@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2D3_HUMAN: (2016-01-13 )
MCSFFLCQTGKQAKISMGEENQTFVSKFIFLGLSQDLQTQILLFILFLIIYLLTVLGNQLIIILIFLDSRLHTPMYFFLRNLSFADLCFSTSIVPQVLVHFLVKRKTISFYGCMTQIIVFLLVGCTECALLAVMSYDRYVAVCKPLYYSTIMTQRVCLWLSFRSWASGALVSLVDTSFTFHLPYWGQNIINHYFCEPPALLKLASIDTYSTEMAIFSMGVVILLAPVSLILGSYWNIISTVIQMQSGEGRLKAFSTCGSHLIVVVLFYGSGIFTYMRPNSKTTKELDKMISVFYTAVTPMLNPIIYSLRNKDVKGALRKLVGRKCFSHRQ
Atome Classification :
(20 SA)
---------------------------------------.........10........20........--30........40........--50......---..60.......-.70........80........90..-......100.......110.......120.....-----..130.......140.......150.......160.......170....-...180.---......190-.....----...-----200.......-210........220.-----.--.....230.....---..240-------------..-------..------..-----------.--------------------250.......260-....----...270.....--.----.---280---------...-....-----------.290------------.........300.......310.......320-.-----.......330------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------M
C
S
F
F
L
CQTGKQ
A
K
I
SMGEE
N
Q
T
F
V
S
K
F
I
--
F
LGLS
Q
D
L
Q
T
Q
I
L
L
F
I
L
F
L
I
--
I
Y
L
L
T
VLG---N
Q
L
I
I
I
L
I
F
LD-SRLH
T
P
M
Y
F
F
L
RNL
S
F
A
D
L
C
FS
T
S
I
-
V
P
Q
V
L
V
H
F
L
V
KRK
T
I
S
F
Y
G
C
M
T
Q
I
I
V
F
L
L
V
G
C
T
E
-----
C
A
L
L
A
V
MSYD
R
Y
V
A
V
C
K
P
L
Y
Y
S
T
I
M
T
Q
R
V
C
L
W
L
S
F
R
SWASG
A
L
V
S
L
VDT-
S
F
T
F
HLP---YW
G
Q
N
I
I
N
--
H
YFCE----
P
P
A
-----
L
L
K
L
A
SIDTY-
S
T
-
E
M
A
I
F
S
M
G
V
V
I
L
-----
L
--
A
P
V
S
L
I
L
G
S
Y
W
N
I
---
I
S
T
V
I
-------------
Q
M-------QS------GE-----------G--------------------
R
L
K
A
F
S
TCG
S
H
L
I
-
V
V
V
L
----
F
YGS
G
I
F
T
Y
MR--P----N---S-
K
---------
T
T
K
-
E
L
D
K
-----------
M
I
--------------
S
V
F
Y
T
A
V
T
P
M
L
N
P
I
I
Y
S
LRNK
D
V
K
G
A
L
R
K
L
V
--
G
-----
R
K
CFSHRQ--------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
87.02
19%
-114
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
--
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
--
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-------
A
P
P
L
V
---
G
W
S
R
Y
I
P
E
GM
Q
C
S
C
G
----
I
D
Y
-----
Y
---
T
P
H
E
E
T
-
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
-----
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
-------------
E
A
AASATTQ
K
A
------
E
K
-----------
E
--------------------
V
T
R
M
V
I
I
M
V
I
A
F
L
-
I
C
W
L
----
P
Y
A
G
V
A
F
Y
I
F
T
--
H
----
Q
---
G
-
S
---------
D
F
G
-
P
I
F
M
-----------
T
I
--------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
-----
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.25
24%
-122
- C3 -
2RH1
9
ADRB2_HUMAN (first)
A:
[45-315]
-------------------------------------------------------------------------------------
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
---
T
-
H
Q
E
A
I
N
--
C
Y
A
E
E
----
T
C
C
-----
D
F
F
T
N
Q
A
Y
A
I
-
A
S
-
S
I
V
S
F
Y
V
P
L
V
I
M
-----
V
--
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---
L
N
I
F
E
-------------
M
L
-------
R
I
------
D
E
-----------
G
L
-------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.02
24%
-123
- C3 -
3NY9
4
ADRB2_HUMAN (first)
A:
[46-316]
-------------------------------------------------------------------------------------
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
---
T
-
H
Q
E
A
I
N
--
C
Y
A
E
E
----
T
C
C
-----
D
F
F
T
N
Q
A
Y
A
I
-
A
S
-
S
I
V
S
F
Y
V
P
L
V
I
M
-----
V
--
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---
L
N
I
F
E
-------------
M
L
-------
R
I
------
D
E
-----------
G
L-------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.77
24%
-124
- C3 -
3D4S
6
ENLYS_BPT4
A:
[46-316]
-------------------------------------------------------------------------------------
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
---
T
-
H
Q
E
A
I
N
--
C
Y
A
E
E
----
T
C
C
-----
D
F
F
T
N
Q
A
Y
A
I
-
A
S
-
S
I
V
S
F
Y
V
P
L
V
I
M
-----
V
--
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---
L
N
I
F
E
-------------
M
L
-------
R
I
------
D
E
-----------
G
L-------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.72
24%
-124
- C3 -
3NYA
3
ADRB2_HUMAN (first)
A:
[46-316]
-------------------------------------------------------------------------------------
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
---
T
-
H
Q
E
A
I
N
--
C
Y
A
E
E
----
T
C
C
-----
D
F
F
T
N
Q
A
Y
A
I
-
A
S
-
S
I
V
S
F
Y
V
P
L
V
I
M
-----
V
--
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---
L
N
I
F
E
-------------
M
L
-------
R
I
------
D
E
-----------
G
L-------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.65
24%
-124
- C3 -
3NY8
7
ENLYS_BPT4
A:
[46-316]
-------------------------------------------------------------------------------------
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
---
T
-
H
Q
E
A
I
N
--
C
Y
A
E
E
----
T
C
C
-----
D
F
F
T
N
Q
A
Y
A
I
-
A
S
-
S
I
V
S
F
Y
V
P
L
V
I
M
-----
V
--
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---
L
N
I
F
E
-------------
M
L
-------
R
I
------
D
E
-----------
G
L-------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.84
23%
-120
- C3 -
3PDS
4
ADRB2_HUMAN (first)
A:
[14-284]
-------------------------------------------------------------------------------------
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
---
T
-
H
Q
E
A
I
N
--
C
Y
A
E
E
----
T
C
C
-----
D
F
F
T
N
Q
A
Y
A
I
-
A
S
-
S
I
V
S
F
Y
V
P
L
V
I
M
-----
V
--
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---
L
N
I
F
E
-------------
M
L
-------
R
I
------
D
E
-----------
G
L-------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
79.65
18%
-139
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-333]
------------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
--
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
-----
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
-
F
G
W
G
A
Y
------
T
L
-
E
G
V
--
L
C
N
C
S
----
F
D
Y
-----
I
S
R
-----
D
S
-
T
T
-
R
S
N
I
L
C
M
F
I
L
G
F
-----
F
--
G
P
I
L
I
I
F
F
C
Y
F
N
I
---
V
M
S
V
S
-------------
N
H
-------
E
K
------
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
-
Q
F
L
L
----
S
W
S
P
Y
A
V
V
A
L
L
--
A
Q
F--
G
---
P
L
E
---------
W
V
T
-
P
Y
A
A
-----------
Q
L
--------------
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
-----
W
V
L
T
C
C
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
79.49
19%
-106
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
AP
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
--
I
-
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-------
P
P
L
V
---
G
W
S
R
Y
I
P
E
GM
Q
C
S
C
G
----
I
D
Y
-----
Y
---
T
P
H
E
E
T
-
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
-----
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
-------------
E
A
-------
A
A
------
Q
Q
-----------
Q
--------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
----
I
M
V
I
A
F
L
I
C
W
L
--
P
----
Y
---
A
-
G
---------
V
A
F
-
Y
I
F
T
H
QGSDFGPIFM
T
I
--------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
-----
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA----------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.81
24%
-128
- C3 -
4DAJ
3
ACM3_RAT (first)
A:
[12-283]
----------------------------------------------------------------------------------
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
---
N
I
L
V
I
V
A
F
K
V
N
-
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
-----
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
T
K
----------
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
--------
Q
Y
F
V
G
KRTV
P
P
G
ECFIQ
F
L
S
E
P
T
I
-
T
F
-
G
T
-
A
I
A
A
F
Y
M
--------------
P
V
T
I
M
T
I
L
Y
W
R
I
---
Y
K
E
T
E
-------------
K
M
N
I
F
E
M
L
-
R
I
------
D
E
-----------
G
L-------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
77.80
20%
-116
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------------------------
P
C
F
R
--------------
E
E
N
A
N
F
----------------
N
K
I
F
L
P
T
I
Y
S
I
--
I
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
-
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
-----
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
-----
L
-
T
I
P
D
F
I
F
---
A
N
V
S
E
A
D
D
--
R
Y
I
C
D
----
R
-------
F
Y
P
N
D
L
W
V
V
V
-
F
Q
-
F
Q
H
I
M
V
G
----
L
-----
I
--
L
P
G
I
V
I
L
S
C
Y
C
I
I
---
I
S
K
L
S
-------------
H
S
-------
G
S
------
N
---------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
-
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
T
--
K
----
S
PS
L
N
-
A
---------
A
K
S
-
E
L
D
K
-----------
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
--
R
-----
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
6
PsiBlast_PDB
77.57
24%
-131
- C3 -
4U14
1
ENLYS_BPT4
A:
[12-283]
----------------------------------------------------------------------------------
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
---
N
I
L
V
I
V
A
F
K
V
N
-
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
-----
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
T
K
----------
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
AIL
F
W
--------
Q
Y
F
V
G
KRTV
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
-
T
F
-
G
T
-
A
I
A
A
F
Y
M
--------------
P
V
T
I
M
T
I
L
Y
W
R
I
---
Y
K
E
T
E
-------------
K
M
-------
N
C
F
E
M
L
R
I
D
E
-----------
G
L-------------------
R
L
K
I
Y
K
D
C
E
G
Y
Y
T
-
I
---------
G
I
G
H
L
L
T
K
S
--
P
----
S
---
L
-
N
---------
A
A
K
S
E
L
D
K
-----------
A
I
--------------
G
R
N
T
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
74.76
14%
-140
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
---------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
--
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
-
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
-----
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
-
Y
Y
S
T
-
T
E
-----
T
--
M
P
S
--
R
V
V
C
M
----
I
E
W
-----
P
E
H
P
---
N
K
I
-
Y
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
-----
F
--
L
P
L
L
V
I
G
Y
A
Y
T
V
V
---
G
I
T
L
W
-------------
A
S
-------
E
I
------
P
G
DSSDRYH
E
Q
V
S
A
--------------------
K
R
K
V
V
K
M
M
I
V
V
V
C
-
T
F
A
I
----
C
W
L
P
F
H
I
F
F
L
L
--
P
Y
I
NP
D
---
L
-
Y
LK-------
K
F
I
-
Q
Q
V
Y
-----------
L
A
--------------
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
-----
C
C
P
F
I
S
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
74.31
17%
-129
- C3 -
1U19
14
OPSD_BOVIN
A:
[35-327]
---------------------------------------------------------------------------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
--
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-
V
G
W
S
R
Y
------
I
P
-
E
G
M
--
Q
C
S
C
G
----
I
D
Y
-----
Y
T
P
---
H
E
E
T
-
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
-----
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
-------------
E
A
-------
A
A
------
Q
Q
-----------
Q
ESA
T
T
Q
K
A
------------
E
K
E
V
T
R
M
V
I
I
M
V
I
-
A
F
L
I
----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
---
Q
---
G
-
S
---------
D
F
G
-
P
I
F
M
-----------
T
I
--------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
-----
C
G
K
N
P
L
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
73.58
17%
-112
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
---
T
H
Q
E
A
I
N
C
--
Y
A
E
E
T
----
C
C
D
-----
F
F
T
N
Q
A
Y
A
I
A
-
S
S
-
I
V
S
F
Y
V
P
L
V
I
M
V
-----
F
--
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
---
N
I
F
E
M
-------------
L
R
-------
I
D
------
E
G
-----------
L
--------------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
-
I
G
I
G
----
H
L
L
T
K
S
P
S
L
N
A
--
A
----
K
---
S
-
E
---------
L
D
K
-
A
I
G
R
-------------------------------
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
-----
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL-----
46
HHSearch
73.21
17%
-139
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[35-323]
----------------------------------------------------------------------------
E
T
L
N
K
Y
V
V
I
I
A
Y
A
L
--
V
F
L
L
S
L
L
G
---
N
S
L
V
M
L
V
I
L
Y
S
-
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
-----
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
-
L
F
R
Q
A
------
Y
H
P
-
N
N
S
--
S
P
V
C
Y
----
E
V
L
-----
G
N
----
D
T
A
K
-
W
R
-
M
V
L
R
I
L
P
H
T
F
G
F
-----
I
--
V
P
L
F
V
M
L
F
C
Y
G
F
T
---
L
R
T
L
F
-------------
K
A
-------
H
M
------
G
------------
Q
--------------------
K
H
R
A
M
R
V
I
F
A
V
V
L
-
I
F
L
L
----
C
W
L
P
Y
N
L
V
L
L
A
--
D
T
L
M
-
R
---
T
-
Q
VIQE
S
C
E
R
R
N
N
I
-
G
R
A
L
-----------
D
A
--------------
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
--
A
-----
M
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
72.26
17%
-126
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------------------------
S
F
K
C
A
--------------------------
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
--
V
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
-
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
-----
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
-
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
----
L
I
V
V
V
A
I
-
S
P
I
L
F
Y
S
---
G
T
G
V
R
K
N
K
--
T
I
T
C
Y
----
D
T
-----------
T
S
D
E
Y
-
L
R
-
S
Y
F
I
Y
S
M
C
T
T
V
A
-----
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
---
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
-------
N
P
------
E
D
-----------
G
--------------------
D
P
D
N
G
V
N
P
G
T
D
F
K
D
I
V
C
P
----
L
C
G
V
G
K
D
Q
F
E
E
--
V
----
E
---
E
-
P
---------
L
R
R
-
K
S
I
Y
-----------
L
V
--------------
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
-
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
--
P
-----
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-----------------------------------------------------------------------------------------------------------------------------
62
Fugue
69.77
17%
-136
- C1 -
4PG7
9
?
A:
[20-446]
H
M
K
K
L
N
I
A
L
LGLG
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
LN
K
D
I
V
I
K
H
I
L
V
R
D
K
S
K
K
R
P
L
N
I
S
Q
Y
H
L
T
E
D
V
N
E
I
--
L
N
D
D
S
L
D
I
I
V
E
V
M
G
G
I
E
P
T
V
--
D
W
L
R
T
A
L
K
---
N
K
K
H
V
I
T
A
N
K
D
L
L
A
V
H
L
K
L
L
E
D
L
A
E
E
N
G
V
A
L
K
F
E
A
S
V
-
A
G
G
-------
P
N
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
EQTT
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
L
N
D
V
K
R
-
R
G
I
S
G
V
T
---
L
T
D
I
N
V
A
D
--
Q
L
--------
G
Y
-----
K
I
K
L
I
G
K
G
I
Y
-
E
N
-
G
K
V
N
A
S
V
E
P
T
L
I
DKKHQ
L
--
A
A
V
E
D
E
Y
N
A
I
Y
V
I
GDA
V
G
D
T
M
-------------
F
Y
-------
G
K
------
G
A
-----------
G
--------------------
S
L
A
T
G
S
A
V
V
S
D
L
L
-
N
V
A
L
----
F
F
E
S
T
L
P
P
H
F
E
--
L
----
K
---
T
-
D
---------
K
T
R
-
E
M
E
K
---------------------------
S
N
F
F
V
V
V
N
H
V
K
G
S
------
I
E
N
F
E
N
E
L
K
A
I
L
--
P
FHR
S
L
R
V
A
N
Y
D
N
Q
S
Y
A
A
V
I
V
GLESSP
E
E
L
I
T
K
H
GYEVD
K
V
Y
P
V
E
GV-----------------------------------------------------------------------------------------------------------------------------
39
HHSearch
64.28
21%
-145
* C3 *
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
--------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
H
W
Y
R
A
-----
T
H
--
Q
E
--
A
I
N
C
Y
----
A
E
---------
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
-----
Y
--
V
P
L
V
I
M
V
F
V
Y
S
R
V
---
F
Q
E
A
K
-------------
R
Q
-------
L
N
------
I
F
-----------
E
--------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
-
K
D
T
E
----
G
Y
Y
T
I
G
I
G
H
L
L
--
T
----
K
---
S
-
P
---------
S
L
N
-
A
A
K
S
-----------
E
L
--------------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
--
I
-----
L
R
N
A
K
L
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
63.53
19%
-156
- C3 -
3EML
8
ENLYS_BPT4
A:
[21-222]
--------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
--
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
G
W
N
N
C
G
---
Q
---------
S
Q
G
C
G
----
E
G
Q
--------
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-----
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
L
A
A
R
-------------
R
Q
-------
L
N
------
I
F
-----------
E
--------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
-
K
D
T
E
----
G
Y
Y
T
I
G
I
G
H
L
L
--
T
----
K
---
S
-
P
---------
S
L
N
-
A
A
K
S
-----------
E
L
--------------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
--
I
-----
L
R
N
A
K
L
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------