@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4F5_HUMAN: (2016-01-13 )
MVTEFIFLGLSDSQELQTFLFMLFFVFYGGIVFGNLLIVITVVSDSHLHSPMYFLLANLSLIDLSLSSVTAPKMITDFFSQRKVISFKGCLVQIFLLHFFGGSEMVILIAMGFDRYIAICKPLHYTTIMCGNACVGIMAVTWGIGFLHSVSQLAFAVHLLFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFVLLIISYTIILMTIQHRPLDKSSKALSTLTAHITVVLLFFGPCVFIYAWPFPIKSLDKFLAVFYSVITPLLNPIIYTLRNKDMKTAIRQLRKWDAHSSVKF
Atome Classification :
(20 SA)
----....-----...-----------------..----------------10........20........30........40........50........60......----..70.........80........90........100.......110.......120.......130.......140.......150.......160-----........170.......180--.......190.......200.......210----------....-------....-.220.-----------.--------------------....------.230...----------------------....240....-...250----...-----..-----.---.260----........270.......280.......290...----------------....300...-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MV
T
E
-----
F
I
F
-----------------LG----------------LS
D
S
Q
E
L
Q
T
F
L
F
M
L
F
F
V
F
Y
G
G
I
V
FG
N
L
L
I
V
I
T
VVSDSHLH
S
P
M
Y
F
L
L
AN
L
S
L
I
D
L
SLS----SVT-
A
P
K
M
I
T
D
F
F
SQRK
V
I
S
F
K
G
C
L
V
Q
I
F
L
L
H
FFGG
S
E
M
V
I
L
I
A
MGF
D
R
Y
I
A
I
CKP
L
H
Y
T
T
I
MCGN
A
C
V
G
I
M
A
V
T
W
G
I
G
F
L
H
S
V
S
Q
L
A
F
A
V
H
L
L
F
------CGP
N
E
V
D
S
F
Y
CD
L
P
R
V
I
K
L
AC--T
D
T
Y
R
L
D
I
M
V
I
ANS
G
V
L
T
V
C
S
F
V
L
L
I
I
S
------------
Y
T
I
I
-------
L
M
T
I
-QHRPL-----------D--------------------K
S
S
K
------
A
L
S
T
L
T
A
----------------------
H
I
T
V
V
L
LFFG
P
-
C
V
F
I
Y
A----WPF-----
P
I
-----
K
---
S
L
D
-----
K
F
L
A
V
F
Y
S
V
I
T
P
L
L
N
P
I
I
Y
T
LRNK
D
M
K
T
A
I
R
Q
L
R
----------------
K
WDAHSSVKF-----------
14
PsiBlast_PDB
88.65
22%
-140
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
---------------------
G
E
R
------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
-----------
2
PsiBlast_PDB
88.08
22%
-148
- C3 -
3REY
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
-----
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
1
PsiBlast_PDB
87.96
22%
-148
- C3 -
3PWH
1
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
-----
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
5
PsiBlast_PDB
87.72
22%
-146
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
-----
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
4
PsiBlast_PDB
87.45
22%
-145
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
-----
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
13
PsiBlast_PDB
87.13
22%
-142
- C3 -
4UG2
3
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
---------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
---------------
3
PsiBlast_PDB
86.67
22%
-144
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
-----
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
11
PsiBlast_PDB
86.56
22%
-141
- C3 -
2YDO
3
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
-
E
S
------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
-----------
7
PsiBlast_PDB
85.81
22%
-149
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
---------------------
G
E
R
------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
----------------
12
PsiBlast_PDB
85.66
22%
-143
- C3 -
2YDV
6
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
----------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
-----------
6
PsiBlast_PDB
83.66
22%
-152
- C3 -
3VG9
8
?
A:
[21-302]
-------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
---
L
G
W
N
N
------
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
-
E
S
Q
P
L
-----------
P
---------------------
G
E
R
------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
-------------------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
---------------
30
HHSearch
83.23
15%
-142
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-325]
------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
----
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
T
----------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
------------
Y
T
V
V
-------
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
------
V
V
K
M
M
I
V
----------------------
V
V
C
T
F
A
I
C
W
L
P
-
F
H
I
F
F
L
----
L
P
Y
-----
I
N
PDLYL
K
KFI
Q
Q
V
-----
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
----------------
R
C
C
P
F
I
S
A
G
D
-----------
33
HHSearch
83.03
17%
-139
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-334]
--------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
----
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----------
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
------------
Y
F
N
I
-------
V
M
S
V
S
N
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
------
L
A
K
I
S
I
V
----------------------
I
V
S
Q
F
L
L
S
W
S
P
-
Y
A
V
V
A
L
----
L
A
Q
-----
F
G
PLEWV
T
---
P
Y
A
-----
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
----------------
P
W
V
L
T
C
C
Q
F
D
-----------
40
Fugue
80.76
19%
-124
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----
M
N
G
T
E
G
PNF
Y
V
P
-----------------
F
S
NKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
T
----
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
------------
F
T
V
K
-------
E
A
A
A
-
Q
Q
Q
E
S
-----------
A
--------------------
T
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS
D
F
-----
G
---
P
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A----------
19
PsiBlast_PDB
76.98
19%
-136
- C3 -
3DQB
4
GNAT1_BOVIN (first)
A:
[55-317]
----------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
----
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
--------------
V
M
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-------
E
A
A
A
-
Q
Q
Q
E
S
-----------
A
--------------------
T
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
H
-----
Q
---
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
----------------
20
PsiBlast_PDB
76.61
19%
-132
- C3 -
3PQR
8
OPSD_BOVIN
A:
[55-317]
----------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FGG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
----
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
--------------
V
M
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-------
E
A
A
A
-
Q
Q
Q
E
S
-----------
A
--------------------
T
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
H
-----
Q
---
G
S
D
FG
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
----------------
17
PsiBlast_PDB
76.35
19%
-123
- C3 -
3C9L
12
OPSD_BOVIN
A:
[55-317]
----------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
----
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
--------------
V
M
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-------
E
A
A
A
-
Q
Q
Q
E
S
-----------
A
--------------------
T
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
H
-----
Q
---
G
S
D
FGPIF
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
D
D
E
-------------
16
PsiBlast_PDB
75.19
19%
-135
- C3 -
3CAP
4
OPSD_BOVIN
A:
[55-317]
----------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
----
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
--------------
V
M
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-------
E
A
A
A
-
Q
Q
Q
E
S
-----------
A
--------------------
T
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
H
-----
Q
---
G
S
D
FG
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
----------------
41
Fugue
75.04
16%
-127
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
P
N
-----
F
Y
V
PFSNKTGVVRSPFEAPQ
Y
Y
----------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
------
E
G
M
Q
--
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
------------
F
T
V
K
-------
E
A
A
A
-
S
A
T
T
Q
-----------
K
--------------------
A
E
K
E
------
V
T
R
M
V
I
I
----------------------
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
----
Y
I
F
T
H
QGS
D
F
-----
G
---
P
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A
18
PsiBlast_PDB
74.68
19%
-117
- C3 -
1F88
7
OPSD_BOVIN
A:
[55-317]
----------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
----
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
--------------
V
M
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
--
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-------
E
A
A
A
-----
S
-----------
A
--------------------
T
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
H
-----
Q
---
G
S
D
FGPIF
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
T
V
-----------