@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1E2_HUMAN: (2016-01-12 )
MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLLIIVLIRLDSHLHTPVYLFLSNLSFSDLCFSSVTMPKLLQNMQNQDPSIPYADCLTQMYFFLYFSDLESFLLVAMAYDRYVAICFPMHYTAICFLLHYTAIMSPMLCLSVVALSWVLTTFHAMLHTLLMARLCFCADNVIPHFFCDMSALLKLACSDTRVNEWVIFIMGGLILVIPFLLILGSYARIVSSILKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCPSANSSTLKDTVMAMMYTVVTPMLTPFIYSLRNRDMKGALERVICKRKNPFLL
Atome Classification :
(20 SA)
-----------.........10----.........--20.----.....--------.------.30........40........50--------........60........70......-..80........90.........100.......110...--....120.......130.......140.......150.......160.......170.......180...---....190-----......--.-------200.......210-.....--...220.......230....---------...240---------.--------------------.----------------.......250......------.260.......270.------.---------.---.---.-------..280-------------.....--------------..290......--.300-.......310--...----.....320.--------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MMGQNQT
S
I
S
-----
D
F
L
L
LGLPI--QPE----QQ
N
L
C
--------
Y
------
A
L
F
L
A
M
Y
L
T
T
L
L
G
N
L
L
I
I
V
L
I
RL--------DSHLH
T
P
V
Y
L
F
L
SNL
S
F
S
D
L
C
F
SSV
T
-
M
P
K
L
L
Q
N
M
QNQDP-SI
P
Y
A
D
C
L
T
Q
M
Y
F
F
L
Y
F
S
D
L
E
S
F
L
L
--
V
A
M
AYD
R
Y
V
A
I
C
F
P
M
H
Y
T
A
I
C
F
L
L
H
Y
T
A
I
M
S
P
M
L
C
L
S
V
V
A
L
S
W
V
L
T
T
F
H
A
M
L
H
T
L
L
M
A
R
L
C
F
C
A
DN
V
I
P
H
---
F
FC
D
M
S
A
-----
L
L
K
LAC--S-------DTRV
N
E
W
V
I
F
I
M--G
G
L
I
L
--
V
I
P
F
L
L
I
L
G
S
Y
A
R
I
V
S
S
I
L
K---------VPSS-----------K--------------------
G
----------------
I
C
K
A
F
S
T
CG
S
H
L
S
V
V
S
------
L
F
Y
G
T
V
I
G
L
Y
LCPSA------N---------S---
S
---
T
-------
L
K
D
T
V
-------------
M
A
M
M
Y
--------------
T
V
V
T
P
M
L
T
P
F
I
--
Y
S
L
R-NR
D
M
K
G
A
L
E
---
R
V
I
----
C
KRKNPFLL--------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
87.03
20%
-169
* C1 *
4N5H
5
?
X:
[1-315]
MADEEAMLAKV
Q
A
S
W
A
Q
T
A
A
R
-----
D
K
A
R
Y
A
D
E
R
--
V
P
E
DVHW
E
T
E
Y
R
--------
Y
EQSADP
Q
Q
T
L
N
L
Y
Y
P
A
K
R
R
N
A
T
M
P
T
V
I
D
I
HGGGWFYG
D
R
N
L
N
R
N
Y
C
R
Y
L
A
S
Q
G
Y
A
V
M
G
M
G
Y
R
L
-
L
P
-------
D
V
D
L
-
R
G
Q
I
Q
D
I
F
A
S
L
R
W
L
S
H
F
G
P
Q
R
G
F
D
L
DH
V
L
L
T
G
D
S
-----
A
G
G
H
L
A
S
L
V
A
C
I
Q
Q
S
A
E
L
Q
E
L
F
G
V
S
R
V
N
F
N
F
----------
T
L
V
A
L
V
C
P
V
A
E
P
S
K
L
P
E
---
A
A
G
D
M
S
D
MAAFY
L
D
K
L
S
G
--
G
-------
D
Q
A
L
V
D
H
L
N
F
S
Q
VV
K
G
L
D
L
--
P
-
P
F
M
L
I
G
G
Q
N
D
S
F
---------------
Y
L
Q
S
-----------
Q
--------------------
A
----------------
L
L
K
V
F
D
A
--
N
H
V
T
Y
T
T
------
K
L
W
P
A
S
A
G
P
H
L
K
H
V
F
------
N
---------
V
---
Q
---
H
-------
W
E
----------------
W
P
E
S
I
--------------
E
T
N
L
E
M
L
R
T
F
D
--
A
L
S
K
-
Q
Q
D
Q
A
E
E
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.11
21%
-153
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
-------------
G
C
G
-----
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
A
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S-------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.89
21%
-155
- C3 -
3PWH
1
?
A:
[14-305]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
-------------
G
C
G
-----
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
A
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S-------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.78
21%
-162
- C3 -
3VG9
8
?
A:
[14-309]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
------------
S
Q
G
C
G
-----
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
S
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S
HV
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.70
21%
-156
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
-------------
G
C
G
-----
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
A
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.54
21%
-155
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
-------------
G
C
G
-----
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
A
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S-------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.32
20%
-148
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[14-314]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
--------
G
C
G
-----
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
----------------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
S
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
--------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.31
21%
-153
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
-------------
G
C
G
-----
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
A
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S-------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
85.12
19%
-125
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------
M
N
G
T
E
G
P
N
F
Y
VPFSN
K
T
G
V
V
R
S
P
F
--
E
A
P
----
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
--------
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
--
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
----------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-------
Y
I
P
E
---
G
------------
M
Q
C
S
C
--
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
--
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
S
-----------
A
--------------------
T
----------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
------
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
------
Y
---------
I
---
F
---
T
H
QGSDFG
P
I
F
M
T
-------------
I
P
A
F
F
--------------
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
---
T
T
L
----
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.94
21%
-161
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[14-308]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
------------
S
Q
G
C
G
-----
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
S
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S
H
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
84.83
20%
-148
- C3 -
2YDO
3
?
A:
[14-314]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
-----
S
Q
G
C
G
-----
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S---------------------------------------T
L
Q
K
E
V
H
A
A
K
S
L
A
I
--
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
S
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
--------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.07
20%
-147
- C3 -
2YDV
6
?
A:
[14-314]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
-----
S
Q
G
C
G
-----
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ--------------------------------------S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
-
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
S
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
--------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.56
20%
-147
- C3 -
4UG2
3
?
A:
[14-309]
-------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
--------
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
-
A
C
--
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
--
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---------
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
-----
S
Q
G
C
G
-----
E
G
Q
V
A
C
LF
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
--
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L-------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
------
T
F
F
C
P
D
C
------
S
---------
H
---
A
---
P
-------
L
W
L
M
Y
-------------
L
A
I
V
L
--------------
S
H
T
N
S
V
V
N
P
F
I
--
Y
A
Y
R
-
I
R
E
F
R
Q
T
F
R
---
K
I
I
R
SHV
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
83.01
18%
-154
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
--------------------------------------------
V
Y
Y
S
L
--------
G
------
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
--------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
--
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
---------
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
---
C
N
C
S
F
D
Y
-----
I
S
R
--------------
D
S
T
T
R
S
N
I
L
C
M
--
F
I
L
G
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
----------------
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
------
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
------
G
---------
P
LEW
V
---
T
-------
P
Y
A
A
Q
-------------
L
P
V
M
F
--------------
A
K
A
S
A
I
H
N
P
M
I
--
Y
S
V
S
-
H
P
K
F
R
E
A
I
S
---
Q
T
F
----
P
W
V
L
T
C
C
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
80.23
17%
-117
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
-----
S
P
F
E
A
P
Q
Y
Y
LA
E
P
W
----
Q
F
S
M
L
--------
A
------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
--------
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
--
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
----
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
----
I
D
---
Y
Y
T
P
H
E
E
-----
T
N
------------------
N
E
S
F
V
I
Y
M
--
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
Q
-----------
Q
--------------------
Q
------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
------
Y
---------
A
---
G
---
V
-------
A
F
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
--------------
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
---
T
T
L
----
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA--------------------------------------------------------------------------------------------------------------------------
28
HHSearch
78.60
16%
-146
- C3 -
2KS9
1
NK1R_HUMAN
A:
[32-324]
---------------------------------------------
I
V
L
W
--------
A
------
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
--------
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
--
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
---------
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
---
V
V
C
M
I
E
W
-----
P
E
H
P
------------
N
K
I
Y
E
K
V
Y
H
I
C
V
--
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
---------
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
----------------
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
------
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
------
N
---------
P
---
D
LYL
K
KFI----
Q
Q
V
Y
L
-------------
A
I
M
W
L
--------------
A
M
S
S
T
M
Y
N
P
I
I
--
Y
C
C
L
-
N
D
R
F
R
L
G
F
K
---
H
A
F
----
R
C
C
P
F
I
S
A
G
--------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
76.89
18%
-148
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------------------------
S
F
K
C
A
L
T
K
--
T
G
F
----
Q
F
Y
Y
L
--------
P
------
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
--------
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
--
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
----------
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
-------
I
L
F
Y
S
G
T
G
V
R
K
NKT
I
T
C
Y
D
T
T
-------------
S
-------
D
E
Y
L
R
S
Y
F
I
Y
S
M
--
C
T
T
V
A
MF
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
----------
K
M
K
-----------
K
--------------------
Y
----------------
T
C
---
T
V
C
G
Y
I
Y
N
P
E
D
GDPDNG
V
N
P
G
T
D
F
K
D
I
V
C
P
L
C
------
G
VGKDQ
F
E
E
V
E
---
E
---
P
-------
L
R
R
K
S
-------------
I
Y
L
V
I
--------------
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
-
T
M
N
L
R
A
R
L
D
FQT
P
A
M
----
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR--------------------------------------------------------------------------------------------------------------
31
HHSearch
76.62
17%
-132
* C3 *
1U19
14
OPSD_BOVIN
A:
[40-328]
---------------------------------------------
F
S
M
L
--------
A
------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
--------
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
--
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
---------
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
----
E
G
M
Q
---
C
S
C
G
I
D
Y
-----
Y
T
P
-----
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
--
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
----------------
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
------
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
-----
Q
GS-------
D
---
F
---
G
-------
P
I
F
M
T
-------------
I
P
A
F
F
--------------
A
K
T
S
A
V
Y
N
P
V
I
--
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
---
T
T
L
----
C
C
G
K
N
P
L
G
D
--------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
68.24
15%
-126
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
--------------------------------------------
N
K
Y
V
V
--------
I
------
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
--------
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
--
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
---------
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
----
N
N
S
S
---
P
V
C
Y
E
V
L
-----
G
N
D
-----
T
--------
A
K
W
R
M
V
L
R
I
L
P
--
H
T
F
G
F
--
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
---------
A
H
M
------------
G
--------------------
Q
----------------
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
------
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
RTQVI
Q
E--------
S
---
C
E
R
R
N
N
I
-----
G
R
A
L
D
-------------
A
T
E
I
L
--------------
G
F
L
H
S
C
L
N
P
I
I
--
Y
A
F
I
-
G
Q
N
F
R
H
G
F
L
---
K
I
L
----
A
M
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
67.68
13%
-127
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------
D
E
V
----
W
V
V
G
M
--------
G
------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
--------
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
--
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
---------
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
---
Q
E
A
I
N
C
Y
-----
A
E
E
T
C
C
--
D
-------
F
F
T
N
Q
A
Y
A
I
A
S
S
--
I
V
S
-
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
I
-----------
F
--------------------
E
----------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
------
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
------
P
---------
S
---
L
---
N
-------
A
A
K
S
E
-------------
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
--
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
---
S
L
D
----
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL