@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4CB_HUMAN: (2016-01-13 )
MQQNNSVPEFILLGLTQDPLRQKIVFVIFLIFYMGTVVGNMLIIVTIKSSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSEKKIITYNECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPTIMSQQVCIILIVLAWIGSLIHSTAQIILALRLPFCGPYLIDHYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFMILIISYIVILHSLRNHSAKGKKKALSACTSHIIVVILFFGPCIFIYTRPPTTFPMDKMVAVFYTIGTPFLNPLIYTLRNAEVKNAMRKLWHGKIISENKG
Atome Classification :
(20 SA)
.........10........20----------------.---------------.......30........40......----------..50........60.........70....-.-.---..80......----------------..90...------.....100........110------........120......---.130-------------------.........-140.....--------------..--.150.......160.-..-----.----...170....-..--.180-.......190.---......200.......210-------.......---.220..---------..-----------...------------230-------------------.-----........240-----.-------...-....---------------.--------250---......------------..260---.-----.-----.------...-.-.270........----280.....-..290.......300.......310------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQQNNSVP
E
F
I
L
LGLTQ
D
P
L
R
----------------
Q
---------------
K
I
V
F
V
I
F
L
I
F
Y
M
G
T
V
VG
N
M
L
I
I
V
T
I----------KSSRTLG
S
P
M
Y
F
F
-
L
F
Y
L
S
F
A
D
S
CFSTST-
A
-
P
---
R
L
I
V
D
A
LSEK----------------
K
I
I
T
Y
N
E
------
C
M
T
Q
V
F
A
-
L
H
L
F
G
C
M
E
I
F
-------
V
L
I
L
M
A
V
D
R
Y
V
A
I
CKPL---RY---------------------PTIMSQ
Q
V
C
-
I
-
I
L
I
V
L
A
--------------
W
I
--
G
S
L
I
H
S
T
A
Q
I
I
L
A
L
R-LP-----F----C
G
P
Y
L
I
D
H
YC-C
D
--
L
Q
P
L
-
L
K
L
A
C
M
D
T
Y
M
I
---
N
L
L
L
VSNSGAIC
S
S
S
F
M
I
--------
L
I
I
S
Y
I
V
---
I
L
H
S
L
R---------NH-----------SAK------------
G
---------------------
K
-----
K
K
A
L
S
A
C
T
S
-------
H
-------
I
I
V
-
V
I
L
F---------------F--------G
P
----
C
I
F
I
Y
T------------RPPT----T-----F-----
P
------
M
D
K
-
M
-
V
A
V
-
F
Y
TI
G
T
P
F
----
L
N
P
L
I
Y
T
L-R
N
A
E
V
K
N
A
M
R
K
L
WH
G
K
IISENKG--------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
84.34
18%
-150
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-332]
--------------------
V
----------------
Y
---------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
----------
T
K
T
K
S
L
Q
T
P
A
N
M
F
-
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
-
P
---
L
M
T
I
S
C
F
L
K
K
----------------
W
I
F
G
F
A
A
------
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
M
-------
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
---
A
A
---------------------
S
K
K
M
S
H
R
R
A
-
F
-
I
M
I
I
F
V
--------------
W
L
--
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
-
Y
T
-----
L
--------
E
G
V
L
C
N
-
C
S
--
F
D
Y
I
-
S
R
-----
D
S
T
T
---
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
--------
I
F
F
C
Y
F
N
---
I
V
M
S
V
S
---------
N
H
-----------
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
-----
M
R
L
A
K
I
S
I
V
-------
I
-------
V
S
Q
-
F
L
L
S
---------------
W
--------
S
P
----
Y
A
V
V
A
L
------------
L
A
Q
F
----
G
-----
P
LEWVT
P
------
Y
A
A
-
Q
-
L
P
V
-
M
F
A
K
A
S
A
I
----
H
N
P
M
I
Y
S
V
-
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.19
20%
-157
- C1 -
4WW3
5
OPSD_TODPA
A:
[54-320]
------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
-
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
---
L
M
T
I
S
C
F
L
K
K
----------------
W
I
F
G
F
A
A
------
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
M
-------
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
---
A
A
---------------------
S
K
K
M
S
H
R
R
A
-
F
-
I
M
I
I
F
V
--------------
W
L
--
W
S
V
L
W
A
I
G
P
I
F
G
----------------
W
G
A
Y
T
L
E
G
V
L
-
C
N
C
S
F
D
Y
I
-
S
R
D
S
T
T
R
S
N
I
L
---
C
M
F
I
L
G
F
F
G
P
I
-----
L
I
--------
I
F
F
C
Y
F
N
---
I
V
M
S
V
S
---------
N
H
E
K
E
M
A
A
M
A
K
RL
N
A
K
------------
E
---------------------
L
-----
R
K
A
Q
A
G
A
N
A
-------
E
M
R
L
A
K
I
S
I
V
I
-
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
--------
G
P
----
L
E
W
V
T
---------------------------------
P
------
Y
A
A
-
Q
-
L
P
V
-
M
F
A
K
A
S
A
I
----
H
N
P
M
I
Y
S
V
-
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.90
20%
-152
- C1 -
3AYM
3
OPSD_TODPA
A:
[62-328]
------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
-
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
---
L
M
T
I
S
C
F
L
K
K
----------------
W
I
F
G
F
A
A
------
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
M
-------
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
---
A
A
---------------------
S
K
K
M
S
H
R
R
A
-
F
-
I
M
I
I
F
V
--------------
W
L
--
W
S
V
L
W
A
I
G
P
I
F
G
----------------
W
G
A
Y
T
L
E
G
V
L
-
C
N
C
S
F
D
Y
I
-
S
R
D
S
T
T
R
S
N
I
L
---
C
M
F
I
L
G
F
F
G
P
I
-----
L
I
--------
I
F
F
C
Y
F
N
---
I
V
M
S
V
S
---------
N
H
E
K
E
M
A
A
M
A
K
RL
N
A
K
------------
E
---------------------
L
-----
R
K
A
Q
A
G
A
N
A
-------
E
M
R
L
A
K
I
S
I
V
I
-
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
--------
G
P
----
L
E
W
V
T
---------------------------------
P
------
Y
A
A
-
Q
-
L
P
V
-
M
F
A
K
A
S
A
I
----
H
N
P
M
I
Y
S
V
-
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.70
20%
-157
- C1 -
2Z73
5
OPSD_TODPA
A:
[62-328]
------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
-
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
---
L
M
T
I
S
C
F
L
K
K
----------------
W
I
F
G
F
A
A
------
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
M
-------
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
---
A
A
---------------------
S
K
K
M
S
H
R
R
A
-
F
-
I
M
I
I
F
V
--------------
W
L
--
W
S
V
L
W
A
I
G
P
I
F
G
----------------
W
G
A
Y
T
L
E
G
V
L
-
C
N
C
S
F
D
Y
I
-
S
R
D
S
T
T
R
S
N
I
L
---
C
M
F
I
L
G
F
F
G
P
I
-----
L
I
--------
I
F
F
C
Y
F
N
---
I
V
M
S
V
S
---------
N
H
E
K
E
M
A
A
M
A
K
RL
N
A
K
------------
E
---------------------
L
-----
R
K
A
Q
A
G
A
N
A
-------
E
M
R
L
A
K
I
S
I
V
I
-
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
--------
G
P
----
L
E
W
V
T
---------------------------------
P
------
Y
A
A
-
Q
-
L
P
V
-
M
F
A
K
A
S
A
I
----
H
N
P
M
I
Y
S
V
-
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.58
20%
-154
- C1 -
3AYN
3
OPSD_TODPA
A:
[62-328]
------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
-
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
---
L
M
T
I
S
C
F
L
K
K
----------------
W
I
F
G
F
A
A
------
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
M
-------
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
---
A
A
---------------------
S
K
K
M
S
H
R
R
A
-
F
-
I
M
I
I
F
V
--------------
W
L
--
W
S
V
L
W
A
I
G
P
I
F
G
----------------
W
G
A
Y
T
L
E
G
V
L
-
C
N
C
S
F
D
Y
I
-
S
R
D
S
T
T
R
S
N
I
L
---
C
M
F
I
L
G
F
F
G
P
I
-----
L
I
--------
I
F
F
C
Y
F
N
---
I
V
M
S
V
S
---------
N
H
E
K
E
M
A
A
M
A
K
RL
N
A
K
------------
E
---------------------
L
-----
R
K
A
Q
A
G
A
N
A
-------
E
M
R
L
A
K
I
S
I
V
I
-
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
--------
G
P
----
L
E
W
V
T
---------------------------------
P
------
Y
A
A
-
Q
-
L
P
V
-
M
F
A
K
A
S
A
I
----
H
N
P
M
I
Y
S
V
-
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.75
20%
-152
- C1 -
2ZIY
2
OPSD_TODPA
A:
[61-327]
------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
-
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
-
G
F
P
---
L
M
T
I
S
C
F
L
K
K
----------------
W
I
F
G
F
A
A
------
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
M
-------
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
---
A
A
---------------------
S
K
K
M
S
H
R
R
A
-
F
-
I
M
I
I
F
V
--------------
W
L
--
W
S
V
L
W
A
I
G
P
I
F
G
----------------
W
G
A
Y
T
L
E
G
V
L
-
C
N
C
S
F
D
Y
I
-
S
R
D
S
T
T
R
S
N
I
L
---
C
M
F
I
L
G
F
F
G
P
I
-----
L
I
--------
I
F
F
C
Y
F
N
---
I
V
M
S
V
S
---------
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
------------
E
---------------------
L
-----
R
K
A
Q
A
G
A
N
A
-------
E
M
R
L
A
K
I
S
I
V
I
-
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
--------
G
P
----
L
E
W
V
T
---------------------------------
P
------
Y
A
A
-
Q
-
L
P
V
-
M
F
A
K
A
S
A
I
----
H
N
P
M
I
Y
S
V
-
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.84
18%
-170
- C1 -
3DQB
4
GNAT1_BOVIN (first)
A:
[44-317]
----------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
K
K
-
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNF
R
F
-------------------------
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
----
C
G
---
I
D
Y
Y
T
-
P
H
--
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
----------
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
A
E
K
E
V
T
R
-------
M
-------
V
I
I
-
M
V
I
A
---------------
F
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
G
----
P
------
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
75.77
18%
-169
- C1 -
3PQR
9
OPSD_BOVIN
A:
[44-317]
----------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
K
K
-
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
-------------------------
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
----
C
G
---
I
D
Y
Y
T
-
P
H
--
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
----------
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
A
E
K
E
V
T
R
-------
M
-------
V
I
I
-
M
V
I
A
---------------
F
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
G----
P
------
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
75.15
16%
-142
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
----------------
S
PFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
----------
V
Q
H
K
K
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---
S
N
---------------------
F
R
-
F
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
-----
P
----
E
G
--
M
Q
C
S
C
G
-
I
D
--
Y
Y
T
P
-
H
E
E
T
N
N
E
S
F
V
I
---
Y
M
F
V
V
-----
H
F
I
I
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
AASAT------
T
Q
K
------------
A
---------------------
E
-----
K
E
V
T
R
M
V
I
I
-------
M
-------
V
I
A
-
F
L
I
C
---------------
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
-----
G
------
P
I
F
-
M
T
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.64
18%
-168
- C1 -
3CAP
4
OPSD_BOVIN
A:
[44-317]
----------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
K
K
-
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-------------------------
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
----
C
G
---
I
D
Y
Y
T
-
P
H
--
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
----------
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
A
E
K
E
V
T
R
-------
M
-------
V
I
I
-
M
V
I
A
---------------
F
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
G----
P
------
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
74.59
23%
-177
- C1 -
4QT9
2
?
A:
[19-432]
--------------
L
S
D
D
A
L
-
M
---------------
D
---------------
T
V
Q
R
R
T
F
L
Y
F
W
E
G
A
E
P
N
S
G
L
A
P
E
R
Y
HVDGVYPQND
A
N
V
V
T
S
G
G
S
G
F
G
I
M
A
I
L
A
G
I
D
R
G
Y
V
T
R
E
E
-
G
-
L
A
R
M
E
R
I
V
S
F
L
E
K
A
DRFHGAYPHWWYGDTG
K
V
K
P
F
G
Q
KDNGGD
L
V
E
T
A
F
L
M
Q
G
L
L
A
V
H
Q
Y
Y
A
NGN
D
K
E
K
A
I
A
Q
R
I
D
R
L
W
R
E
V
D
W
D
---
W
Y
RKGGQNVLYWHWSPTYGWEMD
F
P
I
H
G
Y
N
E
C
M
I
M
Y
I
L
A
A
A
SPTHGVP
A
A
V
Y
H
D
G
W
A
QN
G
A
I
V
S
P
H
K
V
E
G
I
E
L
H
-
L
R
-----
Y
QGTE
A
G
P
L
F
W
A
Q
Y
S
F
L
G
--
L
D
P
V
G
L
K
D
E
Y
C
P
S
Y
F
H
E
M
R
N
L
T
L
V
N
R
A
Y
C
I
R
N
P
K
H
Y
K
GFGPD
C
W
G
L
T
A
S
Y
S
V
DGY
A
A
H
S
P
N
---------
E
Q
-----------
D
D
K
------------
G
---------------------
V
-----
I
S
P
T
A
A
L
S
S
IVYT
P
E
Y
S
-------
L
Q
V
M
R
H
L
Y
---------------
N
M
-------
G
D
----
K
V
F
G
P
F
GFYDAFSETDNW
Y
P
Q
R
----
Y
-----
L
-----
A
------
I
D
Q
G
P
-
I
A
V
M
I
E
N
Y
R
T
G
L
----
L
W
K
L
---
F
M
S
H
P
D
V
Q
A
G
L
T
K
L
G
F
------
N
T
N
--------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.53
18%
-170
- C1 -
3PXO
4
OPSD_BOVIN
A:
[44-317]
----------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
K
K
-
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
-------------------------
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
----
C
G
---
I
D
Y
Y
T
-
P
H
--
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
----------
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
A
E
K
E
V
T
R
-------
M
-------
V
I
I
-
M
V
I
A
---------------
F
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
G
----
P
------
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
74.35
18%
-122
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
---------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
-
K
K
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---
S
N
---------------------
F
R
-
F
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
----
C
G
I
---
D
Y
Y
T
-
P
H
--------
E
E
T
N
N
E
S
F
V
I
---
Y
M
F
V
V
H
F
-----
I
I
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
EAAAQQQES
A
T
-----------
T
Q
K
------------
A
---------------------
E
-----
K
E
V
T
R
M
V
I
I
-------
M
-------
V
I
A
-
F
L
I
C
---------------
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
-----
G
------
P
I
F
-
M
T
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
EA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.29
18%
-158
- C1 -
3C9L
13
OPSD_BOVIN
A:
[44-317]
----------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
K
K
-
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNF
R
F
-------------------------
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
----
C
G
---
I
D
Y
Y
T
-
P
H
--
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
----------
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
A
E
K
E
V
T
R
-------
M
-------
V
I
I
-
M
V
I
A
---------------
F
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
G----
P
------
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.75
18%
-159
- C1 -
1F88
7
OPSD_BOVIN
A:
[44-317]
----------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
K
K
-
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-------------------------
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
----
C
G
---
I
D
Y
Y
T
-
P
H
--
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
----------
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
------------------------------------SATT-
Q
K
A
E
K
E
V
T
R
-------
M
-------
V
I
I
-
M
V
I
A
---------------
F
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
I
F
T
------------
H
Q
G
S
----
D
-----
F
G----
P
------
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.21
19%
-163
- C1 -
2X72
5
GNAT1_BOVIN (first)
A:
[47-318]
----------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
----------
Q
H
K
K
-
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
Q
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
-------------------------
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
EGMQC
S
----
C
G
---
I
D
Y
Y
T
-
P
H
--
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
V
---
H
F
I
I
----------
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
A
E
K
E
V
T
R
-------
M
-------
V
I
I
-
M
V
I
A
---------------
F
L
I
C
W
L
P
Y
A
G
V
----
A
F
Y
I
F
T
------------
H
Q
G
S
----
C
-----
F
G
----
P
------
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
71.12
15%
-148
* C1 *
2KS9
1
NK1R_HUMAN
A:
[35-326]
-------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
----------
L
A
H
K
R
M
R
T
V
T
N
Y
F
-
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
-
V
---
V
N
F
T
Y
A
V
H
N
E
----------------
W
Y
Y
G
L
F
Y
------
C
K
F
H
N
F
F
-
P
I
A
A
V
F
A
S
I
Y
-------
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
---
Q
P
---------------------
R
L
--
S
A
T
A
T
-
K
-
V
V
I
C
V
I
--------------
W
V
--
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
--------------
T
M
P
S
R
V
V
-
C
M
--
I
E
W
P
-
E
H
P
N
---
K
I
Y
E
---
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
--------
I
G
Y
A
Y
T
V
---
V
G
I
T
L
W
---------
A
S
-----------
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
-----
R
K
V
V
K
M
M
I
V
-------
V
-------
V
C
T
-
F
A
I
C
---------------
W
--------
L
P
----
F
H
I
F
F
L
------------
L
P
Y
I
----
N
-----
P
DLYLK
K
FI
Q
---
Q
V
Y
-
L
-
A
I
M
-
W
L
A
M
S
S
T
M
----
Y
N
P
I
I
Y
C
C
-
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
69.21
16%
-132
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-329]
-----------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
----------
V
Q
H
K
K
L
R
T
P
L
N
Y
I
-
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
-
T
---
T
T
L
Y
T
S
L
H
G
Y
----------------
F
V
F
G
P
T
G
------
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---
S
N
---------------------
F
R
-
F
G
E
N
H
A
-
I
-
M
G
V
A
F
T
--------------
W
V
--
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
------------
P
-
E
G
M
Q
C
S
-
C
G
--
I
D
Y
Y
-
T
P
H
---
E
E
T
N
N
---
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
--------
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
---------
E
A
-----------
A
A
Q
------------
Q
QESA
T
T
Q
K
A
------------
E
-----
K
E
V
T
R
M
V
I
I
-------
M
-------
V
I
A
-
F
L
I
C
---------------
W
--------
L
P
----
Y
A
G
V
A
F
------------
Y
I
F
T
H
QGS
D
-----
F
-----
G
P-----
I
F
M
-
T
-
I
P
A
-
F
F
A
K
T
S
A
V
----
Y
N
P
V
I
Y
I
M
-
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
66.78
16%
-130
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------
D
E
V
W
----------------
V
---------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
----------
A
K
F
E
R
L
Q
T
V
T
N
Y
F
-
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
-
P
---
F
G
A
A
H
I
L
M
K
M
----------------
W
T
F
G
N
F
W
------
C
E
F
W
T
S
I
-
D
V
L
C
V
T
A
S
I
E
-------
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
---
K
Y
---------------------
Q
S
L
L
T
K
N
K
A
-
R
-
V
I
I
L
M
V
--------------
W
I
--
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
----------------
T
H
Q
E
-
A
I
--
N
C
Y
A
-
E
E
T
C
C
D
F
F
T
N
Q
---
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
--------
V
F
V
Y
S
R
V
---
F
Q
E
A
K
R
---------
Q
L
-----------
N
I
F
------------
E
---------------------
M
-----
L
R
I
D
E
G
L
R
L
-------
K
-------
I
Y
K
-
D
T
E
G
---------------
Y
--------
Y
T
----
I
G
I
G
H
L
------------
L
T
K
S
----
P
-----
S
-----
L
------
N
A
A
-
K
-
S
E
L
-
D
K
A
I
G
R
N
T
NGVI
T
K
D
E
A
E
K
L
-
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
33
HHSearch
66.49
17%
-136
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
--------------------
N
----------------
K
---------------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
----------
L
Y
S
R
V
G
R
S
V
T
D
V
Y
-
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
-
P
---
I
W
A
A
S
K
-
V
N
G
----------------
W
I
F
G
T
F
L
------
C
K
V
V
S
L
L
-
K
E
V
N
F
Y
S
G
I
L
-------
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
---
R
T
---------------------
L
T
-
Q
K
R
H
L
V
-
K
-
F
V
C
L
G
C
--------------
W
G
--
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
-
Y
H
-------------
P
N
N
S
S
P
V
-
C
Y
--
E
V
L
G
-
N
D
T
----
A
K
W
R
---
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
--------
M
L
F
C
Y
G
F
---
T
L
R
T
L
F
---------
K
A
-----------
H
M
G
------------
Q
---------------------
K
-----
H
R
A
M
R
V
I
F
A
-------
V
-------
V
L
I
-
F
L
L
C
---------------
W
--------
L
P
----
Y
N
L
V
L
L
------------
A
D
T
L
M
RT-
Q
VIQE
S
C
-----
E
R
R
N
N
I
G
R
A
L
-
D
-
A
T
E
-
I
L
G
F
L
H
S
C
----
L
N
P
I
I
Y
A
F
-
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------