@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1A2_HUMAN: (2016-01-12 )
MKKENQSFNLDFILLGVTSQQEQNNVFFVIFLCIYPITLTGNLLIILAICADIRLHNPMYFLLANLSLVDIIFSSVTIPKVLANHLLGSKFISFGGCLMQMYFMIALAKADSYTLAAMAYDRAVAISCPLHYTTIMSPRSCILLIAGSWVIGNTSALPHTLLTASLSFCGNQEVANFYCDIMPLLKLSCSDVHFNVKMMYLGVGVFSLPLLCIIVSYVQVFSTVFQVPSTKSLFKAFCTCGSHLTVVFLYYGTTMGMYFRPLTSYSPKDAVITVMYVAVTPALNPFIYSLRNWDMKAALQKLFSKRISS
Atome Classification :
(20 SA)
----------..-.......10........20----........30........40---......-..50...---.-....60....-....70......-..80........--90...-----.....100..-...--..110.......120.......130...----------------....140-----------.-.-......--------------.150.-----------.......160---------------.........170.........180--.-........190------.....-..-..200.......210.......220....---------.-------.-----------.-----------230------------------.---.---..-----.....240--..-...-...250...----...-------.---.-260----------..-.----------.-------...--270......-.-----280-----.......290.........300-.----------------......---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MK-KENQSFN
L
D
F
I
L
L
GVTSQQ----EQN
N
V
F
F
V
I
F
L
C
I
Y
P
I
TLTG---
N
L
L
I
I
L
-
A
I
C
ADIR---L-HN
P
M
Y
F
L
L
AN-
L
S
L
V
D
I
I
F
SSV
T
-
I
P
K
V
L
A
N
H
L
LG
S
--
K
F
I
S
F
-----
G
G
C
L
M
Q
M
Y
F
M
-
I
A
L--AKADS
Y
T
L
A
A
M
AYD
R
A
V
A
I
SCP
L
H
Y
T
TI----------------MSPR
S
-------------
C
-
I
-
L
L
I
AG
S
--------------
W
V
I-G-----------NTSAL
P
H
T
-----------------
L
L
T
A
S
L
S
FCG--N
Q
E
V
A
N
F
Y
C
D
----
I
-
M
P
L
L
KLSCS--------
D
V
H
F
N
-
V
K
-
M
M
Y
L
G
V
G
V
F
S
L
P
L
L
C
I
I
V
S
Y
V
Q
V
F
S
T
V
FQ---------V-------P-----------
S
-----------
T
--------------------
K
---
S
---
L
F
-----
K
A
F
C
TCG---S
H
-
L
T
V
-
V
F
L
Y
Y-GTT----M
G
M
-------
Y
---
F
-
R
PL----------TS-Y----------S-------PK
D
--
A
V
I
T
V
M
Y
V
A
-V-----TPA-----
L
N
P
F
I
Y
S
L--RNW
D
M
K
A
A
L
Q
K
L
-
F
----------------
S
K
RISS---------------
2
PsiBlast_PDB
88.64
22%
-162
- C2 -
3REY
1
AA2AR_HUMAN
A:
[7-305]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
A
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
-------------------------
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
-------
P
-----------
G
-----------
E
--------------------
R
---
A
R
S
T
L
Q
-----
K
E
V
H
A
A
K
---
S
A
-
A
I
I
-
A
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
-----
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
-------------------
5
PsiBlast_PDB
88.38
22%
-159
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[7-305]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
A
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
-------------------------
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
-------
P
-----------
G
-----------
E
--------------------
R
---
A
R
S
T
L
Q
-----
K
E
V
H
A
A
K
---
S
A
-
A
I
I
-
A
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
-----
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
-------------------
4
PsiBlast_PDB
88.36
22%
-161
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[7-305]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
A
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
-------------------------
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
-------
P
-----------
G
-----------
E
--------------------
R
---
A
R
S
T
L
Q
-----
K
E
V
H
A
A
K
---
S
A
-
A
I
I
-
A
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
-----
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
-------------------
9
PsiBlast_PDB
88.31
22%
-151
- C2 -
2YDV
6
?
A:
[6-307]
--------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
K
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
K
E
-----------------
G
K
A
H
S
Q
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ-----------------------------------------------------------S
T
-
L
Q
-----
K
E
V
H
A
A
K
---
S
L
-
A
I
I
-
V
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
V
L
S
H
T
N
S
V
-----
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
H
V
L
R
---------------
3
PsiBlast_PDB
88.18
22%
-159
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[7-305]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
A
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
-------------------------
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
-------
P
-----------
G
-----------
E
--------------------
R
---
A
R
S
T
L
Q
-----
K
E
V
H
A
A
K
---
S
A
-
A
I
I
-
A
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
-----
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
-------------------
1
PsiBlast_PDB
88.16
22%
-157
- C2 -
3PWH
1
?
A:
[7-305]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
A
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
-------------------------
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
-------
P
-----------
G
-----------
E
--------------------
R
---
A
R
S
T
L
Q
-----
K
E
V
H
A
A
K
---
S
A
-
A
I
I
-
A
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
-----
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
-------------------
10
PsiBlast_PDB
88.13
22%
-152
- C2 -
4UG2
3
?
A:
[6-307]
--------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
K
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
TPMLGW
N
N
C
G
Q
P
K
E
-----------------
G
K
A
H
S
Q
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L----------------------------------------------------------------
A
R
S
T
L
Q
-----
K
E
V
H
A
A
K
---
S
L
-
A
I
I
-
V
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
V
L
S
H
T
N
S
V
-----
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
H
V
L
R
---------------
8
PsiBlast_PDB
87.39
22%
-149
- C2 -
2YDO
3
?
A:
[6-307]
--------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
K
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
K
E
-----------------
G
K
A
H
S
Q
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S------------------------------------------------------------T--
L
Q
-----
K
E
V
H
A
A
K
---
S
L
-
A
I
I
-
V
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
V
L
S
H
T
N
S
V
-----
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
H
V
L
R
---------------
11
PsiBlast_PDB
86.34
22%
-149
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[6-307]
--------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
K
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
P
K
E
-----------------
G
K
A
---
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
-------
P
-----------
G
-----------
E
--------------------
R
---
A
R
S
T
L
Q
-----
K
E
V
H
A
A
K
---
S
L
-
A
I
I
-
V
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
--
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
V
L
S
H
T
N
S
V
-----
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
H
V
L
R
---------------
7
PsiBlast_PDB
85.51
22%
-155
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[6-307]
--------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
K
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
T
PMLGW
N
N
C
G
Q
------------------------
S
Q
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------
P
-----------
G
-----------
E
--------------------
R
A
R
S
T
---
L
Q
-----
K
E
V
H
A
A
K
---
S
L
-
A
I
I
-
V
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
V
L
S
H
T
N
S
V
-----
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
H
V
L
----------------
6
PsiBlast_PDB
85.34
22%
-154
- C2 -
3VG9
8
?
A:
[6-307]
--------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
-
A
V
W
L
N
S
N
---
L
-
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
---
I
S
T
--
G
F
C
A
A
C
----
H
G
C
L
F
I
A
C
F
V
-
L
V
L
--
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----------------
V
T
G
T
R
-------------
A
-
K
-
G
I
I
A
I
C
--------------
W
V
L
-
S
F
A
I
G
L
TPMLGW
N
N
C
G
Q
------------------------
S
Q
G
-
C
G
--
E
G
Q
V
A
C
L
F
E
D
----
V
-
V
P
M
N
Y
M
------------
V
Y
F
N
-
F
F
-
A
C
V
L
------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
-------
P
-----------
G
-----------
E
--------------------
R
A
R
S
T
---
L
Q
-----
K
E
V
H
A
A
K
---
S
L
-
A
I
I
-
V
G
L
F
A
-
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
---
F
-
C
P
D
----------
C
S
-
H
----------
A
-------
P
------
L
W
L
M
Y
L
A
-
I
V
L
S
H
T
N
S
V
-----
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
----------------
R
S
H
V
L
R
---------------
20
PsiBlast_PDB
82.34
24%
-138
- C2 -
4LDE
3
A:
[199-463]
-------------------------------------------------------
G
---
N
V
L
V
I
T
-
A
I
A
K
F
E
R
---
L
-
Q
T
V
T
N
Y
F
I
T
S
-
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-
F
G
A
A
H
I
L
-
T
--
K
T
W
T
F
-----
G
N
F
W
C
E
F
W
T
S
-
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
----------------
L
T
K
N
K
-------------
A
-
R
-
V
I
I
L
M
V
--------------
W
I
V
S
G
-----------
L
T
S
F
L
P
--------------------
I
Q
M
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
Y
A
E
-----------
E
T
C
C
--------
D
F
F
T
N
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
-------
L
-----------
Q
----------------------------------------
K
F
AL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
-
F
T
L
-
C
W
L
P
F
--
F
I
----
V
N
I
-------
V
---
H
-
V
I
Q
----------
D
N
-
L
----------
I
-------
R
K
E
--
V
Y
I
L
L
N
W
I
G
Y
V
-----
N
S
G
-----
F
N
P
L
I
Y
C
---
R
S
P
D
F
R
I
A
F
Q
E
L
-
L
----------------
C
L
-------------------
15
PsiBlast_PDB
82.20
24%
-130
- C2 -
4GBR
1
ADRB2_HUMAN
A:
[22-286]
-------------------------------------------------------
G
---
N
V
L
V
I
T
-
A
I
A
K
F
E
R
---
L
-
Q
T
V
T
N
Y
F
I
T
S
-
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-
F
G
A
A
H
I
L
-
T
--
K
T
W
T
F
-----
G
N
F
W
C
E
F
W
T
S
-
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
----------------
L
T
K
N
K
-------------
A
-
R
-
V
I
I
L
M
V
--------------
W
I
V
S
G
-----------
L
T
S
F
L
P
--------------------
I
Q
M
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
Y
A
E
-----------
E
T
C
C
--------
D
F
F
T
N
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
---
E
---------
A
-------
K
-----------
R
-----------
Q
--------------------
L
---
Q
---
K
I
-----
D
K
F
C
L
-
K
---
E
H
-
K
A
L
-
K
T
L
---
G
I
I
----
M
G
T
-------
F
T
L
C
W
-
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-
L
----------
I
-------
R
K
E
--
V
Y
I
L
L
N
W
I
G
Y
V
-----
N
S
G
-----
F
N
P
L
I
Y
C
---
R
S
P
D
F
R
I
A
F
Q
E
L
-
L
----------------
C
L
-------------------
30
HHSearch
81.51
18%
-130
* C2 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
----------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
-
I
I
L
A
H
K
R
---
M
-
R
T
V
T
N
Y
F
L
V
N
-
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
--
W
Y
Y
G
L
-----
F
Y
C
K
F
H
N
F
F
P
-
I
A
A
--
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
------------------
S
A
T
A
-------------
T
-
K
-
V
V
I
C
V
I
--------------
W
V
L
-
A
-----------
L
L
L
A
F
P
Q
G
-----------------
Y
Y
S
T
T
-
E
T
------
M
P
S
R
V
V
C
M
----
I
-
E
W
P
E
H
P
N
----------
K
I
Y
E
K
-
V
Y
-
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
---------
S
-------
E
-----------
I
PGDSSDRYH
E
Q
V
--------------------
S
---
A
---
K
R
-----
K
V
V
K
M
M
I
---
V
V
-
V
C
T
-
F
A
I
C
W
-
L
P
F
----
H
I
F
-------
F
---
L
-
L
P
Y
----------
I
N
-
P
----------
D
LYLKKFI
Q
Q
V
--
Y
L
A
I
M
W
L
A
M
-
S
-----
S
T
M
-----
Y
N
P
I
I
Y
C
C
--
L
N
D
R
F
R
L
G
F
K
H
A
-
F
----------------
R
C
C
P
F
I
---------------
33
HHSearch
81.34
18%
-131
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
-
L
F
T
K
T
K
S
---
L
-
Q
T
P
A
N
M
F
I
I
N
-
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
--
W
I
F
G
F
-----
A
A
C
K
V
Y
G
F
I
G
-
G
I
F
--
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
----------------
M
S
H
R
R
-------------
A
-
F
-
I
M
I
I
F
V
--------------
W
L
W
-
S
-----------
V
L
W
A
I
G
P
I
-----------------
F
G
W
G
A
Y
T
L
------
E
G
V
L
C
N
C
S
----
F
-
D
Y
I
S
R
------------
D
S
T
T
R
-
S
N
-
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
-------
E
-----------
K
-----------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
---
A
---
E
M
-----
R
L
A
K
I
S
I
---
V
I
-
V
S
Q
-
F
L
L
S
W
-
S
P
Y
----
A
V
V
-------
A
---
L
-
L
A
Q
----------
F
G
-
P
LEW-------
V
T------
P
Y
A
--
A
Q
L
P
V
M
F
A
K
-
A
-----
S
A
I
-----
H
N
P
M
I
Y
S
V
--
S
H
P
K
F
R
E
A
I
S
Q
T
-
F
----------------
P
W
V
L
T
C
---------------
41
Fugue
77.21
18%
-111
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFY
V
P
-
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
----
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
V
Q
H
K
K
---
L
-
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
--
F
V
F
G
P
-----
T
G
C
N
L
E
G
F
F
A
-
T
L
G
--
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-----------------
F
G
E
N
H
-------------
A
-
I
-
M
G
V
A
F
T
--------------
W
V
M
-
A
-----------
L
A
C
A
A
P
P
L
V
GW
S
R
Y
-----------
I
P
E
G
M
Q
C
S
C
G
------
I
D
Y
Y
T
-------------
P
H
E
--------
E
T
N
N
E
-
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
-------
A
AQQQESA
T
T
Q
K
A
-----------
E
--------------------
K
---
E
---
V
T
-----
R
M
V
I
I
M
V
---
I
A
-
F
L
I
-
C
W
L
P
Y
-
A
G
V
----
A
F
Y
-------
I
---
F
-
T
H
Q
G---------
S
D
-
F
----------
G
-------
P
I
F
--
M
T
I
P
A
F
F
A
K
-
T
-----
S
A
V
-----
Y
N
P
V
I
Y
I
M
--
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
QVAPA----------
31
HHSearch
76.44
18%
-132
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-326]
---------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
-
V
T
V
Q
H
K
K
---
L
-
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
--
F
V
F
G
P
-----
T
G
C
N
L
E
G
F
F
A
-
T
L
G
--
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-----------------
F
G
E
N
H
-------------
A
-
I
-
M
G
V
A
F
T
--------------
W
V
M
-
A
-----------
L
A
C
A
A
P
P
L
-----------------
V
G
W
S
R
Y
I
P
E
------
G
M
Q
C
S
C
G
----
I
-
D
Y
Y
T
P
H
--
E
--------
E
T
N
N
E
-
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
-------
A
-----------
A
-----------
Q
QQESA
T
T
Q
------------
K
---
A
---
E
K
-----
E
V
T
R
M
V
I
---
I
M
-
V
I
A
-
F
L
I
C
W
-
L
P
Y
----
A
G
V
-------
A
---
F
-
Y
I
F
----------
T
H
Q
G
----------
S
DFG----
P
I
F
--
M
T
I
P
A
F
F
A
K
-
T
-----
S
A
V
-----
Y
N
P
V
I
Y
I
M
--
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
----------------
C
C
G
K
N
P
---------------
39
Fugue
75.68
17%
-116
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFY
V
P
-
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
----
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
I
N
F
L
-
T
L
Y
V
T
V
Q
H
KK
L
-
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
--
F
V
F
G
P
-----
T
G
C
N
L
E
G
F
F
A
-
T
L
G
--
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-----------------
F
G
E
N
H
-------------
A
-
I
-
M
G
V
A
F
T
--------------
W
V
M
-
A
-----------
L
A
C
A
A
P
P
L
-----------------
V
G
W
S
R
Y
I
P
E
G
---------------------
M
Q
C
S
C
G
I
DYYTPHE
E
T
N
N
E
-
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
AASATTQ
K
-----------
A
-----------
E
--------------------
K
---
E
---
V
T
-----
R
M
V
I
I
M
V
---
I
A
-
F
L
I
-
C
W
L
P
Y
-
A
G
V
----
A
F
Y
-------
I
---
F
T
H
Q
G
----------
S
D
-
F
----------
G
-------
P
I
F
--
M
T
I
P
A
F
F
A
K
-
T
-----
S
A
V
-----
Y
N
P
V
I
Y
I
M
--
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
----------------
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A
44
Fugue
71.44
20%
-138
- C1 -
4QT9
2
?
A:
[19-432]
------LS
D
D
A
L
M
D
T
V
Q
R
R
T
F
L
Y
F
W
E
G
A
E
P
N
S
GLAP
E
R
Y
H
V
D
G
V
Y
P
Q
N
D
A
N
V
V
T
S
G
---
G
S
G
F
G
I
M
A
I
L
A
G
I
D
---
R
G
Y
V
T
R
E
E
G
L
A
R
M
E
R
I
V
S
F
L
E
K
A
D
R
-
F
H
G
A
Y
P
H
W
W
Y
G
D
TG
K
V
K
P
F
GQKDN
G
G
D
L
V
E
T
A
F
L
M
Q
G
L
--
L
A
V
H
Q
Y
Y
A
N
G
N
D
K
E
K
A
I
A
Q
R
I
D
R
L
W
R
E
V
DWDWYRKGGQNVLYWH
W
S
P
T
Y
GWEMD
F
P
I
H
G
YNE
C
M
I
M
Y
I
L
A
A
A
SPTHGVP
A
A
V
Y
H
D
G
W
A
Q
-
N
-----------
G
A
I
V
S
P
H
K
V
EGIELHLRYQGTEAGP
L
F
W
A
Q
Y
S
F
L
G
LD
P
V
G
L
K
D
E
Y
C
P
S
Y
F
H
E
M
R
N
L
T
L
V
N
R
A
--------
Y
C
I
R
N
-
P
K
H
Y
K
G
F
G
P
D
C
W
G
L
T
A
S
Y
S
V
D
G
Y
A
A
H
S
P
N
E
Q
D
DKG------
V
-------
I
-----------
S
-----------
P
--------------------
T
---
A
---
A
L
-----
S
S
I
V
Y
T
P
---
E
Y
S
L
Q
V
M
R
H
L
Y
N
M
G
D
K
VFGP
F
G
F
-------
Y
DA-
F
-
S
E
T
----------
D
N
-
W
----------
Y
-------
P
Q
R
YL
A
I
D
Q
G
P
I
A
V
M
I
-----
E
N
Y
-----
R
T
G
L
L
W
K
L
F
M
S
H
P
D
V
Q
A
G
L
T
K
L
G
F
----------------
N
T
N
------------------
28
HHSearch
70.10
17%
-110
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
-------------------------------
T
----
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
---
N
S
L
V
M
L
-
V
I
L
Y
S
R
V
---
G
-
R
S
V
T
D
V
Y
L
L
N
-
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
--
W
I
F
G
T
-----
F
L
C
K
V
V
S
L
L
K
-
E
V
N
--
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-----------------
Q
K
R
H
L
-------------
V
-
K
-
F
V
C
L
G
C
--------------
W
G
L
-
S
-----------
M
N
L
S
L
P
F
F
-----------------
L
F
R
Q
A
Y
H
P
------
N
N
S
S
P
V
C
Y
----
E
-
V
L
G
N
D
---
T
--------
A
K
W
R
M
-
V
L
-
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
---------
A
-------
H
-----------------------
M
--------------------
G
---
Q
---
K
H
-----
R
A
M
R
V
I
F
---
A
V
-
V
L
I
-
F
L
L
C
W
-
L
P
Y
----
N
L
V
-------
L
---
L
-
A
D
T
----------
L
M
-
R
TQVIQE
S
C
E
R
R
N
N
I
----
G
R
A
--
L
D
A
T
E
I
L
G
F
-
L
-----
H
S
C
-----
L
N
P
I
I
Y
A
F
--
I
G
Q
N
F
R
H
G
F
L
K
I
-
L
----------------
A
M
H
G
-----------------