@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2T2_HUMAN: (2016-01-13 )
MGMEGLLQNSTNFVLTGLITHPAFPGLLFAIVFSIFVVAITANLVMILLIHMDSRLHTPMYFLLSQLSIMDTIYICITVPKMLQDLLSKDKTISFLGCAVQIFLYLTLIGGEFFLLGLMAYDRYVAVCNPLRYPLLMNRRVCLFMVVGSWVGGSLDGFMLTPVTMSFPFCRSREINHFFCEIPAVLKLSCTDTSLYETLMYACCVLMLLIPLSVISVSYTHILLTVHRMNSAEGRRKAFATCSSHIMVVSVFYGAAFYTNVLPHSYHTPEKDKVVSAFYTILTPMLNPLIYSLRNKDVAAALRKVLGRCGSSQSIRVATVIRKG
Atome Classification :
(20 SA)
------------.........10........20........30........40-........50........60........70.......-.80........90-........100.......110......--.120.......130.......140.......150.......160.......170.......180........190-----.-------...------.....200.......210.......220.......--230.-----------.-----------------.-----.---...240...------....250-----.------........260.---------.--.----.---.----.-----------.270.-------......280.--..------....290.......300..---..---------...310.......320..------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------M
G
M
E
G
L
LQNST
N
F
V
L
T
GLITHPA
F
P
G
L
L
F
A
I
V
F
S
I
F
V
V
A
I
T
-
A
N
L
V
M
I
L
L
I
HMDSRL
H
T
P
M
Y
F
L
L
S
Q
L
S
I
M
D
T
I
Y
I
C
I
T-
V
P
K
M
L
Q
D
L
LSKDK-T
I
S
F
L
G
C
A
V
Q
I
F
L
Y
L
T
LIG
G
E
F
F
L
L
G
L
--
M
A
Y
D
R
Y
V
A
V
CNPLRY
P
L
LMNR
R
V
C
L
F
M
V
V
G
S
WVGGSLD
G
F
M
LT
P
V
TMSFPFCRSREI
N
H
F
F
CE-IP
A
V
L
K
L
SC-------T-------
D
T
S
------
L
Y
E
T
L
M
Y
A
C
C
V
L
M
L
L
I
P
L
S
V
I
S
V
S
Y
T
H
I
L
L
T
V
H
RM--NSAE-----------
G
-----------------
R
-----
R
---
K
A
F
A
TCSS
H
------
I
M
V
V
S
-------
V
------
F
YG
A
A
F
Y
T
NVLP---------H--S----Y---H----T-----------P
E
K
D
K
-------
V
V
S
A
F
Y
T
I
L
T
--
P
M
------
L
N
P
L
I
Y
S
LRN
K
D
V
A
A
A
L
R
K
---
V
L
---------
G
RCGSSQ
S
I
R
V
A
T
V
IRKG------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.69
20%
-153
- C2 -
4GBR
1
ADRB2_HUMAN
A:
[9-284]
-----------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
-------
E
T
C
-------
C
-------
D
F
F
------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
Q
K
I
-----------
D
-----------------
K
FC
L
K
E
H
---
K
A
L
K
T
L
G
I
I
------
M
G
T
F
T
-------
L
------
C
W
L
P
F
F
I
V
N
I
V
----------------------
H
----
V
-----------
I
Q
D
N
L
-------
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
---
L
L
---------
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.58
21%
-155
- C2 -
4LDO
3
A:
[186-461]
-----------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
-------
E
T
C
-------
C
-------
D
F
F
------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
-----------
K
-----------------
E
-----
H
---
K
A
L
K
T
L
G
I
I
------
M
G
T
F
T
-------
L
------
C
W
L
P
F
F
I
V
N
I
V
----------------------
H
----
V
-----------
I
Q
D
N
L
-------
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
---
L
L
---------
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.57
21%
-153
- C2 -
4LDL
3
ADRB2_HUMAN
A:
[186-461]
-----------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
-------
E
T
C
-------
C
-------
D
F
F
------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
-----------
K
-----------------
E
-----
H
---
K
A
L
K
T
L
G
I
I
------
M
G
T
F
T
-------
L
------
C
W
L
P
F
F
I
V
N
I
V
----------------------
H
----
V
-----------
I
Q
D
N
L
-------
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
---
L
L
---------
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.47
21%
-152
- C2 -
4LDE
3
A:
[186-461]
-----------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
-------
E
T
C
-------
C
-------
D
F
F
------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
-----------
K
-----------------
E
-----
H
---
K
A
L
K
T
L
G
I
I
------
M
G
T
F
T
-------
L
------
C
W
L
P
F
F
I
V
N
I
V
----------------------
H
----
V
-----------
I
Q
D
N
L
-------
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
---
L
L
---------
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
88.35
21%
-154
- C2 -
4QKX
2
ADRB2_HUMAN
A:
[186-461]
-----------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
-------
E
T
C
-------
C
-------
D
F
F
------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LQ
K
F
A
L
-----------
K
-----------------
E
-----
H
---
K
A
L
K
T
L
G
I
I
------
M
G
T
F
T
-------
L
------
C
W
L
P
F
F
I
V
N
I
V
----------------------
H
----
V
-----------
I
Q
D
N
L
-------
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
SG
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
---
L
L
---------
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
88.11
20%
-124
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
----
S
R
-------
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
S
A
-----------
T
-----------------
T
-----
Q
---
K
A
E
K
E
V
T
R
M
V
I
----
I
M
V
I
A
-------
F
------
L
I
C
W
L
P
Y
A
G
V
A
F
---------
Y
--
I
----
F
---
T
----
H
-----------
Q
G
S
D
F
GPIFM--
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
85.28
15%
-155
* C2 *
2Z73
5
OPSD_TODPA
A:
[34-334]
------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
-
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
--
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
-
L
E
G
V
L
C
N
C
S
-
F
D
Y
I
S
-------------------
R
D
S
------
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
--
E
K
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----
N
A
E
M
R
L
A
K
I
S
I
V
I
------
V
S
Q
F
L
-------
L
------
S
W
S
P
Y
A
V
V
A
L
L
A
---------
Q
--
F
----
G
PLE
W
----
V
-----------
T
P
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
S
--
A
I
------
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
---
T
F
---------
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
82.58
20%
-148
- C2 -
4A4M
4
OPSD_BOVIN
A:
[42-313]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
------
V
T
R
M
V
-------
I
------
I
Y
V
I
A
F
L
I
C
W
L
P
---------
Y
--
A
G
V
A
F
Y
---
I
----
F
-----------
T
H
Q
G
S
C
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
82.41
21%
-150
- C2 -
3DQB
4
GNAT1_BOVIN (first)
A:
[39-312]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
IDYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
--
S
----
D
---
F
----
G
-----------
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
82.25
17%
-149
- C2 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
---------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
-
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
--
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
----
T
M
P
S
R
V
V
C
M
-
I
E
W
P
E
H
P
-----------------
N
K
I
------
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
--
E
I
P
G
DSSDRYH
E
Q
V
S
A
-----------------
K
-----
R
---
K
V
V
K
M
M
I
V
V
------
V
C
T
F
A
-------
I
------
C
W
L
P
F
H
I
F
F
L
L
P
---------
Y
--
I
----
N
---
P
DLYL
K
KF---------
I
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
--
T
M
------
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
---
A
F
---------
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.49
21%
-149
- C2 -
3C9L
13
OPSD_BOVIN
A:
[39-312]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
IDYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
--
S
----
D
---
F
----
G
-----------
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
D
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.14
21%
-150
- C2 -
1F88
7
OPSD_BOVIN
A:
[39-312]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
-------------------------------------
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
--
S
----
D
---
F
----
G
-----------
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
81.05
18%
-113
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
----------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
------
V
T
R
M
V
-------
I
------
I
M
V
I
A
F
L
I
C
W
L
P
---------
Y
--
A
----
G
---
V
----
A
F
Y
I
F
T
H
QGSDF
G
P
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
C
CGKNPLGD
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.73
21%
-153
- C2 -
3PQR
9
OPSD_BOVIN
A:
[39-312]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
IDYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
--
S
----
D
---
F
----
G
-----------
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
80.72
16%
-125
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
--
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
------
E
T
C
C
-------
D
-------
F
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
N
I
F
-----------
E
-----------------
M
-----
L
---
R
I
D
E
G
L
R
L
K
------
I
Y
K
D
T
-------
E
------
G
Y
Y
T
I
G
I
G
H
L
L
T
---------
K
--
S
----
P
---
S
----
L
-----------
N
A
A
K
S
-------
E
L
D
K
A
I
G
R
N
T
NG
V
I
------
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
---
I
L
---------
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
16
PsiBlast_PDB
80.35
21%
-153
- C2 -
3CAP
4
OPSD_BOVIN
A:
[39-312]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
IDYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
--
S
----
D
---
F
----
G
-----------
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
79.29
17%
-121
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
-------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
---
I
-
P
E
G
M
Q
C
S
C
G
-
I
D
Y
Y
T
P
----------
H
-------
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
ESA
T
T
Q
K
A
---------
E
-----
K
---
E
V
T
R
M
V
I
I
M
------
V
I
A
F
L
-------
I
------
C
W
L
P
Y
A
G
V
A
F
Y
I
---------
F
T
H
Q
----
G
S--
D
----
F
-----------
G
P
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
77.85
18%
-135
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
-----
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
-
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
--
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
---
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
------------
K
T
I
T
C
-------
Y
-------
D
T
T
SDEY
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
------------------
K
-----------------
M
-----
K
---
K
Y
T
C
T
V
C
G
Y
------
I
Y
N
P
E
DGDPDNG
V
------
N
P
G
T
D
F
K
D
I
V
C
P
LCGVGKDQ
F
E
--
E
----
V
---
E
----
E
-----------
P
L
R
R
K
-------
S
I
Y
L
V
I
I
V
L
T
--
V
F
------
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
DFQ
T
P
---------
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.76
21%
-141
- C2 -
2X72
5
GNAT1_BOVIN (first)
A:
[42-313]
--------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
Q
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
IDYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
--
S
----
C
---
F
----
G
-----------
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
---------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.67
21%
-138
- C2 -
1LN6
1
OPSD_BOVIN
A:
[40-310]
---------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
-
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
-------
G
IDYYTPH
E
E
T
------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
A
Q
Q
-----------
Q
-----------------
E
-----
S
---
A
T
T
Q
K
A
E
K
E
V
T
R
MVI
I
M
V
I
A
-------
F
LICWLP
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
--
S
----
D
---
F
----
G
-----------
P
-
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
--
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
---
A
T
---------
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
------------------------------------------------------------------------------------------------------------------------------------------------