@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4Q3_HUMAN: (2016-01-13 )
MKKEQDSNVTEFVLLGLSSSWELQLFLFLLFLFFYIAIVLGNLLIVVTVQAHAHLLQSPMYYFLGHLSFIDLCLSCVTVPKMLGDFLQQGKSISFSGCLAQIYFLHFLGASEMFLLTVMAYDRYVAICNPLRYLTVMNPQLCLWLVLACWCGGFIHSIMQVILVIQLPFCGPNELDNFYCDVPQVIKLACMDTYVVEVLVIANSGLLSLVCFLVLLFSYAIILITLRTHFCQGQNKVFSTCASHLTVVSLIFVPCVFIYLRPFCSFSVDKIFSLFYTVITPMLNPLIYTLRNTDMKTAMKKLRIKPCGIPLPC
Atome Classification :
(20 SA)
.........10-------------.........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160......-----.-170........-180.......190-....------....200......-------.210.......220.....-..------230------------...------....240----...-......250...--------....260....-----.----------.--.270-------.-------------.---......--.----280.......290.......300..-----------------.....310.-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKEQDSNV
T
--------------
E
F
V
L
LGLSSS
W
E
L
Q
L
F
L
F
L
L
F
L
F
F
Y
I
A
I
V
LG
N
L
L
I
V
V
T
V
Q
A
H
A
H
L
L
QS
P
M
Y
Y
F
L
G
H
L
S
F
I
D
L
C
L
S
C
V
T
V
P
K
M
L
G
D
F
L
QQGKSI
S
F
S
G
C
L
A
Q
I
Y
F
L
H
F
LGA
S
E
M
F
L
L
T
V
M
AYD
R
Y
V
A
I
CN
P
L
R
Y
L
TVMN
P
Q
L
C
L
W
L
V
L
A
C
W
C
G
G
F
I
H
S
I
M
Q
V
I
L
V
I
QLP-----F-CG-
P
N
E
L
D
N
FY-CD
V
P
Q
V
I
K
L
A
C
M
--
D
T
Y
V
------
V
E
V
L
V
IANS
G
L
L
S
-------
L
V
C
F
L
V
L
L
F
S
Y
A
I
I
L
I
T
L
R
-
T
H
------FCQ------------G
Q
N
------
K
V
F
S
T
------
C
A
S
-
H
L
T
V
V
S
L
I
F
V
P
C
--------
V
F
I
Y
L
R
P
F
CSF-----
S
----------
V
--
D
K
---------
I
-------------
F
---
S
L
F
Y
T
V
--
I
----
T
P
M
L
N
P
L
I
Y
T
LRNT
D
M
K
T
A
M
K
K
LRI-----------------KPCGIPLPC-----------
3
PsiBlast_PDB
94.88
23%
-178
- C3 -
3REY
1
AA2AR_HUMAN
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
Q
P
-------G
C
G
E
G
Q
V
---
A
C
L
F
E
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
QPLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
-------------------
2
PsiBlast_PDB
94.53
23%
-175
- C3 -
3PWH
1
?
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
Q
P
-------G
C
G
E
G
Q
V
---
A
C
L
FE
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
QPLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
-------------------
4
PsiBlast_PDB
94.27
23%
-175
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
Q
P
-------G
C
G
E
G
Q
V
---
A
C
L
F
E
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
-------------------
5
PsiBlast_PDB
93.46
23%
-176
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
Q
P
-------G
C
G
E
G
Q
V
---
A
C
L
F
E
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
-------------------
6
PsiBlast_PDB
93.42
23%
-176
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
Q
P
-------G
C
G
E
G
Q
V
---
A
C
L
F
E
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
-------------------
44
Fugue
92.47
19%
-153
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVRSPF
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
---------------------
A
P
P
L
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
I
-
D
Y
Y
T
PHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
-------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
A-----
A
S
A
------------
T
T
Q
------
K
A
E
K
E
------
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
-----
F
----------
T
--
H
Q
GSDFGPIFM
T
-------------
I
---
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----------------
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A
8
PsiBlast_PDB
91.59
22%
-163
- C3 -
2YDV
6
?
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
-
Q
P
K
E
G
K
A
H
-
S
Q
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
Q--------
S
T
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
H
V
L
R
Q
Q
E
P
-----------
7
PsiBlast_PDB
91.55
22%
-161
- C3 -
2YDO
3
?
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
-
Q
P
K
E
G
K
A
H
-
S
Q
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
----------
T
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
H
V
L
R
Q
Q
E
P
-----------
1
PsiBlast_PDB
90.59
22%
-162
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[17-283]
-------------------------------------------------
L
A
I
V
F
G
N
V
L
-
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-----
W
-
Y
R
-
A
T
H
Q
E
A
I
N
-
C
Y
A
E
E
----
T
C
C
--
D
F
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-------
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-
R
Q
L
Q
KIDK
F
C
L
------------
K
E
H
------
K
A
L
K
T
------
L
G
I
-
I
M
G
T
F
T
L
C
W
L
P
F
--------
F
I
V
N
I
V
H
V
I
Q
D
-----
N
----------
L
IR
K
E
---------
V
-------------
Y
---
I
L
L
N
W
I
G
Y
V
----
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------
L
-------------------
10
PsiBlast_PDB
90.04
22%
-165
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
-
Q
P
K
E
G
K
A
----
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
H
V
L
R
Q
Q
E
P
-----------
18
PsiBlast_PDB
89.80
20%
-156
- C3 -
3C9M
1
OPSD_BOVIN
A:
[31-317]
------------------------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----------------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-----
L
A
C
A
-
A
P
P
L
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
--
I
D
Y
Y
------
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
------
A
A
Q
------------
Q
Q
E
------
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
--------
F
L
I
C
W
L
P
Y
A
G
V
-----
A
F
Y
I
F
T
H
QGSC
F
--
G
P
---------
I
-------------
F
MTI
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----------------
C
G
K
N
P
---------------
12
PsiBlast_PDB
88.43
22%
-170
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
-
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
Q
PLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
H
V
L
----------------
9
PsiBlast_PDB
87.94
22%
-163
- C3 -
4UG2
3
?
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
-
Q
P
K
E
G
K
A
H
-
S
Q
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-
R
Q
------
L
------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
H
V
L
R
---------------
11
PsiBlast_PDB
87.53
22%
-170
- C3 -
3VG9
8
?
A:
[21-302]
----------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
W
N
-----
N
-
C
G
-
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-------
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-
R
Q
------
L
K
Q
------------
M
E
S
Q
PLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-----
A
--------------
P
---------
L
-------------
W
---
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
-----------------
S
H
V
L
R
---------------
34
HHSearch
86.08
17%
-159
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
---------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
-
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
-----------
T
M
P
S
R
V
V
-
C
M
I
E
W
P
E
H
---
P
--
N
K
I
Y
------
E
K
V
Y
H
I
C
V
T
V
L
I
Y
-------
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
-
A
S
------
E
I
P
GDSSDRYH
E
Q
V
S
A
K
R
------
K
V
V
K
M
------
M
I
V
-
V
V
C
T
F
A
I
C
W
L
P
F
--------
H
I
F
F
L
L
P
Y
I
N
P
DLYLK
K
FI
Q
-------
Q
--
V
Y
---------
L
-------------
A
---
I
M
W
L
A
M
--
S
----
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
-----------------
C
C
P
F
I
S
A
G
D
-----------
16
PsiBlast_PDB
85.22
20%
-160
- C3 -
4BEZ
3
OPSD_BOVIN
A:
[34-318]
------------------------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
D
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----------------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-----
L
A
C
A
-
A
P
P
L
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
--
I
D
Y
Y
------
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
------
A
A
Q
------------
Q
Q
E
------
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
--------
F
L
I
C
W
L
P
Y
A
G
V
-----
A
F
Y
I
F
T
H
QG
S
C
F
--
G
P
---------
I
-------------
F
M
T
I
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----------------
C
G
K
N
----------------
17
PsiBlast_PDB
85.21
20%
-157
- C3 -
4BEY
4
OPSD_BOVIN
A:
[34-318]
------------------------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
D
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----------------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-----
L
A
C
A
-
A
P
P
L
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
--
I
D
Y
Y
------
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
------
A
A
Q
------------
Q
Q
E
------
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
--------
F
L
I
C
W
L
P
Y
A
G
V
-----
A
F
Y
I
F
T
H
QG
S
C
F
--
G
P
---------
I
-------------
F
M
T
I
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----------------
C
G
K
N
----------------
14
PsiBlast_PDB
84.85
20%
-161
- C3 -
4A4M
4
OPSD_BOVIN
A:
[34-318]
------------------------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----------------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-----
L
A
C
A
-
A
P
P
L
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
--
I
D
Y
Y
------
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
------
A
A
Q
------------
Q
Q
E
------
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
Y
V
I
A
--------
F
L
I
C
W
L
P
Y
A
G
V
-----
A
F
Y
I
F
T
H
QG
S
C
F
--
G
P
---------
I
-------------
F
M
T
I
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----------------
C
G
K
N
----------------
13
PsiBlast_PDB
84.19
20%
-160
- C3 -
2X72
5
GNAT1_BOVIN (first)
A:
[34-318]
------------------------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----------------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-----
L
A
C
A
-
A
P
P
L
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
--
I
D
Y
Y
------
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-
E
A
------
A
A
Q
------------
Q
Q
E
------
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
--------
F
L
I
C
W
L
P
Y
A
G
V
-----
A
F
Y
I
F
T
H
QG
S
C
F
--
G
P
---------
I
-------------
F
M
T
I
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----------------
C
G
K
N
----------------
43
Fugue
81.64
19%
-157
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVRSPF
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
-
C
G
-
I
D
----
Y
Y
-
T
P
H
E
E
T
----
N
N
--
E
S
F
V
------
I
Y
M
F
V
V
H
F
------------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------
A
Q
Q
------------
Q
E
S
------
A
T
T
Q
K
------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
--------
F
L
I
C
W
L
P
Y
A
G
V
-----
A
----------
F
--
Y
I
---------
F
T
H
QGSDFGPIFM
T
I
---
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------