@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2Z1_HUMAN: (2016-01-13 )
MGDVNQSVASDFILVGLFSHSGSRQLLFSLVAVMFVIGLLGNTVLLFLIRVDSRLHTPMYFLLSQLSLFDIGCPMVTIPKMASDFLRGEGATSYGGGAAQIFFLTLMGVAEGVLLVLMSYDRYVAVCQPLQYPVLMRRQVCLLMMGSSWVVGVLNASIQTSITLHFPYCASRIVDHFFCEVPALLKLSCADTCAYEMALSTSGVLILMLPLSLIATSYGHVLQAVLSMRSEEARHKAVTTCSSHITVVGLFYGAAVFMYMVPCAYHSPQQDNVVSLFYSLVTPTLNPLIYSLRNPEVWMALVKVLSRAGLRQMC
Atome Classification :
(20 SA)
------------.........10-------------....-------------....20.----.......30........40---.-----.......50........60........70--.-----......-..80........90.........100--.......----110.......----120.......130.......140.......150.......160.......-----170.......180....----....--190-----.-------------........200......------.210.---......220------------..----.-----------------------------------------------....230---.--------------------...-----.....240.......250------........260..----.---.------.-..---270-------....-------...------280......------------.290.......300..--.------------------....310..--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MGD
V
N
Q
S
V
A
S
D
-------------
F
I
L
V
-------------
G
L
FSHSG----
S
R
Q
L
L
F
S
L
V
A
V
M
F
V
I
G
L
L
G
---
N
-----
T
V
L
L
F
L
I
RVDSRL
H
T
P
M
Y
F
L
L
S
Q
L
S
LFD---I-----GCPMV
T
-
I
P
K
M
A
S
D
F
LRGEG-ATSYGGG
A
A
Q
I
F
--
F
L
T
L
M
G
V
----
A
E
G
V
L
L
V
L
MS----YD
R
Y
V
A
V
CQPLQ
Y
P
V
L
M
R
R
Q
V
C
L
L
MMGS
S
W
V
V
G
V
LNAS
I
Q
T
S
I
T
L
H
F
P
Y
C
-----
A
S
R
I
V
D
H
F
F
CE-
V
P
A
L
L
----
K
LSC--A-------
D
-------------
T
C
A
Y
E
M
ALSTS
G
V
L
I
L
M
------
L
P
L
S
L
---
I
A
T
S
Y
G
H
V
L
------------
Q
A
----
V
-----------------------------------------------
L
S
M
R
S
-----
E
--------------------
E
A
R
-----
H
K
A
V
T
TCSS
H
I
T
V
V
G
L
F
-------
Y
G
A
A
V
F
M
Y
MVPCA----Y---H------S-PQ---QD
N
-------
V
V
S
L
-------
F
Y
S
------
L
V
T
P
T
L
N
P
L
------------
I
Y
SLR
N
P
E
V
W
M
A
L
V
K
V
--
L
------------------
S
RAGLRQMC--
39
Fugue
94.32
20%
-124
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------
M
N
G
T
E
G
P
N
-------------
F
Y
V
P
FSNKTGVVRSPFE
A
P
Q
Y
Y
L
A
----
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-----
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
---
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
----
I
A
L
W
S
L
V
V
L
A
----
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------------------
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
----
Q
C
S
C
--
G
I
DYYTPH
E
-------------
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
------
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
V
------------
F
T
----
V
-----------------------------------------------
K
E
A
A
A
-----
S
--------------------
A
T
T
-----
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
----
Y
---
I
------
F
-
T
H
---
Q
G
S
DFGPIFM
T
I
P
A
-------
F
F
A
------
K
T
S
A
V
Y
N
P
V
------------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
C
CGKNPSTTV--------
S
K
T
E
T
S
Q
V
A
P
A
3
PsiBlast_PDB
90.16
21%
-125
- C4 -
3VG9
8
?
A:
[18-309]
-----------------------------------------------------------------------------
V
L
A
I
L
G
---
N
-----
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
---
I
-----
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
----
S
I
F
S
L
L
A
I
-
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-----
G
Q
-------
S
Q
-
G
C
G
E
G
----
Q
V
A
C
L
F
E
-------
D
-------------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
------
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
----
L
-----------------------------------------------
P
G
E
R
A
-----
R
--------------------
S
T
L
-----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
------
A
-
P
L
---
W
L
M
-------
Y
L
A
I
-------
V
L
S
------
H
T
N
S
V
V
N
P
F
------------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
------------------
R
S
H
V
L
R
-----
4
PsiBlast_PDB
89.43
21%
-125
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[18-308]
-----------------------------------------------------------------------------
V
L
A
I
L
G
---
N
-----
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
---
I
-----
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
----
S
I
F
S
L
L
A
I
-
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-----
G
Q
-------
S
Q
-
G
C
G
E
G
----
Q
V
A
C
L
F
E
-------
D
-------------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
------
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
----
L
-----------------------------------------------
P
G
E
R
A
-----
R
--------------------
S
T
L
-----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
------
A
-
P
L
---
W
L
M
-------
Y
L
A
I
-------
V
L
S
------
H
T
N
S
V
V
N
P
F
------------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
------------------
R
S
H
V
L
------
44
Fugue
88.28
18%
-121
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------------------
S
F
K
C
-------------
A
L
T
K
T
G
F
----
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
---
N
-----
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
---
F
-----
L
Y
-
V
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
--
I
F
H
V
N
L
Y
----
G
S
I
L
F
L
T
C
I
S
----
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
----
I
L
F
Y
S
G
T
-----
G
V
R
K
N
K
T
I
T
C
Y
-
D
T
T
--------
S
D
--
E
-------
Y
-------------
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
------
V
P
L
V
L
---
I
L
G
C
Y
G
L
I
V
------------
R
A
----
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
E
-----
E
--------------------
P
L
R
-----
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
-------
Y
I
P
F
H
V
M
K
T
M
N
L
R
----
A
---
R
------
L
-
D
F
---
Q
T
P
-------
A
M
C
A
-------
F
N
D
------
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
-------
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
--
F
------------------
R
R
R
--------
18
PsiBlast_PDB
87.64
22%
-131
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[18-305]
-----------------------------------------------------------------------------
V
L
A
I
L
G
---
N
-----
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
---
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
----
S
I
F
S
L
L
A
I
-
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-----
G
Q
P
---------
G
C
G
E
G
----
Q
V
A
C
L
F
E
-------
D
-------------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
------
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
------------
A
A
A
R
R
Q
L
-----------------------------------------------
K
Q
M
E
S
QPLPG
E
--------------------
R
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
------
A
-
P
L
---
W
L
M
-------
Y
L
A
I
-------
V
L
A
------
H
T
N
S
V
V
N
P
F
------------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
------------------
R
S
---------
17
PsiBlast_PDB
87.64
22%
-131
- C4 -
3REY
1
AA2AR_HUMAN
A:
[18-305]
-----------------------------------------------------------------------------
V
L
A
I
L
G
---
N
-----
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
---
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
----
S
I
F
S
L
L
A
I
-
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-----
G
Q
P
---------
G
C
G
E
G
----
Q
V
A
C
L
F
E
-------
D
-------------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
------
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
------------
A
A
A
R
R
Q
L
-----------------------------------------------
K
Q
M
E
S
QPLPG
E
--------------------
R
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
------
A
-
P
L
---
W
L
M
-------
Y
L
A
I
-------
V
L
A
------
H
T
N
S
V
V
N
P
F
------------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
------------------
R
S
---------
16
PsiBlast_PDB
87.50
22%
-129
- C4 -
3PWH
1
?
A:
[18-305]
-----------------------------------------------------------------------------
V
L
A
I
L
G
---
N
-----
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
---
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
----
S
I
F
S
L
L
A
I
-
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-----
G
Q
P
---------
G
C
G
E
G
----
Q
V
A
C
LF
E
-------
D
-------------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
------
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
------------
A
A
A
R
R
Q
L
-----------------------------------------------
K
Q
M
E
S
QPLPG
E
--------------------
R
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
------
A
-
P
L
---
W
L
M
-------
Y
L
A
I
-------
V
L
A
------
H
T
N
S
V
V
N
P
F
------------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
------------------
R
S
---------
20
PsiBlast_PDB
87.34
22%
-131
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[18-305]
-----------------------------------------------------------------------------
V
L
A
I
L
G
---
N
-----
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
---
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
----
S
I
F
S
L
L
A
I
-
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-----
G
Q
P
---------
G
C
G
E
G
----
Q
V
A
C
L
F
E
-------
D
-------------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
------
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
------------
A
A
A
R
R
Q
L
-----------------------------------------------
K
Q
M
E
S
QPLPG
E
--------------------
R
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
------
A
-
P
L
---
W
L
M
-------
Y
L
A
I
-------
V
L
A
------
H
T
N
S
V
V
N
P
F
------------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
------------------
R
S
---------
19
PsiBlast_PDB
87.18
22%
-131
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[18-305]
-----------------------------------------------------------------------------
V
L
A
I
L
G
---
N
-----
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
---
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
----
S
I
F
S
L
L
A
I
-
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-----
G
Q
P
---------
G
C
G
E
G
----
Q
V
A
C
L
F
E
-------
D
-------------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
------
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
------------
A
A
A
R
R
Q
L
-----------------------------------------------
K
Q
M
E
S
QPLPG
E
--------------------
R
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
---
H
------
A
-
P
L
---
W
L
M
-------
Y
L
A
I
-------
V
L
A
------
H
T
N
S
V
V
N
P
F
------------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
------------------
R
S
---------
10
PsiBlast_PDB
85.77
20%
-125
- C4 -
2X72
7
GNAT1_BOVIN (first)
A:
[43-322]
-----------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-----
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
---
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
Q
G
F
--
F
A
T
L
G
G
E
----
I
A
L
W
S
L
V
V
L
A
----
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
--------------
C
-----
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
----
Q
C
S
C
--
G
I------
D
-------------
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
V
------------
F
T
----
V
-----------------------------------------------
K
E
A
A
A
-----
Q
--------------------
Q
Q
E
-----
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
-------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
------
F
-
T
H
---
Q
G
S
C
F
G
P
I
F
M
T
I
P
A
-------
F
F
A
------
K
T
S
A
V
Y
N
P
V
------------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
------------------
C
C
G
K
N
------
40
Fugue
84.77
20%
-104
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
-------------
F
E
A
---------------
P
Q
Y
Y
L
A
----
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-----
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
---
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
----
I
A
L
W
S
L
V
V
L
A
----
I
E
R
Y
V
V
V
C
K
P
M
----------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-----
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
----
Q
C
S
C
--
G
I
DYYTPH
E
-------------
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
------
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
V
------------
F
T
----
V
KEAAAQQQESA------------------------------------
T
T
Q
K
A
-----
E
--------------------
K
E
V
-----
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-------
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
----
S
---
D
------
F
-
G
P
---
I
F
M
-------
T
I
P
A
-------
F
F
A
------
K
T
S
A
V
Y
N
P
V
------------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--
30
HHSearch
82.54
17%
-125
* C4 *
2KS9
1
NK1R_HUMAN
A:
[36-325]
---------------------------------------------------------------------
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
-----
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
---
A
-----
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
--
F
P
I
A
A
V
F
----
A
S
I
Y
S
M
T
A
V
A
----
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
--
Y
S
-
T
T
-------
E
T
M
P
S
R
V
V
C
M
-
I
E
W
P
E
----
H
-----
P
-------
N
-------------
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
------
L
P
L
L
V
---
I
G
Y
A
Y
T
V
V
G
------------
I
T
----
L
-----------------------------------------------
W
A
S
E
I
-----
P
GDSSDRYH
E
Q
V
---------
S
A
K
-----
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
-------
W
L
P
F
H
I
F
F
L
L
P
Y
I
----
N
---
P
DL----
Y
L
K
K
FI
Q
Q
V
Y
-------
L
A
I
M
-------
W
L
A
------
M
S
S
T
M
Y
N
P
I
------------
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
--
F
------------------
R
C
C
P
F
I
S
A
G
--
33
HHSearch
82.38
16%
-133
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-334]
-----------------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
-----
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
---
F
-----
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
--
I
G
G
I
F
G
F
----
M
S
I
M
T
M
A
M
I
S
----
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
--
A
Y
-----
T
-
L
E
G
V
L
C
N
C
S
-
F
D
Y
I
S
------------------
R
-------------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
------
G
P
I
L
I
---
I
F
F
C
Y
F
N
I
V
------------
M
S
----
V
-----------------------------------------------
S
N
H
E
K
-----
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
-----
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
-------
W
S
P
Y
A
V
V
A
L
L
A
Q
F
----
G
PLE
W
------
V
-
T
P
---
Y
A
A
-------
Q
L
P
V
-------
M
F
A
------
K
A
S
A
I
H
N
P
M
------------
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
--
F
------------------
P
W
V
L
T
C
C
Q
F
--
1
PsiBlast_PDB
81.72
20%
-120
- C4 -
4A4M
5
OPSD_BOVIN
A:
[43-322]
-----------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-----
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
---
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
-
G
C
N
L
E
G
-----
F
--
F
A
T
L
G
G
E
----
I
A
L
W
S
L
V
V
L
A
----
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
--------------
C
-----
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
----
Q
C
S
C
--
G
I
------
D
-------------
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
V
------------
F
T
----
V
-----------------------------------------------
K
E
A
A
A
-----
Q
--------------------
Q
Q
E
-----
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
-------
Y
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
------
F
-
T
H
---
Q
G
S
C
F
G
P
I
F
M
T
I
P
A
-------
F
F
A
------
K
T
S
A
V
Y
N
P
V
------------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
------------------
C
C
G
K
N
------
12
PsiBlast_PDB
79.66
20%
-139
- C4 -
4LDL
3
ADRB2_HUMAN
A:
[197-463]
--------------------------------------------------------------------------------
V
F
G
---
N
-----
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
---
L
-----
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-----
T
K
T
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
----
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
-
E
----------
T
C
--
C
-------
D
-------------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
------
V
P
L
V
I
---
M
V
F
V
Y
S
R
V
F
------------
Q
E
----
A
-----------------------------------------------
K
R
Q
L
Q
----------------------------
K
FA
L
K
E
H
K
A
L
K
T
L
G
---
I
I
M
G
T
F
-------
T
L
C
W
L
P
F
F
I
V
N
I
V
----
H
------------
V
I
---
Q
D
N
-------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
------
Y
V
N
S
G
F
N
P
L
------------
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------
11
PsiBlast_PDB
79.43
20%
-140
- C4 -
4LDE
3
A:
[197-463]
--------------------------------------------------------------------------------
V
F
G
---
N
-----
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
---
L
-----
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-----
T
K
T
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
----
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
-
E
----------
T
C
--
C
-------
D
-------------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
------
V
P
L
V
I
---
M
V
F
V
Y
S
R
V
F
------------
Q
E
----
A
-----------------------------------------------
K
R
Q
L
Q
----------------------------
K
FAL
K
E
H
K
A
L
K
T
L
G
---
I
I
M
G
T
F
-------
T
L
C
W
L
P
F
F
I
V
N
I
V
----
H
------------
V
I
---
Q
D
N
-------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
------
Y
V
N
S
G
F
N
P
L
------------
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------
13
PsiBlast_PDB
79.19
20%
-142
- C4 -
4LDO
3
A:
[197-463]
--------------------------------------------------------------------------------
V
F
G
---
N
-----
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
---
L
-----
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-----
T
K
T
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
----
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
-
E
----------
T
C
--
C
-------
D
-------------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
------
V
P
L
V
I
---
M
V
F
V
Y
S
R
V
F
------------
Q
E
----
A
-----------------------------------------------
K
R
Q
L
Q
----------------------------
K
FAL
K
E
H
K
A
L
K
T
L
G
---
I
I
M
G
T
F
-------
T
L
C
W
L
P
F
F
I
V
N
I
V
----
H
------------
V
I
---
Q
D
N
-------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
------
Y
V
N
S
G
F
N
P
L
------------
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------
8
PsiBlast_PDB
77.68
20%
-138
- C4 -
4GBR
1
ADRB2_HUMAN
A:
[20-286]
--------------------------------------------------------------------------------
V
F
G
---
N
-----
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
---
L
-----
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-----
T
K
T
W
T
F
G
N
F
W
C
E
--
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
----
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
--
P
I
Q
M
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
-
E
----------
T
C
--
C
-------
D
-------------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
------
V
P
L
V
I
---
M
V
F
V
Y
S
R
V
F
------------
Q
E
----
A
-----------------------------------------------
K
R
Q
L
Q
-----
K
--------------------
I
D
K
FC
L
K
E
H
K
A
L
K
T
L
G
---
I
I
M
G
T
F
-------
T
L
C
W
L
P
F
F
I
V
N
I
V
----
H
------------
V
I
---
Q
D
N
-------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
------
Y
V
N
S
G
F
N
P
L
------------
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------
31
HHSearch
77.50
17%
-115
- C4 -
1U19
14
OPSD_BOVIN
A:
[43-326]
--------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
-----
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
---
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
----
I
A
L
W
S
L
V
V
L
A
----
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
-
R
Y
------
I
-
P
E
G
M
Q
C
S
C
G
-
I
D
Y
Y
T
----
P
-----
H
-------
E
-------------
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
------
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
V
------------
F
T
----
V
-----------------------------------------------
K
E
A
A
A
-----
Q
QQESA
T
T
Q
------------
K
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
QGS
D
------
F
-
G
P
---
I
F
M
-------
T
I
P
A
-------
F
F
A
------
K
T
S
A
V
Y
N
P
V
------------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
------------------
C
C
G
K
N
P
L
G
D
--
45
Fugue
75.71
21%
-117
- C3 -
4FDT
2
?
A:
[21-425]
------------
M
Q
T
K
I
Q
K
Y
A
G
T
AMPYPNRTDGMTP
F
Y
I
N
-------------
H
L
G
R
H
G
A
RFPT
S
R
K
A
L
D
K
V
E
K
V
L
V
S
A
Q
Q
E
N
---
G
LT
S
E
G
M
A
L
L
S
M
I
R
R
L
S
R
L
F
D
G
Q
W
G
K
L
S
K
L
G
E
T
E
Q
E
G
I
-----
A
G
R
M
I
R
N
Y
P
Q
L
F
S
N
S
A
K
I
E
A
-
I
A
T
Y
V
P
R
S
I
N
S
M
D
A
F
L
S
C
M
I
R
----
H
N
P
A
L
Q
V
Q
R
S
E
G
KQ
Y
N
H
I
L
R
F
F
D
L
N
K
S
Y
V
N
Y
K
E
K
G
D
W
L
P
I
Y
K
A
F
V
H
K
K
I
S
P
V
P
I
M
K
K
F
L
L
N
P
E
Q
YL
D
K
E
A
E
E
F
V
M
A
L
F
S
V
-
A
A
I
L
P
DTSI
P
L
N
L
--
E
-------
D
LFT
L
D
E
W
H
R
Y
W
Q
T
Q
N
L
R
Q
Y
M
S
K
S
S
A
P
V
G
K
M
------
L
P
V
A
I
A
W
P
L
L
S
E
F
I
R
S
A
------------
Q
E
----
V
-----------------------------------------------
I
S
G
K
S
-----
D
YQ
A
-----------------
N
F
R
-----
F
A
H
A
E
T
V
I
P
F
V
S
L
M
G
I
E
-------
K
T
D
V
Q
V
C
R
P
D
S
V
S
----
V
---
Y
WKDYEI
S
-
P
M
---
A
A
N
-------
V
Q
W
L
-------
F
Y
R
D
RDQ
R
I
W
V
K
I
L
L
N
E
E
A
A
A
L
PISTACFP
Y
Y
S
W
E
K
T
R
I
F
F
N
Q
R
I
E
--
M
------------------
A
K
K
T
L
S
V
F
N
--