@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2T1_HUMAN: (2016-01-13 )
MWQEYYFLNVFFPLLKVCCLTINSHVVILLPWECYHLIWKILPYIGTTVGSMEEYNTSSTDFTFMGLFNRKETSGLIFAIISIIFFTALMANGVMIFLIQTDLRLHTPMYFLLSHLSLIDMMYISTIVPKMLVNYLLDQRTISFVGCTAQHFLYLTLVGAEFFLLGLMAYDRYVAICNPLRYPVLMSRRVCWMIIAGSWFGGSLDGFLLTPITMSFPFCNSREINHFFCEAPAVLKLACADTALYETVMYVCCVLMLLIPFSVVLASYARILTTVQCMSSVEGRKKAFATCSSHMTVVSLFYGAAMYTYMLPHSYHKPAQDKVLSVFYTILTPMLNPLIYSLRNKDVTGALKRALGRFKGPQRVSGGVF
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30......--..40..-------......50........60........70........80........90-----.........100..---.....110.......120.....-..130....-...140..--------.....150.......160----........170.......180...---....190.......200.......210.......220.....-..230.......--240-----..--.......250.......260.......270........280---------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------..----.-----------.--....290.......300------........310...------------.------------.-------..320.......330.......340.......350.......360.......------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MW
Q
E
Y
Y
F
L
N
V
F
F
P
L
L
K
V
C
C
L
TINS
H
V
V
I
L
L
P
W
E
C
Y
H
L
--
I
W
K
I
L
P
-------
Y
I
GTTVGS
M
E
EYNTSST
D
F
T
F
M
G
L
FNRKETS
G
L
I
F
A
I
I
S
I
I
F
F
T
A
L
M------AN
G
V
M
I
F
L
I
QTD
L
R
---LH
T
P
M
Y
F
L
L
S
H
L
S
L
I
D
M
M
Y
I
S
T
I
-
V
P
K
M
L
V
N
Y
L
-LDQR
T
I
S
F
--------VGCTA
Q
H
F
L
Y
L
T
L
V
G
A
E
-----
F
F
L
L
G
L
M
A
Y
D
R
Y
V
A
I
CNPLR
Y
P
V
L
---MSRR
V
C
W
M
I
I
A
GSWFGGSLD
G
F
L
L
T
P
I
T
M
SFPFCNSREI
N
H
F
-FCEAP
A
V
L
K
L
AC--A-------
D
T
--
A
L
Y
E
T
V
M
Y
V
C
C
V
L
M
L
L
I
P
F
S
V
V
L
A
S
Y
A
R
I
-
L
T
T
V
Q
C
M
S
S-----------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------EG----
R
-----------
K
--
K
A
F
A
T
C
SS
H
M
T
V
V
S
L
F
-------
Y
G
A
A
M
Y
T
Y
MLPHSY------------H------------K-------P
A
Q
D
K
V
L
S
V
F
Y
T
I
L
T
P
M
L
N
P
L
I
Y
S
LRNK
D
V
T
G
A
L
K
R
A
L
G
RFK
G
P
Q
RVSGGVF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
91.20
19%
-157
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
------
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
---
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
--------
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
-----
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
--------
R
R
E
D
-
K
C
E
T
D
F
Y
D
--------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
-
Y
K
A
V
R
Q
H
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
----
E
-----------
R
--
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
-------
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
------------
K
NC----------
C
-------
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
89.93
20%
-152
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
------
G
N
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
--------
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
----
H
Q
E
A
I
-
N
C
Y
A
E
----
E
T
C
--
C
-------
D
F
--
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
K
R
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
----
E
-----------
H
--
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
-------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
NL----------
I
-------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
88.73
18%
-152
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
------
G
N
G
L
V
C
M
A
V
L
K
E
R
A
---
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
--------
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
-----
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
-------
G
D
P
T
-
V
C
S
I
S
N
-----------------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
-
Y
V
V
L
K
Q
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
----
E
-----------
K
--
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
-------
W
L
P
F
F
L
T
H
V
L
N
T
H
C
QTC---------
H
------------
V
-------
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
82.47
17%
-150
- C4 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
------
G
N
V
V
V
M
W
I
I
L
A
H
K
R
---
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
--------
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
-----
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
V
-
V
C
M
I
E
W
P
E
H
-----
P
-------
N
K
--
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
----
K
-----------
R
--
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
-------
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
------------
P
------------
D
LYLKKF-
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
82.00
16%
-148
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-499]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
------
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
---
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
--------
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
-----
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
-----
A
D
D
R
Y
-
I
C
D
R
F
Y
P
N
---------------
D
--
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
-
I
S
K
L
S
H
S
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
----
K
-----------
R
--
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
-------
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
-------
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
81.87
18%
-158
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-472]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
--------
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
-
G
C
G
E
G
Q
V
---
A
C
--
L
-------
F
E
DV
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-
F
L
A
A
R
R
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
----
E
-----------
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
-------
W
L
P
L
H
I
I
N
C
F
T
F
F
C
PDCS--------
H
------------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
80.74
15%
-147
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
------
G
N
I
L
V
M
V
S
I
K
V
N
R
H
---
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
--------
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
-----
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
--
V
R
T
V
E
D
G
-
E
C
Y
I
Q
F
F
--------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
----
E
-----------
K
--
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
-------
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
------------
A
PC----------
I
-------
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
80.11
16%
-128
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
---------------------------
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
--------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
--------
S
R
Y
-
I
P
E
G
---
M
Q
C
S
C
--
G
I
DYYTPH
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
----
T
-----------
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
------------
I
------------
F
T
H
QGSDF
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
TS
Q
V
A
P
A-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
79.65
16%
-108
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
P
-
N
F
Y
V
P
F
---------------------------------------------
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
--------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
--------
S
R
Y
-
I
P
E
G
---
M
Q
C
S
C
--
G
I
DYYTPH
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
ESA
T
T
-----------
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
------------
I
------------
F
T
H
QGSDF
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
78.06
16%
-153
* C4 *
2Z73
5
OPSD_TODPA
A:
[31-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
------
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
---
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
--------
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
-----
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
-
N
C
S
F
D
Y
I
S
--------------
R
D
--
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
----
E
-----------
M
--
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
-------
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
------------
P
LEW---------
V
-------
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.24
23%
-119
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[76-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
----
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
----
Q
PLPG
E
R
A
R
S
T
L
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-------------
H
------------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.24
23%
-115
- C4 -
2YDO
3
?
A:
[76-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
-
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
-----T
L
---------
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
------------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.97
23%
-116
- C4 -
2YDV
6
?
A:
[76-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
-
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
----
Q
S
T
L
--------
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
------------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.08
23%
-120
- C4 -
4UG2
3
?
A:
[76-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
-
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
-------
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
R
S
T
L
------
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
------------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
72.91
15%
-112
- C4 -
1U19
14
OPSD_BOVIN
A:
[37-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
--------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
----
P
E
G
M
Q
C
-
S
C
G
I
D
Y
Y
T
P
-----
H
-------
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
----
E
-----------
K
--
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS---------
D
------------
F
-------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
72.37
14%
-128
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
------
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
---
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
--------
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
-----
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
----
P
N
N
S
S
P
-
V
C
Y
E
V
L
G
N
------
D
-------
T
A
--
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-
L
R
T
L
F
K
A
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
----
K
-----------
H
--
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
-------
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
------------
R
TQVIQE
S
C
E
R
R
N
N
-------
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
72.23
16%
-145
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
------
E
N
I
F
V
L
L
T
I
W
K
T
K
K
---
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
--------
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
-----
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
I
-------
S
A
L
S
-
S
C
S
T
V
L
P
L
--------------------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
-
Y
S
L
V
R
T
R
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
E
----
N
-----------
V
--
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
-------
W
A
P
L
F
I
L
L
L
L
D
V
G
C
------------
K
VKTC--------
D
-------
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.34
23%
-136
- C4 -
3VG9
7
?
A:
[76-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
----
Q
PLPGERA
R
S
T
L
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
------------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.23
23%
-127
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[76-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
----
Q
PLPGERA
R
S
T
L
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
------------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
70.45
19%
-120
* C2 *
4M1C
2
IDE_HUMAN
A:
[14-982]
NNPAIKRIGNHITKSPEDK
R
E
Y
R
G
L
E
L
ANG
I
K
V
L
L
I
S
D
PTTD
K
S
S
A
A
L
D
V
HIGSLSDPPNIAG
L
S
H
F
L
Q
H
M
L
F
LGTKKYPKEN
E
Y
S
Q
F
L
S
E
H
A
G
S
S
N
A
F
T
S
GE
H
T
N
Y
Y
F
D
V
S
HEH
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
L
F
D
E
S
A
K
D
R
E
V
N
A
V
D
S
E
H
E
K
N
V
MN
D
A
W
R
L
F
Q
L
E
K
A
T
G
NPKHPFSKFGTGNKYTLE
T
R
P
N
Q
E
GIV
R
Q
E
L
L
K
F
H
S
A
YYSSNL
M
A
V
V
V
L
GRES
L
D
D
L
T
N
L
V
V
K
L
F
S
E
V
E
N
K
N
V
P
L
P
-------
E
F
P
E
H
-----
P
F
Q
E
E
H
L
KQ
L
Y
K
I
V
P
IKD
I
R
N
L
Y
V
T
F
P
I
P
D
L
Q
K
Y
Y
K
S
N
P
G
H
Y
L
G
H
L
I
G
H
E
G
P
G
S
L
L
S
E
L
K
S
K
G
W
V
N
T
L
V
G
G
Q
K
E
G
A
R
G
F
M
F
F
I
I
N
V
D
L
T
E
E
G
L
L
H
V
E
D
I
I
L
H
M
F
Q
Y
I
Q
K
L
R
A
E
G
P
--
Q
E
W
V
F
Q
E
L
-
K
D
L
N
A
V
A
F
R
F
KDKER
P
R
G
Y
T
S
K
I
A
G
I
L
H
Y
Y
P
L
E
EVLTA
E
Y
L
L
E
E
F
R
P
D
L
I
E
M
V
L
D
K
L
R
--------
P
E
N
V
R
V
A
I
V
S
K
S
F
E
G
K
T
D
R
T
E
E
W
Y
G
T
Q
Y
K
Q
E
A
I
P
D
E
V
I
K
K
W
Q
N
A
D
L
N
G
K
F
K
L
P
T
--
K
-------
N
E
--
F
I
P
T
N
--------
F
E
I
L
P
L
E
K
E
A
T
P
Y
P
A
L
-
I
K
D
T
A
-
M
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
----
K
-----------
Q
D
D
K
F
F
-----------
L
P
-------
K
A
N
L
N
F
E
F
F
S
P
F
A
Y
------------
V
------------
D
-------
P
L
H
S
N
M
A
Y
L
Y
L
E
L
L
K
D
S
L
N
E
Y
A
Y
A
A
E
L
A
G
L
S
Y
D
L
Q
N
T
I
Y
----------
G
M
Y
L
S
V
K
G
YNDK
Q
P
I
L
L
K
K
I
I
E
K
M
A
T
F
E
I
D
E
K
R
F
E
I
I
K
E
A
Y
M
R
S
L
N
N
F
R
A
EQ
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
TE
V
A
W
T
K
D
E
L
K
E
A
L
D
D
VT
L
P
R
L
K
A
F
I
P
Q
L
L
S
R
L
H
I
E
A
L
L
H
G
NIT
K
Q
A
A
L
G
I
M
Q
M
V
E
D
T
L
I
E
HAH
T
K
P
L
L
PSQL
V
R
Y
R
E
VQLPDR
G
W
F
V
Y
Q
Q
R
NEVHN
N
S
G
I
E
I
Y
YQTDMQS
T
S
E
N
M
F
L
E
L
F
A
Q
I
I
S
E
P
A
F
N
TLRTKEQLGY
I
V
F
S
G
P
R
R
A
NG
I
Q
G
L
R
F
I
I
Q
S
EKP
P
H
Y
L
E
S
R
V
E
A
F
L
I
T
M
E
K
S
I
E
D
MT
E
E
A
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R
D
N
T
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V
A
Y
L
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K
E
D
I
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MLAVDAPRRH
K
V
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V
H
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L
A
REMDSNPN
L
S
Q
A
P
AL
P
Q
P
E
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M
T
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