@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2W6_HUMAN: (2016-01-13 )
MGFYHVGQAAFELLTSSFILVGFSDRPHLELIVFVVVLIFYLLTLLGNMTIVLLSALDSRLHTPMYFFLANLSFLDMCFTTGSIPQMLYNLWGPDKTISYVGCAIQLYFVLALGGVECVLLAVMAYDRYAAVCKPLHYTIIMHPRLCGQLASVAWLSGFGNSLIMAPQTLMLPRCGHRRVDHFLCEMPALIGMACVDTMMLEALAFALAIFIILAPLILILISYGYVGGTVLRIKSAAGRKKAFNTCSSHLIVVSLFYGTIIYMYLQPANTYSQDQGKFLTLFYTIVTPSVNPLIYTLRNKDVKEAMKKVLGKGSAEI
Atome Classification :
(20 SA)
------.........10........20...-.....30........40......---..50.......-.60........70........80........90-----.........100.......110.......120.......130.......140.......150.......160.......170.......180.......190...-------.-------...200.......210.--......220.......230.....----.-----------.240------........250....--------...260.......270.---..---...-------.280--.......290.......300.......310......--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MG
F
Y
H
V
G
Q
A
A
F
E
L
L
T
S
S
F
I
L
V
GFS-DRP
H
L
E
L
I
V
F
V
V
V
L
I
F
Y
L
L
T
L
LG---N
M
T
I
V
L
L
S
A
L
D
-
S
R
LH
T
P
M
Y
F
F
L
A
N
L
S
F
L
D
M
CFTTG
S
I
P
Q
M
L
Y
N
------LWGPDK
T
I
S
Y
V
G
C
A
I
Q
L
Y
F
V
L
A
LG
G
V
E
C
V
L
L
A
V
M
A
Y
D
R
Y
A
A
V
CK
P
L
H
Y
T
I
I
MH
P
R
L
C
G
Q
L
A
S
V
A
W
L
S
GFGN
S
L
I
MAPQ
T
L
MLPRCG
H
R
R
V
D
H
F
L
C
E
M
P
A
L
I
G
M
A
C
-------
V
-------
D
T
M
M
L
E
A
L
A
F
A
L
A
I
F
I
I
--
L
A
P
L
I
L
I
L
I
SYGYVG
G
T
V
L
R
I
KSA----A-----------GR
K
-------
K
A
F
N
TCSSH
L
I
V
V
S
L
--------
F
Y
G
T
I
I
Y
M
Y
LQPANTYS---QD---QG
K
-------
F
L
T
L
--
F
Y
T
I
VTPSVN
P
L
I
Y
TLRN
K
D
V
K
E
A
M
K
K
V
LGKGSAEI--------------------
44
Fugue
88.78
21%
-129
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
---------
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
QQES
A
-----------
T
T
Q
-------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
--------
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
---
Q
G
S
DFGPIFM
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA
43
Fugue
86.49
20%
-133
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
-
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
---------
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
------
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
----
A
-----------
T
T
Q
-------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
--------
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
---
T
H
---
Q
G
S
DFGPIFM
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A------
5
PsiBlast_PDB
80.00
22%
-133
- C4 -
3DQB
6
GNAT1_BOVIN (first)
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
3
PsiBlast_PDB
78.69
22%
-132
- C4 -
3C9L
13
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
--------------------
4
PsiBlast_PDB
78.23
22%
-135
- C4 -
1F88
7
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
DYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
--SATTQ--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
--------------------
9
PsiBlast_PDB
77.77
22%
-130
- C4 -
4PXF
8
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
8
PsiBlast_PDB
77.74
22%
-133
- C4 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
6
PsiBlast_PDB
77.59
22%
-132
- C4 -
3PQR
10
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
14
PsiBlast_PDB
77.25
22%
-139
- C4 -
2I35
4
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
DYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
--------------------
7
PsiBlast_PDB
76.84
22%
-131
- C4 -
3PXO
5
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
10
PsiBlast_PDB
76.65
22%
-124
- C4 -
3OAX
17
OPSD_BOVIN
A:
[48-326]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
2
PsiBlast_PDB
76.46
22%
-134
- C4 -
3CAP
5
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QES
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
13
PsiBlast_PDB
76.31
22%
-130
- C4 -
2I36
2
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
D
YY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QESATTQ
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
ICWLP
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
34
HHSearch
76.23
15%
-147
* C4 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
-
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
------
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
--
T
E
--
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
----
G
DSSDRYH
E
Q
V
S
A
K
R
-------
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
--------
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
LYL
K
K
FI
Q
Q
V
Y
-------
L
A
I
M
--
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
--------------------
12
PsiBlast_PDB
76.03
22%
-127
- C4 -
1HZX
14
OPSD_BOVIN
A:
[48-326]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
DYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
--ATT
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
17
PsiBlast_PDB
76.01
22%
-123
- C4 -
2PED
14
OPSD_BOVIN
A:
[48-326]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
SCGIDYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
20
PsiBlast_PDB
75.58
22%
-126
- C4 -
1U19
14
OPSD_BOVIN
A:
[48-326]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
DYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
19
PsiBlast_PDB
75.53
22%
-129
- C4 -
1L9H
14
OPSD_BOVIN
A:
[48-326]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
HGYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
DYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
--ATT
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
18
PsiBlast_PDB
75.41
22%
-126
- C4 -
2G87
14
OPSD_BOVIN
A:
[48-326]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
DYY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------
16
PsiBlast_PDB
75.19
22%
-129
- C4 -
2HPY
14
OPSD_BOVIN
A:
[48-326]
-----------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-----
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
---
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
D
YY
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
A
----
A
-----------
A
Q
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---
P
------
I
-------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
--------------------