@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1E1_HUMAN: (2016-01-12 )
MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLLIIVLIRLDSHLHTPMYLFLSNLSFSDLCFSSVTIPKLLQNMQNQDPSIPYADCLTQMYFFLLFGDLESFLLVAMAYDRYVAICFPLHYTAIMSPMLCLALVALSWVLTTFHAMLHTLLMARLCFCADNVIPHFFCDMSALLKLAFSDTRVNEWVIFIMGGLILVIPFLLILGSYARIVSSILKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCSSANSSTLKDTVMAMMYTVVTPMLNPFIYSLRNRDMKGALSRVIHQKKTFFSL
Atome Classification :
(20 SA)
-----------.........10----..-------.......--20......--------..30........40.....-----...50........60....------------....70......-..80.......---.90........100.......110.......120.-----------......130----.....-..140......---.150.......160-----...---.------....170..----.....180.......190-........200.--......210----........220-----......---------..230----------..--------------------......240....-------...250-----........260.-...---.------.-------.270.-------------......280.......290...-....300.......310..------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MMGQNQT
S
I
S
-----
D
F
-------
L
L
LGLPI--QPEQQ
N
L
C
--------
Y
A
L
F
L
A
M
Y
L
T
T
L
L
G
N
L
L
I
I
-----
V
L
I
RLDSHLH
T
P
M
Y
L
F
L
SN------------L
S
F
S
D
L
C
FSSV
T
-
I
P
K
L
L
Q
N
M
QNQ---DPSI
P
Y
A
D
C
L
T
Q
M
Y
F
F
L
L
F
G
D
L
E
S
F
L
L
V
A
M
AYD
R
Y
-----------
V
A
I
C
F
P
L
H
Y
----
T
A
I
M
S
-
P
M
L
C
L
A
L
V
A
L
S
---
W
V
L
T
T
F
H
A
M
L
H
T
L
------
L
M
A
---
R
------
L
C
F
C
A
DN
V
I
----
P
H
F
FC
D
M
S
A
L
L
K
L
AFSD--TRV
N
E
W
V
I
F
I
MG--
G
L
I
L
V
I
P
F
-----
L
L
I
L
G
S
Y
A
R
I
------
V
S
S
I
L
K---------VPSS-----------K
G
--------------------
I
C
K
A
F
S
T
CG
S
H
L
S
-------
V
V
S
L
F
------
Y
G
T
V
I
G
L
Y
LCSS-ANS---
S
------
T
-------
L
K
D
T
V
-------------
M
A
M
M
Y
T
V
V
T
P
M
L
N
P
F
I
Y
S
L
RNR-
D
M
K
G
A
L
S
R
V
I
H
Q
K
K
TFFSL------------------
1
PsiBlast_PDB
90.29
22%
-154
- C4 -
3PWH
1
?
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
A
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
A
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
------------
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
----
I
A
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
2
PsiBlast_PDB
89.93
22%
-155
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
A
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
A
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
------------
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
----
I
A
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
4
PsiBlast_PDB
89.78
22%
-154
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
A
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
A
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
------------
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
----
I
A
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
5
PsiBlast_PDB
89.75
22%
-155
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
A
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
A
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
------------
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
----
I
A
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
3
PsiBlast_PDB
89.66
22%
-153
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
A
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
A
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
------------
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
----
I
A
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
10
PsiBlast_PDB
88.98
21%
-147
- C4 -
4UG2
3
?
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
R
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
K
E
G
K
----
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
R
Q
L-----------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
----
I
V
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
6
PsiBlast_PDB
88.98
22%
-161
- C4 -
3VG9
8
?
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
R
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
-----------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
----
I
V
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
7
PsiBlast_PDB
88.46
22%
-158
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
R
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
-----------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
----
I
V
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------------------
9
PsiBlast_PDB
87.48
21%
-147
- C4 -
2YDV
6
?
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
R
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
K
E
G
K
----
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
R
Q
L
K
Q
M
ESQ------------------S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
-----
I
V
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
11
PsiBlast_PDB
87.24
21%
-149
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
R
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
K
E
G
K
----
A
---
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
----
I
V
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
-
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
8
PsiBlast_PDB
87.18
21%
-149
- C4 -
2YDO
3
?
A:
[14-304]
----------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
------------
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
---
C
A
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
-----------
I
A
I
R
I
P
L
R
Y
----
N
G
L
V
T
-
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
-
S
F
A
I
G
L
T
P
M
------
L
G
W
---
N
------
N
C
G
Q
P
K
E
G
K
----
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
F
N
F
--
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
R
Q
L
K
Q
M
E
S-------------------T
L
Q
K
E
V
H
A
A
K
S
L
A
I
------
I
V
G
L
F
A
L
C
W
L
P
L
H
-------
I
I
N
C
F
------------
T
F
F
C
P
D
-
C
S
H
---
A
------
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
------------------
33
HHSearch
86.41
19%
-153
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-333]
----------------------------------------------
A
V
Y
Y
S
L
--------
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
-----
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
------------
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
-----------
N
V
I
G
R
P
M
A
A
----
S
K
K
M
S
-
H
R
R
A
F
I
M
I
I
F
V
---
W
L
W
S
V
L
W
A
I
G
P
I
F
------
G
W
G
---
A
------
Y
T
L
----
E
G
----
V
L
C
N
C
S
F
D
Y
I
S
-----
R
--
D
S
T
T
R
S
N
I
L
C
M
F
--
I
L
G
F
F
G
P
I
-----
L
I
I
F
F
C
Y
F
N
I
------
V
M
S
V
S
N
---------
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
-------
Q
F
L
L
S
------
W
S
P
Y
A
V
V
A
L
L
A
Q
-
F
G
P
LEW
V
------
T
-------
P
Y
A
A
Q
-------------
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------
38
Fugue
84.31
18%
-122
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------
M
N
G
T
E
G
P
N
F
Y
VPFSN
K
T
-------
G
V
V
R
S
P
F
--
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
------------
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
-
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
------
G
W
S
---
R
-------------
Y
I
----
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
--
V
V
H
F
I
I
P
L
-----
I
V
I
F
F
C
Y
G
Q
L
------
V
F
T
V
K
E
---------
A
A
A
S
-----------
A
T
--------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
-------
I
M
V
I
A
------
F
L
I
C
W
L
P
Y
A
G
V
A
-
F
Y
I
---
F
------
T
H
QGSDFG
P
I
F
M
T
-------------
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A------
30
HHSearch
83.68
16%
-151
* C4 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------------------
L
W
--------
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
-----
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
------------
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
---
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
-----------
M
A
I
I
H
P
L
Q
P
----
R
L
--
S
-
A
T
A
T
K
V
V
I
C
V
I
---
W
V
L
A
L
L
L
A
F
P
Q
G
Y
------
Y
S
T
---
T
------
E
T
-----
M
P
----
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
--
K
I
Y
E
K
V
Y
H
I
C
V
T
--
V
L
I
Y
F
L
P
L
-----
L
V
I
G
Y
A
Y
T
V
V
------
G
I
T
L
W
A
---------
S
E
I
P
GDSSDRYH
E
Q
V
S
A
--------------------
K
R
K
V
V
K
M
M
I
V
V
V
C
-------
T
F
A
I
C
------
W
L
P
F
H
I
F
F
L
L
P
Y
-
I
N
P
---
D
LYLKKF
I
-------
Q
Q
V
Y
L
-------------
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
-
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
------------------
17
PsiBlast_PDB
81.43
22%
-141
- C4 -
2ZIY
2
OPSD_TODPA
A:
[64-327]
--------------------------------------------------------------------------------------------
L
Q
T
P
A
N
M
F
I
I
N
------------
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
-----------
N
V
I
G
R
P
M
A
A
----
S
K
K
M
S
-
H
R
R
A
F
I
M
I
I
F
V
---
W
L
W
S
V
L
W
A
I
G
P
I
F
GW
G
A
Y
T
L
E
G
---
V
------
L
C
N
C
S
F
D
Y
I
----
S
R
---
D
---------
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
------
M
A
A
M
A
K
---------
R
L
N
A
-----------
K
E
--------------------
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
-
L
E
W
---
V
------
T
-------
P
Y
A
A
Q
-------------
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------
19
PsiBlast_PDB
80.00
22%
-136
- C4 -
2Z73
5
OPSD_TODPA
A:
[65-328]
--------------------------------------------------------------------------------------------
L
Q
T
P
A
N
M
F
I
I
N
------------
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
-----------
N
V
I
G
R
P
M
A
A
----
S
K
K
M
S
-
H
R
R
A
F
I
M
I
I
F
V
---
W
L
W
S
V
L
W
A
I
G
P
I
F
GW
G
A
Y
T
L
E
G
---
V
------
L
C
N
C
S
F
D
Y
I
----
S
R
---
D
---------
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
------
M
A
A
M
A
K
---------
R
L
N
A
-----------
K
E
--------------------
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
-
L
E
W
---
V
------
T
-------
P
Y
A
A
Q
-------------
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------
20
PsiBlast_PDB
79.95
22%
-137
- C4 -
3AYM
3
OPSD_TODPA
A:
[65-328]
--------------------------------------------------------------------------------------------
L
Q
T
P
A
N
M
F
I
I
N
------------
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
-----------
N
V
I
G
R
P
M
A
A
----
S
K
K
M
S
-
H
R
R
A
F
I
M
I
I
F
V
---
W
L
W
S
V
L
W
A
I
G
P
I
F
GW
G
A
Y
T
L
E
G
---
V
------
L
C
N
C
S
F
D
Y
I
----
S
R
---
D
---------
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
------
M
A
A
M
A
K
---------
R
L
N
A
-----------
K
E
--------------------
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
-
L
E
W
---
V
------
T
-------
P
Y
A
A
Q
-------------
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------
39
Fugue
79.49
17%
-125
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
-----
S
P
-------
F
E
A
P
Q
Y
Y
LA
E
P
W
Q
F
S
M
L
--------
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
------------
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
N
----
F
R
F
G
E
-
N
H
A
I
M
G
V
-
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
------
G
W
S
---
R
Y
I
P
E
GM
Q
C
S
C
G
--------
I
D
Y
Y
T
P
H
E
E
T
N
-----------
N
E
S
F
V
I
Y
M
F
--
V
V
H
F
I
I
P
L
-----
I
V
I
F
F
C
Y
G
Q
L
------
V
F
T
V
K
E
---------
A
A
A
Q
-----------
Q
Q
----------------------
E
S
A
T
T
Q
K
A
E
K
E
-------
V
T
R
M
V
------
I
I
M
V
I
A
F
L
I
C
W
L
-
P
Y
A
---
G
------
V
-------
A
F
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA
31
HHSearch
78.69
17%
-133
- C4 -
1U19
14
OPSD_BOVIN
A:
[37-327]
---------------------------------------------
P
W
Q
F
S
M
L
--------
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
------------
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
-----------
V
V
V
C
K
P
M
S
N
----
F
R
F
-
G
-
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
------
G
W
S
---
R
------
Y
I
---
P
-
E
G
----
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
--
V
V
H
F
I
I
P
L
-----
I
V
I
F
F
C
Y
G
Q
L
------
V
F
T
V
K
E
---------
A
A
A
Q
-----------
Q
Q
ESA
T
T
Q
K
A
------------
E
K
E
V
T
R
M
V
I
I
M
V
I
-------
A
F
L
I
C
------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---
S
DF----
G
-------
P
I
F
M
T
-------------
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
------------------
47
Fugue
74.71
22%
-153
- C1 -
4L9B
5
?
A:
[2-393]
------VLKGI
N
F
P
E
N
E
A
S
I
L
-----
D
L
A
M
QN
R
S
G
V
L
D
G
M
T
I
--
D
I
L
N
T
T
S
---------
N
Q
L
A
L
F
H
G
T
A
V
L
Q
G
Y
G
I
E
I
TGAPD
V
L
V
D
T
T
G
Q
S
N
E
T
M
L
L
C
L
T
I
D
LN
Q
V
N
V
PSGTA
V
D
Y
K
Q
I
R
L
E
F
L
D
-
V
P
T
L
L
K
Q
Y
W
R
D
HSL
H
D
L
I
D
P
R
R
V
I
S
M
P
L
Y
W
I
T
F
G
Q
T
G
T
T
P
L
Y
E
Q
I
K
S
N
Y
IDNSGNPAYGI
A
A
R
C
E
N
F
N
H
F
I
N
K
V
A
V
Q
S
I
P
I
N
G
V
A
N
R
P
V
S
ST
A
S
Q
L
T
N
Y
K
V
W
R
N
P
Y
------
L
C
S
QDP
R
------
D
K
F
A
P
D
N
L
V
I
EED
G
I
Y
R
I
D
I
S
G
S
I
N
I
A
N
Y
T
F
P
A
R
V
G
G
R
Y
F
Q
I
V
C
--
A
R
N
S
S
A
N
N
-----
L
A
E
F
G
A
E
Q
H
L
P
P
S
GVW
T
R
R
V
L
V
---------
G
E
Y
T
-----------
A
G
--------------------
M
T
---
E
Q
A
F
S
S
V
A
-------
T
I
S
L
F
------
K
G
D
N
F
F
L
Q
F
E
T
G
-
T
N
T
---
S
---------------
R
D
S
A
-------------
Y
N
N
G
Y
G
T
S
G
T
H
L
R
N
F
S
Y
T
L
E
R
V
G
D
L
N
G
---
T
A
Y
Y
D
N
G
T
F
---------------------