@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1D4_HUMAN: (2016-01-12 )
MDGDNQSENSQFLLLGISESPEQQQILFWMFLSMYLVTVLGNVLIILAISSDSHLHTPMYFFLANLSFTDLFFVTNTIPKMLVNFQSQNKAISYAGCLTQLYFLVSLVTLDNLILAVMAYDRYVAICCPLHYVTAMSPGLCVLLLSLCWGLSVLYGLLLTFLLTRVTFCGPREIHYLFCDMYILLWLACSNTHIIHTALIATGCFIFLTLLGFMTTSYVRIVRTILQMPSASKKYKTFSTCASHLGVVSLFYGTLAMVYLQPLHTYSMKDSVATVMYAVLTPMMNPFIYSLRNKDMHGAPGRVLWRPFQRP
Atome Classification :
(20 SA)
------------........------.10.......-.--------20...-------.....30........40........50........60........70.--.....-..80........90........100.--......110.......120---.......--130.......-140.......150.......160-.------------.....------.170......-----.--180.......190.......200-...--------.....210.....--..220--........-------230--.-----------.--------------------.......240----..----------.....--------.250---.........260..------.-.----.---..270----..---...--------..280---.........290.......300....---...310----------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MDGDNQSE------NS
Q
F
L
L
L
GIS-E--------SP
E
Q
Q
-------
Q
I
L
F
W
M
F
L
S
M
Y
L
V
T
V
LG
N
V
L
I
I
L
A
ISSDSHLH
T
P
M
Y
F
F
L
ANLS
F
T
D
L
F
--
F
V
T
NT-
I
P
K
M
L
V
N
FQSQNKA
I
S
Y
A
G
C
L
T
Q
L
Y
F
--
L
V
S
L
V
T
L
D
N
L
I
L
A
V
M
AYD
R
---
Y
V
A
I
C
C
P
--
L
H
Y
V
TAMSP
G
-
L
C
V
L
L
L
S
L
C
W
G
L
S
V
L
Y
G
L
L
L
T
F
L
-
L
------------
T
R
V
TF------CGP
R
E
I
H
Y
L
F
-----
C
--
D
M
Y
I
L
L
W
L
ACSN
T
H
I
I
H
T
A
L
I
A
--
T
G
C
--------
F
I
F
L
T
L
L
G
F
M
T
T
S
--
Y
V
R
I
---
V
R
T
I
L
QMP-------S----A-----------S--------------------KK
Y
K
T
F
S
T
C
-----
A
S
----------
H
L
G
V
V
--------
S
L
-----
F
Y
G
T
L
A
M
V
Y
L
QPLH------T-Y----S---
M
K
D
S
V
----
A
T
---
V
M
Y
--------
A
V
L
-----
T
P
M
M
N
P
F
I
Y
S
LRNKDMHGAPGR
V
L
WR---PFQRP-----------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
95.85
22%
-168
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQPKEGK
A
---
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
QPLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
L
--------
A
I
-----
I
V
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
-----
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
95.59
22%
-169
- C3 -
2YDV
6
?
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQPK
E
G
K
A
H
S
Q
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
Q---------------------------------------
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
L
--------
A
I
-----
I
V
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
93.72
23%
-166
- C3 -
3VG9
8
?
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQ-------
S
Q
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
Q
PLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
L
--------
A
I
-----
I
V
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
93.11
22%
-169
- C3 -
2YDO
3
?
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQPK
E
G
K
A
H
S
Q
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
-----------------------------------------
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
L
--------
A
I
-----
I
V
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.61
23%
-167
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQ-------
S
Q
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
Q
PLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
L
--------
A
I
-----
I
V
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.22
22%
-172
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQP--------
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
QPLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
A
--------
A
I
-----
I
A
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
---
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
-----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.04
22%
-173
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQP--------
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
QPLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
A
--------
A
I
-----
I
A
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
---
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
-----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.69
22%
-172
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQP--------
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
QPLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
A
--------
A
I
-----
I
A
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
---
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
-----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.59
22%
-172
- C3 -
3PWH
1
?
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQP--------
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
QPLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
A
--------
A
I
-----
I
A
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
---
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
-----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.16
22%
-172
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQP--------
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
---
R
R
Q
L
K
Q
M
E
-------
S
QPLP
G
-----------
E
--------------------
R
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
A
--------
A
I
-----
I
A
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
---
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
-----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.57
22%
-172
- C3 -
4UG2
3
?
A:
[14-296]
-----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
-
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
GWNNCGQPK
E
G
K
A
H
S
Q
G
------
C
G
E
G
Q
V
A
C
L
F
-----
E
--
D
V
V
P
M
-------
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
L
A
A
---
R
R
Q
L
--------------------------------------------------
A
R
S
T
L
Q
K
E
-----
V
H
----------
A
A
K
S
L
--------
A
I
-----
I
V
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
-
T
-
F
----
F
---
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
87.00
18%
-153
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-333]
--------------------------------------------------
Y
-------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
--
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
---
Y
N
V
I
G
R
P
--
M
A
A
S
K
K
M
S
H
R
-
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
------------
G
A
Y
T
L
----------
E
G
V
L
C
N
-----
C
--
S
F
D
Y
I
S
-----
R
D
S
T
T
R
S
N
I
L
C
--
M
F
I
--------
L
G
F
F
G
P
I
L
I
I
F
F
C
--
Y
F
N
I
---
V
M
S
V
S
N
H
E
-------
K
----
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
-----
I
V
----------
I
V
S
Q
F
--------
L
L
-----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
------
G
-
P
LEW-
V
T--
P
Y
A
A
Q
----
L
P
---
V
M
F
--------
A
K
A
-----
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
---
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
86.63
18%
-155
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
-----------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
--
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
--
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
---
Y
M
A
I
I
H
P
--
L
Q
P
R
L
--
S
A
T
-
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
------------
T
T
E
T
-----------
M
P
S
R
V
V
-----
C
--
M
I
E
W
P
E
H
---
P
N
K
I
Y
E
K
V
Y
H
I
C
--
V
T
V
--------
L
I
Y
F
L
P
L
L
V
I
G
Y
A
--
Y
T
V
V
---
G
I
T
L
W
A
S
E
-------
I
----
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
K
M
M
-----
I
V
----------
V
V
C
T
F
--------
A
I
-----
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
------
N
-
P
DLYL
K
KFI
Q
Q
V
Y
L
----
A
I
---
M
W
L
--------
A
M
S
-----
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
---
C
P
F
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
81.38
17%
-124
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------
M
N
G
T
E
G
P
N
FYVPFS
N
K
T
G
V
V
R
S
P
F
-
E
--------
A
P
Q
Y
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
---
Y
V
V
V
C
K
P
--
M
S
N
F
R
-
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
------------
S
R
Y
I
P
E
GMQC
S
C
G
I
---------------
D
Y
Y
-----
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
--
M
F
V
--------
V
H
F
I
I
P
L
I
V
I
F
F
C
--
Y
G
Q
L
VFT
V
K
E
A
A
A
S
A
-------
T
----
T
-----------
Q
--------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
----------
F
L
I
C
W
--------
L
P
-----
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
------
D
-
F
----
G
---
P
I
F
M
T
----
I
P
---
A
F
F
--------
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
78.11
19%
-138
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
--------------------------------------------------
K
-------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
--
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
---
Y
L
A
I
V
H
A
--
T
R
T
L
T
-
Q
K
R
H
-
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
------------
Q
A
Y
H
P
----------
N
N
S
S
P
V
-----
C
--
Y
E
V
L
G
N
D
----
T
A
K
W
R
M
V
L
R
I
L
--
P
H
T
--------
F
G
F
I
V
P
L
F
V
M
L
F
C
--
Y
G
F
T
---
L
R
T
L
F
K
A
H
-------
M
----------------
G
--------------------
Q
K
H
R
A
M
R
V
I
-----
F
A
----------
V
V
L
I
F
--------
L
L
-----
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
RTQVI
Q
E
S
C
E
R
-
R
N
N
I
G
R
A
L
D
----
A
T
---
E
I
L
--------
G
F
L
-----
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
---
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
77.40
14%
-124
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------
D
E
V
W
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
--
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
--
F
K
Y
Q
S
L
L
T
K
N
-
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
------------
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
EETC
C
--
D
F
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--------
V
I
M
V
F
V
Y
S
R
V
F
Q
E
--
A
K
R
Q
---
L
N
I
F
E
M
L
R
-------
I
----
D
-----------
E
--------------------
G
L
R
L
K
I
Y
K
D
-----
T
E
----------
G
Y
Y
T
I
GIGHLLTK
S
P
-----
S
L
N
A
A
K
S
E
L
D
K
A
I
G
------
R
-
N
----
T
---
N
G
V
I
T
----
K
D
---
E
A
E
--------
K
L
F
-----
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
---
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
32
HHSearch
76.69
17%
-128
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-326]
----------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
---
Y
V
V
V
C
K
P
--
M
S
N
F
R
-
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
------------
S
R
Y
I
P
----------
E
G
M
Q
C
S
-----
C
--
G
I
D
Y
Y
T
P
---
H
E
E
T
N
N
E
S
F
V
I
Y
--
M
F
V
--------
V
H
F
I
I
P
L
I
V
I
F
F
C
--
Y
G
Q
L
---
V
F
T
V
K
E
A
A
-------
A
----
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
E
V
T
R
M
V
-----
I
I
----------
M
V
I
A
F
--------
L
I
-----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
-----
Q
-
G
----
S
DFG
P
I
F
M
T
----
I
P
---
A
F
F
--------
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
75.07
17%
-171
- C2 -
4NWV
2
?
A:
[30-384]
-----SVAPVAK
A
N
A
L
R
T
T
S
------
S
N
S
I
L
L
K
G
C
D
-
R
I
V
T
V
V
DAS
T
Y
D
A
G
-------
S
A
I
V
S
I
P
I
T
P
D
I
A
Y
R
L
G
S
T
A
R
T
F
Q
R
I
K
Y
R
S
L
K
F
R
V
N
A
Q
C
A
T
T
T
A
G
G
Y
V
A
G
F
V
K
D
A
-
A
D
V
L
P
T
G
T
A
S
I
P
Y
L
M
S
N
T
G
S
F
T
Q
P
W
W
K
S
T
V
H
N
V
K
I
P
Q
K
L
F
Y
T
E
A
P
T
R
GAD
A
V
R
E
Y
C
P
G
Q
F
H
V
L
V
D
S
K
P
S
Q
I
C
P
V
T
V
D
L
E
W
V
V
E
L
H
D
A
--------------------
T
F
R
K
E
------
S
D
Q
T
A
I
S
A
I
V
-----
A
--
D
H
T
L
N
V
Y
G
L
P
A
T
S
N
R
V
G
H
I
L
I
S
--
P
I
G
Q
T
P
K
D
LT
P
T
R
F
A
T
F
F
G
F
L
P
D
D
K
F
C
V
R
I
P
T
P
V
D
V
V
L
T
G
D
-------
N
----
V
-----------
Y
--------------------
Q
S
V
E
A
T
H
I
R
-----
A
Y
L
V
N
GGL
G
I
D
F
H
L
A
A
Y
--------
N
D
-----
T
T
H
T
I
Q
P
I
I
P
T
L
W
N
------
V
-
Y
----
D
---
V
T
G
A
V
TAPF
T
S
---
A
I
Y
D
N
------
H
V
W
-----
T
H
K
D
K
F
V
P
V
S
F
Q
D
E
P
I
---
P
G
T
V
F
D
Y
---
L
Y
P
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
75.07
23%
-160
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
----------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
--
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
--
F
K
Y
Q
S
L
L
T
K
N
-
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
------------
Y
R
A
T
H
------
Q
-----
E
A
I
N
-----
C
--
Y
A
----
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
--
S
S
I
--------
V
S
F
Y
V
P
L
V
I
M
V
F
V
--
Y
S
R
V
---
F
Q
E
A
K
R
Q
L
-------
N
----
I
-----------
F
--------------------
E
M
L
R
I
D
E
G
L
-----
R
L
----------
K
I
Y
K
D
--------
T
E
-----
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
------
P
-
S
----
L
---
N
A
A
K
S
----
E
L
---
D
K
A
--------
I
G
R
-----
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
---
L
R
N
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
74.16
17%
-109
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
------
R
S
P
F
E
A
P
Q
Y
Y
L
A
--------
E
P
W
Q
F
-------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
---
Y
V
V
V
C
K
P
--
M
S
N
F
R
-
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
------------
S
R
Y
I
P
------
E
G
M
Q
----
C
S
-----
C
G
I
D
Y
Y
T
P
-----
H
E
E
T
N
N
E
S
F
V
I
Y
--
M
F
V
--------
V
H
F
I
I
P
L
I
V
I
F
F
C
--
Y
G
Q
L
---
V
F
T
V
K
E
A
A
AQQQESA
T
----
T
-----------
Q
--------------------
K
A
E
K
E
V
T
R
M
-----
V
I
----------
I
M
V
I
A
--------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
------
D
-
F
----
G
---
P
I
F
M
T
----
I
P
---
A
F
F
--------
A
K
T
-----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
GKN
P
L
G
D
D
EA
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------------