@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2W5_HUMAN: (2016-01-13 )
MGKDNASYLQAFILVGSSDRPGLEKILFAVILIFCILTLVGNTAIILLLVMDVRLHTPMYFFLGNLSFLDLCFTASIAPQLLWNLGGPEKTITYHGCVAQLYIYMMLGSTECVLLVVMSHDRYVAVCRSLHYMAVMRPHLCLQLVTVAWCCGFLNSFIMCPQTMQLSRCGRRRVDHFLCEMPALIAMSCEETMLVEAIHLCPGGGSPPGAALPHPHLLWRDCSRGAEDEVSSRAKESLPHLLFSPHSGLSLLRNHHLRVPEAGQQLLPRSGEVPDSLLHHRHSQHQPPHLHFEEQGCEGDHEETSGVGERGWGASTRGTL
Atome Classification :
(20 SA)
.........10........-------------20...----------------.....30........40.........50........60........70......-..-------80......--.---.90........100--.......110.......120---.......130.......140.......150.......-------160-.........170------.---........---------180--........190......--.200..--.-....210-----.......220------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.......---.230.......240.......250....----...260-.--.--.-..-...270.......280-.........290.......300.......310.......320---------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGK
D
N
A
S
Y
L
Q
A
F
I
L
VGSSD-------------R
P
G
L
E
----------------
K
I
L
F
A
V
I
L
I
F
C
I
L
T
LV-GNT
A
I
I
L
L
L
V
MD
V
R
LHT
P
M
Y
F
F
LGN
L
S
F
L
D
L
C
F
T
A
S
I
-
A
P
-------
Q
L
L
W
NLGG--P---E
K
T
I
T
Y
H
G
C
V
A
Q
L
Y
--
I
Y
M
M
LGST
E
C
V
L
L
V
V
MSH
D
R
---
Y
V
A
V
C
R
S
L
H
Y
M
A
V
M
R
P
H
L
C
L
Q
L
V
T
V
A
W
C
C
G
F
L
N
S
F
IM-------C---PQ
T
M
Q
L
S
R
C
G
--------
R
---
R
R
V
D
H
F
L
C
---------E
M
---
P
A
L
I
A
MS
C
E
E
T
M
L
V
E
A
I--HLCPGG--G-SPPGAAL-----PHP
H
L
L
W
R
--------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------CSRG
A
E
D
---
E
V
S
S
R
A
K
E
SLPH
L
L
FSPH
S
G
L
S
L
L
R
NHH----LRVPE--A--
G
--
Q
-
Q
L-LPRSGEV
P
D
S
L
L
H
H
---RHSQHQPPH
L
H
F
E
EQGCEGDHEETSGVGERGWGASTRGTL-----------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
89.33
16%
-89
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
-------------
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
-------
T
T
L
Y
T
S
L
H
--
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
---
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
LVGW
S
R
Y
I
---
P
E
G
M
Q
C
S
-
C
G
I
DYYTPHE
E
---
T
N
N
E
S
F
V
I
---------
Y
M
---
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
--
Q
L
V
F
T
V
--
K
-
E
A
A
A
S
A
T
-----
T
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
---
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
----
T
H
-----
Q
--
G
--
S
-
D
F
-
G
P
I
F
M
T
I
P
-
A
F
F
A
K
---
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A-----------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
84.33
14%
-91
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
-
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
-------
L
Y
T
L
Y
T
V
I
--
G
---
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
--
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
---
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
-------
I
---
L
F
W
Q
F
I
V
--
G
--------
V
---
R
T
V
E
D
G
E
C
---------
Y
I
---
Q
F
F
---------
S
N
A
A
V
T
F
G
T
A
I
A
A
--
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
--------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYP--
P
P
S
R
E
K
K
---
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
----
C
A
-----
P
--------
C
-
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
---
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
81.79
14%
-95
- C2 -
2Z73
5
OPSD_TODPA
A:
[32-330]
----------------------------------
A
V
Y
----------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
-
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
-------
L
M
T
I
S
C
F
L
--
K
---
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
--
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
---
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
-------
I
---
F
G
W
G
A
Y
T
L
---------------
E
G
V
L
C
N
C
---------
S
F
---
D
Y
I
S
-----
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
--
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
--------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------
G
A
N
A
E
M
R
---
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
----
G
P
-----------
L
-
E
W
-
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
---
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
-----------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
81.68
13%
-82
- C2 -
1U19
14
OPSD_BOVIN
A:
[40-322]
------------------------------------
F
----------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
-------
T
T
L
Y
T
S
L
H
--
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
---
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
-------
L
---
V
G
W
S
R
Y
I
---------------
P
E
G
M
Q
C
S
C
---------
G
I
---
D
Y
Y
T
P
---
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--------
A
AQQQESA
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
---
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
---------
Q
--
G
-
S
D
-
F
G
P
I
F
M
T
I
P
A
F
F
A
K
---
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
-----------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
81.15
14%
-74
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
VRSPFEAPQYYLA
E
P
W
Q
F
----------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
-------
T
T
L
Y
T
S
L
H
--
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
---
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
---
P
E
G
M
Q
C
-
S
C
G
--------
I
DYY
T
P
H
E
E
T
N
N
---------
E
S
---
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
--
F
F
C
Y
G
Q
L
V
F
-
T
V
K
E
A
A
A
-----
Q
Q
Q
E
S
A
T
T
--------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
---
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
GSDF
G
P
I
F
M
--
T
--
I
--
P
-
A
F
-
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
--
T
S
Q
V
A
P
A
-----------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
79.68
15%
-108
- C1 -
3Q9L
3
MIND_ECOLI
A:
[2-258]
----------
A
R
I
I
V
V
T
S
G
-------------
K
G
G
V
G
----------------
K
T
T
S
S
A
A
I
A
T
G
L
A
Q
K
G
-
K
K
T
V
V
I
D
F
A
I
--------------
G
L
R
N
L
D
L
I
M
---------------------
G
--
C
---
E
R
R
V
V
Y
D
------
F
--
V
N
V
I
Q
G
D
A
T
L
N
Q
A
L
I
K
D
K
R
T
EN
L
Y
I
L
P
A
S
Q
T
R
D
K
D
A
L
T
R
E
G
V
A
K
V
L
D
D
L
K
A
M
D
F
--
E
F
I
V
-------
C
---
D
S
P
A
G
I
---------------------------------
E
T
---
G
A
L
M
A
L
Y
F
A
D
E
A
I
I
T
T
-------------
N
P
E
V
S
S
V
-----
R
D
S
D
R
I
L
G
--------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
S
K
S
R
R
---
A
E
N
G
E
-
E
P
I
K
E
H
L
L
L
T
R
Y
N
P
G
R
V
S
R
G
D
M
----
L
S
M
E
D
--
V
--
L
--
E
-
I
L
R
I
K
L
V
G
V
I
P
E
D
Q
S
V
L
---
R
A
S
N
Q
G
E
P
V
I
L
D
I
N
A
D
A
G
K
A
Y
A
D
T
V
E
R
L
-
L
G
E
E
R
P
F
R
F
I
E
E----------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
77.74
15%
-93
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------
S
F
K
C
A
L
T
K
T
G
F
------------------
Q
F
----------------
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
-
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
-------
L
I
F
Y
Y
F
N
K
--
T
---
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
--
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
---
Y
S
G
V
V
Y
P
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
-------
F
---
Y
-----
S
G
T
G
--------
V
---
R
K
N
K
T
I
T
C
YDTTSDEY
L
R
S
---
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
--
V
L
I
L
G
C
--
Y
-
G
L
I
V
R
A
L
-----
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
G
D
P
D
NGV
N
P
G
T
D
F
K
D
I
V
C
P
L
C
G
V
G
K
D
Q
F
E
E
V
E
E
P
L
----
R
R
K
S
I
--
Y
--
L
--
V
-
I
I
-
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
---
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-------------------------------------------------------------------------------------------------------------------------
42
Fugue
76.49
12%
-72
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
----------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-------
F
G
A
A
H
I
L
M
--
K
---
M
W
T
F
G
N
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
--------
N
---
C
Y
A
E
E
T
C
C
---------
D
F
FTN
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
--
I
M
V
F
V
Y
--
S
-
R
V
F
Q
E
A
K
-----
R
Q
L
N
--
I
F
--------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
G
---
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
----
A
A
K
S
E
--
L
--
D
--
K
-
A
I
-
G
R
N
T
N
G
V
I
T
K
D
E
A
E
---
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
22
HHSearch
74.81
14%
-88
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-496]
-----------------------------------
N
K
----------------
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
-
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
-------
F
W
A
V
D
A
V
---
A
---
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
--
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
---
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
-------
F
---
I
F
A
N
V
S
E
----------------
A
D
D
R
Y
I
C
---------
D
R
---
F
Y
P
N
-----
D
L
-
W
V
V
V
F
Q
F
Q
H
I
M
V
G
--
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
--------
G
SN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGS
K
G
H
Q
K
R
K
---
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
----
I
L
L
E
I
I
K
Q
G
C
E
--
F
-
E
N
-
T
V
H
K
W
I
S
I
T
E
A
L
A
F
---
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
72.77
11%
-87
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-320]
-----------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
-
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
-------
V
N
F
T
Y
A
V
H
--
N
---
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
--
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
---
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
-------
G
---
Y
Y
S
T
T
E
T
----------------
M
P
S
R
V
V
C
---------
M
I
---
E
W
P
E
H
---
P
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
--
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
--------
E
IPGDSSDRYH
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
S
A
K
R
K
---
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
----
N
P
-----
D
--
L
--
Y
L
K
K
-
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
---
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
-----------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
69.32
13%
-92
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
----------------------------------
N
S
I
----------------
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
-
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
-------
N
L
L
L
S
G
A
---
T
---
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
--
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
---
Y
I
T
M
L
K
--------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
-------
I
---
M
G
W
N
C
I
------------------
S
A
L
S
S
C
---------
S
T
---
V
L
P
L
--------
Y
H
K
H
Y
I
-
L
F
C
T
T
V
--
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
--------
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
--
R
S
S
E
N
V
A
---
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
----
C
K
--------
V
--
K
-
T
C
-
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
---
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
68.40
16%
-79
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-319]
-----------------------------------
N
K
----------------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
-
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
-------
I
W
A
A
S
K
-
V
--
N
---
G
W
I
F
G
T
F
L
C
K
V
V
S
L
--
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
---
Y
L
A
I
V
H
A
T
R
T
L
T
Q
-
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
-------
F
---
L
F
R
Q
A
Y
H
---------------
P
N
N
S
S
P
V
C
---------
Y
E
---
V
L
G
N
----
D
T
A
K
W
R
M
V
L
RI
L
P
H
T
F
G
--
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
--------
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
K
H
R
---
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
----
M
R
T
Q
V
--
I
QE
S
C
E
R
-
R
N
-
N
I
G
R
A
L
D
A
T
E
I
L
G
F
---
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
66.43
19%
-158
- C2 -
2RH1
5
ADRB2_HUMAN (first)
A:
[41-176]
-----------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-------
F
G
A
A
H
I
L
M
--
K
---
M
W
T
F
G
N
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
---
Q
M
H
W
Y
R
A
T
H
Q
--------
E
---
A
I
N
C
Y
A
E
E
---------
T
C
---
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--
F
Y
V
P
L
V
--
I
-
M
V
F
V
Y
S
R
-----
V
F
Q
E
A
K
R
Q
--------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
---
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
----
P
S
L
N
A
--
A
--
K
--
S
-
E
L
-
D
K
A
I
G
R
N
T
N
G
V
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
-----------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
65.45
17%
-171
- C2 -
3EML
8
ENLYS_BPT4
A:
[21-159]
------------------------------------
S
----------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
-
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-------
F
A
I
T
I
S
T
-------
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
---
L
G
W
N
N
C
G
Q
S
Q
--------
G
---
C
G
E
G
Q
V
A
C
---------
L
F
---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
--
V
L
V
P
L
L
--
L
-
M
L
G
V
Y
L
R
-----
I
F
L
A
A
R
R
Q
--------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
---
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
----
P
S
L
N
A
--
A
--
K
--
S
-
E
L
-
D
K
A
I
G
R
N
T
N
G
V
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
-----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.40
21%
-167
- C2 -
3SN6
1
R:
[187-316]
----------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
------------
F
G
A
--
A
HIL
T
K
T
W
T
F
G
N
F
W
C
E
F
W
TS
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
---
Q
M
H
W
Y
R
Q
E
A
I
--------
N
---
C
Y
A
E
E
T
C
C
---------
D
F
---
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
--
P
L
V
I
M
V
--
F
-
V
Y
S
R
V
F
Q
-----
E
A
K
R
Q
L
Q
K
--------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
S
E
G
R
C
---
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
----
I
V
H
V
I
--
Q
--
D
--
N
-
L
I
-
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
---
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
---------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.68
20%
-162
- C2 -
3D4S
6
ENLYS_BPT4
A:
[46-175]
----------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
------------
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
---
Q
M
H
W
Y
R
A
T
H
Q
--------
E
---
A
I
N
C
Y
A
E
E
---------
T
C
---
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--
F
Y
V
P
L
V
--
I
-
M
V
F
V
Y
S
R
-----
V
F
Q
E
A
K
R
Q
--------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
---
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
----
P
S
L
N
A
--
A
--
K
--
S
-
E
L
-
D
K
A
I
G
R
N
T
N
G
V
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
-----------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.50
26%
-159
- C2 -
4DKL
8
ENLYS_BPT4 (first)
A:
[20-131]
-------------------------------------------------------
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
-
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
-------
Q
S
V
N
Y
L
M
G
TW
P
---
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
--
Y
N
M
F
---
T
S
I
F
T
L
C
T
M
S
V
D
R
---
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
-------
M
---
F
M
A
T
T
K
Y
R
Q
G
--------
S
---
I
D
C
T
L
T
F
S
---------
H
P
---
T
W
Y
W
E
N
L
L
K
I
C
V
F
I
F
A
F
--
I
M
P
V
L
I
--
I
-
T
V
C
Y
G
L
M
-----
I
L
R
L
K
S
V
R
--------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
---
D
E
G
L
R
L
K
I
Y
K
N
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
--
K
--
S
--
E
-
L
D
-
K
A
I
G
R
N
T
N
G
V
I
T
K
D
---
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
-----------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.47
20%
-156
- C2 -
3NY9
4
ADRB2_HUMAN (first)
A:
[46-175]
----------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
------------
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
---
Q
M
H
W
Y
R
A
T
H
Q
--------
E
---
A
I
N
C
Y
A
E
E
---------
T
C
---
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--
F
Y
V
P
L
V
--
I
-
M
V
F
V
Y
S
R
-----
V
F
Q
E
A
K
R
Q
--------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
---
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
----
P
S
L
N
A
--
A
--
K
--
S
-
E
L
-
D
K
A
I
G
R
N
T
N
G
V
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
-----------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.20
20%
-158
- C2 -
3NYA
3
ADRB2_HUMAN (first)
A:
[46-175]
----------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
------------
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
---
Q
M
H
W
Y
R
A
T
H
Q
--------
E
---
A
I
N
C
Y
A
E
E
---------
T
C
---
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
--
F
Y
V
P
L
V
--
I
-
M
V
F
V
Y
S
R
-----
V
F
Q
E
A
K
R
Q
--------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
---
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
----
P
S
L
N
A
--
A
--
K
--
S
-
E
L
-
D
K
A
I
G
R
N
T
N
G
V
I
T
K
---
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
-----------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
63.07
20%
-156
- C2 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-144]
------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
-
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
-------
M
N
I
L
Y
L
L
M
--
S
---
K
W
S
L
G
R
P
L
C
L
F
W
L
S
--
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
---
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
-------
L
---
G
W
N
H
R
R
E
D
K
C
--------
E
---
T
D
F
Y
D
V
T
W
---------
F
K
---
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
--
F
Y
A
K
I
Y
--
K
-
A
V
R
Q
H
C
N
-----
I
F
E
M
L
R
I
D
--------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
----
D
K
A
I
G
--
R
--
N
--
T
-
N
G
-
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
---
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------------------------------------------------------------------------------------------------------------------------------------