@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2H2_HUMAN: (2016-01-13 )
MVNQSSTPGFLLLGFSEHPGLERTLFVVVLTSYLLTLVGNTLIILLSALDPKLHSPMYFFLSNLSFLDLCFTTSCVPQMLVNLWGPKKTISFLDCSVQIFIFLSLGTTECILLTVMAFDRYVAVCQPLHYATIIHPRLCWQLASVAWVIGLVESVVQTPSTLHLPFCPDRQVDDFVCEVPALIRLSCEDTSYNEIQVAVASVFILVVPLSLILVSYGAITWAVLRINSAKGRRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPYAQERGKFFGLFYAVGTPSLNPLIYTLRNKEVTRAFRRLLGKEMGLTQS
Atome Classification :
(20 SA)
------------.........10......---------------.---.20........30........---40........50........60........-----70....-....80.........90........100.......110.......120......------.130.......140.......150.......160.......170.......180.....-------.-------.190.......200.......210.......220...-....230---------.-----------------.---.......240.......250.......260..---.-------.---.-.--.270-------.-------.-------.....280.......290.......300.-------......310----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MVNQSSTP
G
F
L
L
L
GFSE---------------H---PGL
E
R
T
L
F
V
V
V
L
T
S
Y
L
L
T
L
VG---N
T
L
I
I
L
L
SALDPKLH
S
P
M
Y
F
F
L
SNL
S
F
L
D
L
-----
C
FTT
S
C
-
V
P
Q
M
L
-
V
N
LWGPK
K
T
I
S
F
LDC
S
V
Q
I
F
I
F
L
SLGT
T
E
C
I
L
L
T
V
M
A
F
D
R
Y
V
A
V
CQPL------
H
Y
A
T
II
H
P
R
L
C
W
Q
L
A
S
V
A
W
V
I
G
L
V
E
S
V
VQTP
S
T
LHLPFCPDR
Q
V
D
D
F
V
CEV
P
A
L
I
R
L
SC-------E-------DTS
Y
N
E
I
Q
V
A
V
A
S
V
F
I
L
V
V
P
L
S
L
I
L
V
SYG
A
I
T
W
A
V
L
R
-INSAK-----------G-----------------R---
R
K
A
F
GTCSS
H
L
T
V
V
T
L
F
Y
S
S
V
I
A
V
Y
LQPKNP
Y
---
A
-------
Q
---
E
-R--G
K
F
F
-------
G
-------
L
-------
F
Y
AVGTPSLN
P
L
I
Y
T
LR
N
K
E
V
T
R
A
F
R
R
L
L
-------
G
K
EMGLTQS----------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
86.43
19%
-108
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
---------------
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
--------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
A
A
S
A
-----------
T
-----------------
T
---
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
---
F
-------
T
---
H
-
Q
--
G
S
D
F
GPIFM
T
I
P
-------
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A----------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.06
22%
-119
- C3 -
2I35
4
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PI
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
D
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.24
22%
-121
- C3 -
4PXF
7
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.22
22%
-115
- C3 -
3C9L
13
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
D
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.19
22%
-126
- C3 -
3DQB
4
GNAT1_BOVIN (first)
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
80.04
16%
-124
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
-----------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
-----
S
M
A
A
F
N
-
T
V
V
N
F
-
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
------
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
-----
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
-
S
E
I
P
G
DSSDRYH
E
Q
V
S
A
-----------------
K
---
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
---
D
-------
L
YLK
K
F
I
Q
Q
V
Y
L
A
-------
I
-------
M
-------
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-------
R
C
C
P
F
I
S
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.92
22%
-119
- C3 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
79.50
16%
-101
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------
D
---
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
-----
V
M
G
L
A
V
-
V
P
F
G
A
-
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
------
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
Y
A
E
-----
E
T
C
C
-------
D
-------
F
F
T
-
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
-----------
M
-----------------
L
---
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
---
N
-------
A
---
A
-
K
--
S
E
L
D
-------
K
-------
A
-------
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
-------
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
12
PsiBlast_PDB
79.23
22%
-123
- C3 -
3PXO
4
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.72
22%
-122
- C3 -
3PQR
9
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.63
22%
-106
- C3 -
3OAX
16
OPSD_BOVIN
A:
[48-313]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PI
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
P
L
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
78.49
16%
-123
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-332]
---------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
-----
T
F
S
L
V
N
G
F
P
L
M
T
-
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
------
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
----
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
-
H
E
K
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW
V
-------
T
---
P
-
Y
--
A
A
Q
L
-------
P
-------
V
-------
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-------
P
W
V
L
T
C
C
Q
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.35
22%
-121
- C3 -
3CAP
4
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.78
22%
-108
- C3 -
2HPY
13
OPSD_BOVIN
A:
[48-313]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PI
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
P
L
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.72
22%
-117
- C3 -
2I36
1
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PIFMT
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
77.43
20%
-83
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
---
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
----------------------------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
A
A
Q
Q
-----------
Q
ESA
T
-------------
T
---
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
---
F
-------
T
---
H
-
Q
--
G
S
D
F
-------
G
-------
P
IFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPL
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA-----------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.20
22%
-105
- C3 -
1GZM
15
OPSD_BOVIN
A:
[48-313]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
D
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.07
23%
-104
- C3 -
2X72
5
GNAT1_BOVIN (first)
A:
[48-313]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
Q
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-----------------
Q
---
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
C
F
-------
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.94
22%
-119
- C3 -
1F88
7
OPSD_BOVIN
A:
[45-312]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
P
S
T
T
----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.53
22%
-113
- C3 -
1HZX
14
OPSD_BOVIN
A:
[48-313]
--------------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
--------------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
-
V
K
E
A
A
-----------
A
-------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
---
A
G
V
A
F
Y
I
F
T
---
H
-
Q
--
G
S
D
F
-------
G
PIFM
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
P
L
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------