@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1P1_HUMAN: (2016-01-12 )
MGLTQDFFPPTSELLEGGNQTSTFEFLLWGLSDQPQQQHIFFLLFLWMYVVTVAGNLLIVLAIGTDTHLHTPMYFFLASLSCADIFSTSTTVPKALVNIQTQSRSISYAGCLAQLYFFLTFGDMDIFLPATMAYDRYVAICHLLHYMMIMSLHRCAFLVTACWTLTSLLAMTRTFLIFRLSLCSAILPGFFCDLGPLMKVSCSDAQVNELVLLFLGGAVILIPFMLILVSYIRIVSAILRAPSAQGRRKAFSTCDSHLVVVALFFGTVIRAYLCPSSSSSNSVKEDTAAAVMYTVVTPLLNPFIYSMRNKDMKAAVVRLLKGRVSFSQGQ
Atome Classification :
(20 SA)
.--........10........20........30........40........50........60........70........80........90-........100.......110.......120.......130.......140.......150.......160.......170.......180.......190--........200-------.-------....-.-.210-------.........220.......230.......240--------..-------.-----------.--------------------.-.---..250.......260.......270-----.......-..280----...---------.....290.......300.......310.......320........330------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M--GLTQDFFP
P
T
S
E
L
LEGGNQT
S
T
F
E
F
L
L
WGLSDQPQ
Q
Q
H
I
F
F
L
L
F
L
W
M
Y
V
V
T
VAG
N
L
L
I
V
L
A
IGTDTHLH
T
P
M
Y
F
F
L
A
SL
S
C
A
D
IFSTSTT-VP
K
A
L
V
N
I
QTQSRS
I
S
Y
A
G
C
L
A
Q
L
Y
F
F
L
T
FGD
M
D
I
F
L
P
A
T
M
A
Y
D
R
Y
V
A
I
C
H
L
L
H
Y
M
M
I
M
S
L
H
R
C
A
F
L
V
T
A
C
W
T
L
T
S
L
L
A
M
T
R
T
F
L
I
F
R
L
S
L
C
S
A
I
L
P
G
F
F
---CDLGP
L
M
K
VSC-------S-------DA
Q
V
-
N
-
E
L
---------
V
L
L
F
LG
G
A
V
I
L
I
P
F
M
L
I
L
V
S
Y
I
R
I
V
S
A
I
L
RA---------PS-------A-----------Q--------------------G-
R
---
R
K
A
F
S
TCD
S
H
L
V
V
V
A
L
F
F
G
T
V
I
R
-------
A
Y
LCPSS-SSS-N----SVK---------
E
D
T
A
A
A
V
M
Y
T
V
V
T
P
L
L
N
P
F
I
Y
S
MRNK
D
M
K
A
A
V
V
R
L
L
-
K
GRVSFSQGQ--------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.10
24%
-142
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----G--
C
G
E
G
---
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.89
24%
-143
- C5 -
3PWH
1
?
A:
[18-305]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----G--
C
G
E
G
---
Q
V
A
C
LF-----
E
-------
D
V
V
P
-
M
-
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.74
24%
-143
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----G--
C
G
E
G
---
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.67
24%
-142
- C5 -
3REY
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----G--
C
G
E
G
---
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.26
24%
-143
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----G--
C
G
E
G
---
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
-
M
-
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
A
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.52
23%
-127
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[18-311]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
W
N
N
C
G
Q
P
-------
K
E
G
K
A
---
G
C
-------
G
-------
E
G
Q
V
-
A
-
C
L
FEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
H
V
L
R
Q
Q
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
87.09
24%
-138
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[18-308]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
W
N
N
C
G
Q
--------------
S
Q
G
C
-------
G
-------
E
G
Q
V
-
A
-
C
L
F
EDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.80
24%
-135
- C5 -
3VG9
8
?
A:
[18-309]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
W
N
N
C
G
Q
--------------
S
Q
G
C
-------
G
-------
E
G
Q
V
-
A
-
C
L
F
EDVVPMNY
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PL
P
G
-------
E
-----------
R
--------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.59
23%
-127
- C5 -
2YDO
3
?
A:
[18-311]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
W
N
N
C
G
Q
P
-------
K
E
G
K
A
H
S
Q
G
C
-------
G
-------
E
G
Q
V
-
A
-
C
L
FEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S------------------------------------------------T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
H
V
L
R
Q
Q
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
85.45
18%
-114
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
--
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
---
R
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
-
N
-
E
S
---------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
---------
A
A
-------
S
-----------
A
--------------------
T
-
T
---
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
-------
P
Y
A
G
V
A
F
-
Y
I
F
-
T
----
H
Q
G
SDFGP----
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.08
23%
-129
- C5 -
2YDV
6
?
A:
[18-311]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
W
N
N
C
G
Q
P
-------
K
E
G
K
A
H
S
Q
G
C
-------
G
-------
E
G
Q
V
-
A
-
C
L
FEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ-----------------------------------------------S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
H
V
L
R
Q
Q
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.01
23%
-131
- C5 -
4UG2
3
?
A:
[18-309]
---------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
-
I
A
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
W
N
N
C
G
Q
P
-------
K
E
G
K
A
H
S
Q
G
C
-------
G
-------
E
G
Q
V
-
A
-
C
L
FEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L--------------------------------------------------
A
-
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
-
P
----
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
81.71
19%
-103
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
--
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
-
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------------
P
P
L
V
G
W
S
---
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
-
N
-
E
S
---------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
---------
A
A
-------
Q
-----------
Q
--------------------
Q
-
E
---
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
-------
I
C
W
L
P
Y
A
-
G
V
A
-
F
----
Y
I
F
T
H
QGSDFGP
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.40
23%
-137
- C5 -
3EML
9
ENLYS_BPT4
A:
[23-303]
-----------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
------SQG
C
G
E
G
---
Q
V
A
C
LF-----
E
-------
D
V
V
P
-
M
-
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
N
I
F
E
M
L
R
I
D
-----------
E
--------------------
G
L
R
---
L
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
I
-------
G
H
L
L
T
K
S
-
P
S
L
-
N
----
A
A
K
---------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-
R
N
A
K
L
K
P
V
Y
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
81.25
15%
-141
- C5 -
2KS9
1
NK1R_HUMAN
A:
[34-328]
-----------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
----
M
P
S
R
V
V
---
C
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
-
E
-
K
V
---------
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
---------
E
I
-------
P
GDSSDRYH
E
Q
V
S
--------------------
A
-
K
---
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
-------
F
F
L
L
P
Y
I
-
N
P
D
-
L
YLKK
F
I
Q
---------
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-
R
C
C
P
F
I
S
A
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.40
23%
-129
- C5 -
3QAK
2
ENLYS_BPT4
A:
[23-303]
-----------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
-
I
T
I
S
T
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
-------QG-
C
G
E
G
---
Q
V
A
C
LF-----
E
-------
D
V
V
P
-
M
-
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
N
I
F
E
M
L
R
I
D
-----------
E
--------------------
G
L
R
---
L
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
I
-------
G
H
L
L
T
K
S
-
P
S
L
-
N
----
A
A
K
---------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-
R
N
A
K
L
K
P
V
Y
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
78.81
16%
-119
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
---
E
E
T
------
C
C
---------------
D
F
F
T
-
N
-
Q
A
---------
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---------
L
N
-------
I
-----------
F
--------------------
E
-
M
---
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
-------
G
H
L
L
T
K
S
-
P
S
L
-
N
----
A
A
K
---------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
36
HHSearch
78.54
16%
-143
- C5 -
2Z73
5
OPSD_TODPA
A:
[33-331]
--------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
---
E
G
V
L
C
N
---
C
S
F
D
Y
I
S
-------------------
R
D
S
T
-
T
-
R
S
---------
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
---------
E
K
-------
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
-
E
---
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
-------
V
A
L
L
A
Q
F
-
G
P
L
E
W
----
V
T
P
---------
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
75.55
16%
-127
- C5 -
1U19
14
OPSD_BOVIN
A:
[40-328]
---------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---
P
E
G
M
Q
C
S
---
C
G
I
D
Y
Y
T
P
----------
H
-------
E
E
T
N
-
N
-
E
S
---------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
---------
A
A
-------
Q
-----------
Q
QESA
T
T
Q
K
------------
A
-
E
---
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
-------
V
A
F
Y
I
F
T
H
Q
G
S
-
D
----
F
G
P
---------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-
C
C
G
K
N
P
L
G
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
70.07
26%
-159
- C5 -
3EML
8
ENLYS_BPT4
A:
[23-221]
-----------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
------
S
Q
G
---
C
G
E
G
Q
---
V
A
C
-------
L
-------
F
E
D
V
V
P
M
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---------
L
N
-------
I
-----------
F
--------------------
E
-
M
---
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
-------
G
H
L
L
T
K
S
-
P
S
L
-
N
----
A
A
K
---------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-
R
N
A
K
L
K
P
V
Y
D
--------------------------------------------------------------------------------------------------------------------------------------------------------