@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2M2_HUMAN: (2016-01-13 )
MAWENQTFNSDFILLGIFNHSPPHTFLFFLVLGIFLVAFMGNSVMVLLIYLDTQLHTPMYFLLSQLSLMDLMLICTTVPKMAFNYLSGSKSISMAGCVTQIFFYISLSGSECFLLAVMAYDRYIAICHPLRYTNLMNPKICGLMATFSWILGSTDGIIDAVATFSFSFCGSREIAHFFCEFPSLLILSCNDTSIFEEVIFICCIVMLVFPVAIIIASYARVILAVIHMGSGEGRCKAFTTCSSHLMVVGMYYGAALFMYIRPTSDHSPTQDKMVSVFYTILTPMLNPLIYSLRNKEVTRAFMKILGKGKSESELPHKLYVLLFAKFFFLISIFFYDVKILALIMYIA
Atome Classification :
(20 SA)
----------.........10........20........30........40........50...---.....60........70........-80.....-...90........100.......110........120.......130....---....140.......150.......160.......170.......180.......-------190--..---.....----------200.......210.......220..----.....-------230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.-...---....240...--....250--------......-------...260....------------.--..270.......280.......290.......300.......310.......320.......330.......340.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MAWENQTFNS
D
F
I
L
L
G
I
FNHSP
P
H
T
F
L
F
F
L
V
L
G
I
F
L
V
A
F
MGN
S
V
M
V
L
L
I
Y
LDTQ---LH
T
P
M
Y
F
L
L
S
Q
L
S
L
M
D
L
M
L
I
C
TT
V
P
-
K
M
A
F
N
YL-SGSKS
I
S
M
A
G
C
V
T
Q
I
F
F
Y
I
SLSGS-
E
C
F
L
L
A
V
M
A
YDR
Y
I
A
I
CHP
L
-
R
YTNL---MN
P
K
I
C
G
L
M
A
T
F
S
W
I
LGST
D
G
I
I
D
A
V
A
T
F
S
F
SFCGS
R
E
I
A
H
F
F
C
EFP
S
L
L
I
L
SC-------N
D
T
--
S
I
---
F
E
E
V
I
----------
F
I
C
C
I
V
M
L
V
F
P
V
A
I
I
I
A
S
Y
A
R
V
I
L
A
----
V
I
HMG-------S------------------------------------------------------------------------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------------------------------------------------------------------------------------------E-G
R
C
---
K
A
F
TTCSS
H
L
--
M
V
V
G
M
----------
Y
Y
G
A
A
L
-------
F
M
Y
I
R
PTSDH------------S--P
T
Q
D
K
M
V
S
V
F
Y
T
I
L
T
P
M
L
N
P
L
I
Y
S
LRN
K
E
V
T
R
A
F
M
K
I
LGKGKSESEL
P
H
K
L
Y
V
L
L
F
A
K
F
F
F
L
I
S
I
F
F
Y
D
V
K
I
L
A
L
I
M
YIA
27
HHSearch
94.32
19%
-142
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
----------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
-
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
-
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
----
T
H
Q
E
A
I
N
C
Y
A
E
E
----
T
C
-------
C
D
F
--
F
T
---
N
Q
A
Y
A
----------
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
----
A
K
R
Q
L
-------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
-
K
E
H
---
K
A
L
K
T
L
G
I
I
M
--
G
T
F
T
L
----------
C
W
L
P
F
F
-------
I
V
N
I
V
H
V
I
Q
D
NL----------
I
--
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------
4
PsiBlast_PDB
91.71
21%
-151
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
-
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
---------------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
-------
S
QPLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--
I
I
A
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
3
PsiBlast_PDB
91.51
21%
-151
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
-
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
---------------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
-------
S
QPLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--
I
I
A
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
8
PsiBlast_PDB
91.45
22%
-159
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[14-308]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
--
F
A
I
T
I
S
-
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
-------
G
C
-------
G
E
G
--
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFN-
F
F
A
C
V
L
V
---
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
-------
S
Q
PLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--
I
I
V
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------------------------------
2
PsiBlast_PDB
91.35
21%
-153
- C3 -
3PWH
1
?
A:
[14-305]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
-
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
---------------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
-------
S
QPLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--
I
I
A
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
5
PsiBlast_PDB
91.30
21%
-150
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
-
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
---------------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
-------
S
QPLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--
I
I
A
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
10
PsiBlast_PDB
90.80
22%
-153
- C3 -
2YDV
6
?
A:
[14-315]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
---
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YF
N
-
F
F
A
C
V
L
V
---
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
-------
S
Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--
I
I
V
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
--------------------
12
PsiBlast_PDB
90.57
22%
-150
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[14-315]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
---
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
----------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YFN-
F
F
A
C
V
L
V
---
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
-------
S
QPLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--
I
I
V
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
--------------------------
43
Fugue
90.56
18%
-126
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
S
-----------
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
E
E
--
T
N
---
N
E
S
F
V
----------
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
ASATTQK
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
E
V
T
---
R
M
V
I
I
M
V
I
A
F
--
L
I
C
W
L
----------
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
D
------------
F
--
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------
6
PsiBlast_PDB
90.29
21%
-149
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
-
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
---------------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YFNF
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
-------
S
QPLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--
I
I
A
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
9
PsiBlast_PDB
89.84
22%
-151
- C3 -
2YDO
3
?
A:
[14-315]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
---
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YF
N
-
F
F
A
C
V
L
V
---
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
-------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
L
Q
K
E
V
H
A
A
K
S
L
A
--
I
I
V
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
---------------------
28
HHSearch
89.21
18%
-152
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
-
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
---
C
-------
L
F
E
DV
V
P
---
M
N
Y
M
V
----------
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
----
A
R
R
Q
L
-------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
K
E
V
---
H
A
A
K
S
L
A
I
I
V
--
G
L
F
A
L
----------
C
W
L
P
L
H
-------
I
I
N
C
F
T
F
F
C
P
DCSH--------
A
--
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------------------
23
HHSearch
88.94
18%
-153
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
---------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
---
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
-
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
-
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
------------------
S
---
N
A
A
V
T
----------
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
----
S
K
S
R
I
-------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
R
E
K
---
K
V
T
R
T
I
L
A
I
L
--
L
A
F
I
I
----------
T
W
A
P
Y
N
-------
V
M
V
L
I
N
T
F
C
A
PC----------
I
--
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------
7
PsiBlast_PDB
88.93
22%
-160
- C3 -
3VG9
8
?
A:
[14-309]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
--
F
A
I
T
I
S
-
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
-------
G
C
-------
G
E
G
--
Q
V
A
C
L
F
E
D
V
V
PMNYMVYFN-
F
F
A
C
V
L
V
---
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
-------
S
Q
PLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--
I
I
V
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------
11
PsiBlast_PDB
88.60
22%
-154
- C3 -
4UG2
3
?
A:
[14-309]
-----------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
---
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-------
G
C
-------
G
E
G
--
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YF
N
-
F
F
A
C
V
L
V
---
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--
I
I
V
G
L
----------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
------------
A
--
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------
34
HHSearch
88.08
18%
-154
* C3 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
---
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
-
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
-
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
-------
T
G
D
P
T
V
C
S
I
S
N
-------------------
P
---
D
--
F
V
----------
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
----
L
K
Q
R
R
-------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
-
R
E
K
---
K
A
T
Q
M
V
A
I
V
L
--
G
A
F
I
V
----------
C
W
L
P
F
F
-------
L
T
H
V
L
N
T
H
C
Q
TCH---------
V
--
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------
26
HHSearch
86.00
19%
-151
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
---
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
-
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
-
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
--------
R
R
E
D
K
C
E
T
D
F
Y
D
---------------------
V
T
W
F
K
----------
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
----
V
R
Q
H
C
-------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
R
E
R
---
K
A
A
K
Q
L
G
F
I
M
--
A
A
F
I
L
----------
C
W
I
P
Y
F
-------
I
F
F
M
V
I
A
F
C
K
------------
N
CC
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------
19
PsiBlast_PDB
84.75
21%
-141
- C3 -
1F88
7
OPSD_BOVIN
A:
[44-326]
-------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
--
A
F
T
W
V
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
E
E
--
T
N
---
N
E
S
F
V
----------
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
-------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
F
------------
G
--
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------
20
PsiBlast_PDB
83.93
21%
-151
- C3 -
3DQB
6
GNAT1_BOVIN (first)
A:
[44-326]
-------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
HKK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
--
A
F
T
W
V
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
--
T
N
---
N
E
S
F
V
----------
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
-------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
Q
E
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
F
------------
G
--
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------
24
HHSearch
83.18
19%
-137
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-499]
--------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
---
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
-
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
-
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
-----
S
E
A
D
D
R
Y
I
C
D
R
F
Y
P
N
D
---------------
L
W
---
V
V
V
F
Q
----------
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
----
L
S
H
S
G
-------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
-
Q
K
R
---
K
A
L
K
T
T
V
I
L
I
--
L
A
F
F
A
----------
C
W
L
P
Y
Y
-------
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
--
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------------------