
H
QGSDFG
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
---
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
78.72
18%
-130
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
-------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
S
R
Y
I
P
--
E
--
G
M
-
Q
C
S
C
G
I
D
Y
Y
T
P
----------
H
-------
E
-
E
T
N
N
-
E
S
F
V
---------------------
I
Y
M
F
----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
---
A
A
A
Q
Q
-----------
Q
ESA
T
------------
T
----
Q
K
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
----------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-----
S
---
D
F
G------
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
---
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-
T
T
L
------------------
C
C
G
K
N
P
L
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.03
18%
-140
- C2 -
1LN6
1
OPSD_BOVIN
A:
[40-313]
-------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
-
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-------
E
-------
E
-
T
N
N
E
-
S
F
V
I
---------------------
Y
M
F
-----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
---
A
A
A
Q
Q
-----------
Q
----------------
E
SATT
Q
K
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
LICWLP
Y
A
G
V
----------
A
F
Y
I
F
----
T
H
Q
--
G
S
-----
D
---
F
G
-------
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
---
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-
V
A
T
------------------
T
L
C
C
G
K
N
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
71.21
17%
-136
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
------------------------------------------------
L
N
K
----------------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
-----
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
--
A
L
------
A
-
D
L
L
F
A
L
---------
T
-
L
P
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
C
K
V
V
S
---------------------
L
L
K
E
V
N
F
Y
S
G
-----
I
L
L
L
A
C
--
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
---
L
P
F
F
L
F
R
Q
A
Y
H
P
--
N
--
N
S
-
S
P
V
C
Y
E
V
L
G
N
D
------------------
T
-
A
K
W
R
-
M
V
L
R
---------------------
I
L
P
H
----
T
F
G
F
I
V
P
---
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
------
K
---
A
H
M
-
G
-----------
Q
----------------
K
----
H
R
A
-
M
R
V
I
F
A
V
V
L
I
F
L
L
C
-------
W
L
P
Y
----------
N
L
V
L
L
----
A
D
T
L
M
R
T
QVIQE
S
C
E
R
R
N
-------
N
I
G
R
A
-
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
---
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
-
K
I
L
------------------
A
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
68.18
11%
-122
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------
D
E
V
W
V
----------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
--
A
C
------
A
-
D
L
V
M
G
L
--------
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
---------------------
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
---
F
L
P
I
Q
M
H
W
Y
-
R
A
T
H
Q
E
A
I
N
-
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
-------
A
-------
Y
-
A
I
A
S
-
S
I
V
S
---------------------
F
Y
V
P
----
L
V
I
M
V
F
V
---
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
------
M
---
L
R
I
D
E
-----------
G
----------------
L
----
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
-
I
-------
G
H
L
L
----------
T
K
S
P
S
----
L
N
A
--
A
K
-----
S
---
E
L
-------
D
K
A
---
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
---
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
------------------
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
50
Fugue
67.50
18%
-168
- C1 -
4R5O
10
?
A:
[2-427]
DDC
E
D
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
TFPT
E
S
Q
V
L
E
L
---------------
G
E
T
L
E
----------------
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
V
N
G
K
E
Y
S
TEP
T
F
S
Y
K
I
D
N
P
C
R
A
D
L
S
C
I
I
K
N
K
Y
G
K
V
------
E
M
S
T
S
F
S
S
NHNFSK
G
F
F
Y
-
V
A
D
G
T
F
N
F
Y
D
T
E
K
K
T
A
Y
Q
D
C
Y
A
S
L
N
AGKTLGIGNY
D
S
A
N
I
I
H
S
NG
K
F
Y
L
L
V
G
T
S
T
SNRDH
F
Y
I
V
D
A
KT
L
Y
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
T
I
L
N
E
Q
--
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
SLN
N
V
R
I
K
N
E
R
L
L
C
F
Y
N
S
I
I
Y
N
G
K
V
L
S
N
D
T
Y
K
D
E
S
K
V
-------
K
-------
Y
-
Y
D
V
N
-
E
L
I
A
AKEGEA
P
A
V
T
E
L
DIIQK
Q
K
I
N
F
V
L
A
KDG
N
V
Y
T
L
E
S
A
DNG
C
N
I
V
K
I
K
N
D
F
T
L
E
K
V
F
A
NFQPA
K
---
G
P
Y
H
S
-----------
S
----------------
P
----
T
I
G
M
V
A
S
E
T
E
N
I
I
Y
L
V
S
T
-------
D
G
A
I
----------
Y
K
Y
I
L
----
G
D
S
--
D
S
-----
L
---
K
A
-------
P
F
I
---
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
N
Q
Q
SG
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
-
I
V
V
Y
S
KDGKV-----------
L
H
T
V
D
C
G
E
S
VPS
Q
I
L
F
NN-------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
67.08
22%
-180
- C2 -
3EML
8
ENLYS_BPT4
A:
[22-221]
-------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
--
A
A
------
A
-
D
I
A
V
G
V
--------
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
---------------------
C
F
V
L
V
L
T
Q
S
S
-----
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
L
G
W
N
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
---
V
A
C
-------
L
-------
F
E
D
V
V
P
M
N
Y
M
V
---------------------
Y
F
N
F
----
F
A
C
V
L
V
P
---
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
---
Q
L
N
I
F
-----------
E
----------------
M
----
L
R
I
-
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
----------
G
I
G
H
L
----
L
T
K
--
S
P
-----
S
---
L
N
-------
A
A
K
---
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-
V
R
G
------------------
I
L
R
N
A
K
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.78
21%
-169
- C2 -
2X72
5
GNAT1_BOVIN (first)
A:
[43-242]
-------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
--
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
--
A
V
------
A
-
D
L
F
M
V
F
--------
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
---------------------
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
------
W
S
R
Y
I
P
E
-
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-------
E
-------
E
-
T
N
N
E
-
S
F
V
I
---------------------
Y
M
F
-----
V
V
H
F
I
I
P
---
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------
K
---
E
A
A
A
Q
-----------
Q
----------------
Q
----
E
S
A
-
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-------
I
M
V
I
----------
A
F
L
I
C
----
W
L
P
--
Y
A
-----
G
---
V
A
-------
F
Y
I
---
F
T
H
Q
G
S
C
F
G
P
I
F
M
T
I
P
A
---
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
-
I
M
M
------------------
N
K
Q
F
R
N
C
M
V
----------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
65.93
17%
-162
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
-------------------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
--
A
C
------
A
-
D
L
V
M
G
L
--------
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
---------------------
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
---
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
----
E
-
A
I
N
C
Y
A
----
E
E
T
C
-------
C
-------
D
-
F
F
T
N
-
Q
A
Y
A
---------------------
I
A
S
S
----
I
V
S
F
Y
V
P
---
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
------
R
---
Q
L
N
I
F
-----------
E
----------------
M
----
L
R
I
-
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
----------
G
I
G
H
L
----
L
T
K
--
S
P
-----
S
---
L
N
-------
A
A
K
---
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-
V
R
G
------------------
I
L
R
N
A
K
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.76
31%
-166
- C2 -
4UG2
3
?
A:
[18-144]
------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-----
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
--
A
A
------
A
-
D
I
L
V
G
V
--------
L
A
-
I
P
-
F
A
I
A
I
S
T
-
G
F
C
A
A
C
H
G
C
L
F
I
A
---------------------
C
F
V
L
V
L
T
A
S
S
-----
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
-
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
-------
E
-------
D
-
V
V
P
M
-
N
Y
M
V
---------------------
Y
F
N
F
----
F
A
C
V
L
V
P
---
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
---
Q
L
A
R
S
-----------
T
----------------
L
----
Q
K
E
-
V
H
A
A
K
S
L
A
I
I
V
G
L
F
-------
A
L
C
W
----------
L
P
L
H
I
----
I
N
C
--
F
T
-----
F
---
F
C
-------
P
D
C
---
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
---
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
------------------
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.93
32%
-161
- C2 -
4EIY
18
AA2AR_HUMAN (first)
A:
[43-169]
------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-----
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
--
A
A
------
A
-
D
I
A
V
G
V
--------
L
A
-
I
P
-
F
A
I
T
I
S
T
-
G
F
C
A
A
C
H
G
C
L
F
I
A
---------------------
C
F
V
L
V
L
T
Q
S
S
-----
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
N
-
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
-------
E
-------
D
-
V
V
P
M
-
N
Y
M
V
---------------------
Y
F
N
F
----
F
A
C
V
L
V
P
---
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
---
Q
L
A
D
L
-----------
E
----------------
D
----
N
W
E
-
T
L
N
D
N
L
K
V
I
E
K
A
D
N
-------
A
A
Q
V
----------
K
D
A
L
T
----
K
M
R
--
A
A
-----
A
---
L
D
-------
A
Q
K
---
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
---
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
-
A
A
A
------------------
E
Q
L
K
T
T
R
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.37
31%
-165
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[18-144]
------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-----
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
--
A
A
------
A
-
D
I
L
V
G
V
--------
L
A
-
I
P
-
F
A
I
A
I
S
T
-
G
F
C
A
A
C
H
G
C
L
F
I
A
---------------------
C
F
V
L
V
L
T
A
S
S
-----
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
-------
V
-------
P
-
M
N
Y
M
-
V
Y
F
N
---------------------
F
F
A
C
----
V
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
------
K
---
Q
M
E
S
Q
-----------
P
----------------
L
----
P
G
E
-
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-------
S
L
A
I
----------
I
V
G
L
F
----
A
L
C
--
W
L
-----
P
---
L
H
-------
I
I
N
---
C
F
T
F
F
C
P
D
C
H
A
P
L
W
L
M
Y
---
L
A
I
V
L
S
H
T
N
S
V
V
N
P
-
F
I
Y
------------------
A
Y
R
I
R
E
F
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.73
31%
-163
- C2 -
2YDV
6
?
A:
[18-144]
------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
-----
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
--
A
A
------
A
-
D
I
L
V
G
V
--------
L
A
-
I
P
-
F
A
I
A
I
S
T
-
G
F
C
A
A
C
H
G
C
L
F
I
A
---------------------
C
F
V
L
V
L
T
A
S
S
-----
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
---
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
-
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
-------
E
-------
D
-
V
V
P
M
-
N
Y
M
V
---------------------
Y
F
N
F
----
F
A
C
V
L
V
P
---
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
------
R
---
Q
L
K
Q
M
-----------
E
----------------
S
----
Q
S
T
-
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
-------
V
G
L
F
----------
A
L
C
W
L
----
P
L
H
--
I
I
-----
N
---
C
F
-------
T
F
F
---
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
---
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
-
Y
R
I
------------------
R
E
F
R
Q
T
F
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------