@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4X1_HUMAN: (2016-01-13 )
MVATNNVTEIIFVGFSQNWSEQRVISVMFLLMYTAVVLGNGLIVVTILASKVLTSPMYFFLSYLSFVEICYCSVMAPKLIFDSFIKRKVISLKGCLTQMFSLHFFGGTEAFLLMVMAYDRYVAICKPLHYMAIMNQRMCGLLVRIAWGGGLLHSVGQTFLIFQLPFCGPNIMDHYFCDVHPVLELACADTFFISLLIITNGGSISVVSFFVLMASYLIILHFLRSHNLEGQHKALSTCASHVTVVDLFFIPCSLVYIRPCVTLPADKIVAVFYTVVTPLLNPVIYSFRNAEVKNAMRRFIGGKVI
Atome Classification :
(20 SA)
-----------------------------.........10------------........20........30........---40........50.---.......60........70....-....80.......-.90....-....100........110........120.......130.......140....---...150.......160.-..-----....170.......180.-----.....------.190.......200---.......-----210........220.....----------------.------------.---------------------230.......240--.........250.......260.---.--.---------.---...---------..270...--.----...280.......290.......300...---------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------MVATN
N
V
T
E
I
I
------------
F
V
GFSQNW
S
E
Q
R
V
I
S
V
M
F
L
L
M
Y
T
A
V
V
LG---N
G
L
I
V
V
T
I
L
A
S
K
V---L
T
S
P
M
Y
F
F
L
S
Y
L
S
F
V
E
I
C
Y
C
SVM-
A
P
K
L
I
F
D
S
F
I
K
R
K
-
V
I
S
L
K
G
C
-
L
T
Q
M
F
-
S
L
H
FFG
G
T
E
A
F
-
L
L
M
V
M
A
YD
R
Y
V
A
I
C
K
P
L
H
Y
M
A
I
M
N
Q
R
M
C
G
L
L
V
R
I
A---WGG
G
L
L
H
SVG
Q
T
F
L
I
F
Q-LP-----FCG
P
N
I
M
D
H
Y
FC
D
V
H
P
V
L
-----
E
L
A
CA------D
T
F
F
I
S
L
L
I
I
TNGG---
S
I
S
V
V
S
F
-----
F
V
-
L
M
A
S
Y
L
I
I
L
H
F
L
R
SHN----------------L------------E---------------------
G
Q
H
K
A
L
S
T
C
AS----H
V
T
V
V
D
L
F
FIP
C
S
L
V
Y
IRPC--V---T--L---------P---
A
D
K
---------
I
V
A
V
F
Y
T
V
--
V
----
T
P
L
L
N
P
V
I
Y
S
FR
N
A
E
V
K
N
A
M
R
R
F
IGGKVI---------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
92.44
23%
-156
- C6 -
2Y00
13
ADRB1_MELGA
A:
[6-300]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
QS
R
V
M
----------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
92.43
23%
-153
- C6 -
3ZPQ
11
ADRB1_MELGA
A:
[6-300]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
QS
R
V
M
----------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.28
23%
-156
- C6 -
2Y01
12
ADRB1_MELGA
A:
[6-300]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
QS
R
V
M
----------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
91.72
23%
-156
- C6 -
2Y04
13
ADRB1_MELGA
A:
[6-300]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
EQS
R
V
M
----------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
91.68
23%
-155
- C6 -
4AMJ
12
ADRB1_MELGA
A:
[6-300]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
QS
R
V
M
----------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.33
23%
-156
- C6 -
2Y02
13
ADRB1_MELGA
A:
[6-300]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
QS
R
V
M
----------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.28
23%
-151
- C6 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
----------------------------------------------------------
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
DRAS
K
R
K
R
V
M
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
90.36
23%
-156
- C6 -
3ZPR
11
ADRB1_MELGA
A:
[6-299]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
QM-------------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
89.00
23%
-154
- C6 -
2Y03
9
ADRB1_MELGA
A:
[6-300]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
IRS
R
V
M
--------
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.11
23%
-163
- C6 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
-----------------------------------------------------------
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
IR------------------------------------------------
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.18
23%
-154
- C6 -
2YCY
6
ADRB1_MELGA
A:
[10-298]
-----------------------------------------------------------
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
RDRASKR
K
R
V
M
--
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.13
23%
-150
- C6 -
2YCW
7
ADRB1_MELGA
A:
[6-298]
-------------------------------------------------------
L
S
Q
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
IDRASKRKR
V
M
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.87
23%
-156
- C6 -
2YCZ
2
ADRB1_MELGA
A:
[9-298]
----------------------------------------------------------
Q
W
E
A
G
--
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
---
N
V
L
V
I
A
A
I
G
S
T
Q
R
---
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
---
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
---
W
A
I
S
A
L
V
S
F
---------
L
P
----------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
------
D
-------
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
-----
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
IDRASK
R
K
R
V
M
L
------------
M
---------------------
R
E
H
K
A
L
K
T
L
G
I
----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
--
F
---
N
RD
L
---------
V
---
P
D
W
---------
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
82.55
15%
-150
* C6 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
----------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
---
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
-
K
F
H
N
F
-
F
P
I
A
A
V
F
A
S
I
Y
-
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
---
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
--
T
E
-----
T
----
M
P
S
R
V
V
C
M
I
E
W
P
E
-----
H
P
---------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
---
L
I
Y
F
L
P
L
-----
L
V
-
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
----------------
I
PGDSSDRYH
E
Q
V
S
---------------------
A
K
R
K
V
V
K
M
M
I
V
----
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
--
I
NPD
L
YL
K
---------
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
--
S
----
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
81.58
17%
-148
- C6 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-------------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
---
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
-
K
V
Y
G
F
-
I
G
G
I
F
G
F
M
S
I
M
-
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
---
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
-
Y
T
-----
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
----------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
---
L
G
F
F
G
P
I
-----
L
I
-
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
----------------
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
----
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
GPL
E
WV
T
---------
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
--
A
----
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
80.23
18%
-137
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------------------
M
N
G
T
E
G
P
N
F
Y
V
PFSNKTGVVRSP
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
-
N
L
E
G
F
-
F
A
T
L
G
G
E
I
A
L
W
-
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
-----
P
E
G
--
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-----
E
E
T
N
N
------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
-----
C
Y
-
G
Q
----
L
V
F
T
V
K
E
A
A
A
----------------
S
------------
A
---------------------
T
T
Q
K
A
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
---
Y
--
I
---------
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A-----------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
77.86
17%
-166
- C4 -
3ZPJ
-
?
A:
[1-356]
M
T
T
L
E
E
I
N
L
L
V
E
R
GY
Y
E
E
A
L
A
K
V
YEIED
P
I
E
Q
V
Q
V
L
T
K
I
V
------------
V
T
I
Y
Q
H
D
G
P
M
E
W
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
L
R
D
P
A
N
K
A
V
A
Y
S
I
I
A
S
T
L
---
A
I
------
M
E
Y
E
E
D
A
M
D
F
F
N
R
A
I
-
D
E
A
N
E
I
E
S
-
P
I
E
K
-
G
M
V
L
S
T
L
-
A
Y
H
L
A
-
I
A
G
Y
--
P
D
N
A
L
-
E
I
F
N
I
A
F
D
T
I
I
G
A
E
T
S
Y
T
H
K
V
D
G
I
L
R
I
G
D
L
L
E
K
A
G
D
T
L
P
S
N
E
A
M
D
F
Y
K
M
A
F
D
I
F
D
-
K
L
-----
H
-----
V
N
Q
R
A
A
I
V
E
K
K
I
-----
E
L
A
K
T
V
YDVGL
P
Q
I
R
A
A
L
L
K
G
K
N
H
Y
---
A
L
A
I
I
K
K
K
YSG
V
M
R
-
L
I
G
E
L
E
V
A
L
W
M
K
R
V
N
N
ME
Y
-------------
L
------------
D
---------------------
V
V
D
K
A
F
E
C
C
E
S
PRFT
D
V
N
V
Q
H
I
A
R
L
L
T
E
L
G
N
L
R
R
A
--
L
---
K
--
F
A
K
E
IQN
I
H
K
R
---
S
E
A
---------
L
K
A
I
A
L
E
L
--
V
R
R
KK
F
E
E
V
K
K
I
I
E
S
I
P
D
P
K
I
R
E
E
A
L
N
E
I
G
T
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
75.93
18%
-116
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------------------
M
N
G
T
E
G
P
N
F
Y
V
PFSNKTGVVRSP
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
-
N
L
E
G
F
-
F
A
T
L
G
G
E
I
A
L
W
-
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
---
D
Y
Y
T
P
H
----------
E
E
T
N
N
------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
-----
C
Y
-
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
----------------
S
------------
A
---------------------
T
T
Q
K
A
E
K
E
V
T
R
----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
---
Y
--
I
---------
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA-----------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
71.01
11%
-131
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
-
E
F
W
T
S
-
I
D
V
L
C
V
T
A
S
I
E
-
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
-------
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
----------
C
D
------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
---
S
F
----
Y
-----
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
----------------
R
------------
Q
---------------------
L
N
I
F
E
M
L
R
I
D
E
----
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
--
L
---
L
--
T
---------
K
---
S
P
S
---------
L
N
A
A
K
S
E
L
--
D
----
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
35
HHSearch
70.49
16%
-131
- C6 -
1U19
14
OPSD_BOVIN
A:
[41-326]
---------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
-
N
L
E
G
F
-
F
A
T
L
G
G
E
I
A
L
W
-
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
I
-----
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
-----
P
---
H
------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
---
V
H
F
I
I
P
L
-----
I
V
-
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
----------------
A
------------
Q
QQESA
T
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
----
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---
G
SD
F
G--------
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
--
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------