@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1N1_HUMAN: (2016-01-12 )
MENQSSISEFFLRGISAPPEQQQSLFGIFLCMYLVTLTGNLLIILAIGSDLHLHTPMYFFLANLSFVDMGLTSSTVTKMLVNIQTRHHTISYTGCLTQMYFFLMFGDLDSFFLAAMAYDRYVAICHPLCYSTVMRPQVCALMLALCWVLTNIVALTHTFLMARLSFCVTGEIAHFFCDITPVLKLSCSDTHINEMMVFVLGGTVLIVPFLCIVTSYIHIVPAILRVRTRGGVGKAFSTCSSHLCVVCVFYGTLFSAYLCPPSIASEEKDIAAAAMYTIVTPMLNPFIYSLRNKDMKGALKRLFSHRSIVSS
Atome Classification :
(20 SA)
-------------.........10.....--.--..20.....-...30........40........50........60........70....-....80........90........100.......110.......120.......130.......140.......150.......160---------...----------.....170.......180.....-------.-------.190.......200.......210.......220....------------...230------------------.--------........240.......250...-------....260--.--.---..-----------.-------..270.......280.......290.......300.---------------......310---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------ME
N
Q
S
S
I
S
E
F
F
L
RGIS--A--P
P
E
Q
Q
Q
S
L
F
-
G
I
F
L
C
M
Y
L
V
T
LTG
N
L
L
I
I
L
A
IGSD
L
H
LHT
P
M
Y
F
F
L
AN
L
S
F
V
DMGL
T
S
S
T
-
V
T
K
M
L
V
N
I
QTR
H
H
T
I
S
Y
T
G
C
L
T
Q
M
Y
F
F
L
M
FGD
L
D
S
F
F
L
A
A
M
A
YD
R
Y
V
A
I
C
H
P
L
C
Y
S
TVM
R
P
Q
V
C
A
L
M
L
A
L
C
W
V
L
T
N
I
V
A
L
T
H
T
F
L
M
----------
A
R
L
----------
S
F
C
VTG
E
I
A
H
F
F
CDIT
P
V
L
K
LSC-------S-------DT
H
I
N
E
M
M
V
F
V
LGG
T
V
L
I
V
P
F
L
C
I
V
T
S
Y
I
H
I
V
P
A
I
L
R
V
------------RTRG--------------------G--------V
G
K
A
F
S
T
C
S
S
H
L
C
V
V
C
V
F
Y
G
T
L
F
S
-------
A
YLCPPS--I--A---S
E
-----------
E
-------
K
D
I
A
A
A
A
M
Y
T
I
V
T
P
M
L
N
P
F
I
Y
S
LRNK
D
M
K
G
A
L
K
R
L
F
---------------
S
H
R
SIVSS----------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
94.38
22%
-164
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
-
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQS-------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.80
22%
-164
- C1 -
3PWH
1
?
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.30
22%
-166
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.95
22%
-165
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.91
22%
-164
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.82
22%
-167
- C1 -
3REY
1
AA2AR_HUMAN
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQP--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
92.68
22%
-160
- C1 -
2YDV
6
?
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPK
E
G
K
A
H
S
----------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ--------
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
92.03
22%
-165
- C1 -
3VG9
8
?
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
-
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQS-------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
91.82
22%
-160
- C1 -
4UG2
3
?
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPK
E
G
K
A
H
S
----------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L------------
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
91.50
22%
-159
- C1 -
2YDO
3
?
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPK
E
G
K
A
H
S
----------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S------------------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
--
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
90.79
22%
-156
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[14-302]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
NNCGQPKEGK
A
-------------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
--------------------
T
--------
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-----
H
---
A
P
-----------
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------------
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
90.29
18%
-137
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPF
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
--
Y
LA
E
P
W
Q
F
S
M
L
A
-
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
----------
S
R
------------
Y
I
P
E
G
------------
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
------------
A
A
S
A
--------------------
T
--------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
-------
P
Y
A
G
V
A
F
--
Y
--
I
---
F
T
-----------
H
QGSDFGP
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
---------------
C
C
G
K
N
P
S
T
TVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
85.02
17%
-147
- C1 -
2Z73
5
OPSD_TODPA
A:
[34-332]
--------------------------------------
Y
Y
S
L
G
-
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
----------
G
A
Y
----------
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
------------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--------
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
-------
V
A
L
L
A
Q
F
--
G
--
P
LEW
V
T
-----------
P
-------
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
---------------
P
W
V
L
T
C
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
80.80
18%
-111
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPF
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
YL
A
--
E
P
W
Q
F
S
M
L
A
-
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
----------
S
R
Y
------------------------
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
------------
A
A
Q
Q
--------------------
Q
--------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
-------
I
C
W
L
P
Y
A
--
G
--
V
---
A
F
Y
I
F
T
H
QGSDFG
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
VAPA------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
79.55
17%
-142
- C1 -
2KS9
1
NK1R_HUMAN
A:
[36-324]
------------------------------------------
A
-
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-----------
S
T
T
----------
E
----
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
------------
E
I
P
G
DSSDRYH
E
Q
V
S
---------
A
--------
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
-------
F
F
L
L
P
Y
I
--
N
PD
L
Y--
L
K
-----------
K
FI
Q
----
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
---------------
R
C
C
P
F
I
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
73.96
15%
-131
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------
D
E
V
W
V
V
G
M
G
-
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
----------
W
Y
R
----------
A
--
T
H
Q
E
A
I
N
C
Y
A
E
-----
E
T
C
C
-------
D
-------
F
F
-
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
------------
L
N
I
F
--------------------
E
--------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
-------
G
H
L
L
T
K
S
PS
L
--
N
---
A
A
-----------
K
-------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
---------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
31
HHSearch
73.14
17%
-127
- C1 -
1U19
14
OPSD_BOVIN
A:
[42-327]
----------------------------------------
M
L
A
-
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
----------
S
R
Y
----------
I
---
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
------------
A
A
Q
Q
--------------------
Q
ESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
-------
V
A
F
Y
I
F
T
--
H
--
Q
GSD
F
G
-----------
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
---------------
C
C
G
K
N
P
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.41
25%
-165
- C1 -
4EIY
22
AA2AR_HUMAN (first)
A:
[24-231]
----------------------------
G
--
A
--
P
P
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQPK
E
G
K
N
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
------------
L
A
D
L
--------------------
E
--------
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
-------
A
L
T
K
M
R
A
--
A
--
A
---
L
D
-----------
A
-------
Q
K
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
---------------
E
Q
L
K
T
T
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.84
25%
-171
- C1 -
3EML
8
ENLYS_BPT4
A:
[18-221]
------------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
GQS-------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
------------
L
N
I
F
--------------------
E
--------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
-------
G
H
L
L
T
K
S
--
P
--
S
---
L
N
-----------
A
-------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
---------------
I
L
R
N
A
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.75
25%
-165
- C1 -
3QAK
2
ENLYS_BPT4
A:
[18-221]
------------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
----------
N
N
C
G---------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------------------------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
------------
L
N
I
F
--------------------
E
--------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
-------
G
H
L
L
T
K
S
--
P
--
S
---
L
N
-----------
A
-------
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
---------------
I
L
R
N
A
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------