@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4D6_HUMAN: (2016-01-13 )
MDQINHTNVKEFFFLELTRSRELEFFLFVVFFAVYVATVLGNALIVVTITCESRLHTPMYFLLRNKSVLDIVFSSITVPKFLVDLLSDRKTISYNDCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKPLHYVTMMRKEVWVALVVASWVSGGLHSIIQVILMLPFPFCGPNTLDAFYCYVLQVVKLACTDTFALELFMISNNGLVTLLWFLLLLGSYTVILVMLRSHSGEGRNKALSTCTSHMLVVTLHFVPCVYIYCRPFMTLPMDTTISINNTVITPMLNPIIYSLRNQEMKSAMQRLQRRLGPSESRKWG
Atome Classification :
(20 SA)
-----------.........10........--20.....--...-----30..--......40....-----....50........60........70.--.....-..80........90.......-..100.......--110.......120.........-----130-----........-.140...---....150.......160-------.....-...170.......180.---......--190-----...------------......200....---...210.......220---------------------........---------.230----------.---------------------.---------.----.------.....240......--------.250-.----......-----260.----------.--.-----.---------...270-----------........280...-------....290.......300----------.-----.......310..------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MDQINHTNV
K
E
F
F
F
L
E
LTR--SRE
L
E
F
F
--
L
F
V
-----
V
F
F
A
--
V
Y
V
A
T
V
LGN
A
L
I
-----
V
V
T
I
TCESRLHT
P
M
Y
F
L
LRNK
S
V
L
D
I
V
--
F
S
SI
T
-
V
P
K
F
L
V
D
L
LSDRK-TI
S
Y
N
D
C
-
M
A
Q
I
F
F
F
HFAGG--A
D
I
F
F
L
S
V
M
A
Y
--
D
R
Y
L
A
I
A
K
P
-----
L
-------
H
Y
V
T
M
M
R
K
-
E
V
W
V
A
L
V
---
V
A
S
W
VS
G
G
L
H
S
I
I
Q
V
I
--------
L
MLPF-PFCGPN
T
L
D
A
F
Y
C
Y
V
L
Q
---
V
V
K
L
AC--T-------D
T
F
------------
A
L
E
L
F
M
ISNN
G
L
V
---
T
L
L
W
F
L
L
L
LG
S
Y
T
V
-----------------------
I
L
V
M
L
RSH---------SG------------E---------------------G---------R----
N
------
K
A
L
S
T
C
TS
H
M
L
V
V
T
--------
L
HFV-
P
----
C
V
Y
I
Y
C-----RPFM----------T--L-----P---------MD
T
T
I
------------
S
INN
T
V
I
T
P
M
L
N
P
I
-------
I
Y
S
L
R
N
Q
E
M
K
S
A
M
Q
R
L
-----------
Q
-----
R
RLGPSESRKWG------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
92.72
22%
-144
- C2 -
2YDV
6
?
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
T
A
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
R
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
K
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
---
E
G
Q
V
A
C
LF
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ-------------------------------------------------S
T
L
-
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
-
N
----
C
F
T
F
F
C
P
DCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
S
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
H
V
L
R
Q
Q
E
P
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
92.39
22%
-153
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
T
Q
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
R
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
K
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
-------
S
Q
G
C
G
---
E
G
Q
V
A
C
L
F
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PL
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
-
N
----
C
F
T
F
F
C
PD
C
S
H
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
S
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
92.12
22%
-143
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
T
A
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
R
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
K
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
---
E
G
Q
V
A
C
LF
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
-
N
----
C
F
T
F
F
C
PDCH-
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
S
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
H
V
L
R
Q
Q
E
P
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
91.63
22%
-152
- C2 -
3VG9
8
?
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
T
Q
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
R
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
K
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
-------
S
Q
G
C
G
---
E
G
Q
V
A
C
L
F
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PL
P
G
------------
E
---------------------
R
---------
A
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
-
N
----
C
F
T
F
F
C
PD
C
S
H
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
S
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.89
21%
-134
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
A
Q
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
A
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
A
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
--------
G
C
G
---
E
G
Q
V
A
C
L
F
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
---------
A
---------
K
----
S
------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--------
L
H
I
I
-
N
----
C
F
T
F
F
C
PDCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
A
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
90.84
21%
-134
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
A
Q
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
A
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
A
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
--------
G
C
G
---
E
G
Q
V
A
C
L
F
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
---------
A
---------
K
----
S
------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--------
L
H
I
I
-
N
----
C
F
T
F
F
C
PDCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
A
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.16
21%
-132
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
A
Q
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
A
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
A
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
--------
G
C
G
---
E
G
Q
V
A
C
L
F
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
---------
A
---------
K
----
S
------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--------
L
H
I
I
-
N
----
C
F
T
F
F
C
PDCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
A
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.12
21%
-134
- C2 -
3REY
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
A
Q
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
A
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
A
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
--------
G
C
G
---
E
G
Q
V
A
C
L
F
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
---------
A
---------
K
----
S
------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--------
L
H
I
I
-
N
----
C
F
T
F
F
C
PDCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
A
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.02
21%
-133
- C2 -
3PWH
1
?
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
A
Q
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
A
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
A
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
--------
G
C
G
---
E
G
Q
V
A
C
LF
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPL
P
G
------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
---------
A
---------
K
----
S
------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
--------
L
H
I
I
-
N
----
C
F
T
F
F
C
PDCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
A
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
89.79
22%
-143
- C2 -
2YDO
3
?
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
T
A
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
R
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
K
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
---
E
G
Q
V
A
C
LF
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S--------------------------------------------------T
L
--
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
-
N
----
C
F
T
F
F
C
P
DCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
S
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
H
V
L
R
Q
Q
E
P
F
K
------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.40
22%
-142
- C2 -
4UG2
3
?
A:
[12-304]
-------------------------------------------------
V
E
L
A
--
I
A
V
L
A
I
L
G
N
V
L
V
-----
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
-
C
A
A
C
H
G
C
-
L
F
I
A
C
F
V
L
V
L
T
A
--
S
S
I
F
S
L
L
A
I
A
I
--
D
R
Y
I
A
I
R
I
P
-----
L
-------
R
Y
N
G
L
V
T
G
-
T
R
A
K
G
I
I
---
A
I
C
W
V
---
L
S
F
A
I
G
L
T
--------
P
M
L
G
W
-
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
---
E
G
Q
V
A
C
LF
E
-------
D
V
V
------------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
---
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----------------------
I
F
L
A
A
R
R
Q
L------------------------------------------------------
A
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
-
N
----
C
F
T
F
F
C
P
DCSH
A
P
L
W
----------
L
--
M
-----
Y
---------
L
A
I
V
L
------------
S
H
T
N
S
V
V
----
N
P
F
-------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-----------
I
-----
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
82.35
17%
-132
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
--------------------------------------
L
--
W
A
A
-----
A
Y
T
V
--
I
V
V
T
S
V
V
G
N
V
V
V
-----
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
--
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
-
K
F
H
N
F
F
P
I
A
A
V
F
--
A
S
I
Y
S
M
T
A
V
A
F
--
D
R
Y
M
A
I
I
H
P
-----
L
-------
Q
P
R
L
--
S
A
-
T
A
T
K
V
V
I
---
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
--------
Y
S
T
T
--
E
T
----
M
P
S
R
V
V
C
M
I
E
W
---
P
E
H
-----
P
-------
N
K
I
------------
Y
E
K
V
Y
H
I
C
V
T
V
L
I
---
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
-----------------------
V
G
I
T
L
W
A
S
---------
E
I
PGDSSDRYH
E
Q
V
S
---------------------
A
---------
K
----
R
------
K
V
V
K
M
M
I
V
V
V
C
T
F
A
--------
I
C
W
L
-
P
----
F
H
I
F
F
L
-----
L
P
Y
I
----------
N
--
P
DLYLK
K
FI
Q
------
Q
V
Y
L
A
------------
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
-------
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
-----------
F
-----
R
C
C
P
F
I
S
A
G
D
Y
E
------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
78.17
15%
-125
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-335]
-----------------------------------
V
Y
Y
S
--
L
G
I
-----
F
I
G
I
--
C
G
I
I
G
C
G
G
N
G
I
V
-----
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
-
K
V
Y
G
F
I
G
G
I
F
G
F
--
M
S
I
M
T
M
A
M
I
S
I
--
D
R
Y
N
V
I
G
R
P
-----
M
-------
A
A
S
K
K
M
S
H
-
R
R
A
F
I
M
I
---
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
--------
G
W
G
A
Y
-
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
---
I
S
--------------
R
D
S
------------
T
T
R
S
N
I
L
C
M
F
I
L
G
---
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
-----------------------
I
V
M
S
V
S
N
H
---------
E
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
---------
E
----
M
------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
--------
L
S
W
S
-
P
----
Y
A
V
V
A
L
-----
L
A
Q
F
----------
G
--
P
LEWVT
P
---------
Y
A
A
Q
L
------------
P
V
M
F
A
K
A
S
A
I
H
N
P
M
-------
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
-----------
F
-----
P
W
V
L
T
C
C
Q
F
D
D
K
------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
75.84
17%
-113
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
LA
E
P
W
Q
F
S
M
--
L
A
A
-----
Y
M
F
L
--
L
I
M
L
G
F
P
I
N
F
L
T
-----
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
-
N
L
E
G
F
F
A
T
L
G
G
E
--
I
A
L
W
S
L
V
V
L
A
I
--
E
R
Y
V
V
V
C
K
P
-----
M
-------
S
N
F
R
F
-
G
E
-
N
H
A
I
M
G
V
---
A
F
T
W
V
M
A
L
A
C
A
----------------
A
P
-
P
L
V
G
------
W
S
R
Y
I
P
E
---
G
M
Q
C
S
C
--
G
I
DYYTPH
E
E
T
------------
N
N
E
S
F
V
I
Y
M
F
V
V
H
---
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-----------------------
L
V
F
T
V
K
E
A
A--------
A
S
------------
A
---------------------
T
---------
T
----
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
--------
I
A
F
L
-
I
----
C
W
L
P
Y
A
-----
G
V
A
F
----------
Y
--
I
-----
F
T
H
QGSDFGP
I
F
M
T
I
------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------
L
-----
C
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
74.33
15%
-115
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
--
M
G
I
-----
V
M
S
L
--
I
V
L
A
I
V
F
G
N
V
L
V
-----
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
V
T
--
A
S
I
E
T
L
C
V
I
A
V
--
D
R
Y
F
A
I
T
S
P
-----
F
-------
K
Y
Q
S
L
L
T
K
-
N
K
A
R
V
I
I
---
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--------
M
--------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
---
A
E
E
T
C
C
--
D
-------
F
F
T
------------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
---
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-----------------------
F
Q
E
A
K
R
Q
L
---------
N
I
------------
F
---------------------
E
---------
M
----
L
------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
--------
E
G
Y
Y
-
T
IGIG
H
L
L
T
K
S
-----
P
S
L
N
----------
A
--
A
-----
K
---------
S
E
L
D
K
------------
A
I
G
R
N
T
N
G
V
I
T
K
D
E
-------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
-----------
L
-----
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
46
Fugue
72.50
22%
-166
- C1 -
4FS7
2
?
A:
[2-394]
-------YDFV
I
D
E
I
T
Y
N
F
T
K
E
H
G
T
V
E
V
S
G
--
L
R
E
F
L
N
P
--
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
F
QGCRK
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
E
N
C
S
K
L
E
I
I
N
I
P
D
S
V
K
M
I
G
R
C
T
F
S
G
C
Y
A
L
K
-
S
I
L
L
P
L
-M
L
K
S
I
G
V
E
A
F
K
G
C
DF
K
E
I
T
I
P
E
G
V
T
V
IG
D
E
A
F
A
T
C
E
S
-----
L
-------
E
Y
V
S
L
P
D
S
M
E
T
L
H
N
G
L
FSG
C
G
K
L
K
S
I
K
L
P
R
N
L
K
I
I
RDYCFAEC
I
L
L
E
N
M
E
F
--
P
N
S
L
Y
Y
L
G
D
F
A
L
S
KTG
V
K
N
I
I
I
--
P
-------
D
S
F
TELGKSVFYGCT
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
S
G
L
K
K
V
I
Y
-----------------------
G
S
V
I
V
P
E
K
---------
T
F
------------
Y
---------------------
G
-----------------------
C
S
S
L
T
E
V
K
L
L
D
S
--------
V
K
F
I
G
E
----
E
A
F
E
S
C
-----
T
S
L
V
----------
S
--
I
-----
D
---------
L
P
Y
L
V
EEIGKRSFRGCT
S
L
S
N
I
N
F
P
L
S
L
R
K
I
GANAFQG
C
I
N
L
K
K
V
E
L
P
K
R
L
E
Q
Y
-----------
R
-----
Y
D
F
E
D
T
T
K
F
K
W
I
K-----------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
72.31
16%
-124
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------
S
F
K
C
A
L
T
K
--
T
G
F
Q
F
Y
Y
--
L
P
A
-----
V
Y
I
L
--
V
F
I
I
G
F
L
G
N
S
V
A
-----
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
--
Y
V
-
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
-
K
L
Q
R
F
I
F
H
V
N
L
Y
--
G
S
I
L
F
L
T
C
I
S
A
--
H
R
Y
S
G
V
V
Y
P
KSL
G
R
L
-------
K
K
K
N
A
I
C
I
-
S
V
L
V
W
L
I
---
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
--------
R
K
N
K
T
-
I
T
C
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
---
Y
S
M
C
T
T
--
V
-------
A
M
F
------------
C
V
P
L
V
L
I
L
G
C
Y
G
L
---
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTD
F
K
D
I
V
C
P
L
---------
C
G
------------
V
---------------------
G
---------
K
----
D
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
--------
L
T
V
F
-
A
----
V
S
Y
I
P
F
-----
H
V
M
K
----------
T
--
M
-----
N
---------
L
R
A
R
L
------------
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
-------
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
-----------
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
71.22
18%
-92
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
--
L
A
E
P
W
Q
F
S
M
L
A
A
-----
Y
M
F
L
--
L
I
M
L
G
F
P
I
N
F
L
T
-----
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
-
N
L
E
G
F
F
A
T
L
G
G
E
--
I
A
L
W
S
L
V
V
L
A
I
--
E
R
Y
V
V
V
C
K
P
-----
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-
F
T
W
V
M
A
L
---
A
C
A
--
A
P
P
L
V
G
W
S
R
Y
I
--------
P
E
G
M
Q
-
C
S
C
G
I
D
----
Y
Y
T
-------
P
H
E
E
T
N
--
N
-------
E
S
F
------------
V
I
Y
M
F
V
V
H
F
I
I
P
L
---
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------------------
K
E
A
A
A
Q
Q
Q
---------
E
S
------------
A
---------------------
T
---------
T
----
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
--------
I
A
F
L
-
I
----
C
W
L
P
Y
A
-----
G
V
A
F
----------
Y
--
I
-----
F
T
H
QGSDFGP
I
F
M
T
I
------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDD
E
-----
A
S
T
T
V
S
K
T
E
T
S
Q
VAPA--------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
69.36
15%
-125
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
-----------------------------------
N
K
Y
V
--
V
I
I
-----
A
Y
A
L
--
V
F
L
L
S
L
L
G
N
S
L
V
-----
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
L
C
-
K
V
V
S
L
L
K
E
V
N
F
Y
--
S
G
I
L
L
L
A
C
I
S
V
--
D
R
Y
L
A
I
V
H
A
-----
T
-------
R
T
L
T
-
Q
K
R
-
H
L
V
K
F
V
C
---
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
--------
F
R
Q
A
Y
-
H
---
P
-
N
N
S
S
P
V
C
Y
E
V
L
---
G
N
------
D
-------
T
A
K
------------
W
R
M
V
L
R
I
L
P
H
T
F
G
---
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
-----------------------
T
L
R
T
L
F
K
A
---------
H
M
------------
G
---------------------
Q
---------
K
----
H
------
R
A
M
R
V
I
F
A
V
V
L
I
F
L
--------
L
C
W
L
-
P
----
Y
N
L
V
L
L
-----
A
D
T
L
M
RTQVIQE
S
C
E
R
R
N
-----
N
I
G
-------
R
A
L
D
A
------------
T
E
I
L
G
F
L
H
S
C
L
N
P
I
-------
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
-----------
L
-----
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
68.61
16%
-128
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
-------------------------------------
S
M
--
L
A
A
-----
Y
M
F
L
--
L
I
M
L
G
F
P
I
N
F
L
T
-----
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
-
N
L
E
G
F
F
A
T
L
G
G
E
--
I
A
L
W
S
L
V
V
L
A
I
--
E
R
Y
V
V
V
C
K
P
-----
M
-------
S
N
F
R
F
-
G
E
-
N
H
A
I
M
G
V
---
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--------
G
W
S
R
Y
-
I
P
----
E
G
M
Q
C
S
C
G
I
D
Y
---
Y
T
P
-----
H
-------
E
E
T
------------
N
N
E
S
F
V
I
Y
M
F
V
V
H
---
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-----------------------
L
V
F
T
V
K
E
A
---------
A
A
------------
Q
---------------------
Q
QESA
T
T
Q
K
A
E
----
K
------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
--------
I
C
W
L
-
P
----
Y
A
G
V
A
F
-----
Y
I
F
T
H
Q--------
G
--
S
DFG--
P
---------
I
F
M
T
I
------------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
-------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-----------
L
-----
C
C
G
K
N
P
L
G
D
D
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------