@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4M2_HUMAN: (2016-01-13 )
METANYTKVTEFVLTGLSQTPEVQLVLFVIFLSFYLFILPGNILIICTISLDPHLTSPMYFLLANLAFLDIWYSSITAPEMLIDFFVERKIISFDGCIAQLFFLHFAGASEMFLLTVMAFDLYTAICRPLHYATIMNQRLCCILVALSWRGGFIHSIIQVALIVRLPFCGPNELDSYFCDITQVVRIACANTFPEELVMICSSGLISVVCLIALLMSYAFLLALFKKLSGSGENTNRAMSTCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFNTLIFPLRNPIIYTLRNKEVKAAMRKLVTKYILCKEK
Atome Classification :
(20 SA)
--------------.........--10.......--.20---------------........--------.30........-----40........50........60-------------........70.--..----...-..80.......-.90....-----...---.100....-------------...110.......120.--..---....130.......140.......150.......160...-..-----.-.170.......180--------........190-----...--.....-----.200.......210.......220.......---230---------.-------------------..---.....240.-----......250.--------......260...--.-------.-----.---.270--------........280.........290....--------...300..------------------.....310.------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------META
N
Y
T
K
V
--
T
E
F
V
L
TGLS--QT----------------P
E
V
Q
L
V
L
F
--------
V
I
F
L
S
F
Y
L
F
IL-----PG
N
I
L
I
I
C
T
I
SLDPHLT
S
P
M
Y
F
-------------
L
L
A
N
L
A
F
L
D
I
W
--
Y
S
----SIT-
A
P
E
M
L
I
D
F
F
V
E-RKIISF
D
-----
G
C
I
---
A
Q
L
F
F
L
H
F-------------AGAS
E
M
F
L
L
T
V
M
A
F
D
L
Y
--
T
A
---
I
C
R
P
L
H
Y
A
T
I
M
NQ
R
L
C
C
I
L
V
A
L
SWRG
G
F
I
H
S
I
I
Q
V
A
L
I
VR-LP-----F-CG
P
N
E
L
D
S
Y
F
C
D
I
---------
T
Q
V
V
R
I
A
C
A-------NT
F
--
P
E
E
L
V
-----
M
I
C
SS
G
L
I
S
V
V
C
L
I
A
L
L
M
S
Y
A
F
L
L
A
L
F
K
K
LS---GS----------G-------------------EN---T
N
R
A
M
S
T
C
Y
-----
S
H
I
T
I
V
V
L
M
F--------G
P
S
I
Y
I
Y
A
RPFD--S-------F-----
S
---
L
D
K
---------
V
V
S
V
F
N
T
L
I
--
F
PLRN
P
I
I
Y
T
LR
N
K
E
V
--------
K
A
A
M
R
K
L
V
------------------
T
K
Y
I
LCKEK------------
13
PsiBlast_PDB
89.59
21%
-150
- C4 -
3C9L
13
OPSD_BOVIN
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
D
D
E
-------------
39
Fugue
89.48
19%
-147
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------
M
N
G
T
E
G
--
P
N
F
Y
V
P
F
S
N
--
K
T
GVVRSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
--------
A
Y
M
F
L
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
-----
P
-
E
G
-----------------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
S
----------
A
--------------------
T
---
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
--------
L
I
C
W
L
P
Y
A
G
V
A
F
--
Y
-------
I
-----
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A
15
PsiBlast_PDB
88.48
21%
-152
- C4 -
3DQB
4
GNAT1_BOVIN (first)
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
----------------
16
PsiBlast_PDB
87.84
21%
-152
- C4 -
3PQR
9
OPSD_BOVIN
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
FGG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
----------------
14
PsiBlast_PDB
87.79
21%
-144
- C4 -
1F88
7
OPSD_BOVIN
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
---------------------------------SAT
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
P
S
T
T
------------
18
PsiBlast_PDB
87.62
21%
-151
- C4 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
----------------
12
PsiBlast_PDB
87.34
21%
-151
- C4 -
3CAP
4
OPSD_BOVIN
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
----------------
17
PsiBlast_PDB
87.32
21%
-151
- C4 -
3PXO
4
OPSD_BOVIN
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
----------------
19
PsiBlast_PDB
87.03
21%
-150
- C4 -
4PXF
7
OPSD_BOVIN
A:
[40-317]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
----------------
20
PsiBlast_PDB
86.94
21%
-133
- C4 -
3OAX
16
OPSD_BOVIN
A:
[43-318]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
SA
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
P
L
G
D
------------
32
HHSearch
85.09
16%
-151
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-335]
-------------------------------------------------------
A
V
Y
Y
S
L
G
--------
I
F
I
G
I
C
G
I
I
G
C
-----
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
-------------
F
I
I
N
L
A
F
S
D
F
T
--
F
S
----
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
-
K
W
I
F
G
F
A
-----
A
C
K
---
V
Y
G
F
I
G
G
I
-------------
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
--
N
V
---
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
-
Y
T
-----
L
-----
E
G
V
L
C
N
C
S
F
---------
D
Y
I
-----
S
-------
R
D
S
--
T
T
R
S
N
-----
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
---
K
E
----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
---
E
M
R
L
A
K
I
S
I
-----
V
I
V
S
Q
F
L
L
S
W
--------
S
P
Y
A
V
V
A
L
L
A
Q
F
--
G
-------
P
LEWVT
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
--
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
--------
R
E
A
I
S
Q
T
F
------------------
P
W
V
L
T
C
C
Q
F
------------
10
PsiBlast_PDB
84.39
21%
-136
- C4 -
2X72
5
GNAT1_BOVIN (first)
A:
[43-318]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
Q
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
C
-------
F
-----
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
----------------
40
Fugue
82.47
19%
-126
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
--
F
E
A
P
Q
Y
Y
L
A
--
E
-----------------
P
W
Q
F
S
M
L
A
--------
A
Y
M
F
L
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
-
C
G
I
D
----
Y
Y
T
P
------------------
H
-------
E
E
T
--
N
N
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
AQQ
Q
E
----------
S
-------------------
A
T
---
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
--------
L
I
C
W
L
P
Y
A
G
V
A
F
--
Y
-------
I
-----
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------
46
Fugue
80.50
18%
-156
- C3 -
5AHR
2
A:
[1-343]
-------------S
M
T
C
P
F
Y
K
K
I
PG
T
G
F
T
V
D
A
F
Q
YG
V
V
----------------
E
G
C
T
A
Y
F
L
--------
T
H
F
H
S
D
H
Y
A
-----------------
G
L
S
K
H
F
T
F
P
V
Y
C
S
E
-----------
I
T
G
N
L
L
K
N
K
L
H
VQ
E
Q
----
Y
I
H
-
P
L
P
L
D
T
E
C
I
V
N
G
V
K
V
V
L
L
D
ANHCP
G
A
V
---
M
I
L
F
Y
L
P
N
G
T
V
I
L
H
TG
D
F
R
A
D
P
S
M
E
R
S
L
L
A
D
Q
K
V
H
M
L
Y
LD
T
T
---
Y
C
S
P
-
E
Y
T
F
P
S
Q
Q
E
V
I
R
F
A
I
N
T
A
F
E
A
V
T
L
N
P
--
H
A
L
V
V
C
G
-
T
Y
-----
S
-
I
G
K
E
K
V
F
L
A
I
A
D
V
L
G
S
K
V
G
M
S
Q
E
K
Y
K
T
L
Q
C
L
-------
N
I
---
P
E
I
N
S
-----
L
I
T
T
D
M
C
S
S
L
V
H
L
L
P
M
M
Q
I
N
------
F
K
G
L
Q
---
S
H
----------
L
-------------------
K
K
---
C
G
G
K
Y
N
Q
I
L
-----
A
F
R
P
T
V
I
P
Q
T
--------
K
G
N
I
S
I
Y
G
I
P
Y
S
--
E
-------
H
-----
S
---
S
Y
L
---------
E
M
K
R
F
V
Q
W
L
--
K
P
Q
K
I
I
P
T
V
N
V
G
T
W
K
S
--------
R
S
T
M
E
K
Y
F
------------------
R
E
W
K
L
E
A
G
Y
------------
11
PsiBlast_PDB
79.39
21%
-132
- C4 -
1LN6
1
OPSD_BOVIN
A:
[40-315]
-------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
IMLGF
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
FGGF
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
-----
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
----------------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---------
P
E
G
M
Q
C
S
C
G
-------
I
D
Y
YT
P
H
E
E
T
NNESF
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
-------------------
Q
E
SAT
T
Q
K
A
E
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
LICWLP
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
-------
F
-----
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
V
A
T
------------------
T
L
C
C
G
K
N
P
L
------------
31
HHSearch
77.78
15%
-142
* C4 *
2KS9
1
NK1R_HUMAN
A:
[33-325]
----------------------------------------------------------
V
L
W
A
--------
A
A
Y
T
V
I
V
V
T
S
V
-----
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
-------------
F
L
V
N
L
A
F
A
E
A
S
--
M
A
----
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
-
E
W
Y
Y
G
L
F
-----
Y
C
K
---
F
H
N
F
F
P
I
A
-------------
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
--
M
A
---
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
T
-----------
M
P
S
R
V
V
C
M
I
---------
E
W
P
E
----
H
-------
P
N
K
I-
Y
E
K
V
Y
-----
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
---
I
P
GDSSDRYH
E
Q
V
-------------------
S
A
---
K
R
K
V
V
K
M
M
I
-----
V
V
V
C
T
F
A
I
C
W
--------
L
P
F
H
I
F
F
L
L
P
Y
I
--
N
-------
P
DLYLK
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
S
--
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
--------
R
L
G
F
K
H
A
F
------------------
R
C
C
P
F
I
S
A
G
------------
29
HHSearch
77.39
17%
-134
- C4 -
1U19
14
OPSD_BOVIN
A:
[40-329]
---------------------------------------------------------
F
S
M
L
A
--------
A
Y
M
F
L
L
I
M
L
G
F
-----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
-------------
I
L
L
N
L
A
V
A
D
L
F
--
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
-----
G
C
N
---
L
E
G
F
F
A
T
L
-------------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
--
V
V
---
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
-----
P
-----
E
G
M
Q
C
S
C
G
I
---------
D
Y
Y
T
---
P
H
-------
E
E
T
--
N
N
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
---
A
Q
----------
Q
QESA
T
T
Q
------------
K
A
---
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S------
D
FG---
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
T
L
------------------
C
C
G
K
N
P
L
G
D
------------
27
HHSearch
76.67
19%
-125
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
------------------------------------------------------
T
L
N
K
Y
V
V
I
--------
I
A
Y
A
L
V
F
L
L
S
L
-----
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
-------------
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
----
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
-
G
W
I
F
G
T
F
-----
L
C
K
---
V
V
S
L
L
K
E
V
-------------
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
--
L
A
---
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
-
Y
H
-----
P
-----
N
N
S
S
P
V
C
Y
E
---------
V
L
G
N
----
D
-------
T
A
K
--
W
R
M
V
L
-----
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
---------------
M
-------------------
G
Q
---
K
H
R
A
M
R
V
I
F
-----
A
V
V
L
I
F
L
L
C
W
--------
L
P
Y
N
L
V
L
L
A
D
T
L
--
M
RTQVIQE
S
C
E
R
R
N
N
I
G
-
R
A
L
---------
D
A
T
E
I
L
G
F
L
--
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
--------
R
H
G
F
L
K
I
L
------------------
A
M
H
G
-----------------
45
Fugue
74.28
15%
-150
- C1 -
1A6Q
3
PPM1A_HUMAN
A:
[2-368]
------GAFLDKPK
M
E
K
H
N
A
Q
G
Q
--
G
N
G
L
R
Y
G
L
S
--
S
M
QGWRVEM---------
E
D
A
H
T
A
V
I
G
LPSGLES
W
S
F
F
A
V
Y
D
G
H
A
-----
G
S
Q
V
A
K
Y
C
C
E
H
L
L
D
H
I
T
N
N
Q
D
F
KGSAGAPS
V
E
N
V
K
N
G
I
R
T
G
F
L
E
I
D
--
E
H
----
M
R
V
-
M
S
E
K
--
K
H
G
A
D
-
R
S
G
S
T
A
V
-----
G
V
L
ISP
Q
H
T
Y
F
I
N
C
--------------
G
D
S
R
G
L
L
C
R
N
R
K
V
H
F
F
--
T
Q
D
H
K
P
S
N
P
L
E
K
E
R
I
Q
N
A
G
G
S
V
M
I
Q
R
V
N
G
S
L
A
V
S
R
A
L
G
D
F
D
Y
K
C
V
-
H
G
-----
K
-
G
P
T
E
Q
L
V
S
P
E
P
E
V
---------
H
D
I
E
R
-----------
S
E
E
--
D
D
Q
F
I
-----
I
L
A
C
D
G
I
W
D
V
M
G
N
E
E
L
---
C
D
F
V
R
S
R
L
E
V
T
D
---
D
L
----------
E
-------------------
K
V
---
C
N
E
V
V
D
T
C
L
Y
K
GSR
D
N
M
S
V
I
L
I
C
F
PN------
A
P
K
V
S
P
E
A
V
K
K
E
--
A
-------
E
-----
L
---
D
K
Y
---------
L
E
C
R
V
E
E
I
I
KG
V
P
D
L
V
H
V
M
R
T
L
A
S
E
N
I
PSLPPGGE
L
A
S
K
R
N
V
I
------------------
E
A
V
Y
N
R
L
N
P
Y-----------
25
HHSearch
65.51
20%
-168
- C4 -
3EML
8
ENLYS_BPT4
A:
[21-219]
---------------------------------------------------------
S
S
V
Y
I
--------
T
V
E
L
A
I
A
V
L
A
I
-----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
-------------
F
V
V
S
L
A
A
A
D
I
A
--
V
G
----
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
-----
G
C
L
---
F
I
A
C
F
V
L
V
-------------
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
--
I
A
---
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
-
C
G
-----
Q
--------
S
Q
G
C
G
E
---------
G
Q
---
V
A
C
L
-------
F
E
D
VV
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
---
N
I
----------
F
-------------------
E
M
---
L
R
I
D
E
G
L
R
L
-----
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
I
G
H
L
L
T
K
S
P
--
S
-------
L
-----
N
---
A
A
K
---------
S
E
L
D
K
A
I
G
R
--
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
--------
Q
D
V
D
A
A
V
R
------------------
G
I
L
R
N
A
K
L
K
------------