@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1S2_HUMAN: (2016-01-12 )
MKTLCSFLQISRNMHQENQTTITEFILLGLSNQAEHQNLLFVLFLSMYVVTVVGNGLIIVAISLDIYLHTPMYLFLAYLSFADISSISNSVPKMLVNIQTNSQSISYESCITQMYFSIVFVVTDNLLLGTMAFDHFVAICHPLNYTTFMRARFGTLLTVISWFLSNIIALTHTLLLIQLLFCDHNTLPHFFCDLAPLLKLSCSDTMINELVLFIVGLSVIIFPFVLIFFSYVCIIRAVLGVSSTQGKWKAFSTCGSHLTIALLFYGTTVGVYFFPSSTHPEDTDKIGAVLFTVVTPMMNPFIYSLRNKDMKGALRKLINRKISSL
Atome Classification :
(20 SA)
-------------..-.......10........20........30........40........---50........60......------..70........80-----........90.-........100........110.......-----120.......130-.....--..140..--.....150...-....160.......170.......---180.......190.......-----200-------.-------....-.-.210.......220..------.------....230..---.---....------------240-------..--------------------.--------....250..---.....260-------------...----.-....270------......---..------------280----.........----290------..-......300------.........310---------.......320...-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------
M
K
-
T
L
C
S
F
L
Q
I
S
R
N
MHQE
N
Q
T
T
I
T
E
F
I
L
LGLSN
Q
A
E
H
Q
N
L
L
F
V
L
F
L
S
M
Y
V
---
V
T
VVGN
G
L
I
I
V
A
I
S
L
D
I
Y
------LHT
P
M
Y
L
F
L
A
Y
L
S
F
-----
A
D
I
S
S
I
S
NS-V-
P
K
M
L
V
N
I
QTN-SQSI
S
Y
E
S
C
I
T
Q
M
Y
F
S
I
V
-----
F
V
VTDN
L
L
L
G
T
M
A
-
F
D
H
F
V
--
A
I
CHPL
N
--
Y
T
T
F
M
R
A
R
F
G
T
-
L
L
T
V
I
S
W
F
L
S
N
I
I
A
L
T
H
T
L
L
L
I
Q
L
---
L
F
CDHN
T
L
P
H
F
F
C
D
L
A
P
L
L
K-----LSC-------
S
-------
D
T
M
I
-
N
-
E
L
V
L
F
I
V
G
L
S
V
I
I
F
P
F
------
V
------
L
I
F
F
S
Y
V
C
I
---
I
---
R
A
V
L------------GVS-------ST--------------------Q--------GK
W
K
A
F
S
TC---GS
H
L
T
I
A
--------------
L
L
F
----Y-G
T
T
V
G
V
-------
Y
F
FPSS---TH------------P------E
D
T
D
K
I
G
A
V
----
L
F
-------
T
V
-
V
T
P
M
M
N
P
--------
F
I
Y
S
LRNK
D
M
K
G
---------
A
L
R
K
L
I
N
R
K
ISSL-----------------------
9
PsiBlast_PDB
88.44
21%
-152
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
----------------------------------------------------------
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
L
V
G
V
L
A
-
I
-
P
-
F
A
I
T
I
S
T
G
-
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
-----
L
A
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
A
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
A
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
------------------------------
N
-
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
R
-------
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
---
K
S
A
A
I
I
A
--------------
G
L
F
----
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
H
------------
A
------
P
L
W
L
M
Y
L
A
I
----
V
L
-------
A
H
-
T
N
S
V
V
N
P
--------
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------
T
F
R
K
I
I
R
S
----------------------------
10
PsiBlast_PDB
88.42
21%
-151
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
----------------------------------------------------------
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
L
V
G
V
L
A
-
I
-
P
-
F
A
I
T
I
S
T
G
-
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
-----
L
A
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
A
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
A
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
------------------------------
N
-
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
R
-------
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
---
K
S
A
A
I
I
A
--------------
G
L
F
----
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
H
------------
A
------
P
L
W
L
M
Y
L
A
I
----
V
L
-------
A
H
-
T
N
S
V
V
N
P
--------
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------
T
F
R
K
I
I
R
S
----------------------------
7
PsiBlast_PDB
88.23
21%
-150
- C4 -
3PWH
1
?
A:
[14-305]
----------------------------------------------------------
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
L
V
G
V
L
A
-
I
-
P
-
F
A
I
T
I
S
T
G
-
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
-----
L
A
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
A
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
A
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
------------------------------
N
-
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
R
-------
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
---
K
S
A
A
I
I
A
--------------
G
L
F
----
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
H
------------
A
------
P
L
W
L
M
Y
L
A
I
----
V
L
-------
A
H
-
T
N
S
V
V
N
P
--------
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------
T
F
R
K
I
I
R
S
----------------------------
14
PsiBlast_PDB
87.35
22%
-143
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-307]
----------------------------------------------------------
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
A
V
G
V
L
A
-
I
-
P
-
F
A
I
T
I
S
T
G
-
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
-----
L
T
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
R
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
K
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQS
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
------------------------------
N
-
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
L
A
A
R
R
Q
L
------------
K
Q
M
-------
E
S
--------------------
Q
PLP-----
G
E
-
R
A
R
S
T
L
---
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
----
H
-
I
I
N
C
F
T
-------
F
F
C
P
D
C
---
S
H
------------
A
------
P
L
W
L
M
Y
L
A
I
----
V
L
-------
S
H
-
T
N
S
V
V
N
P
--------
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------
T
F
R
K
I
I
R
S
H
V
L
-------------------------
8
PsiBlast_PDB
87.27
21%
-150
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
----------------------------------------------------------
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
L
V
G
V
L
A
-
I
-
P
-
F
A
I
T
I
S
T
G
-
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
-----
L
A
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
A
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
A
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
------------------------------
N
-
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
R
-------
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
---
K
S
A
A
I
I
A
--------------
G
L
F
----
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
H
------------
A
------
P
L
W
L
M
Y
L
A
I
----
V
L
-------
A
H
-
T
N
S
V
V
N
P
--------
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------
T
F
R
K
I
I
R
S
----------------------------
11
PsiBlast_PDB
87.18
21%
-152
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
----------------------------------------------------------
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
L
V
G
V
L
A
-
I
-
P
-
F
A
I
T
I
S
T
G
-
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
-----
L
A
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
A
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
A
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
------------------------------
N
-
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
---
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP
G
E
R
-------
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
---
K
S
A
A
I
I
A
--------------
G
L
F
----
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
H
------------
A
------
P
L
W
L
M
Y
L
A
I
----
V
L
-------
A
H
-
T
N
S
V
V
N
P
--------
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------
T
F
R
K
I
I
R
S
----------------------------
13
PsiBlast_PDB
84.64
22%
-143
- C4 -
3VG9
8
?
A:
[14-307]
----------------------------------------------------------
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
A
V
G
V
L
A
-
I
-
P
-
F
A
I
T
I
S
T
G
-
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
-----
L
T
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
R
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
K
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
GQS
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
------------------------------
N
-
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
L
A
A
R
R
Q
L
------------
K
Q
M
-------
E
S
--------------------
Q
PLP-----
G
E
-
R
A
R
S
T
L
---
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
----
H
-
I
I
N
C
F
T
-------
F
F
C
P
D
C
---
S
H
------------
A
------
P
L
W
L
M
Y
L
A
I
----
V
L
-------
S
H
-
T
N
S
V
V
N
P
--------
F
I
Y
A
Y
R
I
R
E
F
R
Q
---------
T
F
R
K
I
I
R
S
H
V
L
R
------------------------
37
HHSearch
79.00
16%
-139
- C4 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
---
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
------
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
-----
S
D
F
T
F
S
L
V
N
G
F
-
P
L
M
T
I
S
C
F
L
K
-
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
-----
F
G
F
M
S
I
M
T
M
A
M
I
S
-
I
D
R
Y
N
--
V
I
G
R
P
M
A
--
A
S
K
K
M
S
H
R
R
A
F
-
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------------------
R
D
S
T
-
T
-
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
------
L
------
I
I
F
F
C
Y
F
N
I
---
V
---
M
S
V
S
------------
N
H
E
-------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
L
A
K
I
S
---
I
V
I
V
S
Q
F
--------------
L
L
S
----
W
-
S
P
Y
A
V
V
-------
A
L
L
A
Q
F
---
G
P
LEW---------
V
------
T
P
Y
A
A
Q
L
P
V
----
M
F
-------
A
K
-
A
S
A
I
H
N
P
--------
M
I
Y
S
V
S
H
P
K
F
R
E
---------
A
I
S
Q
T
F
P
W
V
L
T
C
C
-----------------------
35
HHSearch
78.04
16%
-132
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
----------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
---
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
------
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
-----
A
E
A
S
M
A
A
F
N
-
T
-
V
V
N
F
T
Y
A
V
H
N
-
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
-----
A
V
F
A
S
I
Y
S
M
T
A
V
A
-
F
D
R
Y
M
--
A
I
I
H
P
L
Q
--
P
R
L
--
S
A
T
A
T
K
-
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
----
E
----
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
-----
P
-----------------
N
K
I
Y
-
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
------
L
------
V
I
G
Y
A
Y
T
V
V
---
G
---
I
T
L
W
------------
A
S
E
-------
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
V
V
K
M
M
---
I
V
V
V
C
T
F
--------------
A
I
C
----
W
-
L
P
F
H
I
F
-------
F
L
L
P
Y
I
---
N
P
------------
D
LYLKKF
I
Q
Q
V
Y
L
A
I
M
----
W
L
-------
A
M
-
S
S
T
M
Y
N
P
--------
I
I
Y
C
C
L
N
D
R
F
R
L
---------
G
F
K
H
A
F
R
C
C
P
F
I
S
-----------------------
43
Fugue
77.29
17%
-116
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
-
L
I
M
---
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
------
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
-----
A
D
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-----
G
G
E
I
A
L
W
S
L
V
V
L
A
-
I
E
R
Y
V
--
V
V
C
K
P
M
S
--
N
F
R
F
-
G
E
N
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------
P
P
---
L
V
G
W
S
R
Y
I
P
E
G
-------
M
Q
-----
C
S
C
-------
G
I
DYYTPH
E
E
T
N
-
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
------
I
------
V
I
F
F
C
Y
G
Q
L
VFT
V
---
K
E
A
A
------------
A
S
A
-------
T
T
--------------------
Q
--------
K
A
E
K
E
V
T
R
M
---
V
I
I
M
V
I
A
--------------
F
L
I
----
C
-
W
L
P
Y
A
G
-------
V
A
F
Y
I
F
---
T
H
------------
Q
------
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
-------
A
K
-
T
S
A
V
Y
N
P
--------
V
I
Y
I
M
M
N
K
Q
F
R
N
---------
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------
44
Fugue
71.83
18%
-106
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
-
L
I
M
---
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
------
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
-----
A
D
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-----
G
G
E
I
A
L
W
S
L
V
V
L
A
-
I
E
R
Y
V
--
V
V
C
K
P
M
S
--
N
F
R
F
-
G
E
N
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------
P
P
---
L
V
G
W
S
R
Y
I
P
E
G
-------
M
Q
-----
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
-
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
------
I
------
V
I
F
F
C
Y
G
Q
L
---
V
---
F
T
V
K
------------
E
A
A
AQQQESA
T
T
--------------------
Q
--------
K
A
E
K
E
V
T
R
M
---
V
I
I
M
V
I
A
--------------
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
-------
I
F
T
H
Q
G
---
S
D
------------
F
------
G
P
I
F
M
T
I
P
A
----
F
F
-------
A
K
-
T
S
A
V
Y
N
P
--------
V
I
Y
I
M
M
N
K
Q
F
R
N
---------
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA---
46
Fugue
71.22
17%
-132
- C3 -
3THI
1
THI1_PANTH
A:
[1-362]
-------------------
I
T
L
K
V
A
I
Y
P
Y
V
P
D
P
A
R
F
Q
A
A
V
L
D
Q
W
Q
R
Q
E
P
G
V
K
L
E
F
T
D
W
D
S
Y
S
A
---
D
P
P
D
D
L
D
V
F
V
L
D
S
I
F
L
S
H
------
F
V
D
A
G
Y
L
L
P
--
F
G
S
-----
Q
D
I
D
Q
A
E
D
V
-
L
-
P
F
A
L
Q
G
A
K
R
N
-
G
E
V
Y
G
L
P
Q
I
L
C
T
---
N
L
L
-----
F
Y
R
K
G
D
L
K
I
G
Q
V
---
D
N
I
Y
--
E
L
Y
K
K
I
G
TS
H
S
E
Q
I
P
P
P
Q
N
K
G
L
L
I
N
M
A
G
G
T
T
K
A
S
M
Y
L
E
A
L
I
D
V
T
G
---
Q
Y
T
E
Y
D
L
L
P
----
P
L
D
P
L
-----------------
N
-------
D
K
V
I
-
R
-
G
L
R
L
L
I
N
M
A
G
E
K
P
S
Q
Y
------
V
PEDGDA
Y
V
R
A
S
W
F
A
Q
---
G
SG-
R
A
F
I
------------
G
Y
S
-------
E
S
--------------------
M
--------
M
R
M
G
D
Y
A
E
Q
---
V
R
F
K
P
I
S
SSAGQDI-------
P
L
F
----
Y
-
S
D
V
V
S
V
-------
N
--
S
K
T
---
A
H
------------
P
------
E
L
A
K
K
L
A
N
V
----
M
A
S
A
-----
D
T
-
V
E
Q
A
L
R
P
QADGQYPQ
Y
L
L
P
A
R
H
Q
V
Y
E
A
L
MQDYP
I
Y
S
E
L
A
Q
I
V
N
K
P
S
N
R
V
F
R
L
G
PE
V
R
T
W
L
K
D
A
K
Q
V
LPEALG
33
HHSearch
69.77
15%
-127
- C4 -
1U19
14
OPSD_BOVIN
A:
[38-327]
------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
---
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
------
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
-----
A
D
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-----
G
G
E
I
A
L
W
S
L
V
V
L
A
-
I
E
R
Y
V
--
V
V
C
K
P
M
S
--
N
F
R
-
F
G
E
N
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
---
I
---
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---------------
H
-------
E
E
T
N
-
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
------
I
------
V
I
F
F
C
Y
G
Q
L
---
V
---
F
T
V
K
------------
E
A
A
-------
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
---
I
I
M
V
I
A
F
--------------
L
I
C
----
W
-
L
P
Y
A
G
V
-------
A
F
Y
I
F
T
H
QG
S
D
------------
F
------
G
P
I
F
M
T
I
P
A
----
F
F
-------
A
K
-
T
S
A
V
Y
N
P
--------
V
I
Y
I
M
M
N
K
Q
F
R
N
---------
C
M
V
T
T
L
C
C
G
K
N
P
L
-----------------------
49
Fugue
69.32
17%
-144
* C3 *
4R6Y
2
PHNS_SALTY
A:
[1-317]
------------S
M
E
-
S
V
V
T
V
Y
S
I
D
-
G
L
H
D
------------
G
D
N
S
W
Y
Q
V
Q
F
D
A
F
T
K
A
T
G
I
T
V
---
R
Y
V
E
G
G
G
G
V
V
V
E
R
L
A
K
E
R
------
T
N
P
Q
A
D
V
L
V
T
A
P
P
F
-----
I
Q
R
A
A
A
------
E
K
L
L
A
N
F
N
T
D
-
T
A
S
A
I
P
D
A
--
N
N
L
Y
S
P
L
V
K
N
Y
L
S
F
I
Y
N
S
K
L
L
K
T
A
P
A
S
W
Q
D
L
L
DG
K
F
K
N
K
L
Q
--
Y
S
T
P
G
Q
A
A
D
G
T
-
A
V
M
L
Q
A
F
H
S
F
G
--
S
K
D
A
G
F
A
Y
L
G
K
---
L
Q
A
N
N
V
G
P
S
A
S
T
G
K
L
T
A
L
V
N
K
GEIY
V
A
N
-------
G
-------
D
L
Q
M
-
N
-
L
A
Q
M
E
R
N
P
N
V
K
I
F
W
P
A
N
DKG
E
R
S
------
A
L
A
I
P
Y
V
I
G
---
L
-----
V
Q
------------
G
A
P
-------
Q
S
--------------------
E
--------
N
G
K
K
L
I
N
F
L
L
S
K
E
A
Q
T
R
V
S
--------------
E
L
S
----
W
-
G
M
P
V
R
S
-------
D
V
T
P
S
D
------------------------
E
H
Y
K
A
A
T
A
A
----
L
E
-------
G
V
-
Q
S
W
Q
P
N
W
--------
D
D
V
A
V
S
L
S
A
D
I
S
---------
R
W
H
K
V
T
E
S
----------------------------
31
HHSearch
66.40
15%
-112
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
--------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
---
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
------
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
-----
A
D
L
L
F
A
L
-
T
-
L
-
P
I
W
A
A
S
K
-
V
N
-
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
-----
N
F
Y
S
G
I
L
L
L
A
C
I
S
-
V
D
R
Y
L
--
A
I
V
H
A
T
R
--
T
L
T
-
Q
K
R
H
L
V
K
-
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
---
H
---
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
-----------------------
T
A
K
W
-
R
-
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
------
F
------
V
M
L
F
C
Y
G
F
T
---
L
---
R
T
L
F
------------
K
A
H
-------
M
---------------------
G
--------
Q
K
H
R
A
M
R
V
I
---
F
A
V
V
L
I
F
--------------
L
L
C
----
W
-
L
P
Y
N
L
V
-------
L
L
A
D
T
L
---
M
R
TQVIQE
S
C
E
R
R
N
N
------
I
G
R
A
L
D
A
T
E
----
I
L
-------
G
F
-
L
H
S
C
L
N
P
--------
I
I
Y
A
F
I
G
Q
N
F
R
H
---------
G
F
L
K
I
L
A
M
H
G
--------------------------
30
HHSearch
62.33
20%
-161
- C4 -
3EML
8
ENLYS_BPT4
A:
[23-222]
----------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
---
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
------
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-----
A
D
I
A
V
G
V
L
A
-
I
-
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-----
L
T
Q
S
S
I
F
S
L
L
A
I
A
-
I
D
R
Y
I
--
A
I
R
I
P
L
R
--
Y
N
G
L
V
T
G
T
R
A
K
-
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
---
G
Q
-------
S
Q
G
C
G
E
G
Q
--------
V
A
C
-------
L
-------
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
------
L
------
L
M
L
G
V
Y
L
R
I
---
F
---
L
A
A
R
------------
R
Q
L
-------
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
---
R
L
K
I
Y
K
D
--------------
T
E
G
----
Y
-
Y
T
I
G
I
G
-------
H
L
L
T
K
S
---
P
S
------------
L
------
N
A
A
K
S
E
L
D
K
----
A
I
-------
G
R
-
N
T
N
G
V
I
T
--------
K
D
E
A
E
K
L
F
N
Q
D
V
---------
D
A
A
V
R
G
I
L
R
N
A
K
L
-----------------------
51
Fugue
61.53
12%
-179
- C3 -
3TGH
6
?
A:
[1-339]
--------------
K
-
C
Q
L
R
F
A
S
L
G
---
D
W
G
K
D
T
K
G
Q
I
L
N
A
K
Y
F
K
Q
F
I
K
N
E
R
V
T
F
I
V
S
P
G
S
N
F
IDG
V
K
G
L
N
D
P
A
W
K
N
L
Y
E
-
D
V
Y
SEEKGD
M
Y
M
P
F
F
T
V
L
G
T
R
D
W
T
G
N
Y
N
A
Q
L
L
K
G
Q
G
D
-
A
T
N
Y
P
K
W
I
M
P
N
Y
-
W
Y
H
Y
F
T
H
F
T
V
S
H
K
D
L
A
A
A
-----
F
I
F
I
D
T
W
V
L
---------
S
--
S
N
F
P
Y
K
K
--
I
H
E
K
A
W
N
D
L
K
S
-
Q
L
S
V
A
K
K
I
A
D
F
I
I
V
V
G
D
Q
P
I
Y
------
S
S
G
Y
S
R
G
S
S
Y
L
A
Y
Y
L
L
P
L
L
K
-----
D
A
-----------------------
E
V
D
L
Y
I
S
G
H
D
N
N
M
E
V
I
------
E
------
D
N
D
M
A
H
I
T
C
---
G
---
S
G
S
M
------------
S
Q
G
-------
K
S
--------------------
G
--------
M
K
N
S
K
S
L
F
F
---
S
S
D
I
G
F
C
--------------
V
H
E
----
L
S
N
N
G
I
V
T
-------
K
F
V
S
S
K
---
K
--------------------------
G
E
V
----
I
Y
-------
T
H
K
L
N
I
K
K
K
K
--------
T
L
D
K
V
N
A
L
Q
H
F
A
---------
A
L
P
N
V
E
L
T
D
V
P
S
S
GPMG-------------------
27
HHSearch
60.30
18%
-133
- C4 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
--------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
---
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
------
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
-----
A
D
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
H
I
L
M
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
-----
C
V
T
A
S
I
E
T
L
C
V
I
A
-
V
D
R
Y
F
--
A
I
T
S
P
F
K
--
Y
Q
S
L
L
T
K
N
K
A
R
-
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
---
A
T
----
H
Q
E
A
I
N
C
Y
A
----
E
-----
E
T
C
-------
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
------
V
------
I
M
V
F
V
Y
S
R
V
---
F
---
Q
E
A
K
------------
R
Q
L
-------
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
---
R
L
K
I
Y
K
D
--------------
T
E
G
----
Y
-
Y
T
I
G
I
G
-------
H
L
L
T
K
S
---
P
S
------------
L
------
N
A
A
K
S
E
L
D
K
----
A
I
-------
G
R
-
N
T
N
G
V
I
T
--------
K
D
E
A
E
K
L
F
N
Q
D
V
---------
D
A
A
V
R
G
I
L
R
N
A
K
L
-----------------------
25
HHSearch
58.97
20%
-148
- C4 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
----------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
---
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
------
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
-----
A
D
L
I
I
G
V
F
S
-
M
-
N
L
Y
T
L
Y
T
V
I
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
-----
V
S
N
A
S
V
M
N
L
L
I
I
S
-
F
D
R
Y
F
--
C
V
T
K
P
L
T
--
Y
P
V
K
R
T
T
K
M
A
G
-
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
---
V
--
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
----------------------------
F
S
-
N
-
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
------
I
------
I
M
T
V
L
Y
W
H
I
---
S
---
R
A
S
K
------------
S
R
I
-------
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
---
R
L
K
I
Y
K
D
--------------
T
E
G
----
Y
-
Y
T
I
G
I
G
-------
H
L
L
T
K
S
---
P
S
------------
L
------
N
A
A
K
S
E
L
D
K
----
A
I
-------
G
R
-
N
T
N
G
V
I
T
--------
K
D
E
A
E
K
L
F
N
Q
D
V
---------
D
A
A
V
R
G
I
L
R
N
A
K
L
-----------------------
52
Fugue
58.48
16%
-107
- C2 -
4UX8
-
GFRA1_RAT
C:
[25-343]
DRLDCVKASDQCL
K
E
-
Q
S
C
S
T
K
Y
R
T
L
R
Q
C
V
A
G
K
E
T
-
N
F
S
L
T
S
G
L
E
A
K
D
E
C
R
S
A
M
E
A
L
K
Q
K
S
L
Y
---
N
C
R
C
K
R
G
M
K
K
E
K
N
C
L
R
I
Y
------
W
S
M
Y
Q
S
K
G
N
N
C
L
D
A
-----
A
K
A
C
N
L
D
D
T
-
C
-
K
K
Y
R
S
A
Y
I
T
P
C
T
T
S
M
S
N
E
V
C
N
R
R
K
C
H
K
A
L
-----
R
Q
F
F
D
K
V
P
-
A
K
H
S
-
Y
G
M
L
F
--
C
S
C
R
D
I
A
--
C
T
E
R
R
R
Q
T
I
--------------------------
V
---
P
V
C
S
Y
E
E
R
E
R
P
N
C
L
S
---
L
Q
-----
D
S
C
-------
K
-------
T
N
---------------------------------------
Y
I
C
R
---
S
---
R
L
A
D
------------
F
F
T
-------
N
C
--------------------
Q
--------
P
E
S
R
S
V
S
N
C
L--
K
E
N
Y
A
D
C
--------------
L
L
A
----
Y
-
S
G
L
I
G
T
-------
V
M
T
P
N
Y
---
V
---------------------
D
S
S
S
L
S
V
A
----
P
W
CDCSNSG
N
D
-
L
E
D
C
L
K
F
--------
L
N
F
F
K
D
N
T
C
L
K
N
---------
A
I
Q
A
F
G
N
G
----------------------------