@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2T7_HUMAN: (2016-01-13 )
MPTLSFWVCSATPVSPGFFALILLVFVTSIASNVVKIILIHIDSRLHTPMYFLLSQLSLRDILYISTIVPKMLVDQVMSQRAISFAGCTAQHFLYLTLAGAEFFLLGLMSCDRYVAICNPLHYPDLMSRKICWLIVAAAWLGGSIDGFLLTPVTMQFPFCASREINHFFCEVPALLKLSCTDTSAYETAMYVCCIMMLLIPFSVISGSYTRILITVYRMSEAEGRRKAVATCSSHMVVVSLFYGAAMYTYVLPHSYHTPEQDKAVSAFYTILTPMLNPLIYSLRNKDVTGALQKVVGRCVSSGKVTTF
Atome Classification :
(20 SA)
----------------------.........10...---------------.....----20........30........40........50........60.......-.70........80......---..90..------......100.......110.......120-----........130.......140.......150.......160.......170......----.180---.-------.---.......-----190......--.200.......210......-.220--...-----------------..-----------.------...230.......240-------.......-----250--....---..-.-------.--260.-------......270...------....280.......290....------------...300......---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------MP
T
L
S
F
W
V
CSATPV---------------S
P
G
F
F
----
A
L
I
L
L
V
F
V
T
S
I
A
S
N
V
V
K
I
I
L
I
H
IDSRL
H
T
P
M
Y
F
L
L
S
Q
LS
L
R
D
I
L
Y
I
S
T
I
-
V
P
K
M
L
V
D
Q
V
M
S
Q
R
A
I
S
FAG---CTA
Q
H
F
------
L
Y
L
T
LA
G
A
E
F
F
L
L
G
L
MSCD
R
Y
V
A
I
CNPL------H
Y
P
D
L
M
S
R
K
I
C
W
L
I
V
A
A
A
W
LGGSID
G
F
L
LT
P
V
T
M
QFPFCASRE
I
N
H
F
F
CEV
P
A
L
L
K
L
----SC-----T-------D---T
S
A
Y
E
T
A
-----
M
Y
V
C
C
I
M
M
L
--
L
I
P
F
S
V
ISGS
Y
T
R
I
L
I
T
V
Y
R
-MS----EAE-----------------G
R
-----------
R
------
K
A
V
A
TCSS
H
M
V
V
V
S
L
F
-------YG
A
A
M
Y
T
-----
Y
V---LPHS---YH-T-------P--
E
Q
D
K
-------
A
V
S
A
F
Y
T
I
L
T
P
M
------
L
N
P
L
I
Y
S
LRNK
D
V
T
G
A
L
Q
K
V
V
------------
G
R
C
VSSGKVTTF---------
3
PsiBlast_PDB
93.60
21%
-142
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
---
C
L
F
I
A
C
------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
----
A
C
L
F
---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
----
Q
M
E
S
QPLP------------
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
-------------------
2
PsiBlast_PDB
93.53
21%
-144
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
---
C
L
F
I
A
C
------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
----
A
C
L
F
---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
----
Q
M
E
S
QPLP------------
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
-------------------
9
PsiBlast_PDB
93.20
22%
-134
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
A
I
S
T
G
F
---
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
----
A
C
LF---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
----
Q
M
E
S
QPLP------------
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
----
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
Q
Q
E
P
F
K
---------
4
PsiBlast_PDB
93.14
21%
-144
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
---
C
L
F
I
A
C
------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
----
A
C
L
F
---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
----
Q
M
E
S
QPLP------------
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
-------------------
1
PsiBlast_PDB
92.74
21%
-145
- C4 -
3PWH
1
?
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
---
C
L
F
I
A
C
------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
----
A
C
LF---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
----
Q
M
E
S
QPLP------------
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
-------------------
5
PsiBlast_PDB
92.53
21%
-142
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
---
C
L
F
I
A
C
------
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
----
A
C
L
F
---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
----
Q
M
E
S
QPLP------------
G
E
-----------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
-------------------
13
PsiBlast_PDB
92.47
20%
-149
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
---
C
L
F
I
A
C
------
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
----
A
C
L
F
---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
----
Q
M
E
-----------------
S
Q
PLPGERA
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
----------------
6
PsiBlast_PDB
91.53
22%
-130
- C4 -
2YDO
3
?
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
A
I
S
T
G
F
---
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
----
A
C
LF---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
----
Q
M
E
S------------------------------T
L
Q
---
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
Q
Q
E
P
F
K
---------
7
PsiBlast_PDB
91.14
22%
-130
- C4 -
2YDV
6
?
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
A
I
S
T
G
F
---
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
----
A
C
LF---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
----
Q
M
E
SQ-----------------------------S
T
L
Q
--
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
Q
Q
E
P
F
K
---------
8
PsiBlast_PDB
90.62
22%
-132
- C4 -
4UG2
3
?
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
A
I
S
T
G
F
---
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
----
A
C
LF---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
---------------------------------------A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
---------------
12
PsiBlast_PDB
90.55
20%
-149
- C4 -
3VG9
8
?
A:
[14-303]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
---
C
L
F
I
A
C
------
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
----
A
C
L
F
---
E
-------
D
---
V
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
----
Q
M
E
-----------------
S
Q
PLPGERA
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
---
C
P
D
C
---
S
H
-
A
-------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
------
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
---------------
18
PsiBlast_PDB
88.14
21%
-131
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[11-298]
---------------------------------------------------
E
A
G
M
S
----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
------
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
----------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-----
C
-------
D
FVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
--
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
-----
R
-
K
I
----
D
R
A
-----------------
S
K
-----------
R
------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
---
V
N
-
V
-------
F
--
N
R
D
L
-------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
------------
A
F
-------------------
16
PsiBlast_PDB
88.11
21%
-133
- C4 -
2YCW
7
ADRB1_MELGA
A:
[11-298]
---------------------------------------------------
E
A
G
M
S
----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
------
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
----------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-----
C
-------
D
FVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
--
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
-----
R
-
K
I
----
D
R
A
-----------------
S
K
-----------
R
------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
---
V
N
-
V
-------
F
--
N
R
D
L
-------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
------------
A
F
-------------------
19
PsiBlast_PDB
87.68
21%
-134
- C4 -
2YCY
6
ADRB1_MELGA
A:
[11-298]
---------------------------------------------------
E
A
G
M
S
----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
------
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
----------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-----
C
-------
D
FVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
--
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
-----
R
-------
D
R
A
-----------------
S
K
-----------
R
------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
---
V
N
-
V
-------
F
--
N
R
D
L
-------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
------------
A
F
-------------------
17
PsiBlast_PDB
86.52
21%
-123
- C4 -
2YCX
3
ADRB1_MELGA
A:
[11-294]
---------------------------------------------------
E
A
G
M
S
----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
------
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
----------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-----
C
-------
D
FVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
--
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
-----
R
-
K
I
----
D
R
A
-----------------
S
K
-----------
R
------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
-------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
---
V
N
-
V
-------
F
--
N
R
D
L
-------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
------------------------------------
44
HHSearch
84.82
17%
-143
- C4 -
2Z73
5
OPSD_TODPA
A:
[35-333]
----------------------------------------------------
Y
S
L
G
----
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
---
C
K
V
Y
G
F
------
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
------
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
---
G
W
G
A
Y
-
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
---------------------
R
---
D
S
T
T
R
S
N
-----
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
-
H
E
----
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------
N
------
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
-------
L
L
S
W
S
P
Y
-----
A
V
V
A
L
L
A
Q
F
GPL
E
W
-
V
-------
T
--
P
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
------
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
------------
P
W
V
L
T
C
C
Q
F
D
D
K
---------
15
PsiBlast_PDB
84.57
21%
-134
- C4 -
2VT4
8
ADRB1_MELGA
A:
[11-298]
---------------------------------------------------
E
A
G
M
S
----
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
------
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
------
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
H
W
----------
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-----
C
-------
D
FVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
--
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
-----
R
------------------------------------------------------
E
H
K
A
L
K
T
L
G
-------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
---
V
N
-
V
-------
F
--
N
R
D
L
-------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
NSA
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
------------
A
--------------------
41
HHSearch
83.74
17%
-137
- C4 -
2KS9
1
NK1R_HUMAN
A:
[35-326]
------------------------------------------------------
W
A
----
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
---
C
K
F
H
N
F
------
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
------
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
---
Y
Y
S
T
T
--
E
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-------------------
N
---
K
I
Y
E
K
V
Y
-----
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
-
S
E
----
I
P
G
DSSDRYH
E
---------
Q
V
-----------
S
------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
-------
A
I
C
W
L
P
F
-----
H
I
F
F
L
L
P
Y
I
NPD
L
Y
L
K
-------
K
FI
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
------
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
------------
R
C
C
P
F
I
S
A
G
D
Y
E
---------
50
Fugue
79.48
16%
-119
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRS
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
---------------
F
S
M
L
A
----
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
---
C
N
L
E
G
F
------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---
A
P
P
L
V
G
W
----
S
R
-------
Y
I
P
E
G
M
Q
C
----
S
C
-----
G
I
DYYTPH
E
---
E
T
N
N
E
S
F
-----
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
A
----
A
S
A
-----------------
T
T
-----------
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
-----
Y
A
---
G
V
A
F
---
Y
I
-
F
-------
T
--
H
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------------
C
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A
49
Fugue
78.75
18%
-122
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
---
C
N
L
E
G
F
------
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
---------------------
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
----
S
C
G
I
DYY
T
-------
P
---
H
E
E
T
N
N
E
-----
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
A
AQQQ
E
S
A
-----------------
T
T
-----------
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
-----
Y
A
---
G
V
A
F
---
Y
I
-
F
T
H
QGSDF
G
--
P
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
APA------