@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2C1_HUMAN: (2016-01-13 )
MDGVNDSSLQGFVLMGISDHPQLEMIFFIAILFSYLLTLLGNSTIILLSRLEARLHTPMYFFLSNLSSLDLAFATSSVPQMLINLWGPGKTISYGGCITQLYVFLWLGATECILLVVMAFDRYVAVCRPLRYTAIMNPQLCWLLAVIACLGGLGNSVIQSTFTLQLPLCGHRRVEGFLCEVPAMIKLACGDTSLNQAVLNGVCTFFTAVPLSIIVISYCLIAQAVLKIRSAEGRRKAFNTCLSHLLVVFLFYGSASYGYLLPAKNSKQDQGKFISLFYSLVTPMVNPLIYTLRNMEVKGALRRLLGKGREVG
Atome Classification :
(20 SA)
.......------..10-----.........20..----..----....30........40---........50..---.---.....60..-......70......-..80........90........100.----......110..---------------.....120.......130----.........140.......150.......160.......170.......180.......190-----.........200.......210.......220...-----------....230--------------------.--......240.--------------......250.......260...---....270-------.---......280.......290.......300.......310--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDGVNDS------SL
Q
------
G
F
V
L
MGISDHP
Q
L
----
E
M
----
I
F
F
I
A
I
L
F
S
Y
L
L
T
LLG---N
S
T
I
I
L
L
S
R
L
E
A
---
R
---LH
T
P
M
Y
F
F
L
-
S
NLSSL
D
L
A
F
ATS
S
-
V
P
Q
M
L
I
N
LWGPGKTISY
G
G
C
I
T
Q
L
Y
V
----
F
L
W
L
G
A
T
E
C
I
L
---------------
L
V
V
M
A
F
D
R
Y
V
A
V
CRP
L
------
R
Y
T
AIMN
P
Q
L
C
W
L
L
A
V
I
A
C
L
G
GL
G
N
S
V
I
Q
S
T
F
T
L
QLPLCGHR
R
V
E
G
F
LCEV
P
A
M
I
K
LACG-------DT
S
L
N
Q
A
V
L
N
G
V
C
T
F
F
T
A
V
P
L
S
I
I
V
I
S
Y
C
L
I
A
Q
A
V
-----------
L
K
I
RSAE--------------------
G
--
R
R
K
A
F
N
T
C
L
S
--------------
H
L
L
V
V
F
L
F
YGSASY
G
Y
L
LPAKN---SKQD
Q
G
K
-------
F
---
I
S
L
F
Y
S
L
V
T
P
M
V
N
P
L
I
Y
T
L
RN
M
E
V
K
G
A
L
R
R
L
L
GKGREVG--------------------
39
Fugue
90.69
22%
-122
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
------
N
F
Y
VPFSNK
T
G
V
V
R
S
P
F
E
A
P
Q
Y
----
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
---
Q
H
KK
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
----
A
T
L
G
G
E
I
A
L
W
S
---------------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---------------
A
P
P
L
V
G
W
S
R
------
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
A
A
A
S
A
--------------------
T
--
T
Q
K
A
E
K
E
V
T
R
--------------
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
F
T
H
Q
G
S
DFGPIFM
T
---
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A------
40
Fugue
87.19
21%
-115
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
NFYVPF
S
N
K
------
T
G
V
V
R
S
P
F
E
A
P
Q
Y
YLAE
P
W
----
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
----
A
T
L
G
G
E
I
A
L
W
S
---------------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
---------------
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAAQQQESA
T
T
Q
K
A
E
K
--------------------
E
--
V
T
R
M
V
I
I
M
V
I
--------------
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---
D
F
G
P
I
F
M
-------
T
---
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA
2
PsiBlast_PDB
80.26
21%
-134
- C1 -
3C9L
13
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNFRFG
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
--------------------
44
Fugue
79.54
18%
-135
- C1 -
3WI3
17
SLD3_YEAST
A:
[8-275]
----------------------------
Y
S
D
P
K
E
Y
----
I
E
----
S
K
Y
Y
D
A
L
F
S
-----------------------------
I
H
T
P
L
A
Y
F
V
K
S
N
L
V
R
L
K
N
T
C
R
T
K
Y
----------
G
S
D
S
--------------------------------------------------------
Y
K
I
------
A
Y
Q
A
M
L
Q
K
---
F
L
L
S
I
V
Q
F
K
D
R
H
D
N
R
L
L
L
E
P
F
S
S
--
P
I
A
D
E
K
R
K
N
-------
C
L
T
K
F
V
I
Q
-------
D
E
N
K
N
S
S
T
I
A
D
L
C
V
V
L
K
S
R
E
I
K
L
Q
I
L
L
L
L
E
I
I
G
L
N
-----------
D
L
D
W
N
F
R
--------------------
D
FD
Y
C
E
Q
L
D
L
Y
L
D
--------------
R
A
C
I
L
D
I
L
L
S
S
E
T
-
G
T
I
Q
E
H
K
K
---
N
I
L
D
K
S
K
-------
E
---
A
S
L
V
G
F
I
N
Y
V
L
I
P
Y
F
-----
N
K
K
V
P
H
A
V
E
F
I
I
Q
K
L
K
G
P
S
--------------------
4
PsiBlast_PDB
79.38
21%
-148
- C1 -
3DQB
6
GNAT1_BOVIN (first)
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNFRFG
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
7
PsiBlast_PDB
79.27
21%
-145
- C1 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNFRFG
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
8
PsiBlast_PDB
78.90
21%
-146
- C1 -
4PXF
8
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNFRFG
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
6
PsiBlast_PDB
78.80
21%
-146
- C1 -
3PXO
5
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
5
PsiBlast_PDB
78.57
21%
-147
- C1 -
3PQR
10
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
33
HHSearch
77.93
15%
-125
- C1 -
2Z73
5
OPSD_TODPA
A:
[34-332]
---------------------------------------
Y
Y
----
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
---
S
---
L
Q
T
P
A
N
M
F
I
-
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
----
G
G
I
F
G
F
M
S
I
M
T
---------------
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
------
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
---
Y
T
L
-
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----------
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--
E
M
R
L
A
K
I
S
I
V
--------------
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
PLE
W
V
T
P
Y
A
A
-------
Q
---
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
--------------------
13
PsiBlast_PDB
77.59
21%
-137
- C1 -
2I35
4
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNFRFG
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
--------------------
1
PsiBlast_PDB
77.45
21%
-146
- C1 -
3CAP
5
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
12
PsiBlast_PDB
76.93
21%
-135
- C1 -
2I36
2
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
D
YYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
FMT
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
16
PsiBlast_PDB
76.84
21%
-124
- C1 -
2PED
14
OPSD_BOVIN
A:
[46-327]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
10
PsiBlast_PDB
76.79
21%
-122
- C1 -
1GZM
15
OPSD_BOVIN
A:
[46-327]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNFRFG
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
--------------------
9
PsiBlast_PDB
76.51
21%
-129
- C1 -
3OAX
17
OPSD_BOVIN
A:
[46-327]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
14
PsiBlast_PDB
76.04
21%
-145
- C1 -
2I37
1
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
-------------------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
---
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
3
PsiBlast_PDB
75.82
21%
-133
- C1 -
1F88
7
OPSD_BOVIN
A:
[43-326]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
--------------------
17
PsiBlast_PDB
75.75
21%
-129
- C1 -
2G87
14
OPSD_BOVIN
A:
[46-327]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
15
PsiBlast_PDB
75.64
21%
-126
- C1 -
2HPY
14
OPSD_BOVIN
A:
[46-327]
----------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
---
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
--------------------
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
--------------
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
G
I
D
YYTPH
E
E
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
-----------
F
T
V
K
E
A
A
--------------------
A
--
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
---
S
--
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------