@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2H1_HUMAN: (2016-01-13 )
MVNQSSPMGFLLLGFSEHPALERTLFVVVFTSYLLTLVGNTLIILLSVLYPRLHSPMYFFLSDLSFLDLCFTTSCVPQMLVNLWGPKKTISFLGCSVQLFIFLSLGTTECILLTVMAFDRYVAVCQPLHYATIIHPRLCWQLASVAWVMSLVQSIVQTPSTLHLPFCPHQQIDDFLCEVPSLIRLSCGDTSYNEIQLAVSSVIFVVVPLSLILASYGATAQAVLRINSATAWRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPYAQGRGKFFGLFYAVGTPSLNPLVYTLRNKEIKRALRRLLGKERDSRESWRAA
Atome Classification :
(20 SA)
------------.........10......---------------.---.20........30........---40........50........60........-----70----.........80.........90........100.......110.......120.......130.......140.......150.......160.......170.......180......-------.190-------.......200.......210.......220.......230--.........240.......250.......260...-------....270-------.-------.-------.....280.......290.......-------300.-------......310....--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MVNQSSP
M
G
F
L
L
L
GFSE---------------H---PAL
E
R
T
L
F
V
V
V
F
T
S
Y
L
L
T
L
V
G
---
N
T
L
I
I
L
L
S
V
L
Y
P
R
LH
S
P
M
Y
F
F
L
S
D
L
S
F
L
D
L
-----
C
-----FTT
S
C
V
P
Q
M
L
-
V
N
LWGPK
K
T
I
S
FLG
C
S
V
Q
L
F
I
F
L
SLGT
T
E
C
I
L
L
T
V
M
A
F
D
R
Y
V
A
V
CQPL
H
Y
A
T
II
H
P
R
L
C
W
Q
L
A
S
V
A
W
V
M
S
L
V
Q
S
I
VQTP
S
T
LHLPFC
P
H
Q
Q
I
D
D
F
L
C
EV
P
S
L
I
R
LSCG-------DTS
Y
-------
N
E
I
Q
L
A
V
S
S
V
I
F
V
V
V
P
L
S
L
I
L
A
SYGAT
A
Q
A
V
L
R
INS
A
T
----
A
W
R
K
A
F
GTCSS
H
L
T
V
V
T
L
F
Y
S
S
V
I
A
V
Y
LQPKNPYA-------QGRG
K
F
F
-------
G
-------
L
-------
F
Y
AVGTPSLN
P
L
V
Y
TLR
N
K
E
I
K
R
A
L
-------
R
R
L
L-------GKERDS
R
E
SWRAA--------
45
Fugue
85.81
19%
-105
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
---------------
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
-----
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
--------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
-------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
----
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-------
T
H
Q
G
S
D
F
GPIFM
T
I
P
-------
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
-------
V
T
T
L
-------
C
C
G
K
N
P
S
T
T
V
S
K
T
ETS
Q
V
A
P
A
14
PsiBlast_PDB
83.79
23%
-98
- C2 -
2HPY
14
OPSD_BOVIN
A:
[48-335]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PI
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
P
L
-------
G
D
D
E
A
S
T
T
V
S
K
T
E
--------
7
PsiBlast_PDB
83.68
23%
-113
- C2 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[45-326]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
15
PsiBlast_PDB
83.64
23%
-94
- C2 -
2PED
14
OPSD_BOVIN
A:
[48-335]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
P
L
-------
G
D
D
E
A
S
T
T
V
S
K
T
E
--------
9
PsiBlast_PDB
83.57
23%
-96
- C2 -
3OAX
17
OPSD_BOVIN
A:
[48-335]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PI
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
P
L
-------
G
D
D
E
A
S
T
T
V
S
K
T
E
--------
8
PsiBlast_PDB
83.51
23%
-116
- C2 -
4PXF
8
OPSD_BOVIN
A:
[45-326]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
16
PsiBlast_PDB
83.21
23%
-97
- C2 -
2G87
14
OPSD_BOVIN
A:
[48-335]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
P
L
-------
G
D
D
E
A
S
T
T
V
S
K
T
E
--------
4
PsiBlast_PDB
83.02
23%
-120
- C2 -
3DQB
6
GNAT1_BOVIN (first)
A:
[45-326]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
17
PsiBlast_PDB
82.79
23%
-96
- C2 -
1U19
14
OPSD_BOVIN
A:
[48-335]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
P
L
-------
G
D
D
E
A
S
T
T
V
S
K
T
E
--------
5
PsiBlast_PDB
82.55
23%
-116
- C2 -
3PQR
10
OPSD_BOVIN
A:
[45-326]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
6
PsiBlast_PDB
82.30
23%
-116
- C2 -
3PXO
5
OPSD_BOVIN
A:
[45-326]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
18
PsiBlast_PDB
81.70
23%
-125
- C- -
3C9M
1
OPSD_BOVIN
A:
[45-327]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
C
F
-------
G
PIFMTIP
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
P
-----------------------------
2
PsiBlast_PDB
81.40
23%
-116
- C2 -
3CAP
5
OPSD_BOVIN
A:
[45-326]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
11
PsiBlast_PDB
80.71
23%
-113
- C2 -
2I36
2
OPSD_BOVIN
A:
[45-326]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PIFMT
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
43
Fugue
80.69
20%
-85
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
---
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
-----
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------------
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
-------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-------
T
H
Q
G
S
D
F
-------
G
-------
P
IFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
-------
V
T
T
L
C
CGKNPL
G
D
D
E
A
S
T
T
V
S
K
T
E
TSQVAPA-
3
PsiBlast_PDB
79.88
23%
-50
- C- -
3C9L
13
OPSD_BOVIN
A:
[45-332]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
----------
D
D
E
-----------------
12
PsiBlast_PDB
79.47
23%
-54
- C- -
2I35
4
OPSD_BOVIN
A:
[45-332]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
-------
G
PI
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
CCG
K
N
----------
D
D
E
-----------------
1
PsiBlast_PDB
79.30
23%
-95
- C2 -
2X72
7
GNAT1_BOVIN (first)
A:
[48-327]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-----
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
Q
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
C
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
20
PsiBlast_PDB
79.06
23%
-96
- C2 -
4BEY
5
OPSD_BOVIN
A:
[48-327]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
FGD
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
C
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------
19
PsiBlast_PDB
78.43
23%
-95
- C2 -
4BEZ
4
OPSD_BOVIN
A:
[48-327]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
FGD
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
----
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
C
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CG
K
N
------------------------------